Polyploidization-driven transcriptomic dynamics in Medicago sativa neotetraploids: mRNA, smRNA and allele-specific gene expression by D. F. Santoro, G. Marconi, S. Capomaccio, M. Bocchini, A. W. Anderson, A. Finotti, M. Confalonieri, E. Albertini, D. Rosellini

“…Integrated network analysis led to the identification of putative miRNA: mRNA interactions potentially involved in transcriptome reprogramming. …”
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Acceptance of artificial intelligence clinical assistant decision support system to prevent and control venous thromboembolism among healthcare workers: an extend Unified Theory of... by Jingxian Wang, Yun Zhou, Yun Zhou, Kai Tan, Zhigang Yu, You Li

“…However, studies that focused on the acceptance of computerized tools for VTE prevention among healthcare workers were limited.ObjectiveThis study aims to explore what factors are influencing healthcare workers’ acceptance of the Artificial Intelligence Clinical Assistant Decision Support System (AI-CDSS) for VTE prevention based on the extended Unified Theory of Acceptance and Use of Technology (UTAUT).MethodsWe conducted a cross-sectional survey among healthcare workers in three grade-A tertiary hospitals in Shanxi, China. …”
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Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system by Shikha Vashisht, Costantino Parisi, Cecilia L. Winata

“…This approach led to the identification of 2,056 CHD-associated putative enhancers (CHD-enhancers), 38.9% of them overlapping with known enhancers catalogued in human enhancer disease database. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…Methods Convolutional neural network was used to identify an ALS-associated SNP located in the intronic region of MEF2C (rs304152), residing in a putative enhancer element. To examine the alteration of MEF2C transcription by the SNP, we generated HEK293T cells carrying the major or minor allele by CRISPR-Cas9. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

“…This study aimed to assess the neuroprotective effects of the hydroalcoholic extract of Dracocephalum moldavica (DM) on cognitive impairment, biomarker changes, and putative metabolic pathways in a rat model of AD induced by intracerebroventricular streptozotocin (ICV-STZ). …”
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A Bidirectional Mendelian Randomization Study Investigating the Causal Relationship Between Ankylosing Spondylitis and Chronic Obstructive Pulmonary Disease by Pan D, Dai X, Li P, Xue L

“…Di Pan,1,2 Xiaoling Dai,3 Pan Li,4 Luan Xue1 1Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Shanghai Putuo Traditional Chinese Medicine Hospital, Shanghai, People’s Republic of China; 4Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Luan Xue; Xiaoling Dai, Email 610725556@qq.com; 553137182@qq.comBackground: Previous studies have found an association between ankylosing spondylitis (AS) and chronic obstructive pulmonary disease (COPD); however, no research has investigated this relationship using Mendelian randomization (MR).Methods: This study employed a bidirectional two-sample MR approach to assess the causal connection between AS and COPD. …”
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Attitudes towards vaccines and intention to vaccinate against COVID-19: a cross-sectional analysis—implications for public health communications in Australia by Leslie Swartz, Jean Bourbeau, Naja Hulvej Rod, Colleen Norris, Molly Byrne, Samir Gupta, Juhee Cho, Amos Laar, Jacqueline Boyle, Eva Suarthana, Mohsen Sadatsafavi, Bronwynè Coetzee, Susan Michie, Richard Fleet, Jason Bantjes, Beate Ditzen, Justin Presseau, Lucie Byrne-Davis, Claudia Gemme, Valeria Raparelli, Alexandra Kautzky-Willer, Sandra Peláez, Hannah Durand, Olivier Drouin, Sze Man Tse, Louise Pilote, Hagai Levine, Richard Ayah, Drieda Zaçe, Paul Poirier, Helena J Teede, Paula Griffiths, Elizabeth W Kimani-Murage, Lisa Kakinami, Angelos Kassianos, Chiwoza Bandawe, Ariane Belanger-Gravel, Lise Gauvin, Ilda Hoxhaj, Stefania Boccia, Jovana Stojanovic, Keven Joyal-Desmarais, Emily Petherick, Joanne Liu, Linda Booij, Joanne Enticott, Ahmed Abou-Setta, Kyle Warkentin, Roland Grad, Michael Vallis, Gary Garber, Mohsen Alyami, Johannes Thrul, Gregory Ninot, Susanne Fischer, Lauren Sherar, Paula Simão, Daniel Akunga, Jackim Nyamari, John Bosco Isunju, Michel Fournier, Francine Ducharme, Sarah Bernard, Shawn Aaron, Susan Bondy, Rizwana Roomaney, Jiyoung Lee, Violet Naanyu, Chris Noone, Abdhalah Ziraba, Eli Puterman, Jaskirath Singh Gill, Simon L. Bacon, Kim L. Lavoie, Daniel S. Epstein, Shrinkhala Dawadi, Zahir Vally, Analía Verónica Losada, Shajedur Rahman Shawon, Arobindu Dash, Marilia Estevam Cornelio, Darlan Lauricio Matte, Angela Alberga, Tracie Barnett, Silvana Barone, Lisa Maureen Birch, Roxane Borgès Da Silva, Rachel Burns, Tavis Campbell, Linda Carlson, Kim Corace, Mohsen Farhadloo, Carl Falk, Jennifer Gordon, Kim Hellemans, Catherine Herba, Heungsun Hwang, Jack Jedwab, Eric Kennedy, Sunmee Kim, Joshua Rash, Paula A B Ribeiro, Paramita Saha Chaudhuri, Nicolás Bronfman Caceres, Manuel Ortiz, Paula Beatriz Repetto, Mariantonia Lemos-Hoyos, Mathieu Beraneck, Thomas Kubiak, Sam Codjoe, Lily Kpobi, Naorem Kiranmala Devi, Sanjenbam Meitei, Suzanne Tanya Nethan, Lancelot Pinto, Kallur Nava Saraswathy, Dheeraj Tumu, Silviana Lestari, Grace Wangge, Jennifer McSharry, Oonagh Meade, Gerry Molloy, Anat Zaidman-Zait, Stefania Paduano, Ala'S Aburub, Chris Barasa, Pamela Miloya Godia, Nicholas Mutuku, Teresa Mwoma, Hildah Oburu, Joyce Olenja, Dismas Ongore, Loh Siew Yim, Andrea Herbert, Daniela Liggett, Ademola Ajuwon, Nisar Ahmed Shar, Bilal Ahmed Usmani, Rosario Mercedes Bartolini Martínez, Hilary Creed-Kanashiro, Pierre Claver Rutayisire, Abu Zeeshan Bari, Iveta Nagyova, Brendon Barnes, Ashraf Khagee, Tebogo Mothiba, Man-gyeong Lee, Anne Berman, Nouha Saleh Stattin, Debbie Hu, Yasin Kara, Ceprail Şimşek, Bilge Üzmezoğlu, James Mugisha, Joanne Hart, Will Johnson, Nicola Paine, Robert M Bilder, Matthew Burg, Susan Czajkowski, Ken Freedland, Sherri Sheinfeld Gorin, Alison Holman, Gilberto Lopez, Sylvie Naar, Michele Okun, Lynda Powell, Sarah Pressman, Tracey Revenson, John Ruiz, Sudha Sivaram, Claudia Trudel-Fitzgerald, Abehaw Yohannes, Rhea Navani, Kushnan Ranakombu, Daisuke Hayashi Neto, Tair Ben-Porat, Anda Dragomir, Amandine Gagnon-Hébert, Vincent Gosselin Boucher, Mahrukh Jamil, Lisa Maria Käfer, Ariany Marques Vieira, Tasfia Tasbih, Maegan Trottier, Robbie Woods, Reyhaneh Yousefi, Tamila Roslyakova, Lilli Priesterroth, Shirly Edelstein, Tanya Goldfrad, Ruth Snir, Yifat Uri, Comfort Sanuade, Olivia Crescenzi, Katya Grinko, Lalita Angne, Jigisha Jain, Nikita Mathur, Anagha Mithe, Sarah Nethan

“…Secondary outcome: analyses of putative drivers of uptake, including vaccine confidence, socioeconomic status and sources of trust, derived from multiple survey questions.Results Seventy-eight per cent reported being likely to receive a SARS-CoV-2 vaccine. …”
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Skullcapflavone II suppresses TGF-β-induced corneal epithelial mesenchymal transition in vitro by Meng-Xi Li, Zhen Zhang, Yue Zhang, Fan-Ru Zhao, Yu-Fan Li, Yu-Fei Dang, Yang-Yang Yue, Li Li

“…Thus, SCF-II represents a candidate putative therapeutic agent in corneal fibrotic diseases.…”
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Tren Kasus Tuberkulosis Anak di RSUP Dr. M. Djamil Padang Tahun 2014-2016 by Nurul Noviarisa, Finny Fitry Yani, Darfious Basir

“…Rontgen toraks dengan gambaran TB ditemukan pada 92,4% kasus. 78,3% kasus pulih paska 6 bulan pengobatan, 21% pulih dengan pengobatan tambahan, yang lainnya pindah ke pelayanan kesehatan primer dan putus obat. Efek samping obat terjadi pada 6,6% kasus, 6,6% kasus meninggal. …”
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“I’m trying to figure out who the hell I am”: Examining the psychosocial and mental health experience of individuals learning “Not Parent Expected” news from a direct-to-consumer D... by Juliette Careau, Maarten H.D. Larmuseau, Rebekah Drumsta, Rob Whitley

“…Such news may negatively affect mental health, self-identity and familial relationships, while prompting the utilization of putatively helpful resources by affected individuals. …”
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Asymptomatic Bacteriuria among Pregnant Women in Addis Ababa, Ethiopia: Prevalence, Causal Agents, and Their Antimicrobial Susceptibility by Ketema Bizuwork, Haile Alemayehu, Girmay Medhin, Wondwossen Amogne, Tadesse Eguale

“…Logistic regression analysis of the putative risk factors tested in the current study showed that none of them were significantly associated with the occurrence of ASBU (p>0.05). …”
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Molecular-genetic and cytogenetic analyses of cotton chromosome introgression from <i>Gossypium barbadense</i> L. into the genome of <i>G. hirsutum</i> L. in BC₂F<sub>1... by M. F. Sanamyan, Sh. U. Bobokhujayev, Sh. S. Abdukarimov, O. G. Silkova

“…In this work, two lines, CS- B06 and CS-B07, from the American cytogenetic collection with a putative substitution involving chromosomes 6 and 7 of the At-subgenome were analysed. …”
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Characterisation of <i>Staphylococcus aureus</i> Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes <i>lukP/Q</i> by Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht

“…Its <i>lukF</i> component could be regarded as chimaera comprising parts of <i>lukQ</i> and of <i>lukF-P83</i>. A putative kinase gene of 1095 basepairs was found to be associated with equine strains of <i>S. aureus</i>. …”
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Détermination du statut du Chimpanzé, Pan troglodytes verus, dans une zone non protégée de savane boisée à Bagnomba, Sénégal : Implication pour sa conservation by Papa Ibnou Ndiaye, Landing Badji, Stacy Marie Lindshield, Cheikh Tidiane Bâ, Jill Pruetz

“…Les particularités écologiques des habitats du chimpanzé dans cette zone (relief, végétation, disponibilité d’aliments, entre autres) associées à leur caractère sacré par les populations locales constituent des atouts qui favoriseraient la conservation des chimpanzés dans cette zone si des mesures idoines de protection étaient prises. …”
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A temporary cholesterol-rich diet and bacterial extracellular matrix factors favor Salmonella spp. biofilm formation in the cecum by Alonso Cruz-Cruz, Megan E. Schreeg, John S. Gunn

“…Our findings suggest that the cecum, particularly under cholesterol-rich conditions, serves as an adaptative niche for Salmonella spp. aggregates/biofilms and is a putative site for long-term infection.IMPORTANCETyphoid fever is a systemic infectious disease triggered by the gastrointestinal dissemination of Salmonella Typhi and Paratyphi in humans. …”
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Overexpression of miR-21-5p as a potential pathogenesis marker for ovarian endometriosis by Mohamed Mahmoud, Amr Ahmed WalyEldeen, Mohamed A. Samie, Ahmed M. Sadek, Sayed Elakhras, Mohamed Samir, Osama Ahmed, Rasha Mohamed Samir Sayed, Ahmed Abdelaziz Baiomy, Sherif Abdelaziz Ibrahim, Hebatallah Hassan

“…In addition, the level of mRNA expression of lumican (LUM), an extracellular matrix proteoglycan (PG), and a putative target of miR-21-5p was quantified by qPCR. …”
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Nanopore sequencing as a novel method of characterising anorexia nervosa risk loci by Natasha Berthold, Silvana Gaudieri, Sean Hood, Monika Tschochner, Allison L. Miller, Jennifer Jordan, Laura M. Thornton, Cynthia M. Bulik, Patrick Anthony Akkari, Martin A. Kennedy

“…We then leveraged publicly available databases to characterise these loci in putative functional context and prioritise a subset of potentially relevant variants. …”
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Computational thinking in the context of higher education: Analytical review by E. K. Khenner

“…Except for several fundamentally important works of general studies, which reveal the concept of “com­putational thinking”, the author analysed mainly review articles published in the past five years in order to identify and systematise modern solutions related to the purpose of the work.Results and scientific novelty. …”
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A Structural Model of Truncated Gaussia princeps Luciferase Elucidating the Crucial Catalytic Function of No.76 Arginine towards Coelenterazine Oxidation. by Nan Wu, Zhi-Chao Xu, Kai-Dong Du, Shen Huang, Naohiro Kobayashi, Yutaka Kuroda, Yan-Hong Bai

“…GLuc comprises two consecutive repeats that form the enzyme body and a central putative catalytic cavity. However, deleting the C-terminal repeat only limited reduces the activity (over 30% residual luminescence intensity detectable), despite being a key part of the cavity. …”
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N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis by Haisheng Zhang, Cheng Yi, Jianing Li, Yunqing Lu, Haoran Wang, Lijun Tao, Jiawang Zhou, Yonghuang Tan, Jiexin Li, Zhuojia Chen, Gholamreza Asadikaram, Jie Cao, Jianxin Peng, Wanglin Li, Junming He, Hongsheng Wang

“…Furthermore, METTL3 suppressed the expression of GATA3, which regulated SLC7A11 transcription by binding to the putative site at − 597 to − 590 of the SLC7A11 promoter. …”
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