A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s diseaseResearch in context by Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga, Amani M. Norling, Afroditi Boulougoura, Theodoros Vichos, Tamara Tchkonia, Aaron Deisinger, Tamar Pirtskhalava, James L. Kirkland, Thomas G. Travison, Lewis A. Lipsitz

“…Recruitment rate, adverse events, absolute changes in functional outcomes, and percent changes in biomarkers were calculated. …”
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Molecular insights into postharvest seed coat darkening in common beans: a look beyond the P gene by Nishat S. Islam, Nishat S. Islam, Sangeeta Dhaubhadel, Sangeeta Dhaubhadel

“…Many market classes of common beans (Phaseolus vulgaris) have a significant reduction in crop value due to the postharvest darkening of the seed coat. …”
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The Effect of Maternity Support Garments on Alleviation of Pains and Discomforts during Pregnancy: A Systematic Review by Carolina Quintero Rodriguez, Olga Troynikov

“…Three outcome measurements were identified from the included studies: alleviation of pain, improvement of balance, and improvement of functionality and mobility. The study concluded that wearing MSGs during pregnancy could have beneficial effects in women such as LBP and PGP alleviation, improvement of functionality and mobility, and reduction of risk of fall during pregnancy; however, the mechanisms of the garments’ actions as well as the duration of the garments’ effectiveness are not elucidated through the studies. …”
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A Comparative Study on the Effectiveness of Electroconvulsive Therapy and Ketamine in Persons Suffering from Treatment-resistant Depressive Disorder by Vikhram Ramasubramanian, S. Mathumathi, Gautami Thirumalaisamy, Sugaparaneetharan Ayyanar, Gopi Rajendhiran, M. Kannan

“…It is coupled with functional impairment, poor quality of life, suicide ideation and attempts, self-injurious behavior, and a high relapse rate. …”
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Development and Evaluation of a Powered Artificial Gastrocnemius for Transtibial Amputee Gait by Michael F. Eilenberg, Jiun-Yih Kuan, Hugh Herr

“…The data do not support our hypothesis that metabolism decreases for all participants, but some participants demonstrate large metabolic reductions with the biarticular condition. These preliminary results suggest that a powered artificial gastrocnemius may be capable of providing large metabolic reductions compared to a monoarticular prosthesis, but further study is warranted to determine an appropriate controller for achieving more consistent metabolic benefits.…”
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Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation by Eunu Kim, Geon Min Lee, Haeshin Lee

“…This approach demonstrates that hair keratin surfaces can serve as large‐area platforms for controlled release of therapeutic agents, addressing various challenges in hair and scalp health.…”
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Neuroanatomical Correlates of Theory of Mind Deficit in Parkinson's Disease: A Multimodal Imaging Study. by María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, María Ángeles Gómez-Beldarrain, Juan Carlos Gómez-Esteban, Naroa Ibarretxe-Bilbao

“…<h4>Results</h4>PD patients showed impairments in ToM, working memory and executive functions; grey matter loss and white matter reduction compared to healthy controls. …”
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Anti-inflammatory effects of cyclodextrin nanoparticles enable macrophage repolarization and reduce inflammation by Felix E. B. Brettner, Stefanie Gier, Annika Haessler, Jonas Schreiner, Sarah Vogel-Kindgen, Maike Windbergs

“…Addressing these disorders requires balancing inflammation control while preserving essential immune functions. …”
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Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs by Haoqiang Liu, Liyu Gu, Yuanzhen Ye, Minwei Zhang

“…The Au NPs from <i>Auricularia auricula</i> polysaccharide (AAP) were successfully synthesized using a straightforward method. By controlling the mass fraction of AAP, pH, reaction temperature, reaction time, and concentration of gold precursor, the highly dispersed spherical AAP-functionalized Au NPs (AAP-Au NPs) were prepared. …”
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25G Ultrasonic Vitrectomy in Surgical Treatment of Idiopathic Macular Hole by B. M. Aznabaev, T. I. Dibaev, T. N. Ismagilov

“…Idiopathic macular hole (IMH) is a frequent disorder of the posterior segment of the eye that impacts on visual functions leading to the reduction of visual acuity and the manifestation of metamorphopsia. …”
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Increased prolactin levels are associated with impaired processing speed in subjects with early psychosis. by Itziar Montalvo, Alfonso Gutiérrez-Zotes, Marta Creus, Rosa Monseny, Laura Ortega, Joan Franch, Stephen M Lawrie, Rebecca M Reynolds, Elisabet Vilella, Javier Labad

“…If these results are confirmed in future studies, strategies targeting reduction of prolactin levels may improve cognition in this population.…”
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Type I interferons and MAVS signaling are necessary for tissue resident memory CD8+ T cell responses to RSV infection. by Augusto Varese, Joy Nakawesi, Ana Farias, Freja C M Kirsebom, Michelle Paulsen, Rinat Nuriev, Cecilia Johansson

“…IFN-α treatment of MAVS deficient mice during primary RSV infection restored TRM cell expansion upon re-challenge but failed to recover TRM cell functionality. Our data reveal how innate immunity, including the axis controlling type I IFN induction, instructs and regulates CD8+ TRM cell responses to RSV infection, suggesting possible mechanisms for therapeutic intervention.…”
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Targeting Aging Skin with GABALAGEN^®: A Synergistic Marine Nutricosmetic Ingredient Validated Through Human Randomized Trials by Jimin Hyun, Kyoung-Min Rheu, Bae-Jin Lee, Bomi Ryu

“…A 12-week, randomized, double-blind, placebo-controlled trial with 100 adults (aged 35–60) assessed its effects on aging skin. …”
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Hybrid Improved PSO Algorithm for Soil Property Parameter Estimation by Mude Li, Aiping Shi, Yefan Shi, Tao Zhang, Cu Qu, Lihua Ye

“…For multimodal functions (e.g., F3), PSO-EDO significantly outperforms PSO-WOA (Particle Swarm Optimization-Whale Optimization Algorithm) with a 22.3% reduction in error. …”
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Traction splinting (EAVAST protocol) versus operative fixation of proximal phalanx fractures: a comparative study of patient outcomes by Alyse D Hopkins, Nick P Barry, Sebastian RA Bowman, Sivapirabu Sathasivam, Rohit J Kumar, Angelo P Preketes, Michael B Dowd

“…However, closed methods of reduction are increasing. This study aimed to compare functional outcomes for a non-operative cohort using a skin traction method developed by the Nepean Hospital, Sydney, Australia, termed ‘early active vector adjustable skin traction’ or EAVAST, compared to operatively managed patients. …”
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FEATURES OF TOPOGRAPHIC ANATOMICAL AND MORPHOLOGICAL CHANGES OF TMJ ELEMENTS IN PATIENTS WITH UNILATERAL AND BILATERAL DISPOSITION OF ARTICULAR DISK ACCORDING TO MRI SCAN by Yu. S. Lunkova, Yu. V. Stupina, V. M. Novikov

“…Hvatova V.A. (1989) added such new functional disorders into the classification as dislocation of the mandibular condyle and articular disk, subluxation of the articular disk, articular disc disposition with reduction, articular disc prolapse. …”
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Geometrical Analysis of the Hinge Mechanism of a Centrifugal Lift Speed Limiter with Two Output Links by Alexander V. Kutsepolenko

“…The article draws attention to the emergence of new promising designs of double-acting centrifugal speed limiters with a horizontal position of the axes of their devices controlling the excess speed, for example, the design of the speed limiter Vega, manufactured by Dynatech, with a horizontal position of the axis of its centrifugal device controlling the overspeed and the counter arrangement of its working bodies. …”
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Erythrocyte nicotinamide adenine dinucleotide concentration is enhanced by systematic sports participation by Barbara Pospieszna, Krzysztof Kusy, Ewa Maria Slominska, Jacek Zieliński, Monika Ciekot-Sołtysiak

“…Results In all three groups, the erythrocyte NAD+ and NADP+ concentrations significantly decreased with advancing age, suggesting gradual deterioration of NAD-related regulatory functions in older individuals. However, the concentration of erythrocyte NAD(P)+, regardless of age category, was higher in the athletic groups compared to less active controls. …”
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Circulating inflammatory and neurotrophic markers as moderators and/or mediators of cognitive remediation outcome in people with bipolar disorders by Rebecca Strawbridge, Dimosthenis Tsapekos, Allan H. Young

“…We note an absence of associations with cognitive (versus functional) outcomes. These findings require further examination in large well-controlled studies. …”
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LRP6 regulates growth in Litopenaeus vannamei via the Wnt/β-catenin signaling pathway by Sheng Wang, Xiaodi Wang, Hao Yang, Xuanzheng Di, Haoyang Li, Bin Yin, Ziwei Liu, Chaozheng Li, Jianguo He

“…Multiple sequence alignments and phylogenetic analyses indicated that LvLRP6 belongs to the invertebrate LRP6 family and has conserved phosphorylation sites with those of LRP6 in other species. Functional investigations via RNAi technology revealed that silencing LvLRP6 via dsRNA injection resulted in a significant reduction in shrimp growth, as indicated by lower weight gain than that in the control group. …”
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