NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME

“…To confirm our in vivo data, we isolated nanovesicles from HT29 cells treated with the probiotics mix and, remarkably, TDO2 levels were higher in nanovesicles from treated cells compared to the controls4. Our findings suggest that probiotic-induced nanovesicles may influence CNS function through the gut–brain axis and help maintain gut homeostasis under stress. …”
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Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies. by Narinder Janghra, Jennifer E Morgan, Caroline A Sewry, Francis X Wilson, Kay E Davies, Francesco Muntoni, Jonathon Tinsley

“…Lack of dystrophin leads to loss of muscle fibres and a reduction in muscle mass and function. There is evidence from dystrophin-deficient mouse models that increasing levels of utrophin at the muscle fibre sarcolemma by genetic or pharmacological means significantly reduces the muscular dystrophy pathology. …”
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Prevention of arterial stiffening by using low-dose atorvastatin in diabetes is associated with decreased malondialdehyde. by Chih-Hsien Wang, Ru-Wen Chang, Ya-Hui Ko, Pi-Ru Tsai, Shoei-Shen Wang, Yih-Sharng Chen, Wen-Je Ko, Chun-Yi Chang, Tai-Horng Young, Kuo-Chu Chang

“…They were also compared with untreated age-matched diabetic controls. Arterial wave reflection was derived using the impulse response function of the filtered aortic input impedance spectra. …”
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Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. by Tamas Szikra, Peter Barabas, Theodore M Bartoletti, Wei Huang, Abram Akopian, Wallace B Thoreson, David Krizaj

“…Calcium is a messenger ion that controls all aspects of cone photoreceptor function, including synaptic release. …”
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Exploring the Trade-Off in the Variational Information Bottleneck for Regression with a Single Training Run by Sota Kudo, Naoaki Ono, Shigehiko Kanaya, Ming Huang

“…An information bottleneck (IB) enables the acquisition of useful representations from data by retaining necessary information while reducing unnecessary information. In its objective function, the Lagrange multiplier <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>β</mi></semantics></math></inline-formula> controls the trade-off between retention and reduction. …”
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Distinct gut microbiota and metabolomic profiles in HBV-related liver cirrhosis: insights into disease progression by Ke Shi, Lina Sun, Ying Feng, Xianbo Wang

“…Gut microbiota alterations at various stages of liver function were analyzed using 16S rRNA gene sequencing. …”
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FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice by Alba Irisarri, Ana Corral, Núria Perez-Salvador, Aina Bellver-Sanchis, Marta Ribalta-Vilella, Roger Bentanachs, Marta Alegret, Juan Carlos Laguna, Emma Barroso, Xavier Palomer, Daniel Ortuño-Sahagún, Manuel Vázquez-Carrera, Mercè Pallàs, Laura Herrero, Christian Griñán-Ferré

“…The novel object recognition test (NORT) and object location test (OLT) revealed that treated mice exhibited enhanced short- and long-term memory and spatial memory compared to the HFD control group. Additionally, the open field test showed a reduction in anxiety-like behavior after treatment with FB23. …”
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Effects of Saccharomyces boulardii cell wall polysaccharide on growth performance, immunity, antioxidant ability and ileal mucosal morphology of Jinhua weaned piglets in Northern X... by Wenshu Zhu, Xucheng Mo, Wenshuai Zeng, Wantong Ren, Mengjian Liu

“…This enhancement is attributed to the increased antioxidant capacity, improved immune function, enhanced mucosal morphology, and reduced concentrations of inflammatory factors in both the ileal mucosa and serum.…”
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Efficacy analysis of neuroprotective drugs in patients with acute ischemic stroke based on network meta-analysis by Mei Li, Xianhao Huo, Qing Chang, Xiaozhuo Liu, Jianning Zhang, Zhiqi Mao

“…We utilized Stata version 16.0 and Review Manager (RevMan) version 5.3.0 for statistical analysis.ResultsA total of 35 studies were included: 25 randomized control trials, eight retrospective studies, and two prospective studies. …”
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Efficacy and safety of musculoskeletal manipulations in elderly population with musculoskeletal disorders: a systematic review by Alessandro Mauro, Donatella Bagagiolo, Michela Persiani, Luca Cicchitti, Luca Vismara, Irene Bruini, Francesca Buffone

“…For neck pain and low back pain, no statistically significant improvement in functional status and quality of life was observed with MM compared with any control group. …”
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Temporal dynamics of the multi-omic response reveals the modulation of macrophage subsets post-myocardial infarction by Yuan Wu, Panting Wei, Bin Li, Jiaqi He, Ting Zhou, Qingbin Hou, Yunhao Yu, Jingjin Hou, Chenghui Yan, Yaling Han

“…Methods To address this limitation, first, we analyzed the scRNA-seq data from ArrayExpress, after comprehensive quality control, normalization, dimensionality reduction, and clustering analyses, macrophage subsets were systematically classified and annotated using established computational pipelines. …”
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Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics by Ji-Peng Liu, Long-Teng Tu, Ke-Zhen Yang, Yin-Yin Li, Yu Gong, Bing-Xuan Han, Chuan Liu, Tian-Qi Xia, Yu Liu, Xiao-Min Hao, Bing-Nan Yue, Jing Zhang, Bing-Hui Wang, Gui-Rong Luo, Qing-Guo Liu, Meng Xu

“…The SHRs were randomly assigned to three groups: the model group (Group M), the electroacupuncture group (Group EA), and the manual acupuncture group (Group MA), while the WKY rats served as the blank control group. Treatment was given every other day for 8 weeks, and systolic and diastolic blood pressures were measured every 2 weeks during the intervention period. …”
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Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro by Chioma Moneme, Oluyinka O. Olutoye, Michał F. Sobstel, Yuwen Zhang, Xinyu Zhou, Jacob L. Kaminer, Britney A. Hsu, Chengli Shen, Arabinda Mandal, Hui Li, Hui Li, Ling Yu, Ling Yu, Swathi Balaji, Swathi Balaji, Sundeep G. Keswani, Sundeep G. Keswani, Lily S. Cheng, Lily S. Cheng, Lily S. Cheng

“…Piezo1 inhibition prevented a significant reduction in neurite length in stretched neurons. Piezo1 inhibition also led to significantly increased neuronal migration, whereas Piezo1 activation resulted in significantly decreased neuronal migration and slower neuronal recovery from injury.ConclusionMechanotransduction plays an important role in regulating normal GI function. …”
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Directional hand movement can be classified from insular cortex SEEG signals using recurrent neural networks and high-gamma band features by Xiecheng Shao, Ryan S. Chung, Jonathon M. Cavaleri, Roberto Martin Del Campo-Vera, Miguel Parra, Shivani Sundaram, Selena Zhang, Ashwitha Surabhi, Ryan J. McGinn, Charles Y. Liu, Spencer S. Kellis, Brian Lee

“…New evidence points to the role of the insula in motor control, specifically directional hand-movements. …”
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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…Favorable outcomes in terms of albumin on days14 and 28 and CRP levels on day 28 were observed in the IVIG group.ConclusionsThe administration of IVIG was associated with a reduction in sepsis mortality and favorable outcomes in laboratory parameters and the functional status. …”
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Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina. by Youde Jiang, Qiuhua Zhang, Jena J Steinle

“…Whole retinal lysates from control, diabetic, diabetic + control plasmid, and diabetic+ IGFBP-3 NB were analyzed for IGFBP-3, TNFα, suppressor of cytokine signaling 3 (SOCS3), and insulin receptor signaling partners using Western blotting or ELISA. …”
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Ultrasound combined with microbubble enhanced renoprotective effects of NLRP3 inflammasome inhibitor MCC950 in CKD model by Wen Wen, Bin Tu, Xiaomei Ren, Yangli Liu, Rufang Jiang, Xiaofeng Wu, Jian Liu

“…ObjectiveThis study evaluated the effectiveness of the NLRP3 inflammasome inhibitor MCC950 combined with ultrasound (US) and microbubbles (MBs) on kidney function and fibrosis in a rat model of chronic kidney disease (CKD).MethodsAfter establishing the model, SD rats were divided into eight groups (n = 5): Control, CKD, MCC950 (10 mg/kg), MCC950 (5 mg/kg), US + MCC950 (5 mg/kg), US + MBs + MCC950 (5 mg/kg), US and US + MBs. …”
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Endocannabinoid system modulation for visceral abdominal pain in inflammatory bowel disease and irritable bowel syndrome: A protocol for systematic review and meta-analysis [versio... by Rebecca M. Lane, Declan P. McKernan, Siobhain M. O'Mahony, Laurence J. Egan, David P. Finn, Brian E. McGuire

“…The primary outcomes will be the proportion of people with (a) at least a 30% reduction and (b) at least a 50% reduction in pain. …”
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Optical coherence tomography in the diagnosis of glaucomatous optical neuropathy in children with primary congenital glaucoma by L. A. Katargina, N. N. Arestova, E. N. Demchenko, A. Yu. Panova, A. A. Sorokin

“…The thickness of the ganglion cell (GC) layer varied from 8 to 23 μm and averaged 14.64 ± 4.89 μm, with a reduction recorded in most cases (64.7%). All patients showed a decrease in oscillatory potentials (OP) by 40% or more (6.31 ± 2.33) as compared to the control group (20.24 ± 6.28). …”
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MANAGEMENT OF IN-PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION by I. V. Logacheva, V. V. Safronova, N. I. Maximov, S. P. Baranova

“…The treatment was associated with a significant improvement in the psychological health domain (emotional and social functioning).Conclusion. In patients with uncontrolled AH, the in-hospital treatment with Prestans resulted in a mean reduction of SBP/DBP levels by 38,4/19,6 mm Hg, a significant decrease in mean and pulse BP levels, and achievement of target BP levels in 82.9% of the patients as early as at Day 14 of the treatment. …”
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