The Effect of Saliva with Different Nitrogen Compositions on Ruminal Fermentation in a Rumen Simulator Technique (Rusitec^®) System Fed a Lactating Dairy Cow Diet by Ícaro Rainyer Rodrigues de Castro, Luiza de Nazaré Carneiro da Silva, Isabela Fonseca Carrari, Giulia Berzoini Costa Leite, Eduardo Marostegan de Paula, Amanda Moelemberg Cezar, Marcos Inácio Marcondes

“…The efficiency of microbial protein synthesis and N flow exhibited quadratic responses, with the lowest values observed at the highest level of N reduction in the saliva (−30%). These findings suggest that although ruminal function and digestion remain stable with reduced N, microbial protein synthesis efficiency may decline beyond a threshold.…”
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Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway. by Bernardo Papini Gabiatti, Eden Ribeiro Freire, Johanna Odenwald, Janaina de Freitas Nascimento, Fabiola Holetz, Mark Carrington, Susanne Kramer, Martin Zoltner

“…The exon junction complex (EJC) is a key player in metazoan mRNA quality control and is placed upstream of the exon-exon junction after splicing. …”
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Raw and boiled ginger (Zingiber officinale Roscoe) inclusive diet improves fertility parameters in high cholesterol diet-induced obese rats by Akomolafe Seun Funmilola, Atoyebi David Ayodeji

“…Abstract Background Obesity has been implicated in reproductive problems, particularly in male functionality disorder while the therapeutic effects of ginger have been owing to its pharmacological activities. …”
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Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy by Robert Weil, Emmanuel Laplantine, Messaouda Attailia, Anne Oudin, Shannel Curic, Aya Yokota, Elie Banide, Pierre Génin

“…Paradoxically, inhibiting PKD activity enhances the interaction between Optn and LC3, promotes the recruitment of Parkin to mitochondria, and increases the mitophagic function of Optn. This enhancement of mitophagy is characterized by increased production of mitochondrial ROS and a reduction in mitochondrial mass. …”
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Strength training and chromium picolinate supplementation do not reduce adiposity or improve muscle morphology in obese rats by Daniel da Silva, Lucas Domingos, Amanda Madureira, Suellem Torezani-Salles, Danilo Bocalini, Breno Nogueira, Ana Paula Lima-Leopoldo, André Leopoldo

“… Introduction: Obesity induces metabolic dysfunctions, such as insulin resistance and dyslipidemia, which negatively affect skeletal muscle remodeling and function. Strength training (ST) is an effective intervention to combat these changes, improving glycemic control, reducing adiposity, and increasing muscle mass. …”
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PAI-1 participation in hepatocyte epithelial-mesenchymal transition induced by HCV NS5A or Core proteins. by Tania G. Heredia-Torres, Sonia A. Lozano-Sepúlveda, Ana R. Rincón-Sánchez, Ana María G. Rivas-Estilla

“…Likewise at the translational level, Core induced the overexpression of Snail (2.5-fold) and subexpression of E-cadherin (0.4-fold), compared to the control, suggesting the EMT of Huh7. A gene silencing of 60% of PAI-1 was obtained in all groups. this silencing induces a reduction of 50% of vimentin expression at the translational level in all groups. …”
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Therapeutic impact of dietary ginger supplementation in chickens experimentally infected with coccidia—anti-oxidant, biochemical, and pathological evaluations by Alshimaa Saber, Alshimaa Saber, Amany Sayed Mawas, Atef M. Khalil, Ahmed I. Ahmed, Dina M. W. Shibat Elhamd, Esraa Ali, Ibrahim F. Rehan, Ibrahim F. Rehan, Asmaa Elnagar, František Zigo, Mohammed Salah

“…Restoration of normal cecal histological structure and increased absorptive function and goblet cell number were observed in ginger-treated chicks compared to control-positive chicks. …”
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Developing an advanced safety device for bridge-type cranes by A. N. Nazarov, S. D. Ivanov

“…The reasons why it is inadmissible to re-equip cranes under the control of foreign safety systems to the existing domestic devices are explained. …”
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Umbilical Cord-Derived Mesenchymal Stem Cells Infusion in Type 2 Diabetes Mellitus Patients: A Retrospective Cytopeutics’ Registry Study by Chin SP, Kee LT, Mohd MA, Then KY

“…Notably, the treatment significantly improved metabolic indices including glycemic control, liver and renal profile and systemic subclinical inflammation. …”
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A prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 d... by Prabhat K Agarwal, Divendu Bhushan, Amit Bhate, Sunil Naik, Shailesh Adwani, J S Kushwaha, Sumit Bhushan, Abhishek Mane, Rujuta Gadkari, Sanjay Choudhari, Saiprasad Patil, Hanmant Barkate

“…The treatment led to significant improvements in glycemic control and other metabolic parameters over 24 weeks, without compromising renal function or causing serious adverse events. …”
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Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

“…Results: In DHCR24-silenced cells, the loss of cellular cholesterol caused by knock-down of DCHR24 resulted in a significant decrease in the levels of phosphorylated CAMK2 (p-CAMK2) and phosphorylated synapsin-1 (p-synapsin-1) compared to control cells. The reduction in p-CAMK2 and p-synapsin-1 could disrupt SV mobility, thereby reducing replenishment of the readily releasable pool (RRP) from the reserve pool (RP). …”
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Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells by Bootsakorn Boonkaew, Nantawat Satthawiwat, Bianca C. Pachane, Lucy M. Brett, Pisit Tangkijvanich, Chaiyaboot Ariyachet

“…By co-culturing macrophages with lipotoxic Huh7 cells in a transwell system, we demonstrated that PA-treated Huh7 cells exhibited impaired uptake of macrophage-derived EVs. Compared with control Huh7 cells, PA-treated Huh7 cells presented a reduction in the expression of macrophage-derived microRNA-223 (miR-223) after co-culture, accompanied by an increase in the expression of miR-223 target genes. …”
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The regulatory effects of epigallocatechin gallate on growth performance, systemic antioxidant status, immune response, and gut microbiota structure in geese by Mengyu Liu, Yansong Ge, Enshuang Xu, Tingting Zhu, Hongri Ruan, Jiasan Zheng

“…Geese in the EGCG group exhibited significantly higher final body weight (2.93 kg vs. 2.28 kg, P < 0.01) and average daily gain (72.38 g/d vs. 41.4 g/d, P < 0.01) along with a 42.8 % reduction in the feed conversion ratio (3.95 vs. 6.91, P < 0.01) versus the control. …”
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Co-Inoculating <i>Burkholderia vietnamiensis</i> B418 and <i>Trichoderma harzianum</i> T11W Reduced <i>Meloidogyne incognita</i> Infestation of Tomato Plants by Yanqing Jiang, Wenzhe Li, Jishun Li, Jindong Hu, Yanli Wei, Yilian Wang, Hetong Yang, Yi Zhou, Yuanzheng Wu, Shanshan Zhang

“…Root-knot nematodes (RKNs; <i>Meloidogyne incognita</i>) pose a significant threat to tomato crops, necessitating sustainable control methods. This study investigated the inoculation efficacy of co-cultured <i>Burkholderia vietnamiensis</i> B418 and <i>Trichoderma harzianum</i> T11W compared with single-strain treatments for RKNs suppression and their influence on the structure and function of the rhizosphere microbiome. …”
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Lycopene alleviates 5-fluorouracil-induced nephrotoxicity by modulating PPAR-γ, Nrf2/HO-1, and NF-κB/TNF-α/IL-6 signals by Ghadeer M. Albadrani, Ahmed E. Altyar, Osama A. Kensara, Mohie A.M Haridy, Amany A. Sayed, Zuhair M. Mohammedsaleh, Muath Q. Al-Ghadi, Rasha Mohammed Saleem, Mohamed M. Abdel-Daim

“…Rats treated with 5-FU had markedly lower renal levels of PPAR-gamma, HO-1, Nfr2, and Il-10 and higher levels of NF-kB, TNF-alpha, and IL6 compared to the control rats. Co-treatment with LYC attenuated the reduction in PPAR-gamma, HO-1, Nfr2, and IL-10 levels and moderated the elevated levels of NF-kB, TNF-alpha, and IL-6. …”
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Rethinking Advanced Driver Assistance System taxonomies: A framework and inventory of real-world safety performance by Ksander N de Winkel, Michiel Christoph

“…were categorized by functional class (longitudinal/lateral control, monitoring, information systems) and by interaction type (informing, warning, intervening, comfort-enhancing).The data analysis showed that LKA! …”
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Prospective Study on Kidney Dysfunction Markers and Risk for Mortality among South Asians by Ram Jagannathan, Shuchi Anand, Dimple Kondal, Jialin Han, Maria Montez-Rath, Mohammed K. Ali, Shivani A. Patel, Kavita Singh, Roopa Shivashankar, RM Anjana, Ruby Gupta, Sailesh Mohan, Glenn M. Chertow, Viswanathan Mohan, Nikhil Tandon, K.M. Venkat Narayan, Dorairaj Prabhakaran

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Xuebijing alleviates high-voltage electrical burn-induced acute kidney injury by inhibiting neutrophils and inflammation by Xiaopei He, Na Li, Leilei Ma, Meng Yang, Liqing Ren, Jiawen Hao, Xin Xue, Yinghui Pang

“…While it improves kidney function and reduces inflammation, its effects on SOD and MDA levels suggest a complex interaction with the oxidative stress system that requires further investigation, as the observed changes in these markers (decreased SOD, increased MDA) in the Xuebijing group were more pronounced than in the control group. …”
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Role of inhibition of angiogenesis in patients with diabetic retinopathy by E.S. Chekhonin, R.R. Fayzrakhmanov, M.R. Kalanov

“…Peripheral retinal laser coagulation has been standard treatment for PDR for many years, providing control of ischemia and reduction of vascular endothelial growth factor levels with subsequent regression of neovascularization. …”
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Lercanidipine in patients with chronic renal failure: the ZAFRA Study by N. R. Robles, J. Ocon, C. F. Gomez, M. Manjon, L. Pastor, J. Herrera, J. Villatoro, J. Calls, J. Torrijos, V. I. Rodríguez, M. M. A. Rodriguez, M. L. Mendez, A. Morey, F. I. Martinez, J. Marco, A. Liebana, B. Rincon, F. Tornero

“…Blood pressure (BP) significantly decreased from 162±17/93±8.3 mm Hg to 132±12/78±6 mm Hg. 89,2 % of patients showed a significant BP reduction, and 58,1 % achieved optimal BP control (&lt;130/85 mmHg). …”
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