Easy-to-Apply Hydrogel Patch for Field Treatment and Monitoring of Equine Wounds by María Emilia Zambroni, Patricia A. Bertone, Ana Lucía Cabral, Andrés S. Boatti, Silvia V. Romanini, Sol R. Martínez, María Lorena Gómez

“…Wound measurements showed a reduction over time with patch treatment, with complete healing achieved at 116 days. …”
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Adipokinetic Hormones and Their Receptor Regulate the Locomotor Behavior in <i>Tribolium castaneum</i> by Rui-Han Lu, Xu-Dong Pang, Shuang-Qin Wen, Guy Smagghe, Tong-Xian Liu, Shun-Hua Gui

“…The silencing of <i>AKHs</i> or <i>AKHR</i> through RNA interference resulted in a significant reduction in both movement distance and duration. Collectively, these findings highlight the regulatory influence of AKH/AKHR signaling in locomotor activity in <i>T. castaneum</i>, thereby advancing our understanding of the molecular mechanisms underlying locomotor control in this economically important insect species.…”
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Watch out your pins! Periprosthetic femoral fracture at tracking pin site early after robotic-assisted knee arthroplasty treated with dual nail-plate fixation by Jaime Sánchez del Saz, Jaime Coderch Carretero, Javier García Coiradas, Rodrigo García Crespo

“…Robotic-assisted orthopedic surgeries are gaining popularity due to several factors such as its potential for enhanced precision and alignment in prosthetic implant placement, as well as its better pain control and reduction in hospital stay time. However, complications such as pin-related periprosthetic fractures, though rare, highlight the importance of technical precision during pin placement and adequate postoperative monitoring.We present the case of a 76-year-old obese female patient who presented to the Emergency Department with severe pain and deformity around the knee two months after robotic-assisted total knee arthroplasty following a fall from standing height. …”
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Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study by Alessandro Conforti, Cosimo Ruggiero, Nastasja Palombi, Filippo Messina, Marco Bonifacio, Linda Lucchetti, Marco Ruggiero, Giuseppe La Cava, Roberto Piazza, Mario Mangrella

“…Results showed a 30% and 50% pain reduction in 86% and 43% of patients, respectively, alongside significant improvements in functional mobility and sleep quality. …”
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Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis by Niloofar Mirzadzare, Graham A. D. Blyth, Rita Hannawayya, Karina M. Cirone, Geeta Kilari, Priyoshi Lahiri, Yi Lin Tan, Aydin Ivan Herik, Yongpeng Fu, Hayley Gorman, Björn Petri, Kris Chadee, Eduardo R. Cobo

“…We showed that increased fecal shedding and epithelial colonization by C. rodentium in Camp-/- littermates was accompanied by impaired mucus secretion and higher retention of mucin granules and trefoil factor 3 (Tff3) in bloated colonic goblet cells. Reduction in mucus secretion by goblet cells was accompanied by reduced reactive oxygen species (ROS) production during C. rodentium infection in Camp-/- as compared to Camp+/+ littermate controls. …”
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RGS9‐2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models by Paola Bonsi, Giulia Ponterio, Valentina Vanni, Annalisa Tassone, Giuseppe Sciamanna, Sara Migliarini, Giuseppina Martella, Maria Meringolo, Benjamin Dehay, Evelyne Doudnikoff, Venetia Zachariou, Rose E Goodchild, Nicola B Mercuri, Marcello D'Amelio, Massimo Pasqualetti, Erwan Bezard, Antonio Pisani

“…Abstract Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early‐onset DYT1 dystonia. …”
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An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli by Irina Kalita, Ira Alexandra Iosub, Lorna McLaren, Louise Goossens, Sander Granneman, Meriem El Karoui

“…In addition, we observe a less effective reduction of RecB protein fluctuations in the absence of Hfq. …”
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Comparative study of yogic practices and dietary modifications on biochemical variables among middle-aged women on metabolic dysfunction – Associated steatotic liver disease by S. Selva Sundari, C. V. Jayanthy, S. Natarajan

“…Results: The study revealed that the combined Yoga and Diet intervention led to a statistically significant improvement in liver function (alanine aminotransferase, F(2,17)=15.15, p<0.05) and glycemic control (fasting glucose, F(2,17)=6.64, p<0.05) among MAFLD participants, with the Yoga+Diet group showing the greatest mean reductions (-1.43 U/L and -37.06 mg/dL respectively). …”
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Elevated SGO2 expression in lung adenocarcinoma promotes migration and invasion via MAD2 and correlates with poor prognosis by Min Sun, Wenzheng Zhou, Guohao Wei, Mengyao Lv, Yan Sun, Huihui Zhao, Chuandong Zhu

“…However, research on the biological functions of SGO2 in Lung adenocarcinoma remains limited. …”
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Rescue Stenting after Unsuccessful Recanalization of Endovascular Thrombectomy of the Posterior Circulation: A Systematic Review and Meta Analysis by Aaron Brake, Emmanuel Danso, William Liu, Vince Galate, Lane Fry, Michael Abraham

“…Additionally, RS showed a significant reduction in 90‐day mortality (33.28% versus 54.66% in controls; P<0.001) and a lower incidence of symptomatic intracranial hemorrhage (3.74% versus 9.49% in controls; P<0.001). …”
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Heparin-Binding Hemagglutinin-Induced Trained Immunity in Macrophages: Implications for Antimycobacterial Defense by Yongqiang Li, Xiuping Jia, Jinhua Tang, Huilian Qiao, Jiani Zhou, Yueyun Ma

“…Further, metabolic analysis revealed heightened lactate production and the increased expression of glycolytic enzymes. Functionally, HBHA-trained macrophages exhibited improved control of intracellular mycobacteria, as evidenced by a significant reduction in colony-forming units following BCG infection. …”
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Palliative intraarterial chemoradiotherapy as a method of choice in the treatment of unresectable oropharyngeal tumors: a clinical case by R. V. Lutovinin, V. N. Oshchepkov, Yu. A. Shubina, V. V. Kokareva

“…A patient sought medical help at the multidisciplinary clinical medical center “Medical City” where combination treatment was chosen: a course of chemoradiation therapy using an original approach combining external beam 3D-conformal radiotherapy and intraarterial chemotherapy. According to control computed tomography data, dynamics was described as partial response: 30 % reduction in marker lesions. …”
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Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice by Helen Goodluck, Alice Zemljic‐Harpf, Ony Araujo Galdino, Sadhana Kanoo, Natalia Lopez, Young Chul Kim, Volker Vallon

“…Sotagliflozin, initiated 1 week after the last surgery, showed target‐engagement evidenced by glucosuria, 9 mmHg lower SBP, temporal reduction in body weight and GFR, and 30% higher plasma GLP1. …”
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Biomimetic gene delivery system coupled with extracellular vesicle–encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory mi... by Shan He, Zhenhao Li, Lei Xie, Rongtian Lin, Biying Yan, Bixiang Li, Lingxi Luo, Youshan Xv, Huangding Wen, Yaxuan Liang, Cong Huang, Zhiqing Li

“…The encapsulation strategy enables the vesicles to rapidly fuse with endothelial cell membranes, ensuring controlled expression of endogenous VEGF. Results revealed that VEGF-EV-AAV/MSC-Exo@FHCCgel alleviates mitochondrial function in endotheliocyte under oxidative stress. …”
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Bioaugmentation of Industrial Wastewater and Formation of Bacterial–CaCO₃ Coupled System for Self-Healing Cement by Olja Šovljanski, Vesna Bulatović, Tiana Milović, Jovana Grahovac, Tamara Erceg, Miroslav Dramićanin, Ana Tomić

“…Utilizing microbiologically induced calcium carbonate precipitation (MICP), this study evaluates the dual functionality of <i>Bacillus licheniformis</i> and <i>B. muralis</i> strains. …”
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Dynamic evolution of microstructure in thalamic subregions of patients with cirrhosis: A study based on diffusion kurtosis imaging by Qi Zhang, Zhi-Jing Zhang, Yi-Ning Zhang, Wen-Ting Ma, Xiao-Di Zhang, Zi-Ning Lu, Xiao-Dong Zhang, Wen Shen, Yue Cheng

“…Objectives: To investigate the cross-sectional and longitudinal dynamics of the thalamic subregion microstructure in patients with liver cirrhosis by diffusion kurtosis imaging (DKI) and explore its relationship with cognitive function. Materials and methods: DKI was performed on 50 with hepatic encephalopathy (HE), 46 without hepatic encephalopathy (non-HE), and 41 healthy controls (HC). 61 of these cirrhotic patients underwent liver transplantation (LT) surgery and DKI again one month later to compare the diffusion parameters before and after surgery. …”
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Chemical Profile and Promising Applications of <i>Cucurbita pepo</i> L. Flowers by Ritamaria Di Lorenzo, Luigi Castaldo, Raffaele Sessa, Lucia Ricci, Eleonora Vardaro, Luana Izzo, Michela Grosso, Alberto Ritieni, Sonia Laneri

“…CpLfe also upregulated genes crucial for skin hydration (AQP3) and barrier function (CerS2, CerS4, and CerS6). A placebo-controlled, randomized clinical trial further validated CpLfe efficacy, demonstrating marked improvements in moisture retention, wrinkle reduction, and collagen production in women aged 35–55. …”
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Absence of Rnf126 causes male infertility with multiple morphological abnormalities of the sperm flagella by Shengnan Wang, Zihan Qin, Juan Liu, Jie Liu, Qiaohua Xiong, Zexiao Wei, Li Wang, Yuming Cao

“…However, the mechanisms by which Rnf126 controls spermatogenesis are not fully understood. …”
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CRISPR-Cas9-mediated deletions of FvMYB46 in Fragaria vesca reveal its role in regulation of fruit set and phenylpropanoid biosynthesis by Arti Rai, Magne Nordang Skårn, Abdelhameed Elameen, Torstein Tengs, Mathias Rudolf Amundsen, Oskar S. Bjorå, Lisa K. Haugland, Igor A. Yakovlev, May Bente Brurberg, Tage Thorstensen

“…In the FvMYB46-mutant flowers, the flavanol and flavan-3-ol contents, especially epicatechin, quercetin-glucoside and kaempferol-3-coumaroylhexoside, were reduced, and we observed a local reduction in the lignin content in the anthers. Together, these results suggest that FvMYB46 controls fertility and efficient fruit set by regulating the cell wall structure, flavonoid biosynthesis, carbohydrate metabolism, and sugar and ROS signalling in flowers and early fruit development in F. vesca.…”
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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with short bowel syndrome and colon in continuity: an open-label pilot study by Bolette Hartmann, Jens Juul Holst, Rahim Mohammad Naimi, Mark Krogh Hvistendahl, Lise Margrete Thomassen, Hanna Johnsen, Charlotte Bayer Christiansen, Palle Bekker Jeppesen

“…One patient achieved a reduction in PS by 500 mL per administration day.Conclusion Following this negative, small pilot study, larger, placebo-controlled, studies are needed to establish the therapeutic potential of DPP-4 inhibition in patients with SBS.…”
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