Left Ventricular Systolic Dysfunction Due to Atrial Fibrillation: Clinical and Echocardiographic Predictors by Erez Marcusohn, Ofer Kobo, Maria Postnikov, Danny Epstein, Yoram Agmon, Lior Gepstein, Yaron Hellman, Robert Zukermann

“…Patients with reduced LVEF also had higher incidence of tricuspid regurgitation and right ventricular dysfunction. Conclusion: In ‘real-world’ experience, male patients with rapid ventricular response during paroxysmal AF or AFL are more prone to LVEF reduction. …”
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Cardiovascular resource utilization in patients with diastolic dysfunction: A retrospective cohort analysis by Ato Howard, Paulomi Gohel, Virginia Singla, Aditi Naniwadekar, Floyd Thoma, Suresh Mulukutla, Aditya Bhonsale, Krishna Kancharla, Andrew Voigt, Alaa Shalaby, N.A. Mark Estes, III, Sandeep Jain, Samir Saba

“…Introduction: Diastolic dysfunction (DD) is often linked to the development and persistence of atrial fibrillation (AF), but its impact on healthcare resource utilization (HCRU) in patients with or without AF is unclear. …”
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Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021 by Gong Feng, Giovanni Targher, Christopher D. Byrne, Yusuf Yilmaz, Vincent Wai-Sun Wong, Cosmas Rinaldi Adithya Lesmana, Leon A. Adams, Jerome Boursier, George Papatheodoridis, Mohamed El-Kassas, Nahum Méndez-Sánchez, Silvia Sookoian, Laurent Castera, Wah-Kheong Chan, Feng Ye, Sombat Treeprasertsuk, Helena Cortez-Pinto, Hon Ho Yu, Won Kim, Manuel Romero-Gómez, Atsushi Nakajima, Khin Maung Win, Seung Up Kim, Adriaan G. Holleboom, Giada Sebastiani, Ponsiano Ocama, John D. Ryan, Monica Lupșor-Platon, Hasmik Ghazinyan, Mamun Al-Mahtab, Saeed Hamid, Nilanka Perera, Khalid A. Alswat, Qiuwei Pan, Michelle T. Long, Vasily Isakov, Man Mi, Marco Arrese, Arun J. Sanyal, Shiv Kumar Sarin, Nathalie Carvalho Leite, Luca Valenti, Philip N. Newsome, Hannes Hagström, Salvatore Petta, Hannele Yki-Järvinen, Jörn M. Schattenberg, Marlen I. Castellanos Fernández, Isabelle A. Leclercq, Gulnara Aghayeva, Abdel-Naser Elzouki, Ali Tumi, Ala I. Sharara, Asma Labidi, Faisal M. Sanai, Khaled Matar, Maen Al-Mattooq, Maisam Waid Akroush, Mustapha Benazzouz, Nabil Debzi, Maryam Alkhatry, Salma Barakat, Said A. Al-Busafi, John Rwegasha, Wah Yang, Agyei Adwoa, Christopher Kenneth Opio, Mohammadjavad Sotoudeheian, Yu Jun Wong, Jacob George, Ming-Hua Zheng

“…However, the study’s reliance on modeling and available data suggests cautious interpretation, and further research is needed to validate these findings in clinical and real-world settings.…”
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Association of Index and Changes in Fibrosis-4 Score With Outcomes in Metabolic Dysfunction-Associated Steatohepatitis by Semiu O. Gbadamosi, Elizabeth Nagelhout, Danielle Sienko, Neil Lamarre, Sina Noshad, Yingjie Ding, Anthony Hoovler

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Increased miR-132 level is associated with visual memory dysfunction in patients with depression by Liu Y, Yang X, Zhao L, Zhang J, Li T, Ma X

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Allergic seasonal blepharoconjunctivitis therapy optimization in conditions of dry eye and meibomian glands dysfunctions by S. V. Yanchenko, A. V. Malyshev, Sh. J. Teshaev, S. S. Davlatov, M. Yu. Odilov, E. A. Haribova, L. M. Petrosyan, R. R. Boboeva

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Machine learning models for coagulation dysfunction risk in inpatients administered β-lactam antibiotics by Yuqing Hua, Yuqing Hua, Na Li, Jiahui Lao, Zhaoyang Chen, Shiyu Ma, Xiao Li

“…Machine learning methodologies can offer valuable insights into evaluating the risk of coagulation dysfunction associated with β-lactam antibiotics. This study aims to identify the risk factors associated with coagulation dysfunction related to β-lactam antibiotics and to develop machine learning models for estimating the risk of coagulation dysfunction with real-world data. …”
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Targeted therapy for advanced forms of systemic mastocytosis in real clinical practice by D. I. Shikhbabaeva, O. Yu. Vinogradova, A. L. Neverova, M. M. Pankrashkina, M. V. Chernikov, E. O. Detkina, Yu. N. Kobzev, S. G. Malakho, V. V. Ptushkin

“…Midostaurin has shown its effectiveness in clinical trials, however, we know that data from real clinical practice often differ from clinical studies due to the characteristics of patients (preserved comorbid status, stable disease parameters) traditionally included in clinical trials.Aim. …”
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Bromide supplementation exacerbated the renal dysfunction, injury and fibrosis in a mouse model of Alport syndrome. by Tsubasa Yokota, Kohei Omachi, Mary Ann Suico, Haruka Kojima, Misato Kamura, Keisuke Teramoto, Shota Kaseda, Jun Kuwazuru, Tsuyoshi Shuto, Hirofumi Kai

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Electroacupuncture improves cognitive impairment in diabetic cognitive dysfunction rats by regulating the mitochondrial autophagy pathway by Xia Ge, Ling Wang, Qianqian Cui, Hongli Yan, Zhongbao Wang, Shandong Ye, Qingping Zhang, Aihua Fei

“…Abstract Background Diabetes-associated cognitive dysfunction has become a major public health concern. …”
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HMGB1 Aggravates Pressure Overload-Induced Left Ventricular Dysfunction by Promoting Myocardial Fibrosis by Lei Zhang, Ying Yu, Peng Yu, Jian Wu, Aijun Sun, Yunzeng Zou, Yangang Su, Hong Jiang, Junbo Ge

“…Fibrosis had important effects on pressure overload-induced left ventricular (LV) dysfunction. High-mobility group box 1 (HMGB1), which was closely associated with fibrosis, was involved in the pressure overload-induced cardiac injury. …”
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Fecal metabolomics to understand intestinal dysfunction in male dairy beef calves at arrival to the rearing farm by Anna Bassols, Núria Amigó, Marc Pérez-Rodado, Yolanda Saco, Raquel Peña, Raquel Pato, Lucia Pisoni, Maria Devant, Sònia Marti

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Secretagogin Mediates the Regulatory Effect of Electroacupuncture on Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Surgical Trauma by Mizhen Zhang, Jingxian Sun, Yu Wang, Zhanzhuang Tian

“…CRH and SCGN protein levels in the PVN were detected by western blot and immunofluorescence, and CRH and SCGN mRNA levels in the PVN were determined by means of real-time polymerase chain reaction (RT-PCR) and in situ hybridization (ISH). …”
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Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging by Pu Jiang, Ruihu Song, Yue Hu, Xin He, Zewei Zhang, Xuemei Wei, Zhiming Wang, De-an Guo, Hao Chen

“…Here, we developed a multiplexed near-infrared window two (NIR-II) fluorescent bioimaging method that allows for real-time, rapid, and quantitative assessment of multiple organ dysfunctions. …”
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The Influence of Diabetes Mellitus and Kidney Dysfunction on Oxidative Stress, a Reflection of the Multisystem Interactions in Aortic Stenosis by Laura Mourino-Alvarez, Inés Perales-Sánchez, Germán Hernández-Fernández, Gabriel Blanco-López, Emilio Blanco-López, Rocío Eiros, Cristian Herrera-Flores, Miryam González-Cebrian, Teresa Tejerina, Jesús Piqueras-Flores, Pedro Luis Sánchez, Luis F. López-Almodóvar, Luis R. Padial, Maria G. Barderas

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Drug-target Mendelian randomisation applied to metabolic dysfunction-associated steatotic liver disease: opportunities and challenges by Shan Luo, Shiu Lun Au Yeung, Vincent Wai-Sun Wong, Ming-Hua Zheng

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent cause of chronic liver disease worldwide affecting over one-third of the adult population. …”
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Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes. by Xiaoyan Bai, Xiao Li, Jianwei Tian, Zhanmei Zhou

“…In view of increased vascular endothelial growth factor-A (VEGF-A) expression and renal dysfunction in early diabetes, we designed a study to test whether VEGF-A inhibition can prevent early renal injury and dysfunction. …”
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Cuscutae Semen in depression-induced ovarian dysfunction: metabolomics with UPLC-QToF-MS in female mice by Ying Xie, Zhaoxiang Zeng, Jinrong Zhang, Qiangqiang Han, Chengwu Song, Chengwu Song, Shuna Jin, Shuna Jin, Min Zhao, Min Zhao

“…Untargeted metabolomics utilizing ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied to identify differential metabolites of CS in the treatment of depression-induced ovarian dysfunction. These findings were confirmed through real-time quantitative polymerase chain reaction assays. …”
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Role of renin-angiotensin-aldosterone system gene polymorphisms in the development of diastolic dysfunction in female patients with hypertension by Mariya A. Grenaderova, Nadezhda V. Izmozherova, Elena V. Kudryavtseva, Muraz A. Shambatov, Danila L. Zornikov, Artem A. Popov, Anna A Vikhareva, Daniil O. Kornilov, Mikhail A. Tryapitsyn, Veronika M. Simarzina, Aleksey A. Bekhter

“…Single-nucleotide polymorphisms in the ADD1, AGT, AGTR1, AGTR2, CYP11B2, GNB3, NOS3 genes were analyzed using real-time polymerase chain reaction. Renin-angiotensin-aldosterone system-related gene polymorphisms were evaluated in patients with and without diastolic dysfunction, as assessed by transthoracic echocardiography. …”
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Protocol for a prospective longitudinal cohort study on the effects of non-surgical weight loss on pelvic floor dysfunction

“…However, limited studies are detecting the effect of weight loss on other types of pelvic floor dysfunctions (PFDs), as well as on the quality of life (QoL) and the related influencing factors.Methods and analysis The 'Weight Loss on Pelvic Floor Dysfunction'(WLPFD) observational study is a 6 months prospective, longitudinal real-world cohort study aiming to recruit 200 patients. …”
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