PATHOMORPHOLOGICAL AND COMPUTERIZED TOMOGRAPHY STUDY OF IBUPROFEN AND COMBINATION WITH 2-PHENYL-3-CARBETHOXY-4-DIMETHYLAMINOMETHYL-5-OKSIBENZOFURAN HYDROCHLORIDE (VINBORON) INFLUEN... by F. V. Hladkykh, V. O. Student, N. H. Stepaniuk, S. V. Vernyhorodskyi

“…The use of ibuprofen in combination with vinboron was accompanied by restoration of the structure and function of the cartilage and bone tissues, evidenced by the appearance of acidic and sulfated glycosaminoglycans. …”
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Nicotinamide Phosphoribosyltransferase Acetylation Mediating Muscle Dysfunction Contributes to Sleep Apnoea in Obesity by Liu Zhang, Ya Ru Yan, Shi Qi Li, Ying Ni Lin, Yi Wang, Yu Qing Wang, Ning Li, Fang Ying Lu, Xian Wen Sun, Li Yue Zhang, Jian Ping Zhou, Yong Jie Ding, Qing Yun Li

“…ABSTRACT Background Obstructive sleep apnoea (OSA) occurs frequently among individuals with obesity, which is attributed to upper airway muscle dysfunction. Muscle function is regulated by the dynamic balance of the nicotinamide adenine dinucleotide (NAD+) and its reduced form (NADH), which is controlled by the enzyme nicotinamide phosphoribosyltransferase (NAMPT). …”
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A phase I/II trial evaluating the safety of increased-dose S- 1 with oxaliplatin and nivolumab in HER2-negative advanced gastric cancer by Keisuke Baba, Nobumi Suzuki, Chiyo K. Imamura, Eisuke Booka, Masashi Takeuchi, Daisuke Takahari, Takeshi Kawakami, Hirofumi Kawakubo, Chiyoe Kitagawa, Yoshiyasu Kono, Keiji Ogura, Yosuke Kito, Kei Saito, Shinzo Yamamoto, Hiroya Takeuchi, Toshihiro Kudo, Takuya Tsunoda, Takuro Mizukami, Toshifumi Yamaguchi, Hirokazu Shoji, Kanako Saito, Kenro Tanoue, Eishi Baba, Kengo Nagashima, Narikazu Boku

“…Abstract Background We developed and refined an S-1 dosage formula based on renal function, sex, and body surface area (BSA) to achieve the target area under the concentration–time curve of 5-fluorouracil in two prospective pharmacokinetic studies. …”
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Visnagin treatment attenuates DSS-induced colitis by regulating inflammation, oxidative, stress, and mucosal damage by Vemula Sravathi, Madhuri Doppalapudi, Ravi Kumar Yadala, Anilkumar Banothu, Vijaya Kumar Anumolu, Hanuman Donga Durga Veera, Bhaskar Debbarma

“…Its ability to modulate inflammatory pathways and enhance intestinal barrier function suggests its potential as an alternative treatment for UC.…”
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Reduced IFN-γ-expressing SARS-CoV-2 specific CD4+ T cells and transient CD8 + T cell activation associate with higher HOMA-IR 1-year post COVID-19 in obese individuals by Rona Kartika, Dicky Levenus Tahapary, Farid Kurniawan, Syahidatul Wafa, Tika Pradnjaparamita, Simon P. Jochems, Heri Wibowo, Imam Subekti

“…This reduction, along with the decreased frequencies of both functional CD4⁺ within 12 months of convalescence, suggests a potential association between impaired SARS-CoV-2-specific T cell function and the development of insulin resistance following COVID-19. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…Histological analysis revealed that the triple‐loaded OACDP hydrogels are effective in achieving immediate neuroprotection, i.e., reduction the loss of tyrosine hydroxylase in substantia nigra compacta and striatum (retained ≈10‐fold versus control), decreasing oxidative stress, reducing astrocyte and microglia activation, and stimulating the AMPK/PGC‐1α axis to regulate the mitochondrial function, providing a multi‐dimensional PD therapy. …”
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The intestinal microbiota modulates the visceral sensitivity involved in IBS induced by restraint combined with tail clustering by Na Deng, Na Deng, Siqin Xie, Qin Liu, Huiyi Peng, Leyao Fang, Junxi Shen, Xiaoyuan Lin

“…The mice in the BCTM group had significantly higher gastric residue rates and 5-HT levels, with a marked reduction in pain tolerance. The gut microbiota of the mice in the BM, CTM, and BCTM groups all exhibited dysbiosis, with changes in the diversity, structural composition, and function of the microbial community. …”
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Impact of aging on gene expression in human oocytes: a comparative analysis of young and older patients by Raoul Orvieto, Omri Nayshool, Louisa Cohen, Yuval Yung, Adva Aizer, Efrat Glick Saar, Dan Dominissini

“…Gene expression quantification was performed using feature Counts from the Subread package (v1.5.3), and comprehensive quality control reports were generated using MultiQC (v1.25.1). …”
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multi-objective mathematical model for optimizing the collection and recycling of urban waste under conditions of uncertainty(The subject of study : Karaj city) by Mohsen Bijanpoor, Reza Ehtesham Rasi, Davood Gharakhany

“…Considering the collection and recycling supply chain network presented in this research and also based on the literature review, issues such as routing the movement of waste collection and transportation trucks in the mentioned network, production and storage planning for recycling centers,  using heuristic and meta-heuristic solution methods to solve the model which are combined with other exact mathematical solution methods such as Lagrange release, considering environmental objective functions such as pollution reduction in the waste transportation and recycling process and considering the uncertainty in the capacity of facilities can be considered as the subject of future research.…”
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Metabolomics and proteomics insights into hepatic responses of weaned piglets to dietary Spirulina inclusion and lysozyme supplementation by Cátia Falcão Martins, Manolis Matzapetakis, David M. Ribeiro, Josipa Kuleš, Anita Horvatić, Nicholas Guillemin, Peter David Eckersall, João P. B. Freire, André M. Almeida, José A. M. Prates

“…Results Growth performance showed an average daily gain reduction of 9.5% and a feed conversion ratio increase of 10.6% in groups fed Spirulina compared to the control group. …”
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Lorlatinib overcomes alectinib‐induced hemolytic anemia in an ALK fusion positive non‐small‐cell lung cancer patient with severe tumor‐associated liver failure: A case report... by Kei Kunimasa, Akito Miyazaki, Motohiro Tamiya, Takako Inoue, Takahisa Kawamura, Tsunehiro Tanaka, Shun Futamura, Kiyohide Komuta, Shigenori Nagata, Keiichiro Honma, Kazuyoshi Ohkawa, Kazumi Nishino

“…In this case, lorlatinib effectively controlled the tumor and improved the patient's liver function and performance status. …”
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Ginkgo ketone ester tablets for the treatment of cognitive impairment associated with chemotherapy for breast cancer - a prospective cohort study by Jiajing Chen, Lixin Chen, Kexin Jiang, Dandan Wang, Chunyu Wu, Yuenong Qin, Sheng Liu

“…Biochemical analysis revealed substantial GSH elevation (56% increase) and ROS reduction (41% decrease) at week 24, while TNF-α remained unchanged. …”
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Pulmonary Arterial Hypertension-Induced Reproductive Damage: Effects of Combined Physical Training on Testicular and Epididymal Parameters in Rats by Mírian Quintão Assis, Luciano Bernardes Leite, Luiz Otávio Guimarães-Ervilha, Rui Adão, Emily Correna Carlo Reis, Antônio José Natali, Mariana Machado-Neves

“…<b>Background/Objectives:</b> Pulmonary arterial hypertension (PAH) affects the pulmonary vasculature and cardiac function. While its impact on target organs has been extensively studied, little is known about its effects on highly vascularized organs, such as those from the male reproductive system. …”
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Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways by Hadeer Badry, Nadia M. El-Beih, Aya M. Hussein, Hanaa F. Abd El-Kareem, Wael M. El-Sayed

“…Results AD treatment led to significant reductions in body weight, increased relative kidney weight, and disrupted kidney and liver function markers, including elevated urea, creatinine, ALT, GGT, and glucose levels. …”
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PAK4 promotes the cytoskeletal organization and meiotic maturation via phosphorylating DDX17 in oocyte by Hengjie Wang, Ming Gao, Qing Cheng, Shuai Zhu, Yu Chen, Ling Gu, Xuejiang Guo, Ran Huo, Bo Xiong, Qiang Wang

“…Abstract PAK4 has been widely reported to function in somatic cells. However, its role and the underlying mechanisms in meiotic oocytes are largely unknown. …”
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Sauropus androgynus chlorophyll ameliorates the hazardous effect of sodium nitrite-induced oxidative stress in adult female rats by S. Suparmi, M. Fasitasari, F. Latifah, L. Ifroza, N. H. Taufiqurrokhim, L. A. Lestanu, D. Irmadhani, D. P. A. S. Wahyudi, N. Rustanti

“…Over 30 days, the haematological and liver function were assessed from blood samples. Exposure to NaNO2 resulted in significant reductions in packed cell volume (PCV), haemoglobin (Hb) concentration, and red blood cell (RBC) count, alongside elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, and gamma-glutamyl transferase (γ-GT). …”
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Infection dynamics and management in patients undergoing extracorporeal membrane oxygenation: a retrospective analysis by Zhu Yuan, Shili Zhong, Qiqi Tang, Yunting Liu, Zhen Wang, Hong Xiao

“…Early bacterial culture; and prophylactic, empirical, and targeted antimicrobials contribute to infection control. …”
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Recentralization within decentralization: County hospital autonomy under devolution in Kenya. by Edwine W Barasa, Anthony M Manyara, Sassy Molyneux, Benjamin Tsofa

“…<h4>Conclusion</h4>Increasing the autonomy of county hospitals in Kenya will improve their functioning. County governments should develop legislation that give hospitals greater control over resources and key management functions.…”
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Carbohydrate metabolism parameters in angina patients treated with metoprolol and its combination with trimetazidine by E. V. Bochkareva, O. V. Aleksandrovich, P. Yu. Bardybakhin, E. K. Butina, N. G. Kucheryavaya, I. N. Ozerova, V. A. Metelskaya

“…In total, 28 men aged 46-68 years, with Functional Class (FC) II-III stable angina, positive exercise stress test (EST), and no prior β-AB therapy were examined. …”
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Bortezomib-induced peripheral neuropathy in patients with multiple myeloma: pain syndrome and psychopathological aspects by E. Z. Irugova, L. P. Mendeleeva, D. E. Vybornykh, M. V. Soloveva, S. Yu. Fedorova, M. V. Solovev

“…A control electroneuromyography conducted 100 days after auto‑HSCT confirmedpartial or complete restoration of nerve fibers functional state. …”
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