Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study by Hua Y, Geng Y, Liu S, Xia S, Liu Y, Cheng S, Chen C, Pang C, Zhao Z, Peng B, Dai Y, Ji J, Wu D

“…Through statistical analysis, differences in brain functional activity and connectivity between the cancer pain group and the healthy control group were investigated, followed by machine learning classification.Results: The results showed that compared to the normal group, reductions in the ALFF were primarily observed in the bilateral inferior temporal gyrus; ReHo increased in the right middle temporal gyrus and decreased in the left cerebellum Crus2. …”
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Analysis Method for the Pouring Stage of Concrete-Filled Steel Tube (CFST) Arch Bridges Considering Time-Varying Heat of Hydration and Elastic Modulus by Mengsheng Yu, Xinyu Yao, Kaizhong Xie, Tianzhi Hao, Xirui Wang

“…Firstly, based on the composite index model of the hydration heat and through the reduction of the participating materials, the heat source function of the hydration heat of the arch rib was obtained, and its accuracy was verified by using two test components. …”
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Experimental study on gas permeability and radon control performance of red clay covering layer on uranium mill tailings pond by Guokai Xiong, Jianyong Dai, Hong Wang, Pei Lv, Xiangjiang Wang

“…Abstract The decommissioning of uranium mill tailings pond generally employs covering layer to diminish radon exhalation, with soil permeability, thickness, and moisture content being essential considerations in assessing the efficacy of radon reduction. This research uses a proprietary multi-field coupled seepage testing apparatus and a simulated covering layer radon exhalation device to evaluate samples’ permeability and radon control effectiveness across different covering layer thicknesses, pressure gradients, and moisture content levels. …”
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Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease by R. A. Müller, F. Klimeš, A. Voskrebenzev, L. Behrendt, T. F. Kaireit, M. Wernz, M. Zubke, A. L. Kern, M. R. Prince, W. Shen, C. B. Cooper, R. G. Barr, J. M. Hohlfeld, J. Vogel-Claussen

“…MPT in combination with phase-resolved functional lung (PREFUL) MRI can be used to assess stress-driven ventilation dynamics globally and regionally. …”
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Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans, a pilot exploratory study by Juliana Zimmermann, Rachel Nuttall, Daniel Golkowski, Gerhard Schneider, Andreas Ranft, Rüdiger Ilg, Afra Wohlschlaeger, Christian Sorg, Marlene Tahedl

“…A significant source of cholinergic innervation comes from basal forebrain cholinergic nuclei (BFCN), with bi-directional connections between anterior BFCN and the default mode network (DMN). Since DMN functional connectivity (FC) is consistently reduced during anesthesia-induced unresponsiveness in humans, we hypothesized that BFCN-FC during anesthesia-induced unresponsiveness is reduced and particularly, anterior BFCN-FC reductions might be related to DMN-FC reductions. …”
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Effects of sodium bicarbonate therapy on cognitive and cerebrovascular function in midlife and older adults with chronic kidney disease: a pilot randomized trial by Fangning Gu, Zhiying You, Nell Hawkins, Rachael Reddin, Rahaf Hamour, Allison Shapiro, Christina Coughlan, Douglas Seals, Seth Furgeson, Angelina Dixon, Kristen L. Nowak, Jessica Kendrick

“…Trials examining the effect of sodium bicarbonate (NaHCO3) on cognitive function are lacking. Methods We conducted a randomized, double-blind, placebo-controlled pilot study examining the effect of 12 months of NaHCO3 on cognitive function in 34 patients aged 50–80 years with CKD stage 3b-4 (eGFR 15–44 ml/min/1.73m2) with metabolic acidosis (serum bicarbonate level 16–22 mEq/L). …”
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Impaired right atrial function preceding right ventricular systolic dysfunction: clinical utility and long-term prognostic value in pulmonary hypertension by Fan Yang, Yan Yan, Wang Jiang, Zhouming Wang, Caixin Wu, Qian Wu, Yuanlin Deng, Yamin Du, Zhenwen Yang, Zhang Zhang, Dong Li

“…However, a reduction in RA booster pump function was observed only in the PH-RVSD group (p < 0.001). …”
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Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention by Giulia Marafioti, Laura Culicetto, Desirèe Latella, Angela Marra, Angelo Quartarone, Viviana Lo Buono

“…Functional imaging studies reveal disruptions in the default mode network (DMN), executive control networks (ECN), and sensorimotor networks (SMN), indicating both compensatory mechanisms and early dysfunction. …”
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Barbigerone attenuates 3-nitropropionic acid-induced Huntington’s disease-like neuropathology in rats via antioxidant, anti-inflammatory, and neuroprotective mechanisms by Sattam Khulaif Alenezi

“…Male Wistar rats were randomized into four groups: a normal control group, a 3-NPA control group, and two groups treated with different doses of barbigerone along with 3-NPA. …”
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Evaluating the Effect of Thermal Treatment on Phenolic Compounds in Functional Flours Using Vis–NIR–SWIR Spectroscopy: A Machine Learning Approach by Achilleas Panagiotis Zalidis, Nikolaos Tsakiridis, George Zalidis, Ioannis Mourtzinos, Konstantinos Gkatzionis

“…These first findings suggest that the proposed non-destructive spectroscopic approach enables rapid classification and quality assessment of functional flours, supporting future applications in precision food formulation and quality control.…”
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Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing by Qiang Zhang, Qiang Zhang, Qiang Zhang, Qiang Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Hui Chen, Hui Chen, Hui Chen, Hui Chen, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang

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Retrospective Analysis of Sacubitril/Valsartan vs Benazepril for Treating Heart Failure Following Acute Myocardial Infarction by Zhao L, Ren Y, Qin D, Yang X, Chen Z, Zhang N

“…After six months of treatment, the observation group demonstrated significantly greater improvements in left ventricular function parameters (LVESV, LVEDD, and LVEF) and reductions in inflammatory markers (hs-CRP, IL-6) and NT-proBNP levels compared to the control group (P < 0.05). …”
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Passive head-up tilt positioning as an early mobilization strategy in neurocritical care: a prospective-retrospective controlled study by Geng Jia, Yi Feng, Zhenwei Liu, Changchun Yang, Ya Peng, Naiyuan Shao

“…Primary outcomes included NSICU/hospital length of stay, duration of ventilation, complication rates, and long-term functional outcomes.ResultsPassive verticalization was well-tolerated and associated with a significant reduction in ICP (10.62 ± 2.13 vs. 8.38 ± 2.27 mmHg, p &lt; 0.05) without affecting CPP or PRx. …”
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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis by Raimondo Sollazzo, Domenica Donatella Li Puma, Giuseppe Aceto, Fabiola Paciello, Claudia Colussi, Maria Gabriella Vita, Guido Maria Giuffrè, Francesco Pastore, Alessia Casamassa, Jessica Rosati, Agnese Novelli, Sabrina Maietta, Francesco Danilo Tiziano, Camillo Marra, Cristian Ripoli, Claudio Grassi

“…This study aims to investigate the molecular and functional differences between human induced pluripotent stem cells (hiPSCs) derived from patients with sporadic AD (sAD) and age-matched controls (healthy subjects, HS), focusing on their neuronal differentiation and synaptic properties in order to better understand the cellular and molecular mechanisms underlying AD pathology. …”
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Microstate Dynamics in Working Memory: Exploring Spatial Information Coding of Stimulus and Behavioral Performance by Hamideh Norouzi, Mohammad Reza Daliri

“…The four canonical microstates (classes A, B, C, and D) have been widely reported and associated with various cognitive functions. However, the relationship between microstate parameters and behavioral responses in cognitive functions, such as working memory (WM), has not been sufficiently investigated. …”
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Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes by Li Z, Wu P, Chen Q, Tong X, Yang Q

“…The observation group demonstrated a significantly greater reduction in seizure frequency compared to the control group (P = 0.014). …”
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Non-operative versus operative treatment of suprasyndesmotic ankle fractures: protocol for a prospective, multicentre, randomised controlled trial by Wender Figved, Frede Frihagen, Jan Erik Madsen, Ola Saatvedt, Martin Riiser, Marius Molund, Håvard Furunes

“…The primary study outcome is patient-reported ankle function and symptoms as measured by the Olerud-Molander Ankle Score at 2-year follow-up. …”
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Proposing a Novel Method for Optimal Location Finding Based on Machine Learning Algorithms and Gray Wolf Optimization by Fatemeh Heydari Pirbasti, Mahmoud Modiri, Kiamars Fathi-Hafshejani, Alireza Rashidi-Komijan

“…In order to apply the gray wolf optimization algorithm, a multivariate target function is defined. Cluster centers as were chosen as location of waste disposal. …”
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The analysis of generative adversarial network in sports education based on deep learning by Eerdenisuyila Eerdenisuyila, Hongming Li, Wei Chen

“…The results validate the effectiveness of the proposed text generation model in semantic control. This study aims to advance the level of mental health education among college and university students in the sports domain, providing theoretical references for enhancing the effectiveness of quality education assessments in other subjects as well.…”
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Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial. by Akhirunnesa Mily, Rokeya Sultana Rekha, S M Mostafa Kamal, Abu Saleh Mohammad Arifuzzaman, Zeaur Rahim, Lamia Khan, Md Ahsanul Haq, Khaliqu Zaman, Peter Bergman, Susanna Brighenti, Gudmundur H Gudmundsson, Birgitta Agerberth, Rubhana Raqib

“…<h4>Methods</h4>Adult TB patients (n = 288) were enrolled in a randomized, double-blind, placebo-controlled trial conducted in Bangladesh. Primary endpoints included proportions of patients with a negative sputum culture at week 4 and reduction in clinical symptoms at week 8. …”
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