Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…In addition, midregion PTHrP appears to be imported in the nucleoplasm of cultured MDA-MB231 cells and in vitro, it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor–like DNA-binding ability. …”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…Other approaches have included intact putative autoantigens or autoantigen peptides. Considerable logistical outlays have been deployed to develop and to translate humanised antibodies targeting immune cells, cytokines, and cytokine receptors to the clinic. …”
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The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Releva... by Kvido Smitka, Hana Papezova, Karel Vondra, Martin Hill, Vojtech Hainer, Jara Nedvidkova

“…These neuronal circuits include neuropeptides ghrelin, neuropeptide Y (NPY), peptide YY (PYY), cholecystokinin (CCK), leptin, putative anorexigen obestatin, monoamines dopamine, norepinephrine (NE), serotonin, and neutralizing autoantibodies. …”
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Genomic analysis of three medieval parchments from German monasteries by Felix Heinrich, Henner Simianer, Jörg Bölling, Hedwig Röckelein, Christian Roos, Christian Reimer, Armin O. Schmitt

“…Finally, the genetic distances between the parchment samples show a putative association with the dates when the documents were written, indicating the usefulness of genetic analysis for provenance research.…”
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The Sublingua of <i>Lemur catta</i> and <i>Varecia variegata</i>: Only a Cleaning Function? by Juan Francisco Pastor, Magdalena Natalia Muchlinski, Josep María Potau, Aroa Casado, Yolanda García-Mesa, José Antonio Vega, Roberto Cabo

“…Comparative studies of macro and microanatomy are scarce or incomplete for primates; thus, the putative function remains unclear. To better understand the functional significance of the sublingua, we studied this structure in <i>Lemur catta</i> and <i>Varecia variegata</i> specimens using histochemical staining techniques and scanning electron microscopy with microanalysis. …”
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A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates by Iqra Younus, Robert C. Ford, Stephen M. Prince

“…After partial purification and in the presence of the detergent (n-dodecyl-β-D-maltoside), the kinetic parameters of the ATP hydrolysis reactions of the orthologs were determined, as well as the extent of stimulation of their activity when presented with putative substrates. We discuss the efficiency of such bioinformatics approaches and make suggestions for their improvement and wider application in membrane protein-structure determination.…”
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RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration by Scott E. Ugras, James Shorter

“…In a recent study, Couthouis et al. screened for protein candidates that were also involved in RNA processing, contained a predicted prion domain, shared other phenotypic similarities with TDP-43 and FUS, and identified TAF15 as a putative ALS gene. Subsequent sequencing of ALS patients successfully identified ALS-linked mutations in TAF15 that were largely absent in control populations. …”
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Chemical versus physical pressure effects on the structure transition of bilayer nickelates by Gang Wang, Ningning Wang, Tenglong Lu, Stuart Calder, Jiaqiang Yan, Lifen Shi, Jun Hou, Liang Ma, Lili Zhang, Jianping Sun, Bosen Wang, Sheng Meng, Miao Liu, Jinguang Cheng

“…A linear extrapolation of P c versus the average size of A-site cations (<r A >), yields a putative critical value of <r A >c ≈ 1.23 Å for P c ≈ 1 bar. …”
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Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model by Juan Sebastian Yakisich, Neelam Azad, Rajkumar Venkatadri, Yogesh Kulkarni, Clayton Wright, Vivek Kaushik, Anand Krishnan V. Iyer

“…In the absence of serum, CSCs/CS-LCs have the ability to grow as lung tumorspheres (LTSs), and this system is routinely used for isolation and characterization of putative CSCs/CS-LCs. Methods to isolate LTSs are usually performed in serum-free media supplemented with specific additives such as epidermal growth factor and basic fibroblast growth factor. …”
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The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer by Evan D. Paul, Barbora Huraiová, Natália Valková, Natalia Matyasovska, Daniela Gábrišová, Soňa Gubová, Helena Ignačáková, Tomáš Ondris, Michal Gala, Liliane Barroso, Silvia Bendíková, Jarmila Bíla, Katarína Buranovská, Diana Drobná, Zuzana Krchňáková, Maryna Kryvokhyzha, Daniel Lovíšek, Viktoriia Mamoilyk, Veronika Mancikova, Nina Vojtaššáková, Michaela Ristová, Iñaki Comino-Méndez, Igor Andrašina, Pavel Morozov, Thomas Tuschl, Fresia Pareja, Jakob N. Kather, Pavol Čekan

“…Our consensus subtyping and risk groups mitigate single sample discordance, provide early and late prognostic information, and identify high risk patients with enriched immune signatures, which predict response to neoadjuvant immunotherapy in the multicenter, phase II, prospective I-SPY2 trial. We identify putative antibody-drug conjugate (ADC)-responsive patients, as evidenced by a 19-feature T-DM1 classifier, validated on I-SPY2. …”
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Allestire prospettive inedite nei piccoli paesi by Nicola Flora

“…L’articolo vuole dare testimonianza di esperienze di ricerca applicata sia in piccoli paesi dell’Italia meridionale che in un’area complessa del centro della città di Napoli, dove grazie all’allestire (provvisorio e/o stabile) si sono potute esperire modalità di valorizzazione di patrimoni immateriali e materiali di luoghi altrimenti destinati all’abbandono, con grande perdita di valori civili e culturali di comunità in cerca di affermazione della propria identità e nuova consapevolezza della propria specificità in un mondo che sembra aver perso l’attenzione per il piccolo ed il fragile. …”
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Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity by Appalaraju Jaggupilli, Eyad Elkord

“…We mainly focus on analysing the significance of CD44 and CD24 as CSC surface markers in combination or with other putative markers in different types of cancer.…”
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The irreconcilability of insight by Eli Shupe

“…In the field of comparative cognition, there is rising interest in the question of whether non-human animals are capable of insightful problem-solving. Putative cases of animals demonstrating insight have generally attracted two types of criticism: first, that insight is being conflated with other cognitive capacities (e.g., causal cognition, or mental trial and error); and, second, that the relevant performances merely reflect associative learning—and on the received understanding of insight within comparative cognition, insight necessarily involves non-associative processes. …”
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A‐CHAIM: Near‐Real‐Time Data Assimilation of the High Latitude Ionosphere With a Particle Filter by Ben Reid, David R. Themens, Anthony McCaffrey, P. T. Jayachandran, Magnar G. Johnsen, Thomas Ulich

“…The performance of A‐CHAIM is assessed by comparing the model outputs to unassimilated ionosonde observations, as well as to in‐situ electron density observations from the SWARM and DMSP satellites. …”
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Performance of Large Language Models on the Korean Dental Licensing Examination: A Comparative Study by Woojun Kim, Bong Chul Kim, Han-Gyeol Yeom

“…We used the KDLE questionnaire from 2019 to 2023 as inputs to the LLMs and then used the outputs from the LLMs as the corresponding answers. …”
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Usability of ChatGPT in the english essay writing proficiency of the BEED students by Karl Alvin Aglibot, Edrian Mark Tomines, Janel Talaman, Janabeth Soguilon, Rowena Bongolto, Rhona Marielle Abayon

“…Moreover, this study recommended further research to explore ChatGPT's use in other academic outputs, refine the rubrics to include vocabulary, grammar, and sentence structure criteria, and provide training for effective AI tool management among students. …”
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Application of a theoretical simulator to the optimisation of risk-based invasive species surveillance by Thomas I. Gibson, Rebecca S. Millard, Isla MacMillan, Nick Taylor, Mark Thrush, Hannah Tidbury

“…Sensitivity and elasticity analyses were conducted to identify variables which influence model outputs. The interaction between sampling method detection probability and changes in NIS abundance was modelled. …”
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Hydrogel as an alternative to agar for laboratory rearing of the green peach aphid Myzus persicae by Ana Paula Nascimento Silva, Camila Faria Chagas, Emanuel Lucas de Andrade Alves, Vinícius de Castro Carvalho, Khalid Haddi

“…Results The hydrogel concentration of 0.6 g allowed the production of aphids in high numbers, similarly to the agar (1 g), without affecting their life cycle parameters or their reproductive outputs. Furthermore, the most significant differences between the evaluated treatments resulted mostly from the combined effects of the host plants and the temperatures. …”
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Effects of heat generation and absorption on thermal radiative MHD flow of chemically reacting Casson nanofluids over a wedge by S. Venkateswarlu, B. Hari Babu, M. Veera Krishna

“…To vindicate the current analysis, the computational outputs are comparing by the previous available works which is accessible in the literature and they determined to be in the good concurrence. …”
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Benchmarking of snow water equivalent (SWE) products based on outcomes of the SnowPEx+ Intercomparison Project by L. Mudryk, C. Mortimer, C. Derksen, A. Elias Chereque, P. Kushner

“…Assessing these gridded products fills an important gap in the literature, since individual gridded products are frequently chosen without prior justification as the basis for evaluating land surface and climate model outputs, along with other climate applications. The top-performing product across the range of tests performed is ERA5-Land, followed by the Crocus snow model. …”
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