Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

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The Muscle Cells in Pelvic Floor Dysfunctions: Systematic Review by Ana Margarida Vieira, Maria Leonor Faleiro, Miguel Mascarenhas-Saraiva, Sandra Pais

“…The aim of this study was to perform an update on the pelvic floor muscle structure and function alterations of women with pelvic floor dysfunctions. …”
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Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis by Yao Zhang, Nan Mu, Shun Qi, Chuanzhu Sun, Yang Rao, Xinyi Yang, Jianying Guo, Yunfeng Mu

“…GRETNA software was used to analyze brain network characteristics according to graph theory.ResultsA total of 32 patients (aged 18-55) and 28 healthy controls (aged 20-51) had been recruited. Patients after IT-TMS treatment had significant reduction in suicidal ideation and depressive symptom. …”
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Early mobilization in patients with aneurysmal subarachnoid haemorrhage may im-prove functional status and reduce cerebral vasospasm rate: a systematic review with meta-analysis by Adéla Foudhaili, Brice Leclere, Florence Martinache, Anthony Chauvin, Damien Vitiello, Benjamin Chousterman

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STUDY OF URSODEOXYCHOLIC ACID INFLUENCE ON EFFICACY AND SAFETY OF STATIN THERAPY IN PATIENTS WITH DISEASES OF THE LIVER, GALL BLADDER AND/OR BILIARY TRACT (THE RAKURS STUDY) by S. Yu. Martsevich, N. P. Kutishenko, L. Yu. Drozdova, O. V. Lerman, V. A. Nevzorova, I. I. Reznik, G. V. Shavkuta, D. A. Yahontov

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Modern fixation techniques versus traditional tension band wiring for olecranon fractures: a systematic review and meta-analysis of functional outcomes, healing time, and complicat... by Chengjing Wang, Changqing Li

“…We included randomized controlled trials and comparative cohort studies evaluating surgical fixation techniques for adult olecranon fractures. …”
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Efficacy of Dry Needling Combined with Eccentric Exercise Versus Oral and Topical NSAID Treatment in Patients with Tennis Elbow: A Randomized Controlled Trial by Zacarías Sánchez-Milá PhD, Vanesa Abuín-Porras PhD, Helena Fidalgo-Gómez PhD, Isabel Mínguez-Esteban MSc, Jaime Almazán-Polo PT, MSc, PhD, Jorge Velázquez-Saornil PhD

“…Objective The study aimed to compare the effects of a combined intervention of dry needling and eccentric exercises versus oral and topical NSAID treatment, each combined with eccentric exercises, on pain intensity and hand function in patients with lateral epicondylalgia. Design A single-blind, randomized controlled trial. …”
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Effects of Lacticaseibacillus paracasei K56 on perceived stress among pregraduate students: a double-blind, randomized, placebo-controlled trial by Yiran Guan, Ruixin Zhu, Wen Zhao, Langrun Wang, Li You, Zhaozhong Zeng, Qiuyue Jiang, Zeyang Zhu, Jiayu Gou, Qi Zhang, Jie Guo, Keji Li, Liang Zhao, Yixuan Li, Pengjie Wang, Bing Fang, Weilian Hung, Jian He, Liwei Zhang, Ran Wang, Jingjing He

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Graded motor imagery as an adjunct to comprehensive physiotherapy in chronic rotator cuff-related pain: a single blind randomized controlled trial by Seda Sırlan, Nuray Alaca, Hacı Ahmet Yarar, Onur Başcı

“…Results Both groups showed significant within-group improvements in pain intensity, range of motion, functionality, and pain-related fear (p < 0.05). The CP + GMI group demonstrated earlier reductions in pain intensity and improvements in mechanical sensitivity, laterality judgment, motor imagery skills (p < 0.05). …”
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Effects of Renal Denervation on Cardiac Remodeling, Cardiac Function, and Cardiovascular Neurohormones in Heart Failure with Reduced Ejection Fraction Patients: A Meta-Analysis and... by Fei Si, Qian Liu, Xin Ma, Jing Yu

“… Introduction: The objective of this study was to evaluate the effects of renal denervation (RDN) on cardiac remodeling, cardiac function, and cardiovascular (CV) neurohormones in heart failure patients with reduced ejection fraction (HFrEF). …”
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Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial by Richard Emsley, Verity Westgate, Daniel Freeman, Thomas Kabir, José Leal, Anthony Morrison, Kate Chapman, Robert Dudley, Laina Rosebrock, Felicity Waite, Louise Isham, Jason Freeman, Stephanie Common, Alex Kenny, Ariane Beckley, Natalie Rouse, Megan McGovern

“…We will also test whether Feeling Safer works equally across gender, age, ethnicity and cognitive functioning (moderation) and whether Feeling Safer works via the targeted psychological processes (mediation).Methods and analysis The study design is a multicentre, single-blind (outcome assessor), parallel, four-arm randomised controlled trial; 484 patients with persistent persecutory delusions will be randomised to one of the four conditions (1:1:1:1): Feeling Safer (added to treatment as usual (TAU)) supported by peer-support workers, or Feeling Safer (added to TAU) supported by graduate mental health workers including assistant psychologists, or Feeling Safer (added to TAU) supported by CBT therapists or TAU. …”
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The effect of osteopathic manipulative treatment on lenght of stay and pain relief in pediatric appendectomy: a pilot non-randomized time-controlled clinical trial by Roberto Lo Piccolo, Roberto Lo Piccolo, Michele Maria Cantagalli, Tommaso Ferroni, Florinda Fracchiolla, Antonino Morabito, Antonino Morabito

“…Secondary outcomes included bowel function, mobilization, and nausea/vomiting. Data were analyzed using multivariate statistics and t-tests, with p &lt; 0.05 as the significance threshold.ResultsThe OMT group showed a shorter mean hospital stay (4.6 vs. 7 days) and significantly greater reductions in abdominal and shoulder pain compared to controls. …”
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Effects of replacing Laminaria japonica with mixed seaweed meal on growth performance, digestive and metabolic enzyme activities, and immune function of the sea cucumber Apostichop... by Bin Xia, Zhengyong Liu, Qingfei Li, Dongxue Xu, Ji Liu, Jinghua Chen

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Effects of whole-body vibration training as an adjunct to conventional rehabilitation exercise on pain, physical function and disability in knee osteoarthritis: A systematic review... by Yan Peng, Qi Qi, Chai Li Lee, Yan Ling Tay, Siaw Chui Chai, Mohd Azzuan Ahmad

“…The systematic review found that WBVT combined with conventional rehabilitation significantly reduced pain and improved physical function in KOA patients. The meta-analysis quantified these effects, showing that WBVT significantly (i) reduced knee pain (MD = -0.43, 95% CI [-0.70, -0.16], p = 0.002), with greater reductions observed from high-frequency WBVT, and (ii) increased isokinetic knee peak torque compared to rehabilitation exercise alone. …”
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Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospect... by Jussi Seppälä, Eva Grasa, Anna Alonso-Solis, Alexandra Roldan-Bejarano, Marianne Haapea, Matti Isohanni, Jouko Miettunen, Johanna Caro Mendivelso, Cari Almazán, Katya Rubinstein, Asaf Caspi, Zolt Unoka, Kinga Farkas, Elisenda Reixach, Jesus Berdun, Judith Usall, Susana Ochoa, Iluminada Corripio, Erika Jääskeläinen

“…These results should be corroborated by performing a controlled trial.…”
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TRENDS IN DISEASE ACTIVITY, FUNCTIONAL STATUS, AND RADIOGRAPHIC CHANGES IN EARLY RHEUMATOID ARTHRITIS: RESULTS OF A 5-YEAR FOLLOW-UP WITHIN THE RUSSIAN RADIKAL PROGRAM by Yu. A. Ermakova, D. E. Karateev, E. L. Luchikhina, N. V. Demidova

“…Monitoring was made according to the tight control principle. Determination of main clinical and laboratory parameters, DAS28, HAQ disability index (DI) and functional class, as well as hands and feet X-ray were done every year. …”
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Plasma club cell secretory protein reflects early lung injury: comprehensive epidemiological evidence by Jiajun Wei, Jinyu Wu, Hongyue Kong, Liuquan Jiang, Yong Wang, Ying Guo, Quan Feng, Jisheng Nie, Yiwei Shi, Xinri Zhang, Xiaomei Kong, Xiao Yu, Gaisheng Liu, Fan Yang, Jun Dong, Jin Yang

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Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration. by Katherine S Marsay, Sarah Greaves, Harsha Mahabaleshwar, Charmaine Min Ho, Henry Roehl, Peter N Monk, Tom J Carney, Lynda J Partridge

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Effects of anti-osteoporotic drugs in patients with chronic kidney disease: a systemic review and network meta-analysis of bone mineral density, clinical fracture rate and renal fu... by Chih-Hsuan Wung, Hao-Yu Liu, Tsung-Ting Tsai, Tsung-Ting Tsai, Jia-Jin Chen

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A Bioclimatic Design Approach to the Energy Efficiency of Farm Wineries: Formulation and Application in a Study Area by Verónica Jiménez-López, Anibal Luna-León, Gonzalo Bojórquez-Morales, Stefano Benni

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