Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability by Bin Gao, Luca Maccioni, George Kunos, Szabolcs Dvorácskó, Grzegorz Godlewski, Resat Cinar, Malliga R Iyer

“…Mechanistically, we found that alcohol activated intestinal epithelial CB1R-ERK1/2 pathway with subsequent downregulation of tight junction proteins and reduction in villi length. In addition, targeting intestinal CB1R and downstream ERK1/2 was able to reverse this process, with subsequent upregulation of tight junction proteins and increased villi length, thus improving gut barrier function. …”
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The influence of the NRG1/ERBB4 signaling pathway on pulmonary artery endothelial cells by Jin‐Bo Huang, Qin Shen, Zhi‐Qi Wang, Song‐Shi Ni, Fei Sun, Yun Hua, Jian‐An Huang

“…Abstract This study aimed to examine the influence of the Neuregulin‐1 (NRG1)/ERBB4 signaling pathway on the function of human pulmonary artery endothelial cells (HPAECs) and investigate the underlying mechanisms. …”
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The Effect of Vitamin E, &Bgr;-Carotene, and Acidophilus Probiotics on The Salivary Gland Flow Rate in Streptozotocin-Induced Diabetes in Rats: An in-vivo Study by Felemban MF, Bin Mubayrik AF, Alotaibi O

“…They were randomly divided into control and experimental groups, which were further subdivided into ten subgroups: 2-week and 4-week saline, oil, vitamin E, β-carotene, and Probiotic Blend. …”
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Angelica sinensis polysaccharide as potential protectants against recurrent spontaneous abortion: focus on autophagy regulation by Yeli Sun, Guohua Li, Mengwen Kong, Junyuan Li, Shuyun Wang, Yuan Tan

“…Metabolomic analyses further identified significant changes in phosphatidylethanolamine levels between ASP-treated and control groups, with differential metabolites enriched in pathways related to glycolysis/gluconeogenesis, glycerolipid metabolism, and glycine, serine, and threonine metabolism. …”
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Dissecting the endothelial cell landscape in meningioma: single-cell insights into PLVAP+ subpopulations and their role in tumor angiogenesis by Liang Zhao, Hongling Jia, Zhikai Xiahou, Li Ren, Yanbing Song, Hao Xu, Zhihan Wang, Jin Xing

“…The transcription factor (TF) networks of EC subpopulations were constructed using pySCENIC, and the function of ETS1 was validated in vitro experiments.ResultsThe MEN and temporal lobe tissues’ datasets were processed through quality control and screening, and dimensionality reduction clustering identified eight cell types. …”
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Physiological traits underlying sodicity tolerance in Jamun (Syzygium cumini L. Skeels) cultivars by Anshuman Singh, Ashwani Kumar, Jai Prakash, Daya Shankar Mishra

“…Conclusions Membership function analysis revealed a reasonable resilience to sodicity stress only in cultivar J-37. …”
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The Influence of Emphysema on Treatment Response to Biologic Therapy in Severe Asthma by Biener L, Morobeid H, Pizarro C, Kuetting D, Nickenig G, Skowasch D

“…Patients with ≥ 5% emphysema were more often ex-smokers (80% vs 41%, p=0.002), had poorer lung function (FEV1 median 1.3 [interquartile range: 1.0;1.6] vs 1.8[1– 2;2.4] L, p=0.037), and more comorbid COPD (50% vs 21%, p=0.012). …”
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Aegeline improves doxorubicin-induced liver toxicity by modulating oxidative stress and Bax/Bcl2/caspase/NF-κB signaling by Tariq G. Alsahli, Khalid Saad Alharbi, Sattam Khulaif Alenezi, Reem Alqahtani, Muhammad Afzal, Nadeem Sayyed

“…Administration of aegeline at both tested doses led to a significant (P < 0.05) reduction in liver enzyme levels such as ALT, ALP, and AST—in rats with DOX-induced hepatotoxicity, indicating improved liver function. …”
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The value of echocardiography in the staging of preexcitation syndrome and the assessment of left ventricular wall dyskinesia in children by Yahui Yuan, Shu Li, Jun Chen, Yu Mao, Ming Yang, Shiwei Yang, Wentao Kong, Hao Liu

“…ROC curve analysis showed GLS, TDSD, TDRV−LV, PSD and MPTD could predict the prognosis of recovering post RFA.ConclusionsConventional echocardiography and two-dimensional speckle tracking imaging have the capacity to provide reference data for the reduction of cardiac function and ventricular wall motion disorder caused by WPWs. …”
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Effects of a Food Supplement Containing Hydrolyzed Collagen on Pain Perception, Joint Range, and Quality of Life in People with Chronic Knee Pain by Juan Carlos Salinas-Camargo, Cristian Marín-Pagán, Rosario Victoria Álvarez-Gil, Francisco Javier Martínez-Noguera, María Cabrera-Cabrera, Josep Manuel Llabrés-Laguarda, María Isabel Vasallo-Morillas, Pedro E. Alcaraz

“…Background: Joint pain can impair joint function and limit a person’s ability to perform basic tasks and quality of life. …”
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Alternative audio-graphic method for presenting structural information in mathematical graphs designed for low-vision users by Ewa Dzierzgowska, Michał Maćkowski, Mateusz Kawulok, Piotr Brzoza, Stella Maćkowska, Dominik Spinczyk

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Study of toxicological parameters in laboratory animals under the influence of hypochloritic acid in a chronic experiment by O. M. Brezvyn, I. Ya. Kotsiumbas, A. F. Obrazhei, O. B. Velichenko, O. B. Shmychkova, T. V. Luk'yanenko, D. V. Hyrenko, L. V. Dmitrikova

“…At the same time, using a concentration of 300 mg/l caused a slight reduction in the physical capabilities of the experimental animals; namely, the swimming time decreased by 18.2 % compared to animals of the control group. …”
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Antidiabetic assessment of mango and soursop leaves bioactive phytochemical formulation on streptozotocin-induced rat model by Churchill Chisom Ogbonna, Samuel Chidi Iwuji, Taofik Oladimeji Azeez, Raymond Maduabuchi Okoronkwo, Tochukwu Nze Ugorji, Christian O. Asadu

“…FTIR showed the presence of pharmaceutically active functional groups. LD50 of 1264.91 mg/kg b.w was calculated. …”
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Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder by Ming Zhou, Qian Xiao, Ling Xiao, Jiale Hou, Shuo Hu, Huixi Dong, Zhiyou He

“…Cognitive function was assessed using the Wisconsin Cart Sorting Test (WCST) in patients with OCD and HCs. …”
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INTERDISCIPLINARY APPROACH TO THE TREATMENT OF POSTMASTECTOMY LYMPHEDEMA by T. I. Grushina, D. B. Sidorov

“…A prospective randomized controlled clinical study included 80 women aged 54.9 ± 8 years, who underwent radical surgery for breast cancer and had late postmastectomy lymphedema (II–IV degree). …”
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Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias by Anke Schumann, Ainhoa Martinez-Pizarro, Eva Richard, Christoph Schell, Anna Laura Kössinger, Karina A. Zeyer, Stefan Tholen, Oliver Schilling, Michael Barry, Björn Neubauer, Michael Köttgen, Luciana Hannibal, Lourdes R. Desviat, Ute Spiekerkötter

“…Our investigations revealed altered mitochondrial networks shifted towards fission and a marked reduction of mitophagy. We observed a steep reduction of PGC-1-α, the key mediator modulating mitochondrial functions and a counter actor of mitochondrial fission. …”
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Influence of pyridinic nitrogen on tautomeric shifts and charge transport in single molecule keto enol equilibria by G. R. Berdiyorov

“…These findings can be valuable in the development of functional molecular devices based on the keto-enol isomerization phenomenon.…”
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Nutritional Enhancement of Rice Noodles with Watermeal (<i>Wolffia globosa</i>) by Nidthaya Seephua, Yu Liu, Hua Li, Apichaya Bunyatratchata, Onanong Phuseerit, Sirithon Siriamornpun

“…The addition of watermeal powder (1, 3, 5%) significantly enhanced the nutritional and functional attributes of the noodles. The formulation with 5% watermeal (WF5) demonstrated a twofold increase in protein content compared to the control, along with a marked increase in the chlorophyll content as the watermeal concentration increased (<i>p</i> < 0.05). …”
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Patterning the Pore Orientation of Nanoporous Metal via Self‐Organization in Flow Cells by Congcheng Wang, Yang Li, Xiangwei Geng, Jiatao Mao, Qing Chen

“…The process creates randomly oriented pores, in which slow mass transport has limited the functional applications of nanoporous metals. Here the control of the pore orientation is demonstrated with a dealloying analogy, reduction‐induced decomposition, achieved in flow cells. …”
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ADVANCED LARYNGEAL CANCER (LITERATURE REVIEW) by Z. A-G. Radzhabova, M. A. Kotov, M. A. Ebert, A. S. Mitrophanov, M. A. Radzhabova, E. V. Levchenko

“…Laryngeal cancer treatment is aimed at achieving tumor control while optimizing functional outcomes.Objective: to review available data on surgical and non-surgical treatment options for locally advanced laryngeal cancer, as well as the evidence supporting each of these, including oncological outcomes (overall survival, disease-free survival, local control of the disease, functional outcomes and quality of life).Material and Methods. …”
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