Strategies to Identify Recognition Signals and Targets of SUMOylation by Elisa Da Silva-Ferrada, Fernando Lopitz-Otsoa, Valérie Lang, Manuel S. Rodríguez, Rune Matthiesen

“…Furthermore, an integrative analysis of known and putative SUMO substrates illustrates an updated landscape of several SUMO-regulated events. …”
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Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease by Katharina E. Rosenbusch, Arjan Kortholt

“…Importantly, PD mutations in LRRK2 have been linked to a decreased GTPase and impaired kinase activity, thus providing putative therapeutic targets. To fully explore these potential targets it will be crucial to understand the function and identify the pathways responsible for LRRK2-linked PD. …”
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Cloning and Characterization of Immunological Properties of Haemophilus influenzae Enolase by Yesenia Osorio-Aguilar, Maria Cristina Gonzalez-Vazquez, Patricia Lozano-Zarain, Ygnacio Martinez-Laguna, Alejandro Carabarin-Lima, Rosa del Carmen Rocha-Gracia

“…In this study, 10 linear B cell epitopes and 13 CTL epitopes and a putative plasminogen-binding motif (252FYNKENGMY260) and the presence of enolase on the surface of different strains of H. influenzae were identified in the enolase sequence of H. influenzae. …”
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Novel mitochondrial-targeted alkyl chains act as fungal specific inhibitors of C. neoformans by Elizabeth S. M. Edrich, Luke Young, John Spencer, Andrew McGown, Anthony L. Moore, Campbell W. Gourlay

“…Two derivatives of Colletochlorin B, which we modified to improve delivery to mitochondria, were identified as putative fungal-specific inhibitors. ALTOX094 and ALTOX102 were able to inhibit Aox and cytochrome bc1in vitro and demonstrated strong inhibitory effects against C. neoformans growth and viability. …”
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Eye tracking to support assessment of patients with prolonged disorder of consciousness – a case series by Jan Johansson, Marika Möller, Kristina Franzon, Jonas Stenberg, Alison K. Godbolt

“…Conclusion: Eye tracking showed potential to be more effective in the detection of putative voluntary eye movements compared with conventional examination. …”
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Diagnostics and treatment of biliary dyskinesia: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, Yu. O. Shulpekova, Ye. K. Baranskaya, A. V. Okhlobystin, A. S. Trukhmanov, T. L. Lapina, A. A. Sheptulin

“…Contractility disorders along with increased lithogenicity followed by cyclooxygenase-2 overactivation in biliary tract tissue play significant pathogenic role; putative change in bile acid composition may be involved as well. …”
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Complete Genomic Landscape Reveals Hidden Evolutionary History and Selection Signature in Asian Water Buffaloes (Bubalus bubalis) by Jingfang Si, Dongmei Dai, Neena Amatya Gorkhali, Mingshan Wang, Sheng Wang, Saroj Sapkota, Ram Chandra Kadel, Amir Sadaula, Aashish Dhakal, Md Omar Faruque, Abdullah Ibne Omar, Eka Meutia Sari, Hidayat Ashari, Muhammad Ihsan Andi Dagong, Marnoch Yindee, Hossam E. Rushdi, Hussein Elregalaty, Ahmed Amin, Mohamed A. Radwan, Lan Doan Pham, W. M. M. P. Hulugalla, G. L. L. Pradeepa Silva, Wei Zheng, Shahid Mansoor, Muhammad Basil Ali, Farhad Vahidi, Sahar Ahmed Al‐Bayatti, Alfredo Pauciullo, Johannes A. Lenstra, J. Stuart F. Barker, Lingzhao Fang, Dong‐Dong Wu, Jianlin Han, Yi Zhang

“…Abstract To identify the genetic determinants of domestication and productivity of Asian water buffaloes (Bubalus bubalis), 470 genomes of domesticated river and swamp buffaloes along with their putative ancestors, the wild water buffaloes (Bubalus arnee) are sequenced and integrated. …”
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Epibiotic bacterial community composition varies during different developmental stages of Octopus mimus: Study of cultivable representatives and their secondary metabolite producti... by Martha B Hengst, Stephanie Trench, Valezka Alcayaga, Cristian Sepúlveda-Muñoz, Jorge Bórquez, Mario Simirgiotis, Fernando Valenzuela, Mario Lody, Lenka Kurte, Coral Pardo-Esté

“…Organic extracts from Bacillus megaterium M8-1 were obtained, and UHPLC-MS analysis detected seventeen putative compounds, including two phenolic acids, three indole derivatives, and twelve oxylipins. …”
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Screening and marker trait association for salinity tolerance in rice (Oryza sativa L.) by P. Hima Bindu1*, G. Shiva Prasad2, R.M. Sundaram3, K. Sumalini1 and C.H. Damodar Raju4

“…Nine of the 16 polymorphic markers RM3412, RM10843, RM562, RM10793, RM 10748, RM8094, RM10694, RM1287 and RM493 showed statistically significant marker-trait relationships, suggesting the presence of important putative genetic loci linked to chromosome 1 with ability to withstand salinity. …”
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Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report by Evangelos Koumasopoulos, Evangelia-Anna Spiteri, Aigli G Vakrakou, Panagiotis Toulas, Georgios Velonakis, George Stranjalis, Leonidas Stefanis, Maria-Eleptheria Evangelopoulos, Maria Anagnostouli

“…In our opinion, the presented case supports the putative neoplastic nature of the disease, at least in the long term, and/or along with Epstein–Barr virus involvement, which is known that have been related to other immune-mediated diseases such as multiple sclerosis and malignancies, especially with specific human leukocyte antigen haplotypes. …”
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Methylobacterium populi VP2: Plant Growth-Promoting Bacterium Isolated from a Highly Polluted Environment for Polycyclic Aromatic Hydrocarbon (PAH) Biodegradation by Valeria Ventorino, Filomena Sannino, Alessandro Piccolo, Valeria Cafaro, Rita Carotenuto, Olimpia Pepe

“…Fourteen strains able to grow on minimal selective medium with a complex mixture of different classes of xenobiotic compounds as the sole carbon source were isolated from the soil of the ex-industrial site ACNA (Aziende Chimiche Nazionali Associate) in Cengio (Savona, Italy). The best putative degrading isolate, Methylobacterium populi VP2, was identified using a polyphasic approach on the basis of its phenotypic, biochemical, and molecular characterisation. …”
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Measuring the Cytochrome c Nitrite Reductase Activity—Practical Considerations on the Enzyme Assays by Célia M. Silveira, Stéphane Besson, Isabel Moura, José J. G. Moura, M. Gabriela Almeida

“…The catalytic parameters were discussed on the basis of the mediator reducing power and also taking into account the location of their putative docking sites with ccNiR. Due to the fast kinetics of ccNiR, electron delivering from reduced electron donors is rate-limiting in all spectrophotometric assays, so the estimated kinetic constants are apparent only. …”
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Degradation of aflatoxins in weakly alkaline conditions by Natalie Sandlin, Jiu Lee, Marco Zaccaria, Marek Domin, Babak Momeni

“…Further analysis also provided a putative structure of the AFG2 degradation byproduct. …”
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L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle by Roger F. Butterworth

“…Randomized clinical trials and meta-analyses confirm that L-ornithine L-aspartate (LOLA) is an effective ammonia-lowering agent currently employed for the treatment of hepatic encephalopathy (HE) that stimulates both urea synthesis by residual hepatocytes and muscle glutamine synthesis together with putative hepatoprotective actions. Treatment of cirrhotic patients with LOLA limits ammonia-induced sarcopenia by improving muscle protein synthesis and function. …”
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Non-random mating behaviour between diverging littoral and pelagic three-spined sticklebacks in an invasive population from Upper Lake Constance by Tobias Zeidler, Albert Ros, Samuel Roch, Arne Jacobs, Juergen Geist, Alexander Brinker

“…This study documents the emergence of behavioural barriers during early divergence in an invasive and rapidly diversifying stickleback population and discusses their putative role in facilitating reproductive isolation and adaptive radiation within this species.…”
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Colitis in spondyloarthritis by Muhammed Hafis, Vikas Agarwal

“…Mucosal inflammation leads to disruption of the epithelial barrier and activation of antigen-presenting cells and T-helper cells, which then home to synovium to cause inflammation maintaining the gut synovial axis. Several putative gut bacteria are implicated in the pathogenesis of SpA. …”
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APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence by Jingyi Xie, Daniel G. Chen, William Chour, Rachel H. Ng, Rongyu Zhang, Dan Yuan, Jongchan Choi, Michaela McKasson, Pamela Troisch, Brett Smith, Lesley Jones, Andrew Webster, Yusuf Rasheed, Sarah Li, Rick Edmark, Sunga Hong, Kim M. Murray, Jennifer K. Logue, Nicholas M. Franko, Christopher G. Lausted, Brian Piening, Heather Algren, Julie Wallick, Andrew T. Magis, Kino Watanabe, Phil Mease, Philip D. Greenberg, Helen Chu, Jason D. Goldman, Yapeng Su, James R. Heath

“…Here, we describe Antigen-TCR Pairing and Multiomic Analysis of T-cells (APMAT), an integrated experimental-computational framework designed for the high-throughput capture and analysis of CD8 T cells, with paired antigen, TCR sequence, and single-cell transcriptome. Starting with 951 putative antigens representing a comprehensive survey of the SARS-CoV-2 viral proteome, we utilize APMAT for the capture and single cell analysis of CD8 T cells from 62 HLA A*02:01 COVID-19 participants. …”
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Antibodies from a Patient with Type 1 Diabetes and Celiac Disease Bind to Macrophages that Express the Scavenger Receptor CD163 by Brigitte Sonier, Alexander Strom, Gen-Sheng Wang, Christopher Patrick, Jennifer A Crookshank, Majid Mojibian, Amanda J MacFarlane, Fraser W Scott

“…The novel finding of putative autoantibodies against tolerogenic intestinal CD163+ macrophages suggests that regulatory macrophages were targeted in this patient with celiac disease and T1D.…”
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Availability and occurrence of coelenterazine in a Swedish fjord to maintain Amphiura filiformis bioluminescence by Constance Coubris, Khaled Mirzaei, Laurent Duchatelet, Jérôme Mallefet

“…To date, no studies have investigated the putative source of coelenterazine in the brittle star diet. …”
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Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates by Miklós Bege, Miklós Lovas, Dániel Priksz, Brigitta Bernát, Ilona Bereczki, Rasha Ghanem Kattoub, Richárd Kajtár, Simon Eskeif, Levente Novák, Jan Hodek, Jan Weber, Pál Herczegh, István Lekli, Anikó Borbás

“…In this work, new cysteine-selective nucleoside-H2S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable dithioacetyl group. 5′-Dithioacetate derivatives were synthesized from the canonical nucleosides (uridine, adenosine, cytidine, guanosine and thymidine), and the putative 5′-thio metabolites were also produced from uridine and adenosine. …”
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