T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Rα targeting by Jelena Pesic, Juan José Nieto-Fontarigo, Juan José Nieto-Fontarigo, Katerina Pardali, Stephen Delaney, Henric Olsson, Lena Uller

“…Our results suggest a novel mechanism by which IL-4Rα mAb controls exacerbations and improves lung function.…”
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Decreased impulsiveness and MEG normalization after AI-digital therapy in ADHD children: a RCT by Danylyna Shpakivska Bilan, Irene Alice Chicchi Giglioli, Pablo Cuesta, Elena Cañadas, Ignacio de Ramón, Fernando Maestú, Jose Alda, Josep Antoni Ramos-Quiroga, Jorge A. Herrera, Alfonso Amado, Javier Quintero

“…Notably, improvements in inhibitory control correlated with spectral profile normalization in the parieto-temporal cortex. …”
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Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways by Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie

“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted to elucidate the functions of pivotal targets within the protein–protein interaction network. …”
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Mindfulness for Motor and Nonmotor Dysfunctions in Parkinson’s Disease by Nadeeka N. W. Dissanayaka, Farah Idu Jion, Nancy A. Pachana, John D. O’Sullivan, Rodney Marsh, Gerard J. Byrne, Paul Harnett

“…The mindfulness intervention tailored for PD is associated with reduced anxiety and depression and improved cognitive and motor functioning. A randomised controlled trial using a large sample of PD patients is warranted.…”
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Treatment outcome in refractive accommodative esotropia by Osama A Al-Morsy, Ahmed E Ramadan, Asmaa I. Abd-Elaal, Manar F. Dawoud

“…It is often intermittent, and the deviation is typically eliminated by controlling the accommodative effort with optical correction of hypermetropia. …”
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Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression by Lina Gliaudelytė, Steven P. Rushton, Rolando Berlinguer-Palmini, Alan J. Thomas, Christopher M. Morris

“…STED imaging demonstrated the presence of α-synuclein within individual dopaminergic terminals in the sgACC, α-synuclein presence showing a significant positive correlation with increased synaptosomal associated protein 25 kDa (SNAP25) volumes in depressed DLB cases. A reduction in dopaminergic innervation in the sgACC was observed in DLB cases with depression compared to controls (p < 0.001), but not in non-depressed DLB donors, along with reduced levels of multiple dopaminergic markers and receptors. …”
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Fabrication and characterization of a colorimetric sensor using EDTA-capped copper oxide nanoparticles for phenolic compound detection by Mehwish Shahzad Abbasi, Umaima Saleem Memon, Abdul Wahab Memon, Murk Saleem Memon

“…Textural characterization of the prepared CuONPs was studied using advanced techniques, for example, Fourier transmission infrared (FTIR) to study the functional transition (EDTA reduction), scanning electron microscopy (SEM) to analyze the shape of CuONPs, X-ray diffraction patterns to examine the crystalline nature of the particles. …”
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Gene expression profiling identifies molecular pathways associated with collagen VI deficiency and provides novel therapeutic targets. by Sonia Paco, Susana G Kalko, Cristina Jou, María A Rodríguez, Joan Corbera, Francesco Muntoni, Lucy Feng, Eloy Rivas, Ferran Torner, Francesca Gualandi, Anna M Gomez-Foix, Anna Ferrer, Carlos Ortez, Andrés Nascimento, Jaume Colomer, Cecilia Jimenez-Mallebrera

“…We identified 389 genes which are differentially regulated in UCMD relative to controls. In addition, there were 718 genes differentially expressed between UCMD and dystrophin deficient muscle. …”
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METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4 by Yuhua Chen, Weicong Fan, Ying Lyu, Jingsheng Liao, Ying Zhou

“…The expression levels of METTL14 were analyzed via qRT-PCR and western blot. In vitro functional experiments evaluated the effects of METTL14 overexpression on the viability of DSS-induced NCM460 cells and ferroptosis markers. …”
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Simulating CO2 dynamics in Brackish Lake Obuchi, Japan: Low pCO2 maintenance through diverse nutrient inputs by Kazuhiro Misumi, Takaki Tsubono, Daisuke Tsumune, Takeshi Yoshimura, Shinji Ueda

“…Here, we used a three-dimensional hydrodynamic-ecosystem model to investigate CO2 dynamics and its controlling factors in Lake Obuchi, a brackish lake in Aomori Prefecture, Japan. …”
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LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway by Jianwei Li, Xinghua Huang, Haodong Chen, Caifu Gu, Binyu Ni, Jianhua Zhou

“…Our results demonstrate that the LINC01088/miR-22/CDC6 axis functions in PCa progression and provide a promising diagnostic and therapeutic target.…”
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Selenium foliar application alleviates salinity stress in sweet william (Dianthus barbatus L.) by enhancing growth and reducing oxidative damage by Haider Adnan Alvan, Zohreh Jabbarzadeh, Javad Rezapour Fard, Parviz Noruzi

“…Indeed, at 10µM application level in most of salinity treatments and controls, enhancing the salinity tolerance was reflected. …”
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Effects of Adolescent Childbearing on Maternal Depression and Problem Behaviors: A Prospective, Population-Based Study Using Risk-Set Propensity Scores. by Alison E Hipwell, Joseph Murray, Shuangyan Xiong, Stephanie D Stepp, Kate E Keenan

“…Adolescent mothers are reportedly at risk for depression and problem behaviors in the postpartum period, but studies have rarely considered developmental context and have yet to disentangle the effects of childbearing on adolescent functioning from selection effects that are associated with early pregnancy. …”
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Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents. by Daniel L Halligan, Athanasios Kousathanas, Rob W Ness, Bettina Harr, Lél Eöry, Thomas M Keane, David J Adams, Peter D Keightley

“…We observe pronounced reductions in mean diversity around nonsynonymous sites (whether or not they have experienced a recent substitution). …”
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Efficacy of Fluorinated Nematicides for Management of Root-knot Nematodes in California Processing Tomatoes by Ploeg Antoon T., Edwards Scott, Loffredo Angelo, Becker Jörn Ole

“…On average, tomato root-galling (0 – 10 scale) at harvest was reduced by 3.2, 2.3, and 2.5 by fluazaindolizine, fluensulfone, and fluopyram, respectively, compared to the untreated control. These reductions in root-galling corresponded with estimated yield gains of approximately 21%, 14%, and 15%, respectively, over the untreated control. …”
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Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis by Judith Cantó-Santos, Laura Valls-Roca, Ester Tobías, Francesc Josep García-García, Mariona Guitart-Mampel, Félix Andújar-Sánchez, Adrià Vilaseca-Capel, Anna Esteve-Codina, Beatriz Martín-Mur, Joan Padrosa, Emma Peruga, Irene Madrigal, Paula Segalés, Carmen García-Ruiz, José Carlos Fernández-Checa, Pedro J. Moreno-Lozano, Albert Selva O’Callaghan, Ana Sevilla, José César Milisenda, Glòria Garrabou

“…To contribute to unveil disease underpins we developed a cell model based on myotubes derived from induced pluripotent stem cells (iPSC-myotubes) from IBM patients and compared the molecular phenotype vs. age and sex-paired controls (n = 3 IBM and 4 CTL). We evaluated protein histological findings and the gene expression profile by mRNA-seq, alongside functional analysis of inflammation, degeneration and mitochondrial function. …”
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Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages by Alessio Menga, Marina Serra, Simona Todisco, Carla Riera‐Domingo, Ummi Ammarah, Manuel Ehling, Erika M Palmieri, Maria Antonietta Di Noia, Rosanna Gissi, Maria Favia, Ciro L Pierri, Paolo E Porporato, Alessandra Castegna, Massimiliano Mazzone

“…Abstract Glutamine synthetase (GS) generates glutamine from glutamate and controls the release of inflammatory mediators. In macrophages, GS activity, driven by IL10, associates to the acquisition of M2‐like functions. …”
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Substituting ethoxyquin with tea polyphenols and propyl gallate enhanced feed oxidative stability, broiler hepatic antioxidant capacity and gut health by Yong Xiao, Xuyang Gao, Jianmin Yuan

“…This study evaluated the effects of partially substituting ethoxyquin with tea polyphenols and propyl gallate on feed oxidative stability, hepatic antioxidant properties, intestinal morphology and barrier functions, as well as the antioxidant and anti-inflammatory profiles of the intestinal mucosa in broilers. …”
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Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability by Nicole Shelley, Bradley Judge, Dmitriy A. Yablonskiy, Robert T. Naismith, Matthew R. Brier, Anne H. Cross

“…ABSTRACT Objective The claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS). …”
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Cold sintering process: A green route to fabricate thermoelectrics by Jinxue Ding, Jing Guo, Ruijuan Yan, Wei Li, Shuailing Ma, Yanqin Fu, Wenjie Xie, Ralf Riedel, Anke Weidenkaffa

“…Cold sintering is a newly developed low-temperature sintering technique that has attracted extensive attention in the fabrication of functional materials and devices. Low sintering temperatures allow for a substantial reduction in energy consumption, and simple experimental equipment offers the possibility of large-scale fabrication. …”
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