Expression of VISTA regulated via IFN-γ governs endogenous T-cell function and exhibits correlation with the efficacy of CD19 CAR-T cell treated B-malignant mice by Li Zhao, Kai Zhao, Donghai Tang, Fen Yan, Chunxiao Ren, Kailin Xu

“…Furthermore, we examined the role of VISTA controlled by interferon (IFN)-γ signaling in regulating endogenous T-cell activation and functionality in B-ALL mice.Results We demonstrated that the administration of CD19 CAR-T or hCAIX CAR-T cell therapy elicited augmented immune responses of endogenous T cells within the TME of B-ALL, lymphoma, and melanoma mice, thereby substantiating the efficacy of CAR-T cell efficacy. …”
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Speckle Strain Analysis of Left Ventricular Dysfunction in Paediatric Patients with Bicuspid Aortic Valve—A Pilot Study by Amalia Făgărășan, Simina-Elena Ghiragosian-Rusu, Claudiu Ghiragosian, Liliana Gozar, Carmen Suteu, Daniela Toma, Flavia Cristina Al-Akel, Manuela Cucerea

“…The study enrolled children aged 6 to 17 years with BAV who were undergoing periodic evaluation, as well as a control group. The primary objective was to analyse the systolic function (global and segmental LV) using the classical method (LV EF) and speckle tracking echocardiography (STE). …”
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Morphological and biochemical composition of blood in early post-partum cows when feeding a complex of biologically active substances by R. V. Rusakov, N. A. Garifullina

“…The duration of the period from calving to the first insemination was 3.7 and 6.7 days shorter in comparison with the control in the first and second experimental groups, respectively. …”
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Rationale and design of the open-label, prospective, randomized study of the efficacy of intravenous versus oral iron deficiency therapy in improving left ventricular systolic func... by D R Khastieva, M I Malkova, E B Zakirova, I I Zakirova, I H Valeeva, N R Khasanov

“…Iron has a protective effect on cardiomyocytes during hypoxia, while iron deficiency (ID) directly affects its function, disrupting mitochondrial respiration, reducing their contractility and relaxation. …”
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Slowing down in PNP: relationship of joint velocities in an arm-movement test and the fast TUG test by Isabelle D. Walz, Sarah Waibel, Vittorio Lippi, Albert Gollhofer, Christoph Maurer

“…Moreover this reduction of joint velocities was almost evenly distributed across the velocity traces as a function of time. …”
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Exogenous proline enhances salt acclimation in soybean seedlings: Modifying physicochemical properties and controlling proline metabolism through the ornithine-glutamate dual pathw... by Lei Yan, Mu Lu, Muhammad Riaz, Kaiqing Tong, Hualong Yu, Guang Gao, Yusheng Niu

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Different light color temperatures in the morning on the effectiveness of rehabilitation training in patients with ischemic stroke: a prospective, single-center, randomized control... by Nan Wang, Yan Xue, Tongyue Wang, Fengxi Qiu, Cheng Li, Zhiyuan Wang, Jianke Jiang, Yi Lu, Yingqi Shao, Zhongfei Bai, Danmei Lan, Qilong Hu, Hengjing Wu

“…Methods The study was designed as a prospective, single-center, randomized controlled trial. 48 patients with ischemic stroke were randomly divided into three groups (1:1:1): warm light group (WLG, 500 lx, 3000 K, n = 16), cold light group (CLG, 500 lx, 6500 K, n = 16), and control group (CG, 500 lx, 5000 K, n = 16). …”
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Parboiled Rice and Glycemic Control: Effects on Postprandial Glucose, Insulin Sensitivity, and Incretin Response in Healthy and Type 2 Diabetic Individuals, a Pilot Study by Sara Alkandari, Tasleem A. Zafar, Suleiman Al-Sabah, Mohammed Abu Farha, Jehad Abubaker, Fahd Al-Mulla

“…Nevertheless, the impact of PBR consumption on insulin sensitivity, β-cell function, and incretin hormone responses remains poorly understood. …”
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Acute health effects of ambient air pollution including ultrafine particles in a semi-experimental setting in young, healthy individuals by Elisabeth Folwarczny, Felix Forster, Rudolf A. Jörres, Stefan Rakete, Sheng Ye, Mark Wenig, Nadine Gawlitta, Jürgen Schnelle-Kreis, Richard Winterhalter, Alexander Müller, Dennis Nowak, Stefan Karrasch

“…Abstract Background Multiple effects of ultrafine particles (UFP) on human subjects are known but there is less knowledge of how relative exposure levels between ultrafine and fine particles as typically encountered in large cities affect lung function and cardiovascular parameters. Methods Four sites with high/low levels of ultrafine particles and/or fine particles were selected in the city of Munich, Germany: control area (woodland), urban environment, heavy traffic site, biomass combustion (beech wood). …”
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Effects of a 12-week intrinsic foot muscle strengthening training (STIFF) on gait in older adults: a parallel randomized controlled trial protocol by Lydia Willemse, Eveline J. M. Wouters, Martijn F. Pisters, Benedicte Vanwanseele

“…Strengthening the plantar intrinsic foot muscles might benefit mobility in older adults, which may contribute to the reduction of fall risk. The aim of this paper is to provide a protocol to investigate the effect of a plantar intrinsic foot muscle strengthening training versus no training on gait and intrinsic foot muscle function in older adults who are involved in a functional exercise program. …”
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Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia by Binyu Xing, Cunyi Shen, Ting Lin, Xiaoning Li, Wenjun Tan

“…After treatment, in both groups, symptom scores for fever, cough, expectoration, and dyspnea were reduced, with the combined group showing more significant improvement; SaO2 and PaO2 levels increased, and PaCO2 decreased, with the combined group achieving greater improvement; FEV1, FVC, and PEF values increased, with higher values observed in the combined group; serum IL-6, TNF-α, and CRP levels decreased, with the combined group showing more substantial reductions (all P < 0.05). The incidence of adverse events was 4.35% in the combined group and 2.90% in the control group (P > 0.05).ConclusionModified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride demonstrated ideal clinical efficacy in treating severe pneumonia, alleviating symptoms and pulmonary inflammation and improving arterial blood gas indicators and lung function.…”
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Changes in thyroid hormone status following induction chemotherapy in patients with pediatric acute lymphoblastic leukemia by Jingzi Zhong, Haini Yang, Dan Zeng, Dan Lan

“…Through a prospective analysis of 96 newly diagnosed ALL patients against healthy controls, we assessed thyroid function at diagnosis and after induction chemotherapy. …”
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Effect of low-dose aspirin on reducing cardiovascular events and mortality in individuals with CKD stages 3–5: a meta-analysis of randomized controlled trials by Jingwen Lin, Xueqiong Cao, Wu Fu, Liu Yang, Wanxian Zeng, Na Li, Maobai Liu, Hongfu Cai

“…Methods Randomized controlled trials (RCTs) regarding the use of low-dose aspirin for cardiovascular primary prevention for patients with CKD were searched in PubMed, Embase, and the Cochrane Library. …”
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The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult... by Toby M Maher, A John Simpson, Anthony Cahn, David Thickett, Luke Vale, Allan B Clark, Nazia Chaudhuri, Ian Forrest, Lisa G Spencer, Christopher Ward, Stephen Jones, Ganesh Raghu, Andrew M Wilson, Helen Parfrey, Megan Jones, Matthew Hammond, Jaclyn Ann Smith, Shajahan Wahed

“…We aim to undertake an adequately powered double-blind placebo-controlled randomised multicentre clinical trial to assess the change in forced vital capacity (FVC), cough and other important patient-reported outcomes, following 12-month therapy with PPIs in people with IPF.Methods and analysis A total of 298 patients with IPF diagnosed by a multidisciplinary team according to international guidelines who are not receiving PPIs will be enrolled. …”
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Experimental Study of the Kinematics of a Double-Row Planetary Mechanism Using Two Elliptical External Gears by A. A. Prikhodko, N. N. Belina, A. V. Novitskiy, M. M. Shchetinin

“…Mechanisms with non-circular gears are of wide interest to researchers and inventors due to their compactness and the implementation of a wide range of transfer functions. The development of this area is stimulated by the advancements and reduction in cost of mechanical processing and additive manufacturing technologies, as well as the use of applied mathematical modeling packages for the analysis and synthesis of non-circular gears. …”
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Pelvic Floor Adaptation to a Prenatal Exercise Program: Does It Affect Labor Outcomes or Levator Ani Muscle Injury? A Randomized Controlled Trial by Aránzazu Martín-Arias, Irene Fernández-Buhigas, Daniel Martínez-Campo, Adriana Aquise Pino, Valeria Rolle, Miguel Sánchez-Polan, Cristina Silva-Jose, Maria M. Gil, Belén Santacruz

“…Six months after delivery, there was an absolute risk reduction of 32.5% of levator ani muscle avulsion in the exercise group compared to the control group (53.3% and 20.8%, respectively; <i>p</i> = 0.009). …”
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Evaluation of the efficiency and safety of magnet therapy for osteoarthritis. Results of the multicenter blind placebo-controlled study COSMO (Clinical Evaluation of Current Magnet... by A. E. Karateev, E. Yu. Pogozheva, M. L. Sukhareva, A. M. Lila, A. V. Ivanov, I. P. Osnovina, O. V. Shchashkova, S. V. Borisova, N. Е. Larinsky, Yu. A. Israelyan, S. А. Afoshin, T. P. Bondarenko, E. А. Repchanskaya, L. A. Chernyavskaya, S. P. Pupina, T. V. Darmova

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Controlled Synthesis of TiB2-TiC Composite: Substantiation of the Homogenizing Joule Thermostatting Efficiency and Improvement of SHS-Compaction Technology in a Vacuum by Gigo Jandieri, David Sakhvadze

“…For this purpose, an improved technological approach is proposed, which is based on the known method of SHS-compacting but differs by the possibility of controlled Joule influence on the synthesis products, which is achieved by the use of a special electrothermal vacuum press-mold functioning according to a particular control algorithm. …”
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Comparison of outcome of ultrasound-guided suprascapular nerve block versus intra-articular steroid injection in adhesive capsulitis of shoulder: A randomized control trial by Davinder Kumar Verma, Osama Neyaz, Srishti Nanda, Gita Handa

“…The aim of the present study was to compare the effectiveness of ultrasound-guided suprascapular nerve block (USNB) with intra-articular steroid injection (IASI) in AC of shoulder in providing pain relief, functional improvement, and reduction of disabilities. …”
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Effectiveness of adapted self-help plus (SH+) to reduce psychological distress among university students in Indonesia (APRESIASI): protocol of a randomized controlled trial by Dhini Andriani, Fredrick D. Purba, Anke B. Witteveen, Neily Zakiyah, Marit Sijbrandij

“…The secondary outcomes are symptoms of depression, anxiety, perceived stress, functioning, resilience, quality of life, identified problems, treatment acceptability, and cost-effectiveness. …”
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