Case Report: Genetic predisposition to low-dose NSAID-induced liver injury in real-world China by Yuan Lyu, Yangjie Li, Yingying Jiang, Qi Li, Chen Shao, Chunlei Fan, Ying Han, Hui Liu, Lingna Lyu, Huiguo Ding

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Safety evaluation of baloxavir marboxil: analysis and discussion utilizing real adverse events from the FAERS database by Xiaolong Lai, Liuyin Jin, Yixia Zhou, Yang Li, Lindan Sheng, Guomin Xie, Jianjiang Fang

“…Abstract Background As a novel anti-influenza agent, baloxavir marboxil lacks real-world safety data in large populations. Therefore, this study aimed to investigate adverse drug events (ADEs) associated with baloxavir marboxil by analyzing the Food and Drug Administration Adverse Event Reporting System (FAERS) database. …”
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INFLUENCE OF ARTIFICIAL LUNG VENTILATION ON REAL ENERGY EXPENDITURE VALUE OF SURGICAL INTENSIVE CARE UNIT PATIENTS by I. V. Polyakov, K. N. Zolotukhin, I. N. Leyderman

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Evaluating Cognitive Outcomes in Multiple Sclerosis: Real-World Impact of Ozanimod on Processing Speed Using BICAMS by Aurora Zanghì, Paola Sofia Di Filippo, Carlo Avolio, Emanuele D’Amico

“…Abstract Introduction Cognitive dysfunction represents a major burden in multiple sclerosis (MS). …”
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An analysis of real-life data of infants born to mothers with autoimmune thyroiditis: do they need to be followed-up? by Beatrice Righi, Nives Melli, Alessandra Cassio, Alessio Canovi, Francesco Leo, Chiara Sartori, Alessandra Polese, Rossana Colla, Alessandro De Fanti, Giancarlo Gargano, Maria Elisabeth Street

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Rutin ameliorates stress–induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin–5 axis by Zhao–Wei Sun, Zhao–Xin Sun, Yun Zhao, Ling Zhang, Fang Xie, Xue Wang, Jin–Shan Li, Mao–Yang Zhou, Hong Feng, Ling–Jia Qian

“…Furthermore, the molecular mechanisms by which rutin restores BBB endothelium dysfunction were explored via RNA–seq, quantitative real–time PCR, western blotting, immunofluorescence and chromatin immunoprecipitation. …”
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Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction by Sandrine Cabantous, Belco Poudiougou, Aurélie Bergon, Abdoulaye Barry, Aboubacar A. Oumar, Abdoulaye M. Traore, Christophe Chevillard, Ogobara Doumbo, Alain Dessein, Sandrine Marquet

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Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway by Wuxia Gu, Hongyan Li, Wenjing Yuan, Xiaoqiong Fu, Rui Wang, Xiaohui Xu, Xuemei Liao, LingJuan Liu, Bo Pan, Jie Tian, Haixin Yuan, Yi Huang, Tiewei Lu

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Modified Hemocorrection in the Complex Treatment of Patients with Pyoinflammatory Lung Diseases by V. V. Gavrikov, V. T. Dolgikh, K. K. Kozlov

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Real world telehealth delivery of an evidence based self-management education program for people with epilepsy and cognitive comorbidity by Elaine T. Kiriakopoulos, Elaine T. Kiriakopoulos, Elaine T. Kiriakopoulos, Sarah J. Kaden, Lisa P. Sackett, Maureen T. Quigley, Trina Dawson, Laura DeMuro, Kathryn E. Giordano, Kathryn E. Giordano, Jessica DeNaples, Meredith E. Olenec, Stephanie Jennings, Ambereen Burhanuddin, Joanne Harris, Suzanne Lenz, Robert Ross-Shannon, Todd MacKenzie, Todd MacKenzie, Todd MacKenzie, Barbara Jobst, Barbara Jobst

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Artificial Sensing: AI-Driven Electronic Nose for Real-Time Gas Leak Detection and Food Spoilage Monitoring by Lubna Aziz, Hassan Adil, Raheel Sarwar

“… Olfactory dysfunction poses a significant threat to health and safety by hindering the detection of hazards like gas leaks and spoiled food, highlighting the limitations of subjective and non-real-time traditional methods. …”
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Real-world analysis of leuprorelin acetate microspheres-based neoadjuvant therapy for patients with high-risk prostate cancer by Changde Fu, Jun Xin, Jinjin Lai, Xu Zeng, Yongnan Wang, Wei Zhang

“…ObjectiveBoennuokang® leuprorelin acetate microspheres show a certain efficacy in patients with prostate cancer, but its utilization as neoadjuvant therapy in patients with high-risk prostate cancer remains unclear. Hence, this real-world study investigated the efficacy and safety of Boennuokang® leuprorelin acetate microspheres-based treatment as neoadjuvant therapy in patients with high-risk prostate cancer.MethodsThis retrospective study included 53 patients with high-risk prostate cancer who received Boennuokang® leuprorelin acetate microspheres as neoadjuvant therapy and laparoscopic radical prostatectomy.ResultsThe median prostate-specific antigen (PSA) was 34.1 ng/mL before neoadjuvant therapy and reduced to 0.8 ng/mL after neoadjuvant therapy (P<0.001). …”
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Early Real-World Experience with CoreValve Evolut PRO and R Systems for Transcatheter Aortic Valve Replacement by Gaurav Rao, Shikha Sheth, Joseph Donnelly, Andrew Scatola, Umair Tariq, Saaron Laighold, Cindy Grines, Bruce Rutkin

“…The purpose of this study was to compare the efficacy and safety of the Evolut PRO to the Evolut R valve in a real-world setting. Background. The next-generation self-expanding transcatheter aortic valve replacement (TAVR) system, the CoreValve Evolut PRO was designed with an outer pericardial skirt to improve valve-sealing performance. …”
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Quantitative Real-Time RT-PCR Verifying Gene Expression Profile of Cavitations Within Human Jaw Bone by Shahram Ghanaati, Eva Dohle, Fabian Schick, Johann Lechner

“…These localized pathologies are implicated in systemic immune dysfunctions. <b>Methods:</b> This study is designed to determine whether BMDJ/FDOJ samples are indicative of medullary bone pathology by evaluating FDOJ gene expression patterns using quantitative real-time PCR. …”
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Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Aged Mice with Postoperative Cognitive Dysfunction Based on BDNF/TrkB Signaling Pathway by LI Min, YANG Xiao, REN Lulu, WU Tingmei, ZHANG Hong

“…The rTMS group received 5 Hz rTMS real stimulation for 10 consecutive days before operation, then underwent an experimental laparotomy, and continued with another four days of rTMS real stimulation after operation, once a day, with a magnetic stimulation intensity of 0.84 T, frequency of 5 Hz, 100 pulses per sequence, a 30-second interval time, 10 repetitions for a total of 1 000 pulses. …”
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Differential expression profiles and bioinformatics analysis of microRNAs in brown adipose tissue dysfunction induced by chronic intermittent hypoxia in obstructive sleep apnea by Meilin Ji, Meilin Ji, Yaopeng Guo, Jinjie Zhang, Jinjie Zhang, Shu Lin, Shu Lin, Liangyi Li, Qingshi Chen

“…In conclusion, we first discovered that OSA-induced BAT dysfunction is associated with abnormal miRNA expression. …”
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Real-World Analysis of the Efficacy and Adverse Events of T-DM1 in Chinese Patients With HER2-Positive Breast Cancer by Gu H, Zhu T, Ding J, Yang Z, Qi S, Guo G

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Atherosclerotic renal artery stenosis, mediating biomarkers, and risk of cardiac among individuals with hypertension: A real-world study by Yanwei Li, Zhulu Chen, Rui Lan, Tao Ran, Jingyi He, Jialian Li, Qiuyue Shi, Min Mao, Zhong Zuo

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Treatment challenges and survival analysis of human epidermal growth factor receptor 2-positive breast cancer in real world by Praveen Adusumilli, Meher Lakshmi Konatam, Sadashivudu Gundeti, Stalin Bala, Lakshmi Srinivas Maddali

“…There is very limited real world data regarding treatment challenges and survival analysis of these patients. …”
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Self-navigating the “Island of Reil”: a systematic review of real-time fMRI neurofeedback training of insula activity by Yuan Zhang, Benjamin Becker, Keith M. Kendrick, Qiong Zhang, Shuxia Yao

“…Abstract Real-time fMRI (rtfMRI) neurofeedback (NF) is a novel noninvasive technique that permits individuals to voluntarily control brain activity. …”
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