Peripheral blood transcriptomic differences predict depression status in individuals undergoing bariatric surgery by Rebecca Milton, Anna P. McLaughlin, Nicole Mariani, Melisa Kose, Zuzanna Zajkowska, Giulia Lombardo, Naghmeh Nikkheslat, Esperanza Perucha, Valeria Mondelli

“…More than one third of candidates for bariatric surgery suffer with clinical depression. Significant reduction in depression following bariatric surgery has been shown, but this is not consistent for all patients. …”
Get full text

Modulation of NETosis in Swine Neutrophil–Spermatozoa Co-Cultures In Vitro: Effects of Butylated Hydroxytoluene, Albumin, Prostaglandin E₂, and Seminal Plasma by Fabiola Zambrano, Felipe Pezo, André Furugen Cesar de Andrade, Rodrigo Rivera-Concha, Pamela Uribe, Mabel Schulz, Henricco Zapparoli, Luan Mendes de Oliveira Bezerra, Carlos Hermosilla, Anja Taubert, Raúl Sánchez

“…BHT (0.5 mM) and PGE₂ (10 µM) produced the most significant inhibitory effects, reducing NETotic cell percentages from 34.5 ± 2.7% (sperm-exposed controls) to 12.2 ± 1.3% and 14.5 ± 2.1%, respectively (<i>p</i> < 0.01). …”
Get full text

Iptacopan in Idiopathic Immune Complex–Mediated Membranoproliferative Glomerulonephritis: Protocol of the APPARENT Multicenter, Randomized Phase 3 Study by Marina Vivarelli, Andrew S. Bomback, Matthias Meier, Yaqin Wang, Nicholas J.A. Webb, Uday Kiran Veldandi, Richard J.H. Smith, David Kavanagh

“…Key secondary end points will assess kidney function measured by eGFR, patients who achieve a proteinuria-eGFR composite end point, and patient-reported fatigue. …”
Get full text

The Molecular Motor Myosin 5B and Its Folding Chaperone UNC45A Are Decreased in Colorectal CancerSummary by Sarah A. Dooley, Rachel Stubler, Priti Parsanna Maity, Jorge Múnera, Antonis Kourtidis, Melinda A. Engevik, Amy C. Engevik

“…Previous studies have found that the molecular motor Mysoin 5b (MYO5B) is decreased at the level of mRNA in CRC, but the mechanism behind this reduction remains unknown. In normal cells, MYO5B function is contingent on proper folding by the chaperone protein unc-45 myosin chaperone A (UNC45A). …”
Get full text

Bone quality relies on hyaluronan synthesis – Insights from mice with complete knockout of hyaluronan synthase expression by A. Saalbach, M. Stein, S. Lee, U. Krügel, M. Haffner-Luntzer, K. Krohn, S. Franz, J.C. Simon, J. Tuckermann, U. Anderegg

“…RNAseq analysis revealed that MSC from Has-tKO are characterised by decreased expression of genes annotated for bone and organ development, whereas expression of genes associated with chemokine related interactions and cytokine signalling is increased.Taken together, we present a novel mouse model with complete deletion of HA synthases in adult mice which has the potential to study HA function in different organs and during age-related HA reduction. …”
Get full text

Breaking the Cycle: Enhancing Cardiovascular Health in the Elderly Through Group Exercise by Lovorka Bilajac, Mihaela Marinović Glavić, Zulle Kristijan, Bilobrk Matea, Denis Juraga, Ana Jelaković, Tomislav Rukavina, Vanja Vasiljev, Bojan Jelaković

“…Results revealed significant reductions in systolic blood pressure (mean −3.4 mmHg) and pulse pressure among hypertensive participants, highlighting improved cardiovascular function. …”
Get full text

Putative Mechanisms of Electroconvulsive Therapy in Treatment-Resistant Schizophrenia Examined Using Magnetic Resonance Imaging by Neelabja Roy, Dhruva Ithal, Urvakhsh Meherwan Mehta, Rakshathi Basavaraju, Rose Dawn Bharath, Nicolas R. Bolo, Jagadisha Thirthalli, Bangalore N. Gangadhar, Matcheri S. Keshavan

“…Methods: We used an inductive (whole-brain, hypothesis-free) approach to examine structural and functional brain changes and their association with clinical response (positive symptom reduction) in clozapine-refractory schizophrenia (n = 30) after ECT (median 8 sessions). …”
Get full text

A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment o... by Yan Gong, James Rogers, Christian Friedrich, Sanjay Patel, Alexander Staab, Jorge Luiz Gross, Daniel Polhamus, William Gillespie, Brigitta Ursula Monz, Silke Retlich

“…The final model described HbA1c levels as function of time, dose, baseline HbA1c, washout status/duration and ethnicity. …”
Get full text

Enhanced engraftment and immunomodulatory effects of integrin alpha-2-overexpressing mesenchymal stromal cells in lipopolysaccharide-induced acute lung injury by Hana Kang, Ok-Hyeon Kim, Eun Seo Chang, Jinho Kim, Ji-Young Kim, Geun-Seup Shin, Chul-Hong Kim, Younghyun Lim, Young-Jin Seo, Jung-Woong Kim, Hyun Jung Lee

“…Results ITGA2-MSCs effectively ameliorated lung tissue injury and lowered blood IL-6 levels compared to that of the control group. Additionally, CD206 expression was highest in the ITGA2-MSC group, which was associated with the activation of M2 macrophage polarization, which contributed to inflammation reduction and tissue repair. …”
Get full text

Impact of Extra-Virgin Olive Oil Storage Conditions on Phenolic Content and Wound-Healing Properties by Francesca Blasi, Maria Rachele Ceccarini, Stefano Bistarelli, Francesco Galli, Lina Cossignani, Desirée Bartolini, Federica Ianni

“…Storage conditions significantly impact the quality and functional properties of extra-virgin olive oil (EVOO). …”
Get full text

Third-degree nasal tip burn in a preterm infant treated with amniotic membrane (Case report) by Paula Andrea Pérez Franco, Sebastian Murcia Espino, María Paula Ruiz Díaz, Juan David Rodríguez Parra

“…Introduction: Non-fatal burns are a global health issue with a considerable impact on morbidity as well as aesthetic and functional sequelae. Facial burns in neonates are rare and often occur in hospital settings due to medical devices. …”
Get full text

Permanent Strain Engineering of Molybdenum Disulfide Using Laser-Driven Stressors for Energy-Efficient Resistive Switching Memory Devices by Heeyoon Jang, Seok-Ki Hyeong, Byeongjin Park, Tae-Wook Kim, Sukang Bae, Sung Kyu Jang, Yonghun Kim, Seoung-Ki Lee

Get full text

Mechanisms of microbial-gut-brain axis modulation by electroconvulsive therapy in the treatment of depression by Jiaming Ji, Jinyan Guo, Jirong Yang, Siyang Zeng, Xue Han, Ziqing Hei, Weifeng Yao, Chaojin Chen

“…In addition, we explore mechanisms by which ECT alters the composition and functioning of gut microbiota through the microbiota-gut-brain axis. …”
Get full text

Simple surface modification of poly(methyl methacrylate) microfluidic microplates for enhanced ultrasensitive multiplexed detection of infectious diseases by Sharma T. Sanjay, Sapna Kannan, XiuJun Li

“…Conventional colorimetric enzyme-linked immunosorbent assay (ELISA) is a widely used laboratory technique for medical diagnostics, quality control, and research applications. However, nonspecific absorption of proteins may lead to a reduction of functional sites, resulting in high background and low sensitivity in ELISA. …”
Get full text

Biologic Agents in Idiopathic Hypereosinophilic Syndrome by Ourania Papaioannou, Fotios Sampsonas, Panagiota Tsiri, Vasilina Sotiropoulou, Ioannis Christopoulos, Dimitrios Komninos, Argyrios Tzouvelekis

“…All patients with concomitant asthma (<i>n</i> = 8) experienced elimination of asthma flares, asthma control (ACQ < 0.75), functional improvement (mean ΔFEV1: 857 ± 594 mL), and an 82% reduction in oral corticosteroids, <i>p</i> = 0.0001. …”
Get full text

Endoscopic debridement of chronic plantar fasciitis with heel spur resection – a prospective cohort study by Patrick Buliński, Bartosz Bartosz, Artur Banach, Pavle Milanovic, Sorin Barbu, Jakub Naczk, Tomasz Piontek

“…These findings indicate a substantial reduction in pain and enhancement in functional abilities.Conclusions. …”
Get full text

UC-MSCs Secretome Induces Proliferation of CD4+ T Cells, CD8+ T Cells, NK Cells, and Increases sPD-1 Levels in Severe COVID-19’s Whole Blood by Winna Soleha, Heri Wibowo, Murdani Abdullah, Saraswati Pradipta, Lucky Novita Syari, Isabella Kurnia Liem, Arleni Bustami, Anna Rozaliyan

“…Following secretome treatment, CD4+ T cell counts significantly increased compared to pre-treatment, although this change was not significant in the negative control group. Additionally, there was a minimal reduction in B cell count and an increase in sPD-1 levels. …”
Get full text

Harmful Freshwater Algal Blooms, With an Emphasis on Cyanobacteria by Hans W. Paerl, Rolland S. Fulton, Pia H. Moisander, Julianne Dyble

“…While single nutrient input constraints may be effective in some water bodies, dual N and P input reductions are usually required for effective long-term control and management of harmful blooms. …”
Get full text

Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection by Frauke Lange, Jonathan Garn, Matthias Bruhn, Thomas Pietschmann, Arnaud Carpentier

“…Background &amp; Aims: Stem cell-derived hepatocyte-like cells (HLCs) are an in vitro model of hepatocytes reproducing mature hepatic functions. However, heterogeneous or imperfect differentiation may limit their biological relevance. …”
Get full text

UV-C and Nanomaterial-Based Approaches for Sulfite-Free Wine Preservation: Effects on Polyphenol Profile and Microbiological Quality by Kamila Pachnowska, Jolanta Kochel-Karakulska, Adrian Augustyniak, Valentina Obradović, Ireneusz Ochmian, Sabina Lachowicz-Wiśniewska, Ireneusz Kapusta, Klaudia Maślana, Ewa Mijowska, Krzysztof Cendrowski

“…These results open up discussion on the possible use of the proposed hurdle technology in winemaking to control the polyphenol composition and alcohol reduction.…”
Get full text