Survival after myocardial infarction according to left ventricular function and heart failure symptoms by Jarle Jortveit, Peder L. Myhre, Kristian Berge, Sigrun Halvorsen

“…Recent trials of patients with LV dysfunction post‐AMI have demonstrated low event rates during follow‐up. …”
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Effects of microplastics and tetracycline induced intestinal damage, intestinal microbiota dysbiosis, and antibiotic resistome: metagenomic analysis in young mice by Yanan Xia, Yuzhi Lan, Yunping Xu, Faqun Liu, Xiangxiang Chen, Jinghua Luo, Hengyi Xu, Yang Liu

“…In this study, we developed a young mouse model exposed to polystyrene MPs, either alone or in combination with TC for 8 weeks to simulate real-life dietary exposure during early life. Our findings revealed that concurrent exposure to MPs and TC caused the most severe intestinal barrier dysfunction driven by inflammatory activation and oxidative imbalance. …”
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Montreal Cognitive Assessment (MoCA) use in general practice for the early detection of cognitive impairment: a feasibility study by Cassandre Carton, Matthieu Calafiore, Charles Cauet, Nassir Messaadi, Marc Bayen, David Wyts, Wassil Messaadi, Teddy Richebe, Sabine Bayen

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Relationship between the expression level of microRNA and the features of clinical course of the gallbladder and Оddi's sphincter functional disorders in children by O. Ye. Abaturov, V. L. Babуch

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Dry eye treatment optimization in patients prior to refractive surgery by S. N. Sakhnov, S. V. Yanchenko, A. V. Malyshev, Z. M. Blyagoz, G. A. Klimenova

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A multi-country time and motion study to describe the experience and burden associated with the treatment of Fabry disease with enzyme replacement therapy with agalsidase alfa and... by Ian Keyzor, Ana Maria Martins, Sema Kalkan Uçar, Hiroyuki Yamakawa, Yin-Hsiu Chien, Nur Arslan, Dau-Ming Niu, Leyla Tümer, Laura Baldock, Simon Shohet, Joseph D. Giuliano

“…These evidence gaps were addressed by generating real-world data quantifying the burden of agalsidase alfa and beta infusions for FD treatment. …”
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Plasma cytomegalovirus DNA load predicts outcomes in liver transplant recipients by Hao‐Chien Hung, Po‐Jung Hsu, Jin‐Chiao Lee, Yu‐Chao Wang, Chih‐Hsien Cheng, Tsung‐Han Wu, Ting‐Jung Wu, Hong‐Shiue Chou, Kun‐Ming Chan, Wei‐Chen Lee, Chen‐Fang Lee

“…We aimed to evaluate the efficacy of real‐time DNA quantitative polymerase chain reaction (qPCR) in the early detection of CMV and predicting post‐transplant outcomes. …”
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The severity of endothelial dysfunction, oxidative stress, lipid metabolism disorders, decreased elastic properties and tone of peripheral vessels in patients with different POAG c... by Yu. E. Filippova, T. N. Malishevskaya, S. N. Kolomeichuk, D. G. Gubin, A. S. Vlasova

“…The hospitalized patients were examined for daily melatonin profile and key biological clock genes typed by real-time polymerase chain reaction. The genetic material was taken by buccal scraping. …”
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Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and polymorphic variants of TREM-1 in the development of multiple organ dysfunction syndrome after coronary ar... by M. V. Khutornya, A. V. Ponasenko, A. V. Tsepokina, A. S. Radivilko, I. I. Zhidkova, A. G. Kutikhin, S. S. Krutitsky, A. S. Golovkin, E. V. Grigoriev

“…The key etiopathological factor of the induction phase of the complex pathological process, which ultimately leads to dysfunction of organs and systems, is the dysfunction of the immune response. …”
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Impact of HbA1c variability and time‐in‐range fluctuations on large and small nerve fiber dysfunction in well‐controlled type 2 diabetes: A prospective cohort observational study... by Yun‐Ru Lai, Wen‐Chan Chiu, Ben‐Chung Cheng, I‐Hsun Yu, Ting‐Yin Lin, Hui‐Ching Chiang, Chun‐En Aurea Kuo, Cheng‐Hsien Lu

“…This study aimed to evaluate the association of long‐term GV, measured by glycated hemoglobin (HbA1c) average real variability (ARV), and short‐term GV, assessed by time‐in‐range (TIR) ARV, with large and small nerve fiber dysfunction in individuals with well‐controlled Type 2 Diabetes (T2D). …”
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Discrepancy between clinical guidelines and real-world management of heart failure with reduced ejection fraction at University Medical Center Ho Chi Minh City, Vietnam by Hoang Vu Vu, The Dung Bui, Hai An Do, Dang Duy Quang Pham, Quang Binh Truong

“…However, achieving target doses remains a challenge, highlighting the gap between clinical guidelines and real-world practice due to factors such as low blood pressure, advanced age, and renal dysfunction.…”
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PD-1/PD-L1 inhibitors monotherapy vs. combination therapy in elderly advanced NSCLC: a real-world study and nomogram for survival prognosis by Yunye Mao, An Wang, Xiangwei Ge, Jinzhao Zhai, Yi Hu, Jinliang Wang

“…Real-world comparisons of monotherapy versus combination therapy in this vulnerable group are lacking, hindering personalized clinical decisions. …”
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CytoSorb^® Hemadsorption in Cardiogenic Shock: A Real-World Analysis of Hemodynamics, Organ Function, and Clinical Outcomes During Mechanical Circulatory Support by Julian Kreutz, Lukas Harbaum, Cem Benin Barutcu, Amar Sharif Rehman, Nikolaos Patsalis, Klevis Mihali, Georgios Chatzis, Maryana Choukeir, Styliani Syntila, Bernhard Schieffer, Birgit Markus

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Multidimensional assessment of adverse events of finasteride：a real-world pharmacovigilance analysis based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024. by Xiaoling Zhong, Yihan Yang, Sheng Wei, Yuchen Liu

“…<h4>Background</h4>Finasteride is commonly utilized in clinical practice for treating androgenetic alopecia, but real-world data regarding the long-term safety of its 0adverse events(AEs) remains incomplete, necessitating ongoing supplementation. …”
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Identification of pediatric MASLD using insulin resistance indices by Kyungchul Song, Eunju Lee, Hye Sun Lee, Young Hoon Youn, Su Jung Baik, Hyun Joo Shin, Hyun Wook Chae, Ji-Won Lee, Yu-Jin Kwon

“…Results: The MASLD group had higher TG/HDL, TyG, METS-IR, and obesity proportions but lower SPISE than the normal group in both NHANES and real-world data. All markers were significantly related to MASLD in logistic regression analyses, even after adjusting for age and sex, in both the NHANES and real-world clinic data (all p <0.001). …”
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Plant-based meat analogues aggravated lipid accumulation by regulating lipid metabolism homeostasis in mice by Yunting Xie, Linlin Cai, Zhiji Huang, Kai Shan, Xinglian Xu, Guanghong Zhou, Chunbao Li

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Advancing Meibography Assessment and Automated Meibomian Gland Detection Using Gray Value Profiles by Riccardo Forni, Ida Maruotto, Anna Zanuccoli, Riccardo Nicoletti, Luca Trimigno, Matteo Corbellino, Sònia Travé-Huarte, Giuseppe Giannaccare, Paolo Gargiulo

“…<b>Conclusions</b>: This tool provides a robust, scalable metric for integrating quantitative meibography into clinical practice, making it suitable for real-time screening and advancing the management of dry eyes owing to meibomian gland dysfunction.…”
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Triple cardiovascular disease detection with an artificial intelligence-enabled stethoscope (TRICORDER): design and rationale for a decentralised, real-world cluster-randomised con... by Azeem Majeed, Rasha Al-Lamee, Ceire Costelloe, Daniel B Kramer, Carla M Plymen, Carys Barton, Emanuela Falaschetti, Nicholas S Peters, Josephine Mansell, Patrik Bachtiger, Mihir A Kelshiker, Camille F Petri, Abdullah Alrumayh, Saloni Nakhare, Melanie T Almonte, Alexei Peters

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Clinical and functional state of the retina after inadequate laser coagulation of peripheral vitreochorioretinal dystrophies. Part 1. Electroretinography by V. V. Neroev, G. Yu. Zakharova, I. V. Tsapenko, M. V. Zueva, T. D. Okhotsimskaya, B. M. Magamadov

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N-acetylcysteine stimulates organelle malfunction in endometriotic cells via IFN-gamma signaling by Elif Karakoç, Sevil Oskay Halaçlı, Rumeysa Havvanur Hanelçi, Selda Ayhan, Cemil Can Eylem, Emirhan Nemutlu, Pergin Atilla

“…For this purpose, we performed a real time-dependent cell impedance assay, Annexin V/PI and ER tracking by flow cytometry, immunofluorescence, western blotting, and metabolomic assays. …”
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