Association of a high rate of glycolysis and the activity of the uncoupling of oxidation and phosphorylation in the blood cells of patients with late-stage knee osteoarthritis and... by E. B. Chetina, G. A. Markova, K. E. Glemba, M. A. Makarov

“…Prior to TKA, the blood of 50 patients with stage III–IV knee OA and complaints of constant pain and joint dysfunction was analyzed. The control group consisted of 26 healthy individuals. …”
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Retrospective Analysis of Healthcare Resource Use, Treatment Patterns, and Treatment-related Events in Patients with Huntington’s Disease–associated Chorea Initiated on Tetrabenazi... by Victor W. Sung, Sanjay K. Gandhi, Victor Abler, Brian Davis, Debra E. Irwin, Karen E. Anderson, Ravi G. Iyer

“…# Background Huntington’s disease (HD) is a multifaceted neurodegenerative disorder characterized by involuntary movements, specifically chorea, as well as behavioral and psychiatric disturbance, and cognitive dysfunction. Tetrabenazine was the first approved treatment for chorea, although tolerability concerns exist…”
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Determination of molecular mechanisms of development and course of experimental diabetes mellitus in Wistar rats by T. V. Ivanenko

“…The polymerase chain reaction method with real-time reverse transcription was used to analyze gene expression using the RTI Profiler™ PCR Array Rat Diabetes kit (QIAGEN, Germany), where the pancreas was the object of research in experimental animals. …”
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Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO‐1 Pathway by Hui‐Zhuang Guo, Sheng‐Long Yu, Han‐Wei Chen

“…Mechanistic evaluations through Western blot and reverse transcription quantitative real‐time polymerase chain reaction techniques identified MOAH‐induced activation of the Nrf2/HO‐1 signaling pathway, with observed abolition of protective efficacy under Nrf2 knockdown conditions. …”
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Multinational association for supportive care in cancer (MASCC) versus clinical index of stable febrile neutropenia (CISNE): evaluation of predictive performance and clinical utili... by Süleyman Alpar, Sarper Yılmaz

“…However, there remains no consensus on which score performs better in real-world emergency settings. Methods This retrospective, two-center study included adult patients diagnosed with FN who presented to the emergency departments of two tertiary hospitals between January 2022 and December 2024. …”
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Decreased Insulin Secretion but Unchanged Glucose Homeostasis in Cadmium-Exposed Male C57BL/6 Mice by Xiaoyin Li, Mengyang Li, Jiming Xu, Xiang zhang, Wei Xiao, Zengli Zhang

“…Accumulating evidence suggests that Cd exposure is associated with islet dysfunction and development of diabetes, but the association remains controversial. …”
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Extravasation of Borrelia burgdorferi Across the Blood–Brain Barrier is an Extremely Rare Event by Linus Wang, Zikai Xia, Anjan Singh, Bhavna Murarka, Nicole Baumgarth, John N. Aucott, Peter C. Searson

“…In addition, circulating Bb do not induce endothelial activation in iECs or iBMECs, but induces barrier dysfunction in iECs. These findings provide a further understanding of Bb vascular dissemination.…”
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Comprehensive bioinformatics analysis reveals novel potential biomarkers associated with aging and mitochondria in osteoporosis by Ke Bi, Yuxi Chen, Yuhang Hu, Song Li, Weiming Li, Zhange Yu, Lei Yu

“…Aging and mitochondrial dysfunction are involved in the onset and progression of OP, but the specific mechanisms have not been elucidated. …”
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Advances in the diagnosis and treatment of atopic eruption in pregnancy by LIU Ping, REN Shiju, ZENG Qifeng, CAI Min, DIAO Qingchun, WANG Yuyi

“…Clinical decision-making must balance disease control with fetal safety, and future research should focus on real-world data to optimize treatment strategies. …”
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Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα by Jing Yang, Fengyue Wang, Weiju Sun, Yanli Dong, Mingyu Li, Lu Fu

“…Myocardial ischemia leads to metabolic remodeling, ultimately resulting in ATP deficiency and cardiac dysfunction. In the present study, the effects of testosterone replacement on the ischemic heart were assessed in a castrated rat myocardial infarction model established by ligating the left anterior descending coronary artery 2 weeks after castration. …”
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Transjugular Helix Leadless Pacing System Implantation in Adult Congenital Heart Disease Patient with Previous Tricuspid Valve Surgery for Ebstein Anomaly by Giuseppe Sgarito, Antonio Cascino, Giulia Randazzo, Giuliano Ferrara, Annalisa Alaimo, Sabrina Spoto, Sergio Conti

“…Currently, two different LPSs are available. In a real-world setting, implanting an LPS in patients after tricuspid valve (TV) surgery seems to be a straightforward procedure with a low risk of complications, with patients showing no valvular dysfunction after the intervention. …”
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Emerging perspectives on osteonecrosis of the femoral head: the role of circular RNAs and long non-coding RNAs - a systematic review by Feifei Lin, Shicheng Zhou, Min Yi, Qingyu Wang

“…A total of 37 circRNAs and 42 lncRNAs were identified using quantitative real-time PCR (qRT-PCR). Dynamic changes in lncRNA and circRNA expression are associated with the proliferation and apoptosis of bone marrow stem cells (BMSCs), bone marrow endothelial cells (BMECs), and necrotic bone tissues in ONFH. …”
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BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production. by John E S Park, Dongmin Shao, Paul D Upton, Patricia Desouza, Ian M Adcock, Rachel J Davies, Nicholas W Morrell, Mark J D Griffiths, Stephen J Wort

“…However, increased ET-1 production by endothelial cells as a consequence of BMPR II dysfunction may be clinically relevant in the pathogenesis of PAH.…”
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Targeting Sepsis: Disease Tolerance, Immune Resilience, and Compartmentalized Immunity by Alexis Garduno, Ignacio Martín-Loeches

“…<b>Conclusions:</b> A deeper understanding of compartmentalized immune responses and the dynamic immune landscape in sepsis is critical for developing precision therapies. Real-time immune monitoring and organ-targeted interventions could revolutionize sepsis management, although significant barriers remain in clinical translation. …”
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Perioperative complications in primary intramedullary tumors of the spine in adults. A multicenter surveillance study of 307 patients from the German Spine Registry (DWG-Register) by Juan Manuel Vinas-Rios, Vincent J. Heck, Fatima Azucena Medina-Govea, Mario Alberto Islas-Aguilar, Nikolaus Kernich, DWG-Registry Group

“…In rare pathologies such as intramedullary tumors, the data from the DWG Register can be used to describe spinal surgery care in “real life.”…”
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URBAN MANAGEMENT TESTED BY INFORMATION ON LAND TRANSACTIONS IN THE CITY OF MOYEN MONO 1 (TOGO) by Mawussi Kossi NYALEWO, Karl Martial NASSI

“…The majority of city dwellers in Moyen Mono 1 do not have real property rights (in the modern sense of the term) but rather presumed title. …”
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Three-Dimensional Echocardiography in Evaluating LA Volumes and Functions in Diabetic Normotensive Patients without Symptomatic Cardiovascular Disease by Mohamed Hamza, Ahmed Mamdouh, Dina Ezzeldin, Adnan Tawfik, Ahmed Nayel

“…To evaluate the effect of diabetes mellitus on left atrial volumes and functions by using real-time 3-dimensional echocardiography in normotensive patients free from cardiovascular disease. …”
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Expression Profiles of lncRNAs and mRNAs in the Mouse Brain Infected with Pseudorabies Virus: A Bioinformatic Analysis by Yanwei Li, Teng Tu, Yan Luo, Xueping Yao, Zexiao Yang, Yin Wang

“…Pseudorabies virus (PRV) is a pathogen that causes severe neurological dysfunction in the host, leading to extensive neuronal damage and inflammation. …”
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Feasibility and Safety of Endoscopic Balloon-Assisted Laser Treatment (EBLT) for Gastroesophageal Reflux Disease: Functional, Structural, and Gene Expression Analysis in Preclinica... by Boram Cha, Hyejin Kim, Van Gia Truong, Sun-Ju Oh, Seok Jeong, Hyun Wook Kang

“…Gastroesophageal reflux disease (GERD) is a prevalent disorder caused by lower esophageal sphincter (LES) dysfunction, often requiring long-term treatment. This study assessed the feasibility of endoscopic balloon-assisted laser treatment (EBLT) using a porcine GERD model. …”
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The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome by Yuanji Dong, Rongfen Gao, Kailin He, Jixin Zhong, Lingli Dong

“…IL-33 and ST2 were detected by immunohistochemistry and real-time quantitative PCR in the liver and spleen of mice. …”
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