The Safety of Non‐immunogenic Recombinant Staphylokinase in Elderly Patients With Massive Pulmonary Embolism: A Randomized Clinical Trial FORPE by Stanislav G. Leontyev, Elena B. Yarovaya, Vladimir A. Kutsenko, Oleg E. Ivlev, Anna G. Soplenkova, Andrey M. Semenov, Mikhail P. Semenov, Sergey V. Ivanov, Yulia A. Romashova, Sergey S. Markin

“…A total of 310 patients aged 18 years and older with massive PE proven by computed tomography pulmonary angiography, right ventricular dysfunction, and hemodynamic instability were included. …”
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Acupuncture treatment for functional gastrointestinal disorders: Identification of major acupoints using network analysis by Heeyoung Moon, Yeonhee Ryu, In-Seon Lee, Younbyoung Chae

“…These findings could be applied in future acupuncture research on therapy for gastrointestinal system dysfunction. They may also help bridge the gap between the traditional meridian theory, which assumes that there is a link between diseases/symptoms and the specific body region being treated, and real-world clinical evidence.…”
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Reward-related neural activation during social media exposure in young women with non-suicidal self-injury: evidence for a continuum of severity in the reward network by Stella Nicolaou, Anna Julià, Daniela Otero, Carlos Schmidt, Juan Carlos Pascual, Joaquim Soler, Josep Marco-Pallarés, Daniel Vega

“…Results highlight reward system dysfunction as central to NSSI pathology, with both clinical and subclinical groups showing altered processing of social media-based feedback. …”
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Feasibility of three dimensional and strain transthoracic echocardiography in a single-centre dedicated NHS cardio-oncology clinic by Patrick O’Driscoll, David Gent, Liam Corbett, Rod Stables, Rebecca Dobson

“…The lower feasibility of 3D-LVEF limits its real-world clinical application, even though only a small difference in agreement with 2D-LVEF calculation was found when successfully performed.…”
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Therapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy by Yusuke Iizuka, Masanori Sasaki, Kojiro Terada, Takuro Sakai, Yoshinobu Nagaoka, Shinobu Fukumura, Jeffery D. Kocsis, Takeshi Tsugawa, Osamu Honmou

“…<b><i>Background:</i></b> Podocytes are essential for kidney function, and their dysfunction can result in nephrotic syndrome, such as minimal change disease (MCD). …”
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Efficacy and safety of the combined use of celecoxib, diacerein and a combination of glucosamine and chondroitin for the control of musculoskeletal pain associated with osteoarthri... by A. E. Karateev, E. Yu. Polishchuk, A. M. Lila, A. N. Ananyev, L. V. Ananyeva, A. V. Bondarev, A. A. Bondareva, A. R. Bukanbaeva, S. V. Vorster, S. A. Gadzhieva, D. G. Danilov, R. I. Eliseev, I. S. Zabelin, M. Yu. Ignatenko, I. V. Itkina, A. E. Kolesnikov, M. Yu. Konoplyanskaya, Yu. G. Krasnoyarova, S. I. Kukushkin, V. A. Lila, O. V. Makareva, V. S. Myagkikh, I. V. Nelgovskaya, N. V. Ocheredko, R. A. Panov, I. A. Polyakov, A. S. Prozorov, S. S. Rubina, M. E. Ryabochkina, M. A. Takhaev, E. R. Tokareva, T. V. Tolbina, M. I. Fominykh, V. V. Tsarev, E. I. Sharipova, M. V. Sheven, G. I. Shcherbakov, S. A. Yanchenkova

“…However, there are few studies evaluating the efficacy of this approach in real practice.Objective: to determine the efficacy and safety of the combined use of celecoxib, diacerein, and the combination of glucosamine + chondroitin in osteoarthritis (OA) and chronic nonspecific low back pain (NSLBP).   …”
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ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma by Liyan Wu, Zelin Weng, Xia Yang, Yuhua Huang, Yansong Lin, Shuo Li, Lingyi Fu, Jingping Yun

“…EcoTyper analysis indicated that ARL8Bhigh HCCs had a lower proportion of carcinoma ecotype 6, a cellular ecosystem common in normal tissues but rare in tumors. Bioinformatics and real-world analysis showed a positive correlation between ARL8B and PD-L1 expression. …”
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Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells by Burak Durmaz, Latife Merve Oktay Çelebi, Ayşe Çekin, Ayshan Ahadova, Nur Selvi Günel, Hatice Kalkan Yıldırım, Ali Mert Özgönül, Eser Yıldırım Sözmen

“…Recently, it has been shown that protein phosphatase 2A (PP2A) dysfunction was common in many cancer types and was mediated by various inactivation mechanisms. …”
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Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes by Qi Shen, Yufan Yuan, Zelin Li, Ying Ling, Jian Wang, Mingjing Gao, Peng Wang, Mengli Li, Lizhong Lai, Jinlan Jin

“…IntroductionSeptic cardiomyopathy (SCM) arises as a consequence of sepsis-associated cardiovascular dysfunction, for which there is currently no specific targeted therapy available. …”
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Tear substitution therapy optimization of dry eye syndrome and cataract patients by S. N. Sakhnov, S. V. Yanchenko, A. V. Malyshev, A. R. Ceeva, L. M. Petrosyan, O. A. Baskakov, G. L. Kolomiec

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Mobile-phone-based e-diary derived patient reported outcomes: Association with clinical disease activity, psychological status and quality of life of patients with multiple scleros... by Daniel Golan, Smadar Sagiv, Lea Glass-Marmor, Ariel Miller

“…Changes in e-diary derived PROs over time predict clinical MS relapses on the group level and thus carry the potential of usage in clinical research as well as for improved MS care in real world setting.…”
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The crossroads of anxiety: distinct neurophysiological maps for different symptomatic groups by Gerez M, Suarez E, Serrano C, Castanedo L, Tello A

“…Addressing the underlying dysfunctions should improve treatment response. By its own nature, neurophysiology can be the best tool to address dysfunctional processes.Purpose: To search for neurophysiological dysfunctions and differences among panic disorder (PD), agoraphobia-social-specific phobia, obsessive&amp;ndash;compulsive disorder (OCD) and generalized anxiety disorder.Methods: A sample population of 192 unmedicated patients and 30 aged-matched controls partook in this study. …”
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Association between NOS3 gene rs1799983 polymorphism and the risk of developing preeclampsia as well as susceptibility to SARS-CoV-2 infection during pregnancy by R. I. Gabidullina, A. V. Ganeeva, P. L. Kapelyushnik, T. N. Shigabutdinova, E. V. Valeeva, A. F. Nurgatina

“…Preeclampsia (РЕ) is a complication of pregnancy resulting from a generalized vascular dysfunction. Systemic endotheliopathy also emerges due to a viral infection such as caused by SARS-CoV-2. …”
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Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats by Wafa A. AL-Megrin, Manal F. El-Khadragy, Manal H. Hussein, Shahenda Mahgoub, Doaa M. Abdel-Mohsen, Heba Taha, Ashraf A. A. Bakkar, Ahmed E. Abdel Moneim, Hatem K. Amin

“…Administration of green coffee could represent a promising therapeutic agent which can help the treatment of type 2 DM-induced testicular dysfunction.…”
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Nuclear factor erythroid 2‐related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis by Xuyun Xia, Qin Zhang, Xia Fang, Ling Li, Gangyi Yang, Xiaohui Xu, Mengliu Yang

“…Abstract Background The epidemic of metabolic dysfunction‐associated fatty liver disease linked to excessive high‐fat diet (HFD) consumption has sparked widespread public concern. …”
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The role of sTNFSF14 in the liver mitochondrial dynamics in obese patients by A. A. Komar, D. A. Skuratovskaia, M. A. Vulf, H. Q. Vu, A. Darinskas, N. D. Gazatova, N. M. Todosenko, P. A. Zatolokin, E. V. Kirienkova, L. S. Litvinova

“…The level of relative gene expression in the liver biopsy samples was investigated by real-time PCR. Semi-quantitative determination of proteins in the liver biopsy samples was studied by western blotting.Results. …”
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Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer’s-like Disease Rat Model by Paulina Sepúlveda, Ana Flavia Fernandes Ferreira, Cristian Sandoval, Giovanna Bergoc, Ana Caroline Rippi Moreno, Maria Tereza Nunes, Andréa da Silva Torrão

“…Thyroid hormones play a crucial role in the development of the central nervous system and are considered pivotal to cognitive functions in the adult brain. Recently, thyroid dysfunction has been associated with Alzheimer’s disease. …”
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Sex-specific differences and risk factors for 30-day mortality in acute pulmonary embolism - results from the Serbian University Multicenter Pulmonary Embolism registry by Matijašević Jovan, Mirić Milica, Vučićević-Trobok Jadranka, Peković Sandra, Andrijević Ilija, Džudović Boris, Subotić Bojana, Obradović Slobodan

“…Age, obesity, hypertension, renal dysfunction, anemia, community-acquired pneumonia, and smoking history presented statistically significant sex-specific differences. …”
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Comparison of the Mitophagy and Apoptosis Related Gene Expressions in Waste Embryo Culture Medium of Female Infertility Types by Duygu Kütük, Çağrı Öner, Murat Başar, Berkay Akcay, İbrahim Orçun Olcay, Ertuğrul Çolak, Belgin Selam, Mehmet Cincik

“…After the isolation of total RNA from the collected samples, MFN1, MFN2, PINK1, PARKIN, SMN1, SMN2, p53 and Humanin gene expressions were determined by Real Time-PCR. The average age of only the POR-A was determined to be higher than the NOR (<i>p</i> < 0.001). …”
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Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy by Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan

“…BACE1 siRNA slowed down Aβ production and Cu2+ chelation by metallothionein (MT) synergistically inhibited Aβ aggregation. Ruthenium (Ru) could real‐timely track Aβ degradation and aggregation. …”
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