Detection of <i>Ehrlichia</i> spp. and <i>Theileria</i> spp. in <i>Hyalomma anatolicum</i> ticks collected in Tajikistan by M. Yu. Kartashov, Yu. V. Kononova, I. D. Petrova, N. L. Tupota, T. P. Mikryukova, V. A. Ternovoi, F. H. Tishkova, V. B. Loktev

“…The isolate Tajikistan-5 is closely related to the putative novel species Ehrlichia mineirensis. The Tajik isolates of Theileria spp. were clustered with T. annulata isolates from Turkey, Iran, Pakistan, and China by phylogenetic analyses.…”
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Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A by Mingliang Zhang, Xiaomin Nie, Yeqing Yuan, Yansu Wang, Xiaojing Ma, Jun Yin, Yuqian Bao

“…Although the G protein-coupled receptor family C group 6 subtype A (GPRC6A) is the putative receptor of osteocalcin, there is no direct evidence showing that GPRC6A mediates the effects of uncarboxylated osteocalcin in alleviating NAFLD in mice. …”
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SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells by Melissa Bernhardt, Anne Rech, Marion Berthold, Melina Lappe, Jan-Niklas Herbel, Florian Erhard, Annette Paschen, Bastian Schilling, Bastian Schilling, Andreas Schlosser

“…Moreover, we identified putative tumor-specific cryptic HLA peptides linked to these processes that might represent exploitable targets for cancer immunotherapy.ConclusionsWe have developed a new mass spectrometric approach that allowed us to investigate the effects of common MAPK inhibitors on the immunopeptidome of melanoma cells. …”
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Large morphological transitions underlie exceptional shape diversification in an adaptive radiation by Katherine B. Starr, Emma Sherratt, Thomas J. Sanger

“…Abstract Adaptive radiations are characterized by an increase in species and/or phenotypic diversity as organisms fill open ecological niches. Often, the putative adaptive radiation has been studied without explicit comparison to the patterns and rates of evolution of closely related clades, leaving open the question whether notable changes in evolutionary process indeed occurred at the origin of the group. …”
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Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners by Katarzyna Popiolek-Barczyk, Anna Piotrowska, Wioletta Makuch, Joanna Mika

“…Our study provides evidence that biphalin diminishes neuropathy symptoms, which might be partially related to reduced pronociceptive mediators released by activated microglia. Biphalin may be a putative drug for future pain therapy, especially for the treatment of neuropathic pain, when the lower analgesic effects of morphine are correlated with profound microglial cell activation.…”
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Recovery of Bioactive Constituents from Olive Leaf Pruning Waste of Five Different Cultivars: A Comparison of Green Extraction Techniques to Maximize Health Benefits by Hamid Mushtaq, Simona Piccolella, Jose A. Mendiola, Lidia Montero, Elena Ibáñez, Severina Pacifico

“…PLE extracts showed better antiradical activities, putatively due to a higher content of flavonoids, secoiridoids, and HCA derivatives than UAM-EtOH ones, as these latter also contained 20–40% (cultivar-dependent) of triterpenes. …”
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Detection of Francisellaceae and the differentiation of main European F. tularensis ssp. holarctica strains (Clades) by new designed qPCR assays by Kristin Köppen, Kerstin Rydzewski, Julia Zajac, Marwah Al-Senwi, Sema Evcimen, Darius Schulze, Daniela Jacob, Klaus Heuner

“…In addition to these Francisella species, further genera of the family Francisellaceae have been described, such as Allofrancisella, Parafrancisella and Pseudofrancisella, but less is known about the distribution and putative virulence of these genera. The methods currently available were not made for a fast and easy detection of all these strains and genera of Francisellaceae. …”
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PcWRKY1 Represses Transcription of Yellow Stripe‐Like 3 (PcYSL3) to Negatively Regulate Radial Cadmium Transport in Poplar Stems by Xin Chen, Yuhong Zhang, Yao Cheng, Wenjian Yu, Lingyu Yang, Peiqi Shu, Jing Zhou, Payam Fayyaz, Zhi‐Bin Luo, Shurong Deng, Wenguang Shi

“…Cadmiun‐nicotianamine (Cd‐NA) in xylem vessels in poplar stem‐wood is unloaded to adjacent ray parenchyma cells and further radially transported to bark‐phloem. PcYSL3 is putatively identified as involved in Cd radial transport in poplar stems. …”
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Predicted Cold Shock Proteins from the Extremophilic Bacterium Deinococcus maricopensis and Related Deinococcus Species by Michael J. LaGier

“…A tertiary model of Dm-Csp1 revealed an anticipated Csp structure containing five anti-parallel beta-strands, and ligand prediction experiments identified N-terminally located residues capable of binding single-stranded nucleic acids. Putative Csps were identified from 100% of (27 of 27) Deinococci species for which genome information is available; and the Deinococci-encoded Csps identified contain a C-terminally located region that appears to be limited to members of the class Deinococci.…”
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Unlocking engagement: exploring the drivers of elderly participation in digital backfeeding through community education by Sijie Sun

“…Using an integrated framework of the UTAUT, TTF, and TAM models, the research surveyed 482 elderly participants in community centers in Taiyuan, China, focusing on variables such as task and technology characteristics, social influence, facilitating conditions, perceived usefulness, ease of use, and technology anxiety. …”
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Unraveling Community Potential Interactions by Environmental DNA in the Hong Kong Coastal Waters by Sangwook Scott Lee, Zhimeng Xu, Yingdong Li, Xiaodong Zhang, Jinping Cheng, Hongbin Liu

“…The southern and eastern regions of Hong Kong waters exhibit distinct environmental seasonality, and our investigation focused on comparing the potential interaction networks and the keystone taxa between these two regions. The putative species interaction networks across various groups (i.e., bacteria, protists, and metazoans) were revealed by using weighted correlation network analysis (WGCNA). …”
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In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…More than 1,200 miRNAs were assayed for putative protective effects in light-stressed 661W photoreceptor-like cells, and the top-performing miRNAs were further validated in independent in vitro assays. miR-429 showed the strongest cell-protective effect in vitro. …”
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A study of serum brain-derived neurotrophic factor level in individuals with obsessive compulsive disorder and their first-degree relatives as compared to the healthy population by Shaily Mina, Rupam Dhiman, Prakamya Singal, Sukanya Gangopadhyay, Pankaj Verma, Shivani Kathuria

“…In obsessive-compulsive disorder (OCD), various putative biomarkers such as neuropsychological, neurophysiological, neuroradiological, brain-derived neurotrophic factor (BDNF), etc., have been explored. …”
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Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy by Fermín E. González, Alexey Chernobrovkin, Cristián Pereda, Tamara García-Salum, Andrés Tittarelli, Mercedes N. López, Flavio Salazar-Onfray, Roman A. Zubarev

“…Some of the HS-induced proteins, such as haptoglobin, could be also considered as DAMPs and candidates for further immunological analysis in the establishment of new putative danger signals with immunostimulatory functions.…”
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Relationship between personality traits and spontaneous coronary artery dissection risk: evidence from Mendelian randomization by Kun Zheng, Kun Zheng, Mengdi Wu, Junhua Wang, Junhua Wang, Jinjin Sun, Yuqian Li, Peng Wang, Zhiyue Zhang, Xiuming Pan, Yifeng Yang, Tianqi Li, Yujie Guo

“…This investigation endeavored to discern a genetic basis for personality traits influencing SCAD susceptibility.MethodsBidirectional univariate and multivariate Mendelian randomization (MR) analyses were hereby conducted to investigate the putative causal nexus between personality dimensions and SCAD risk. …”
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Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics by Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon

“…Using longitudinal, genetically determined expression, we implement a predictive causality framework, evaluating the prediction of future values of a target gene expression using prior values of a putative regulatory gene. Collectively, the results of this work demonstrate the insights that can be gained into the molecular underpinnings of disease by quantifying the genetic control of gene expression at single-cell resolution.…”
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Interrogating the global application of e-certification of seafarers by Margie Mendoza Mataac, Michael Ekow Manuel, Anne Pazaver

“…A modified Unified Theory of Acceptance and Use of Technology (UTAUT) model was used to determine the stakeholders’ usage behavior regarding seafarers’ e-certification. …”
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Comparative technoeconomic analysis of centralised and decentralised water source heat pump systems using CATHeaPS by Orestis Angelidis, Anastasia Ioannou, Daniel Friedrich, Alan Thomson, Gioia Falcone

“…CATHeaPS provides a complete project cashflow for each supply option and is verified against published data and outputs from a UK industrial case study, with slightly altered data to ensure confidentiality. …”
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A Novel Approach to Optimize Key Limitations of Azure Kinect DK for Efficient and Precise Leaf Area Measurement by Ziang Niu, Ting Huang, Chengjia Xu, Xinyue Sun, Mohamed Farag Taha, Yong He, Zhengjun Qiu

“…Furthermore, a semantic information-guided depth inpainting method was proposed, designed to repair void and flying pixels commonly observed in Azure Kinect DK outputs. The semantic information was extracted using a joint YOLOv11-SAM2 model, which utilizes supervised object recognition prompts and advanced visual large models to achieve precise RGB image semantic parsing with minimal manual input. …”
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Identifying and prioritizing appropriate strategies for customer loyalty in a mass environment (case study: clothing house) by Zahra Joorbonyan, Ali Sorourkhah, Seyyed Ahmad Edalatpanah

“…Afterwards, environmental advertising, collaborative production, and customer relationship management were placed in subsequent rankings. The outputs of the proposed approach indicate that considering the country's foreseeable future conditions, higher-priority strategies minimize environmental risks and their impact on the business.Originality/Value: The problem of choosing a customer loyalty strategy is a decision-making problem that can be addressed with the help of decision-making knowledge. …”
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