Integrated bioinformatics and functional studies identify CDK9 as a potential prognostic biomarker and therapeutic target in AML by Zhibin Xie, Yang Xia, Zhongyu Li, Mengmeng Zhang, Yuanyuan Tan, Yuqing Han, Meng Wang, Pingping Zhang, Jiajia Li

“…Abstract Background Acute myeloid leukemia (AML) is a highly heterogeneous disease characterized by complex genetic and molecular features that contribute to poor prognosis and low cure rates. Therefore, identifying novel therapeutic targets is crucial for improving treatment efficacy and patient survival. …”
Get full text

Consensus on Coping Mechanisms towards Occupational Stress among Psychiatric Nurses using Modified Delphi Technique by Ahmed Hassan Shujaa, Adel Saeed Bashatah

“…Literature reviews were used to develop statements about coping mechanisms toward occupational stress. Recruited Delphi process psychiatric nurses and faculty rated the extent of their agreement with the statements over three rounds (round 1-3: email survey). …”
Get full text

Controlled electrochemical nutrient delivery to enhance marine primary productivity by Paul Marsh, Stephen Crafton-Tempel, Charles F. Hibbeln, Peter J. Valdez, Christopher R. Myers, Venkata Bhuvaneswari Vukkum, Arun Devaraj, Aashish Rohatgi, Michael Huesemann, Scott J. Edmundson, Chinmayee V. Subban

“…Our study uses commercial stainless-steel electrodes to deliver low concentrations of iron to enhance growth rates in the microalga Picochlorum celeri TG2. To demonstrate the process control offered by the CEND method, we evaluate iron delivery as a function of pulse time, pulse frequency, and rest time between pulses. …”
Get full text

Analyzing the effects of a Maxwell nanofluid with graphene oxide on rectangular, triangular, and chamfered baffles on the surface of a stretched surface by Mohammed Ali, Rassol Hamed Rasheed, Hasan A. Al-Asadi, Saif Ali Kadhim, Dhuha Radhi Nayyef, Farhan Lafta Rashid, Karrar A. Hammoodi, Pooya Pasha

“…The investigation of nanofluid (NF) flow under external fields and their influence on heat transfer rates has become a key focus in both engineering and medical sciences. …”
Get full text

Simulating High-redshift Galaxies: Enhancing UV Luminosity with Star Formation Efficiency and a Top-heavy IMF by Tae Bong Jeong, Myoungwon Jeon, Hyunmi Song, Volker Bromm

“…Using our simulation results, we derive several observables such as effective radius, UV slope, and emission-line rates, which could serve as valuable theoretical estimates for comparison with existing spectroscopic results and forthcoming data from the JWST NIRSpec and MIRI instruments.…”
Get full text

Unmet Occupational Health Needs of Malawian Ex-Miners from the South African Gold Mines by Rinila Haridas, Rodney Ehrlich, Yotam Moyo, Annalee Yassi, Jerry Spiegel, Khumbo Kalua

“…Methods: This study, conducted in the Blantyre region of Malawi, draws from field observations and interviews with 14 ex-gold miners who had worked on South African gold mines, supplemented by five key informant interviews. Data were analysed using a phenomenological and thematic analysis approach. …”
Get full text

Advancing blood cell detection and classification: performance evaluation of modern deep learning models by Shilpa Choudhary, Sandeep Kumar, Pammi Sri Siddhaarth, Guntu Charitasri, Monali Gulhane, Nitin Rakesh, Feslin Anish Mon, Amal Al-Rasheed, Masresha Getahun, Ben Othman Soufiene

“…Additionally, an annotated blood cell data set was generated for this study. A diverse set of blood cell images with fine-grained annotations is contained in this dataset to make it useful for deep learning models training and evaluation. …”
Get full text

Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth by Li-Yan Zhang, Tian-Tian Li, Hong-Xin Liao, Jin-Rui Wen, Hong-Yan Nie, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong

“…By integrating the RNA-seq data with the ChIP-seq results, we identified 110 DEGs associated with reduced H3K27ac modification primarily associated with ribosome biogenesis. …”
Get full text

Formation of a comprehensive rehabilitation program for patients considering the clinical and diagnostic features of the course of vertebral thoracic pain due to degenerative-dystr... by Ye. I. Maramukha

“…According to the results of the Spearman correlation analysis the progression of signs of mental disorders is directly proportionally associated with the intensity of manifestations of myofascial syndromes due to DDPS, as showed statistically significant relationships between the values of the results of the Spielberger anxiety and Montgomery–Asberg depression rating scales, on the one hand, and the integral indicator of the cumulative thoracic vertebral-mechanical index (Rs = +0.69 and +0.78 at p < 0.01 for all cases), confirming the important pathogenetic relationship between these pathological processes, which indicates the urgent need for rehabilitation measures according to generally accepted (A. …”
Get full text

Construction of a clinical prediction model for overall survival and cancer-specific survival in malignant phyllode tumor of the breast based on the SEER database by Chenggeng Pan, Ruokuo Han, Senzhe Xia, Dingwei Fan, Daqing Yang, Haiguang Ma

“…Methods From the Surveillance, Epidemiology, and End Results (SEER) database, clinicopathological data of MPTB patients diagnosed between 2000 and 2020 were collected. …”
Get full text

GENERAL PB‐ISOTOPE SYSTEMATICS OF SOURCES FOR VOLCANIC ROCKS OF THE LATEST GEODYNAMIC STAGE IN ASIA by S. V. Rasskazov, I. S. Chuvashova, Т. A. Yasnygina, Yi‐min Sun, Е. V. Saranina

“…The modern theory of the evolving Earth is based on integrated isotopic data obtained for the accessible part of the planet and cosmic bodies, in which the U–Pb isotope system plays a key role. …”
Get full text

Prevalence and determinants of multidrug-resistant uropathogenic Klebsiella species and associated antimicrobial resistance genes in Port Harcourt, Nigeria by Moore Ikechi Mike-Ogburia, Tombari Pius Monsi, Easter Godwin Nwokah

“…Midstream urine samples were processed using standard bacteriological techniques, followed by antimicrobial susceptibility testing using the Kirby-Bauer disk diffusion method. …”
Get full text

Mortality of Children Born on Early Gestational Age: is it the Impassable Barrier or the Reserve for Reducing the Infants Mortality? by Anatoly S. Simakhodsky, Yulia V. Gorelik, Konstantin D. Gorelik, Sergey L. Ivanov, Yulia V. Lukashova

“…The authors have analyzed the fertility and mortality rates of premature infants, the group of children with ELBW has been established. …”
Get full text

Meningitis caused by Aspergillus fumigatus: a case report by Yifei Zhang, Yu Ma, Rushuang Yue, Yuan Meng, Yue Jin, Chengwei Yin, Qianmei Zhou, Rong Shi

“…The emitted fluorescence signals are digitally captured and computationally processed to generate high-accuracy base sequence data. …”
Get full text

Demonstration of Physicochemical and Functional Similarity of Biosimilar Pegfilgrastim-cbqv to Pegfilgrastim by Henriette Kuehne, Janice M. Davis, LeeAnne Merewether, Matthew McQueen, Elizabeth Valentine, Glen Young, Benjamin T. Andrews, Dimitri Diaz, Karen J. Miller

“…Conclusion The structural, functional, and stability data demonstrate that pegfilgrastim-cbqv is highly similar to the reference product, pegfilgrastim.…”
Get full text

Sleep disturbances and female infertility: a systematic review by Jing Li, Yali Huang, Shirong Xu, Ying Wang

“…Studies that described sleep patterns or any type of sleep disturbance, sleep breathing disorders and their associations with female infertility or female fecundity, published between January 1, 2010, and November 1, 2023, were identified and extracted. The screening, data extraction, and quality assessment processes were independently performed by paired reviewers. …”
Get full text

Evaluation of long-term effectiveness of modified laparoscopic one-anastomosis gastric bypass in patients with morbid obesity by A. V. Klymenko, V. M. Klymenko, B. S. Kravchenko, K. P. Polishchuk

“…Anthropometric parameters were monitored dynamically; quality of life was assessed according to the Short Form 36 questionnaire, esophagoduodenoscopy with chromography and biopsy were performed to detect bile reflux. Statistical data were processed using the Statistica for Windows 13.0 software package. …”
Get full text

Analgesia and sedative effects of a fixed nitrous oxide/oxygen mixture on supragingival scaling patients: a study protocol for a randomised controlled trial by Lu Tang, Yuchen Wang, Fan Sun, Chenxi Sun, Xiaochen Jiang, Weifeng Wang, Xueling Qiu, Xiaona Sui, Lingjun Zhou

“…The primary outcomes will be pain scores and anxiety scores, which will be assessed using the Numeric Rating Scale and the Visual Analogue Scale for Anxiety. …”
Get full text

Comparative analysis of pore structure parameters of coal adsorbed by different gas probe molecules by Lin HONG, Wentong LIU, Dameng GAO, Wei LIANG, Jundan ZHAO, Xingzhu CHE

“…The results show that the adsorption processes of Ar, N2 and O2 by coal include micropore filling, single-layer adsorption, multi-layer adsorption and capillary condensation. …”
Get full text

Assessment of toxic elements contamination in cigarettes sold in algeria and associated health risks by A.I. CHEBLI, Z. CHELIGHEM, A. ZERGUI, A. AMZIANE, Y. ZEBBICHE, A. BELLOUM, S. ABDENNOUR

“…Given the scarcity of data on this issue in the region, our findings emphasize the need for stricter regulations and further studies to better assess and mitigate the exposure of Algerian smokers to these toxic elements.…”
Get full text