Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma by Naga Malleswara Rao Nakka, Hari Krishnareddy Rachamala, Ramcharan Singh Angom, Nagamalleswara Rao Indla, Shamit Kumar Dutta, Enfeng Wang, Santanu Bhattacharya, Annadanam V. Sesha Sainath, Hani Babiker, Krishnendu Pal, Debabrata Mukhopadhyay

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Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells by Arianna Romani, Giada Lodi, Fabio Casciano, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Olga Bortolini, Giuseppe Valacchi, Daniele Ragno, Agnese Bondi, Mascia Benedusi, Elisabetta Esposito, Rebecca Voltan

“…Nutlin-3a-loaded ethosomes induced morphological changes in the HT144 cell line, with evident apoptotic cells and a reduction in the number of viable cells of over 80%. …”
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Clinical outcome changes in sarcopenic obesity: a meta-analysis of exercise training methods by Lei Chen, Haojing Zhou, Yichen Gong, Yi Tang, Hai Su, Zhongyi Zhang, Peijian Tong, Guoqian Chen

“…Methods Two independent reviewers systematically searched English and Chinese databases (PubMed, Embase, Cochrane Library, Web of Science, CNKI) for randomized controlled trials on various exercise training effects in sarcopenic obesity patients until October 2023. …”
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Sleeve gastrectomy as a bridge to cardiac recovery - A retrospective comparative cohort study by Thomas Goubar, MD, Samuel Kim, MD, David Cistulli, MD, Douglas Fenton-Lee, MBBS, R. Louise Rushworth, PhD, Peter S. Macdonald, MD, PHD, Anne M. Keogh, MBBS

“…Outcomes were compared with controls matched for age, sex, LVEF, and BMI receiving standard care. …”
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Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina by Sol A. Cataldo, Andrea Micciulli, Laura Margulis, Melina Cibeyra, Sabrina Defeo, Silvina G. Horovitz, Analía Martino, Raul Melano, Milagros Mena, Francisco Parisi, Diego Santoro, Florencia Sarmiento, Martin A. Belzunce

“…Neuroimaging studies have identified structural alterations in brain regions linked to cognitive functions. However, most of these studies have focused on patients within months of their initial infection. …”
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Perturbations in gut microbiota in autism spectrum disorder: a systematic review by Xiangkun Tao, Zhuocan Li, Dongfang Wang, Dongfang Wang, Dongfang Wang, Juncai Pu, Juncai Pu, Yiyun Liu, Yiyun Liu, Yiyun Liu, Siwen Gui, Siwen Gui, Siwen Gui, Xiaogang Zhong, Xiaogang Zhong, Xiaogang Zhong, Dan Yang, Haipeng Zhou, Wei Tao, Weiyi Chen, Xiaopeng Chen, Yue Chen, Xiang Chen, Peng Xie, Peng Xie, Peng Xie

“…These findings suggest that the disrupted intestinal microecology and functional changes in ASD are characterized by an enrichment of pro-inflammatory genera, a reduction of specific probiotics, lactic acid-producing and utilizing bacteria, and an imbalance of anti-inflammatory butyrate-producing bacteria. …”
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SHP2 inhibition and adjuvant therapy synergistically target KIT‐mutant GISTs via ERK1/2‐regulated GSK3β/cyclin D1 pathway by Chunxiao He, Jiaying Yu, Shuang Mao, Shaohua Yang, Xianming Jiang, Lei Huang, Mingzhe Li, Yulong He, Xinhua Zhang, Xi Xiang

“…Rescue experiments confirmed that cyclin D1 is functional and critical for cell proliferation. Additionally, SHP2 inhibition synergised with approved KIT TKIs in inhibiting GIST cells. …”
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Efficient removal of cadmium (II) and arsenic (III) from water by nano-zero-valent iron modified biochar-zeolite composite by Mengyuan Wu, Lijuan Wu, Wen Zhang, Xianbao Zhong, Runfeng Guo, Ziying Cui, Yajun Yang, Jialong Lv

“…Kinetic analysis showed that the adsorption process is primarily controlled by chemical adsorption and follows a monolayer adsorption mechanism. …”
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MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study by Shengbo Yang, Litao Zhang, Mingli Hu, Weina He

“…Hepatic outcomes were assessed via ultrasonography, hepatic steatosis index (HSI), controlled attenuation parameter (CAP), and fibrosis-4 (FIB-4) index. …”
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Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p/NOTCH1 signaling by Lu Yang, Siyuan Zhao, Xu Liu, Yuchen Zhang, Shaorong Zhao, Xuan Fang, Jin Zhang

“…Methods Primary CAFs were isolated from high-grade BC tissues (Grade III) and characterized (α-SMA⁺/CD34⁻/pan-CK⁻), with normal fibroblasts (NFs) from reduction mammoplasty as controls. Hypoxic CAF-derived exosomal circSTAT3 stability was validated using RNase R resistance and actinomycin D assays. …”
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Vision guides the twilight search for oviposition sites of the Asian tiger mosquito, Aedes albopictus. by Si Yu Zhao, Hong Kai Liu, Zhen Sheng Xie, Yi Ming Wu, Pei Lin Wu, Tong Liu, Wen Qiang Yang, Jing Wu, JunYu Fu, Chun Mei Wang, Anthony A James, Xiao-Guang Chen

“…Behavioral tests of both mutant and control strains revealed that the rho-l△807 mutant mosquitoes had a significant decrease in their ability to search for preferred oviposition sites that correlated with a reduced ability to recognize long-wavelength red light. …”
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Talinum trangulare (Waterleaf) Stem Extract Has Reno-Hepato Protective Potentials than Ameliorative Effects on Acetaminophen Toxicity in Sprague-Dawley Rats by Theophilus Ogie Erameh1,2, Ifueko Mercy Moses-Otutu1, Anthony Chukwuemeka Nwaobi2, Efosa Bolaji Odigie1*, Blessing Eshovo Akpeji1 and Ramatu Yahaya2

“…Blood sample was collected through cardiac puncture to determine kidney and liver functions while related organs were processed histologically. …”
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Case Report: Successful management of refractory palmoplantar pustulosis with upadacitinib by Boyun Yang, Hanxiao Yu, Wo Yao, Huiying Wang

“…Palmoplantar Pustulosis (PPP) is a rare chronic skin disorder characterized by recurrent sterile pustules on palms and soles, leading to significant pain and functional impairment. Treatments include topical medications, phototherapy, systemic treatments, and biologics, but nonconclusive strategy exists. …”
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Pyriproxyfen, villain or good guy? A brief review by Andressa Pereira Cabral, Fabrício Pereira dos Santos Maia, D’Angelo Carlo Magliano, Jones Bernardes Graceli, Paula Soares, Eduardo Andrés Rios Morris, Leandro Miranda-Alves

“…Indirect effects include shifts in food web dynamics and ecosystem functioning. Reductions in insect populations, induced by PPF, can disrupt food availability for higher trophic levels, potentially destabilizing community structure and ecosystem equilibrium. …”
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Trauma and the default mode network: review and exploratory study by Aldrich Chan, Aldrich Chan, Aldrich Chan, Philip Harvey, Rene Hernandez-Cardenache, Noam Alperin, Sang Lee, Christopher Hunt, Christopher Hunt, Nick Petersen, Georg Northoff, Nadine Robertson, Jason Ouyang, Jason Ouyang, Ryan Karasik, Ryan Karasik, Kate Williams, Kate Williams

“…This study revealed that in comparison to the control group, the trauma-exposed group had reductions in their capacity for self-referential processing, social cognition, autobiographical recall, prospection, and increased mind-wandering. …”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…Data urge for larger placebo-controlled trials.…”
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Effectiveness of drainage, depressurization and gas production of coalbed methane wells based on production data: A case study of the Zhijin Block in Western Guizhou by Chen GUO, Kang SHI, Yong QIN, Hang YUAN, Zhenlong CHEN, Wei GAO, Lingling LU, Houqiang LI, Xuyang ZHANG, Xiang WANG, Hongbin HE, Runhan ZHANG

“…The research results can provide methodological references for the dynamic analysis of CBM production and the diagnosis of main factors controlling productivity in the context of the development of superimposed CBM systems.…”
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Innovative treatment of toxic oily petroleum wastewater with magnetic sludge under UVA light by Saeedeh Rastgar, Habibollah Younesi, Hassan Rezeai, Hajar Abyar

“…The experimental work was conducted in a controlled batch system to evaluate the effectiveness of the photocatalyst under varying conditions. …”
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p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development by Byron Zhao, Jinsook Suh, Yan Zhang, Eric Yin, Chiho Kadota-Watanabe, Chiho Kadota-Watanabe, In Won Chang, Jun Yaung, Isabelle Lao-Ngo, Nathan M. Young, Reuben H. Kim, Ophir D. Klein, Ophir D. Klein, Christine Hong

“…On postnatal day 7 (P7), p75NTR−/− mice exhibited reduced skull length compared to wild-type controls. By P28, micro-CT analysis revealed significant reductions in calvarial bone volume and trabecular bone thickness in p75NTR−/− mice. …”
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Development and feasibility testing of a new device for home-based leg heat therapy in patients with lower extremity peripheral artery disease by Bohyun Ro, MSc, John P. Spence, BBA, Paul A. Spence, MD, Christian Buckley, BS, Raghu L. Motaganahalli, MD, Bruno T. Roseguini, PhD

“…Emerging evidence suggests that regular heat therapy (HT) may improve cardiovascular and physical function in patients with PAD. However, the lack of accessible, practical modalities for unsupervised HT, especially for elderly individuals, has hindered clinical implementation. …”
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