The prophylactic anti-aging effect of aspirin (acetylsalicylic acid) on oxidative stress-induced damage in the buccal mucosa of D-galactose-induced aged rats by Mohamed Khaled Mohamed Maria, Maha Hassan Bashir, Amira E. Fares, Nermeen AbuBakr

“…Abstract Most living organisms experience time-dependent functional deterioration as they age. To combat aging, aspirin was proposed as an already well-studied drug. …”
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Features of angiotensin II expression in the arcuate nucleus of the hypothalamus of experimental rats with arterial hypertension of various etiology by S. V. Tishсhenko

“…The important role of the arcuate nucleus (ArC) both as the intrahypothalamic regulator of the functional activity of its nuclear structures, and the coordinator over the suprasegmental and segmental centers of blood pressure regulation is proved. …”
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The nonhost mycorrhizal status of weeds and its relevance to weed management in agroecology by Irene Pagliarani, Arianna Grassi, Monica Agnolucci, Alessandra Turrini, Luciano Avio, Manuela Giovannetti

“…This review provides qualitative and quantitative data on the interactions between AMF and nonhost weeds and on the mechanisms underlying weed fitness reduction. The lack of extensive field studies highlights the need for experimental works under real crop conditions to determine whether the combination of AMF with cover crops – a weed management practice adopted in agroecology – could serve as a valuable strategy for weed control, promoting the agroecological transition towards low-input, safe, and resilient agroecosystems.…”
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Analysis of the SUMO2 Proteome during HSV-1 Infection. by Elizabeth Sloan, Michael H Tatham, Marine Groslambert, Mandy Glass, Anne Orr, Ronald T Hay, Roger D Everett

“…Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. …”
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INFLAMMATORY REACTIONS IN EXPERIMENTAL MYOCARDIAL DAMAGE by L. D. Khidirova, N. N. Mayanskaya

“…Myocardial infarction was verified by ECG analysis, and by histological control. Nitroblue tetrazolium test (NBT-test) both spontaneous and zymosan induced NBT-test was used to determine the oxygen-dependent functional activity of neutrophils and their biocidal reserve. …”
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Brief Mindfulness Meditation Induces Gray Matter Changes in a Brain Hub by Rongxiang Tang, Karl J. Friston, Yi-Yuan Tang

“…In this longitudinal study using a randomized design, we therefore examined the effect of a 10 h of mindfulness training, the Integrative Body-Mind Training (IBMT) on gray matter volume of the PCC compared to an active control—relaxation training (RT). We found that brief IBMT increased ventral PCC volume and that baseline temperamental trait—an index of individual differences was associated with a reduction in training-induced gray matter increases. …”
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The content of adiponectin, resistin in serum and their ratio in patients with chronic heart failure in overweight and obesity depending on severity of disease, body mass index, ag... by P. P. Bidzilya

“…We examined 100 patients of the main group who had CHF of II–III functional class (FC) on the background of normal, overweight and obesity I–III degree. …”
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Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus by R. R. Samedov, A. B. Bakhshaliev

“…This 12-month study included 30 patients with functional Class (FC) II-III CHF by NYHA classification, LV ejection fraction (EF) <40% and DM-2. …”
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Efficacy and Renal Safety of Dapagliflozin in Patients with Type 2 Diabetes Mellitus Also Receiving Metformin: A Real-Life Experience by Alessandro Scorsone, Gabriella Saura, Mattia Fleres, Lucia Spano, Vito Aiello, Davide Brancato, Anna Di Noto, Francesca Provenzano, Vincenzo Provenzano

“…In those with inadequate glycemic control, insulin or glimepiride was added after 30 days (DAPA + MET + other glucose-lowering drugs). …”
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Built environment and residential blocks carbon emissions: a study using advanced metering infrastructure data by Xiaoping Zhang, Xiaoping Zhang, Zixuan Cui, Chaoxian Feng, Xin Wen, Huabin Xiao, Jianbo Ni

“…Spatial autocorrelation analysis indicates a significant positive correlation and a west-south clustering pattern. (3) Land area (LA) is the main emissions affecting factor, followed by green space ratio (GSR) and Land use mixing degree (LMD), whose inhibitory effect exceeds that of traditional high-intensity development indicators. (4) Targeted planning strategies such as strictly controlling land use expansion, improving GSR, and promoting functional combination were proposed. …”
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Long-term outcomes of dupilumab therapy in severe asthma: A retrospective, multicenter, real-world study by Carlo Mümmler, MD, Alexandra Lenoir, MD, Jeremias Götschke, MD, Michael Gerckens, MD, Merle Kaiser, MD, Moritz Kayser, MD, Nora Drick, MD, Hendrik Suhling, MD, Leonie Biener, MD, Carmen Pizarro, MD, Dirk Skowasch, MD, Nikolaus Kneidinger, MD, PhD, Jürgen Behr, MD, Katrin Milger, MD

“…Patients who continued dupilumab for 36 months had significant reductions in annual exacerbations (−1; P < .0001) and oral corticosteroid dose (−5.5 mg/day; P < .001) as well as significant improvements in asthma control (asthma control test +5; P < .0001) and lung function (percent predicted of FEV1 +7%; P < .001) compared with baseline. …”
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Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metaboli... by Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta

“…Astrocyte yield (GFAP-immunopositive) was comparable between LRRK2-I1371V and healthy control (HC) populations; however, the astrocytic capability to mitigate oxidative stress in terms of glutathione content was significantly reduced in the mutant astrocytes, along with a reduction in the gene expression of the enzymes involved in glutathione machinery and nuclear factor erythroid 2-related factor 2 (Nrf2) expression. …”
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Health program for prEvention of cardiovascuLar disEases based on a risk screeNing strategy with Ankle-brachial index: HELENA study protocol by Gina Domínguez-Armengol, Gina Domínguez-Armengol, Francesc Ribas-Aulinas, Francesc Ribas-Aulinas, Elisabet Balló, Maite Alzamora-Sas, Maite Alzamora-Sas, Mar Serrat-Costa, Anna Ruiz-Comellas, Anna Ruiz-Comellas, Anna Ruiz-Comellas, Maria Jose Forcadell-Peris, Maria Jose Forcadell-Peris, Pere Toran, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Anna Ponjoan, Anna Ponjoan, Anna Ponjoan, Jordi Blanch, Lia Alves-Cabratosa, Lluís Zacarías-Pons, Lluís Zacarías-Pons, Eric Tornabell-Noguera, Eric Tornabell-Noguera, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Anna Berenguera-Ossó, Anna Berenguera-Ossó, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, The HELENA Study Group

“…Survival analysis will estimate the effectiveness of adding the ABI screening strategy, with Cox models (intention-to-treat) and marginal structural models controlling for confounding variables.Results and discussionDirect health improvements in the intervened population are expected, including a reduction in CHD incidence and its risk factors. …”
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Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis by Jingru Duan, Xiaowei Zhou, Hanfei Zhu, Mingjuan Zhou, Mengyu Liu, Yan Zhou, Wenzhu Li, Bufang Xu, Aijun Zhang

“…In the adenomyosis mouse model, we observed a decrease in LEF1 expression and a reduction in implantation sites compared to control mice, accompanied by impaired decidualization and receptivity. …”
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Exploring corrosion behavior, antimicrobial evaluation, molecular docking and DFT calculation of thiosemicarbazone ligand and its metal complexes by Howida S. Mandour, Lobna A. Khorshed, Amr M. Abdou, Basma Ghazal

“…The results deducted from cyclic voltammetry technique showed that, the oxidation–reduction process of the ligand (HL) and its metal complexes Ni (II), Co (II) and Cd (II) under quasi-reversible system and the reaction occurred on the metal surface under diffusion control. …”
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Knockdown of <i>POLG</i> Mimics the Neuronal Pathology of Polymerase-γ Spectrum Disorders in Human Neurons by Çağla Çakmak Durmaz, Felix Langerscheidt, Imra Mantey, Xinyu Xia, Hans Zempel

“…Impaired function of Polymerase-γ (Pol-γ) results in impaired replication of the mitochondrial genome (mtDNA). …”
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Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo. by Buthaina Al Shueili, Arthur Dantas, Etienne Mahe, Tak Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand Masson, Hiba Omairi, Kenichi Ito, Roman J Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol

“…Consistent with ING5 serving a tumor suppressive role, ING5 KO mice developed germinal centre diffuse large B-cell lymphomas at a rate 6-fold higher than control mice at 18 months of age. These data suggest that ING5 functions in vivo to maintain stem cell character in multiple organs, that reduction of stem cell populations is not limiting for murine lifespan and that like a subset of other ING family members, ING5 functions as a tumor suppressor in hematopoietic cells in vivo.…”
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AZU1 as a DNA Methylation-Driven Gene: Promoting Oxidative Stress in High-Altitude Pulmonary Edema by Qiong Li, Zhichao Xu, Qianhui Gong, Liyang Chen, Xiaobing Shen, Xiaowei Chen

“…To further validate the function of AZU1, we conducted experimental studies using a hypobaric hypoxia injury model in Human Umbilical Vein Endothelial Cells (HUVEC). …”
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Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy by Raghda S. Al-Najjar, Nehaya M. Al-Aubody, Salah Z. Al-Asadi, Majid Alabbood

“…There was a statistically significant P100 latency delay and P100 amplitude reduction in both groups A and B in comparison with the controls. …”
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Effectiveness of acupuncture and moxibustion combined with rehabilitation training for post-stroke shoulder-hand syndrome: a systematic review and meta-analysis by Huawei Gao, Zhihong Li, Wei Chen, Fangfang Shen, Yan Lu

“…BackgroundPost-stroke shoulder-hand syndrome (SHS) significantly impacts patients' quality of life and functional recovery. While both acupuncture and rehabilitation training have shown promise individually, their combined effect needs systematic evaluation.MethodsA comprehensive search was conducted across seven databases (PubMed, Embase, Cochrane Library, Web of Science, Sinomed, CNKI, and Wanfang) for randomized controlled trials comparing combined acupuncture-moxibustion-rehabilitation therapy vs. rehabilitation alone. …”
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