Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease by Jianshe Wei, Gilbert Ho, Yoshiki Takamatsu, Eliezer Masliah, Makoto Hashimoto

“…Since no radical therapies are available for PD, the objective of this paper is to discuss a mechanistic role for amyloidogenic evolvability, a putative physiological function of αS, among PD subtypes, and the potential relevance to therapy. …”
Get full text

Synergistic effect of blocking cancer cell invasionrevealed by computer simulations by Kazuhisa Ichikawa

“…Based on these findings, we next tested the effect of a putative inhibitor for MT1-MMP and found that such inhibitor was ineffective in blocking ECM degradation. …”
Get full text

Transcriptome of the Deep-Sea Black Scabbardfish, Aphanopus carbo (Perciformes: Trichiuridae): Tissue-Specific Expression Patterns and Candidate Genes Associated to Depth Adaptatio... by Sergio Stefanni, Raul Bettencourt, Miguel Pinheiro, Gianluca De Moro, Lucia Bongiorni, Alberto Pallavicini

“…Comparison of functional genes at both the protein sequences and protein stability levels, associated with adaptations to depth, revealed similarities between A. carbo and other bathypelagic fishes. A selection of putative genes was standardized to evaluate the correlation between number of contigs and their normalized expression, as determined by qPCR amplification. …”
Get full text

Genomic Analysis of a Serotype 5 Streptococcus pneumoniae Outbreak in British Columbia, Canada, 2005–2009 by Ruth R. Miller, Morgan G. I. Langille, Vincent Montoya, Anamaria Crisan, Aleksandra Stefanovic, Irene Martin, Linda Hoang, David M. Patrick, Marc Romney, Gregory Tyrrell, Steven J. M. Jones, Fiona S. L. Brinkman, Patrick Tang

“…The sequences were analyzed for single nucleotide variants (SNVs) and putative genomic islands. Results. The peak of the outbreak in British Columbia was in 2006, when 57% of invasive S. pneumoniae isolates were serotype 5. …”
Get full text

Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration by Maj Schneider Thomsen, Serhii Kostrikov, Lisa Greve Routhe, Kasper Bendix Johnsen, Steinunn Sara Helgudóttir, Johann Mar Gudbergsson, Thomas Lars Andresen, Torben Moos

“…Chronic neurodegenerative diseases are characterized by substantial inflammation with putative impairment of the brain vasculature also commonly observed. …”
Get full text

Evidence for microbially-mediated tradeoffs between growth and defense throughout coral evolution by Hannah E. Epstein, Tanya Brown, Ayọmikun O. Akinrinade, Ryan McMinds, F. Joseph Pollock, Dylan Sonett, Styles Smith, David G. Bourne, Carolina S. Carpenter, Rob Knight, Bette L. Willis, Mónica Medina, Joleah B. Lamb, Rebecca Vega Thurber, Jesse R. Zaneveld

“…Interpreting these data in their phylogenetic context, we show that microbial dominance predicts disease susceptibility, and traced this dominance-disease association to a single putatively beneficial symbiont genus, Endozoicomonas. …”
Get full text

Magnetic Resonance Imaging of Cells Overexpressing MagA, an Endogenous Contrast Agent for Live Cell Imaging by Donna E. Goldhawk, Claude Lemaire, Cheryl R. McCreary, Rebecca McGirr, Savita Dhanvantari, R. Terry Thompson, Rene Figueredo, Jim Koropatnick, Paula Foster, Frank S. Prato

“…One such gene is MagA , a putative iron transporter. We have examined expression of MagA in mouse neuroblastoma N2A cells and characterized their response to iron loading and cellular imaging by MRI. …”
Get full text

Biodiversity of Lecanosticta pine-needle blight pathogens suggests a Mesoamerican Centre of origin by Ariska van der Nest, Michael J. Wingfield, Paulo C. Ortiz, Irene Barnes

“…Two species of Lecanosticta, L. brevispora and L. guatemalensis, have recently been described from Mexico and Guatemala respectively based on morphology and sequence-derived phylogenetic inference. However, the putative native pathogen, L. acicola, was not found in those areas. …”
Get full text

Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from <i>Taenia solium</i> Using Computational and Bioinformatics Tools by César Sánchez-Juárez, Roberto Flores-López, Lluvia de Carolina Sánchez-Pérez, Ponciano García-Gutiérrez, Lucía Jiménez, Abraham Landa, Rafael A. Zubillaga

“…Representative structures from these simulations and a putative binding site with low conservation relative to human GSTs, identified via the SILCS methodology, were employed for virtual screening through ensemble docking against a commercial compound library. …”
Get full text

Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito <i>Anopheles stephensi</i> and Its Capacity to Mobilize Pantothenate and Biotin by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart, Michael A. Riehle

“…Furthermore, we examined how Pan was mobilized in the mosquito via a putative Pan transporter, the <i>A. stephensi</i> sodium multi-vitamin transporter. …”
Get full text

Analysis of Polygala tenuifolia Transcriptome and Description of Secondary Metabolite Biosynthetic Pathways by Illumina Sequencing by Hongling Tian, Xiaoshuang Xu, Fusheng Zhang, Yaoqin Wang, Shuhong Guo, Xuemei Qin, Guanhua Du

“…We also obtained many candidates CYP450s and UGTs by the analysis of genes in the secondary metabolite biosynthetic pathways, including putative terpenoid backbone and phenylpropanoid biosynthesis pathway. …”
Get full text

Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension by Mark Duncan, Brandie D. Wagner, Keri Murray, Jenna Allen, Kelley Colvin, Frank J. Accurso, D. Dunbar Ivy

“…Twelve cytokines and growth factors putatively associated with lung or vascular disease were examined in plasma specimens from 70 children with PH using multiplex protein array technology. …”
Get full text

Weighted gene co-expression network analysis reveals key stromal prognostic markers in pancreatic cancer by G. Mantini, A. Agostini, M. Tufo, S. Rossi, M. Kulesko, C. Carbone, L. Salvatore, G. Tortora, G. Scambia, L. Giacò

“…These findings suggest that we uncovered a stromal specific signature through WGCNA and found putative prognostic markers.…”
Get full text

A Follow-up Association Study of Genetic Variants for Bone Mineral Density in a Korean Population by Seokjin Ham, Tae-Young Roh

“…Thirteen genomic loci among 56 loci were significantly associated with BMD variations, and 3 loci were involved in known biological pathways related to BMD. In order to find putative functional variants, nearby SNPs in relation to linkage equilibrium were annotated, and their possible functional effects were predicted. …”
Get full text

Identification and characterization of the COPII vesicle‐forming GTPase Sar1 in Chlamydomonas by Kin Pan Chung, Daniel Frieboese, Florent Waltz, Benjamin D. Engel, Ralph Bock

“…Here we identified a putative Sar1 homolog (CrSar1) in the model green alga Chlamydomonas reinhardtii through amino acid sequence similarity. …”
Get full text

Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation by Yong Zhao, Hao Wang, Ming Lu, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue

“…Target genes of the differentially expressed miRNAs were predicted using TargetScan, MiRanda, and PicTar software programs. The putative target genes were subjected to KEGG functional analysis. …”
Get full text

Functional investigation suggests CNTNAP5 involvement in glaucomatous neurodegeneration obtained from a GWAS in primary angle closure glaucoma. by Sudipta Chakraborty, Jyotishman Sarma, Shantanu Saha Roy, Sukanya Mitra, Sayani Bagchi, Sankhadip Das, Sreemoyee Saha, Surajit Mahapatra, Samsiddhi Bhattacharjee, Mahua Maulik, Moulinath Acharya

“…This study provides the first direct functional evidence of a putative role of CNTNAP5 in visual neurodegeneration.…”
Get full text

CD24 is expressed in HNSCC and is correlated with a dampened immune response by Deborah C. Schubert, Marvin Hürter, Dimo Dietrich, Sebastian Strieth, Peter Brossart, Peter Altevogt, Christine Sanders, Glen Kristiansen

“…Conclusion: CD24 is commonly expressed in HNSCC and may contribute to an immunosuppressive tumor microenvironment in HNSCC. Its role as a putative therapy target should be clarified in further studies.…”
Get full text

Analysis of Factors Affecting Use Behavior towards Mobile Payment Apps: A SEM Approach by Ashish A. Linge, Tushar Chaudhari, Baldeo B. Kakde, Mahesh Singh

“…The researchers used the UTAUT2 theory to examine the relationship between the independent and dependent variables mentioned above. …”
Get full text

Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus by Jordan M. Sampson, Kimberly A. Morrissey, Kieran J. Mikolajova, Kourtney M. Zimmerly, Neil J. Gemmell, Michael G. Gardner, Terry Bertozzi, Terry Bertozzi, Robert D. Miller

“…Our analyses include a putative new TCR locus. This novel locus contains V, D, and J gene segments that undergo V(D)J recombination, albeit with a limited number of gene segments in most squamate species. …”
Get full text