Impact of SGLT2 inhibitors on myocardial fibrosis in diabetic HFpEF: a longitudinal study by Arif Albulushi, Kimia M. Askari, Ammar M. Al-Abedi, Malak A. Al-Kulaibi, Murtadha S. Hasan, Zahra Hosseini, Mezon T. Al-Rahman, Desmond B. Tanoh, Amjad S. Hasan, Yaseen Al-Helli, Ahmed Basouni

“…Additional benefits included greater reductions in LVMI (− 8.2 g/m2 vs. − 2.1 g/m2; p = 0.002), improved glycemic control (HbA1c: − 1.2% vs. − 0.4%; p = 0.01), and enhanced functional capacity (+ 45 m vs. + 10 m in 6MWT; p = 0.01). …”
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Cost-Effectiveness Analysis of a Machine Learning–Based eHealth System to Predict and Reduce Emergency Department Visits and Unscheduled Hospitalizations of Older People Living at... by Charlotte Havreng-Théry, Arnaud Fouchard, Fabrice Denis, Jacques-Henri Veyron, Joël Belmin

“…MethodsThis study was a comparative, retrospective, and controlled trial on data collected between May 31, 2021, and May 31, 2022, in one health care and home nursing center located in Brittany, France. …”
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A one year longitudinal study of cortical myelination changes following pediatric mild traumatic brain injury by Jessica R. McQuaid, Tracey V. Wick, Josef Ling, Andrew B. Dodd, Divyasree Sasi Kumar, Upasana Nathaniel, Samuel D. Miller, Vadim Zotev, Harm J. van der Horn, John P. Phillips, Richard A. Campbell, Robert E. Sapien, Timothy B. Meier, Andrew R. Mayer

“…The current study examined the impact of pmTBI on cortical myelination relative to healthy controls (HC) by estimating myelin content using the T1w/T2w ratio method. …”
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Development of Antimicrobial and Antioxidative Chicken Patties Using Liquid-Fermented <i>Ganoderma lucidum</i> and <i>Pleurotus djamor</i> Fruiting Body Biomass by Nur Asyiqin Zahia-Azizan, Chong Shin Yee, Muhammad Ameer Ushidee-Radzi, Zul Ilham, Muhamad Hafiz Abd Rahim, Siva Raseetha, Nazimah Hamid, Adi Ainurzaman Jamaludin, Wan Abd Al Qadr Imad Wan-Mohtar

“…These were compared to a negative control (0% mushroom flour chicken patty) and a commercial patty. …”
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Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence by Juan Chen, Lili Fu, Mengjin Li, Kun Xie, Xinming Li, Xu-jie Zhou, Li Yang, Liming Zhang, Cheng Xue, Cheng Xue, Zhiguo Mao

“…BackgroundChronic kidney disease (CKD) is a progressive disorder characterized by declining renal function and systemic metabolic disturbances. Brain-derived neurotrophic factor (BDNF), a key member of the neurotrophic family, plays critical roles in neuronal function and muscular metabolism. …”
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Effect of CFTR modulators on glucose homeostasis in children and young adults with cystic fibrosis-related diabetes: a systematic review by Paola Giordano, Giuseppina Leonetti, Vanja Granberg, Rosa Maria Pia Casolino, Giuseppe Lassandro, Maurizio Delvecchio, Giovanna Linguiti

“…Conversely, lumacaftor/ivacaftor exhibits inconsistent effects, with some studies indicating glucose tolerance improvements while others report insulin sensitivity decline.DiscussionETI therapy shows modest but generally positive effects on glycemic control, with reductions in HbA1c and fasting glucose, though without significant changes in insulin secretion. …”
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Cortical Reorganization Is Associated with Surgical Decompression of Cervical Spondylotic Myelopathy by Andrew Green, Priscilia W. T. Cheong, Stephanie Fook-Chong, Rajendra Tiruchelvarayan, Chang Ming Guo, Wai Mun Yue, John Chen, Yew Long Lo

“…Group B did not show significant reduction in sMEP or N after surgery, or significant correlation of cMEP or NDiff with all hand function tests. …”
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Oxidative Stress and Keap1-Nrf2 Pathway Involvement in Bisphenol A-Induced Liver Damage in Rats by Juan Tang, Kai Wang, Dan Shen, Chunmei Li

“…Concurrently, Nrf2 and cleaved caspase-3 expression levels were elevated in the BPA-treated group compared to the controls. These findings suggest that BPA may contribute to metabolic disorders of liver function and poses a hepatotoxicity risk. …”
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Effect of midlife exercise on lipid metabolism in aging mice: comparable to lifelong exercise, better than ceasing midlife exercise by Ling Yang, Tuanhui Peng, Xu Yan, Pengjie Lin

“…Five-week-old male BALB/c mice were randomly assigned to five groups: young control group (YC), natural ageing control group (AC), exercise cessation group (DE), middle-aged commencing exercise group (ME), and lifelong exercise group (LE). …”
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Efficacy and Safety of an Ayurveda Herbal Formulation in Uncomplicated Type 2 Diabetes mellitus by Bilesha Perera BSc, PhD, Colvin Goonaratna MBBS, FRCP, PhD, Hettiarchchige Ariyawansa DAMS, PhD, Nirmala Senaratna DAMS, MD, Jennifer Perera MBBS, MD

“…Due to the small sample size, unblinded nature of this preliminary study, and the lack of a control arm, a randomized double-blinded controlled clinical trial on a larger group of patients is recommended.…”
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Texture analysis of T1- and T2-weighted images identifies myofiber atrophy and grip strength decline in streptozotocin-induced type 1 diabetic sarcopenia rats by Dong Xing, Fang Liu, Yufan Gao, Ziyan Fei, Yunfei Zha

“…Materials and methods Twenty SD rats were randomly and evenly allocated to the control (CON) and diabetic sarcopenia (DS) groups. …”
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NFκB1: a common biomarker linking Alzheimer's and Parkinson's disease pathology by Adam Cunningham, Emma Barrett, Sebastian Risch, Peter H. U. Lee, Peter H. U. Lee, Chan Lee, Abhay Moghekar, Prabir Patra, Joon W. Shim

“…A significant 10-fold reduction in hemoglobin subunit alpha (HbA1) RNA was observed in disease groups compared to controls, indicating compromised oxygen transport and cellular stress. …”
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Long-term retinal microvascular alterations after endoscopic endonasal surgery in patients with sellar region tumors by Sebnem Kaya Ergen, Anil Ergen, Busra Gunduz, Ecem Cemre Ceylan, Sevgi Subasi, Melih Caklili, Burak Cabuk, Ihsan Anik, Savas Ceylan

“…RESULTS: Baseline OCT-A values revealed significantly reduced papillary and foveal vessel densities in almost all quadrants in sellar tumor patients compared to controls (P<0.05, respectively). While VF MD values improved significantly postoperatively (P<0.001), no significant improvement was observed in microvascular vessel density or retinal nerve fiber layer (RNFL) thickness (P>0.05, respectively); instead, a tendency toward reduction was noted over 12mo. …”
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Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting arsenic accumulation in plants. by Dai-Yin Chao, Yi Chen, Jiugeng Chen, Shulin Shi, Ziru Chen, Chengcheng Wang, John M Danku, Fang-Jie Zhao, David E Salt

“…Using genome-wide association (GWA) mapping of loci controlling natural variation in arsenic accumulation in Arabidopsis thaliana allowed us to identify the arsenate reductase required for this reduction, which we named High Arsenic Content 1 (HAC1). …”
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Systematic Review and Meta-Analysis of Chicory Inulin-Type Fructans Supplementation on Weight Management Aspects by Yoghatama Cindya Zanzer, Stephan Theis

“…Increasing evidence from in vivo mechanistic and clinical studies has shown that the gut microbiota is interacting with the host's physiological function in regulating energy intake and body weight. …”
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Optimal sizing and placement of STATCOM, TCSC and UPFC using a novel hybrid genetic algorithm-improved particle swarm optimization by Urbanus Mwanzia Ngei, Abraham Mutunga Nyete, Peter Musau Moses, Cyrus Wekesa

“…Static Synchronous Compensator (STATCOM), Thyristor Controlled Series Capacitor (TCSC) and Unified Power Flow Controller (UPFC) are the three FACTS devices considered. …”
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Breathless Strength: Ultrasonographic Insights into Expiratory Muscle Dysfunction in Spinal Cord Injury by Burak Kutuk, Kadriye Ones, Yunus Emre Dogan

“…<i>Materials and Methods:</i> A case-controlled, cross-sectional study was conducted with 36 SCI patients and 30 age- and sex-matched healthy controls. …”
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Substrate induced denitrification over or under estimates shifts in soil N₂/N₂O ratios. by Nicholas J Morley, David J Richardson, Elizabeth M Baggs

“…The role of organic carbon in controlling N₂O reduction is poorly understood, and mostly based on application of glucose. …”
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Markers of intracellular energy supply under conditions of hypoxia in premature babies by O.S. Godovanets

“…The well-being of the intrauterine environment and birth, morphological and functional maturity at birth are the basis for the child’s postnatal adaptation. …”
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The Use of Tricyclic Antidepressants for Postherpetic Neuralgia – A Case Series by Jamal Hasoon, Syed Mahmood

“…All four patients experienced notable reductions in pain intensity on the Numeric Rating Scale (NRS), resulting in improved daily function and better pain tolerance. …”
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