Platelet miRNAs as early biomarkers for progression of idiopathic REM sleep behavior disorder to a synucleinopathy by Laura Arnaldo, Jorge Mena, Mònica Serradell, Carles Gaig, David Adamuz, Dolores Vilas, Daniela Samaniego, Lourdes Ispierto, Angelica Montini, Gerard Mayà, Ramiro Álvarez, Pau Pastor, Alex Iranzo, Katrin Beyer

“…Changes in hsa-miR- 142 - 3p, hsa-miR- 139 - 5p, and hsa-miR- 191 - 5p expression were found in IRBD platelets and might represent early biomarkers for LBD involving cytoskeleton dysfunction. Increased expression of WASL could indicate that altered platelet activation occurs early during the development of LBD.…”
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Expert perspectives on the use of safinamide for Parkinson’s disease in Portugal: insights from a Portuguese Delphi Consensus by Ana Margarida Rodrigues, Cristina Costa, Miguel Gago, Miguel Grunho, Leonor Correia Guedes, Ana Morgadinho, Maria Jose Rosas, Rita Simoes, Ana Graca Velon

m6A-methylated TAL1 exacerbates lipid accumulation in ethylene bisdithiocarbamate metabolite–induced anorectal malformations in rat fetuses via miR-205/LCOR signaling by Yifan Yao, Shuo Yang, Yuzuo Bai, Zhengwei Yuan, Zhonghua Yang

“…Methods: The potential molecular mechanisms were investigated using bioinformatics, RNA stability, RNA immunoprecipitation (RIP) assay, chromatin immunoprecipitation (ChIP)–quantitative real-time polymerase chain reaction (ChIP-qPCR), and dual-luciferase reporter assays in HEK 293 T cells. …”
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Evaluating functional C1INH with multiple laboratory methods across Hereditary Angioedema types by Maine Luellah Demaret Bardou, Rosemeire Navickas Constantino-Silva, Maria Luiza Oliva Alonso, Ana Júlia Ribeiro Teixeira, Pedro Francisco Giavina-Bianchi, Eli Mansour, João Bosco Pesquero, Solange Oliveira Rodrigues Valle, Anete Sevciovic Grumach

“…The comparative approach aims to improve early detection and understanding of C1INH dysfunction in all HAE subtypes to reflect real-world diagnostic scenarios.MethodsWe assessed the diagnostic performance of four fC1INH assays in a cohort of 148 HAE patients: 84 with HAE-C1INH (72 type 1 and 12 type 2) and 64 with HAE-nC1INH (53 HAE-FXII and 11 HAE-UNK). …”
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Ocular surface changes in allergic blepharoconjunctivitis and dry eye syndrome: diagnosis and therapy possibilities by S. N. Sakhnov, S. V. Yanchenko, A. V. Malyshev, Sh. J. Teshaev, M. Yu. Odilov, G. R. Odilova

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Identification and validation of neutrophil-related biomarkers in acute-on-chronic liver failure by Wei Lin, Yongping Chen, Yongping Chen, Mingqin Lu, Cheng Peng, Cheng Peng, Xiang Chen, Xiang Chen, Xiaoqin Liu, Yunyun Wang, Yunyun Wang

“…Dysfunction of peripheral blood neutrophils occurs in acute-on-chronic liver failure (ACLF). …”
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Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy by Hiroki Matsushita, Koki Kurono, Mikie Nakabayashi, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada, Masashi Ichinose, Yumie Ono, Keita Saku

“…Abstract Background Microcirculatory dysfunction is a poor prognostic indicator for the management of critically ill patients, highlighting the need for the development of appropriate assessment methods. …”
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TJ0113-induced mitophagy in acute liver failure detected by Raman microspectroscopy by Chunlian Huang, Jiaqi Liao, Xufeng Cen, Changwei Jiao, Sijia Chen, Dong Liu, Hang-Shuai Qu, Jiansheng Zhu, Sailing He

“…Impaired mitophagy underlies the pathophysiology of acute liver failure (ALF) and is closely associated with tissue damage and dysfunction. A novel mitophagy inducer, TJ0113, was used for treatment during ALF pathogenesis. …”
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Dynamic cardiac changes in low cardiovascular risk patients with triple negative breast cancer treated with chemo-immunotherapy by Jean Philippe Nesseler, Katrina D. Silos, Olivia Peony, Asneh Singh, Patrick Belen, Mitchell R. Kamrava, Julie K. Jang, Stephen L. Shiao, Alan C. Kwan, Cody Ramin, Raymond H. Mak, Andriana P. Nikolova, Katelyn M. Atkins

“…As anthracyclines, pembrolizumab, and radiotherapy may each contribute to an increased risk of cardiovascular events, real-world assessment of early cardiovascular changes is of clinical interest. …”
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Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes by Paola Giustina Simeone, Sarah Costantino, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Armando Tartaro, Alessandro Mengozzi, Francesco Cosentino, Francesco Cipollone, Agostino Consoli, Francesco Paneni, Francesca Santilli

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cardiovascular risk (CV) factor. …”
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Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway by Jiaxin Wen, Lingxian Yi, Lei Chen, Jinhan Xu, Yanmin Zhang, Qiheng Cheng, Hangyu Ping, Huanyu Wang, Feng Shuang, Wei Chai, Tujun Weng

“…Abstract Background Mesenchymal stem cells (MSCs) have potential for treating degenerative and immune diseases, but their clinical efficacy is limited by senescence, characterized by mitochondrial dysfunction, impaired mitophagy, and metabolic imbalance. …”
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Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke by Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Shensen Zhang, Chao Han, Chengcheng Tan, Yubing Huang, Zhaokai Sun, Liang Wang, Jing Liu

“…In vivo, H2O2 was used in HT22 cells to simulate the OS environment in MCAO, and then its protective effects on HT22 were evaluated by co-culturing with hNSC-Exos, including immunofluorescence staining, western blotting (WB), quantitative real time PCR (qRT-PCR). In the process of exploring specific mechanisms, we utilized RNA sequencing (RNA-seq) to detect the potential induction of mitophagy in OS-induced HT22 cells. …”
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Identification of key modules and hub genes for sepsis-induced myopathy using weighted gene co-expression network analysis by Siming Lin, Siming Lin, Siming Lin, Kexin Cai, Kexin Cai, Kexin Cai, Ai Chen, Weibin Wu, Guili Lian, Shaodan Feng, Shaodan Feng, Zhihong Lin, Zhihong Lin, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie

“…Notably, validation through real-time quantitative polymerase chain reaction (RT-qPCR) confirmed the significant upregulation of key hub genes, including Cxcl10, Il6, and Stat1. …”
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(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway by Shengnan Li, Shengnan Li, Shengnan Li, Jingjing Zhang, Jingjing Zhang, Jingjing Zhang, Yuewen Zhao, Li Kang, Haipeng Jie, Haipeng Jie, Haipeng Jie, Bo Dong, Bo Dong, Bo Dong

“…Primary cardiomyocytes were stimulated with high glucose and PRR overexpression or PRR knockdown was achieved by adenovirus transfection, we also used the inhibitor of AMPK to decrease the activity of AMPK. Western blot, Real-time PCR, Immunofluorescence and ELISA were used to detect the level of PRR and pyroptosis in cardiomyocyte.ResultsWe found that high glucose increased the expression of PRR in heart. …”
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Rice bran-derived peptide KF-8 attenuates dexamethasone-induced myopathy in Caenorhabditis elegans by regulating locomotion-related genes by Yixin Wu, Jianqiang Wang, Fang Huang, Yajuan Chen, Qinlu Lin, Zhongxu Chen, Zhigang Liu, Yao Jiang, Wenqing Xie, Hengzhen Li, Yusheng Li, Ying Liang

“…The molecular mechanisms of KF-8 were investigated using transcriptome sequencing, quantitative real-time PCR (qRT-PCR), RNA interference, and Western blot analysis. …”
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A virtual reality system for delivery of military-specific vestibular rehabilitation after mild traumatic brain injury: the Praxis study protocol by Abdulmohsen M. Alroumi, Carrie W. Hoppes, Carrie W. Hoppes, Susan L. Whitney, Zhihao Li, Lisa Holt, Sridhar Ramakrishnan, Shannon L. Barnicott, Meghan T. Logeais, Holly Richard, Shane R. Salter, Jeffrey M. Tiede, Michael D. Wirt, Pedram Hovareshti

“…Mild traumatic brain injury (mTBI) is a prevalent issue among military service members, often resulting in persistent vestibular dysfunction that can impair operational performance. …”
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The association of PTEN/PI3K/Akt pathway gene expression with insulin indices in adipose tissues of non-diabetic female adults: a cross-sectional study by Maryam Zarkesh, Romina Saba, Hamidreza Aghazadeh, Farshad Teymoori, Mahdi Akbarzadeh, Golaleh Asghari, Marzieh Montazeri, Asghar Ghasemi, Emad Yuzbashian, Azita Zadeh-Vakili, Mehdi Hedayati, Alireza Khalaj

“…Expression of PTEN, PI3K, and Akt genes were evaluated using Real-Time qRT-PCR. Insulin-related metabolic indices such as hyperinsulinemia, HOMA-IR, HOMA-B, HOMA-S, QUICKI, and TyG indexes were defined and calculated. …”
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Islet Stellate Cells Regulate Insulin Secretion via Wnt5a in Min6 Cells by Wei Xu, Peter M. Jones, Houfa Geng, Rui Li, Xuekui Liu, Yinxia Li, Qian Lv, Ying Liu, Jie Wang, Xiuli Wang, Zilin Sun, Jun Liang

“…Accumulating evidence has shown that β-cell dysfunction is an important mechanism underlying diabetes mellitus. …”
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Identification and validation of key biomarkers associated with immune and oxidative stress for preeclampsia by WGCNA and machine learning by Tiantian Yu, Tiantian Yu, Tiantian Yu, Guiying Wang, Guiying Wang, Guiying Wang, Xia Xu, Xia Xu, Xia Xu, Jianying Yan, Jianying Yan, Jianying Yan

“…BackgroundPreeclampsia (PE), a major obstetric disorder marked by dysfunction in both placental and maternal vascular systems, continues to pose critical challenges in global maternal healthcare. …”
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