A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease by Patricia Gómez-Suaga, Elena Fdez, Marian Blanca Ramírez, Sabine Hilfiker

“…Here, we will discuss current knowledge about mechanism(s) by which mutant LRRK2 may regulate autophagy, which highlights additional putative therapeutic targets.…”
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The transcriptional and translational landscape of HCoV-OC43 infection. by Stefan Bresson, Emanuela Sani, Alicja Armatowska, Charles Dixon, David Tollervey

“…These included several potential short upstream ORFs and a putative ORF nested inside the M gene. In parallel, we analyzed the cellular response to infection. …”
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A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions by Xi Xi, Jiaqi Li, Jinmeng Jia, Qiuchen Meng, Chen Li, Xiaowo Wang, Lei Wei, Xuegong Zhang

“…Some regulators reveal potential new therapeutic targets, drug repurposing possibilities, and putative causal single nucleotide polymorphisms. This method to analyze single-cell multi-omics data demonstrates how the interpretable design of neural networks can better decode biological systems.…”
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Transport of Alzheimer's associated amyloid-β catalyzed by P-glycoprotein. by James W McCormick, Lauren McCormick, Gang Chen, Pia D Vogel, John G Wise

“…We observed transport of Aβ40 and Aβ42 monomers by P-gp in explicit MD simulations of a putative catalytic cycle. In in vitro assays with P-gp overexpressing cells, we observed enhanced accumulation of fluorescently labeled Aβ42 in the presence of Tariquidar, a potent P-gp inhibitor. …”
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Enrichment of rare alleles within epigenetic chromatin marks in the first intron by Shin-Sang Jo, Sun Shim Choi

“…Meanwhile, transcription factor binding sites were significantly more enriched in the 2-kb upstream regions (i.e., the regions of putative promoters of genes) than in the first introns. …”
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Wine, beer and Chinese Baijiu in relation to cardiovascular health: the impact of moderate drinking by Qiao Kang, Jinyuan Sun, Bowen Wang, Baoguo Sun

“…In addition, protective effects and putative mechanisms of both ethanol and non-ethanol components of wine, beer, and Chinese Baijiu, the three most representative alcoholic beverages worldwide, are to be evaluated within the context of a rational drinking pattern.…”
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Differential Dynamics of ATR-Mediated Checkpoint Regulators by Daniël O. Warmerdam, Roland Kanaar, Veronique A. J. Smits

“…Little was known about the spatio and temporal behaviour of the proteins involved, and we, therefore, examined the behaviour of the ATRIP-ATR and Rad9-Rad1-Hus1 putative DNA damage sensor complexes and the downstream effector kinase Chk1. …”
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Gene fitness landscapes of Vibrio cholerae at important stages of its life cycle. by Heather D Kamp, Bharathi Patimalla-Dipali, David W Lazinski, Faith Wallace-Gadsden, Andrew Camilli

“…We additionally identified 76 new pathogenicity factors and 414 putatively essential genes for V. cholerae growth. Our results provide a comprehensive framework for understanding the biology of V. cholerae as it colonizes the small intestine, elicits profuse secretory diarrhea, and disseminates into the aquatic environment.…”
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Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster by Herbert Izo, Ninsiima, Emmanuel Tiyo, Ayikobua, Josephine, Kasolo, Keneth Iceland, Kasozi, Ejike, Daniel Eze

“…Background: The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. …”
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Designing supply chain scenarios and investigating how it affects relevant variables in the National Company of Southern Oil-bearing Regions by Amin Mirshekar, Ghanbar Amirnejad, Mohammad Hemati, Ali Kangarani Farahani

“…The results of the surveys showed that the excessive increase in the sending capacity, the increase in the volume of orders, and the decrease in the time of sending the orders will have their own positive and negative results, which the creation of a favorable and optimal situation based on the various outputs of the model will be fruitful in the context of adopting the organization's policy. …”
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Designing and planning a bioethanol supply chain network under uncertainty using a data-driven robust optimization model under disjunctive uncertainty sets by Farzaneh MansooriMooseloo, Maghsoud Amiri, Mohammad Taghi Taghavi Fard, Mostafa Hajiaghaei-Keshteli

“…Purpose: Most research in the field of designing and planning bioethanol supply chains has been based on deterministic models, which do not consider dynamic environmental conditions and thus do not provide reliable outputs. Classic robust models did not have this weakness, but due to their excessive conservatism, they increased supply chain costs, making them unattractive to investors. …”
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Sensitivity of global solar irradiance to transposition models: Assessing risks associated with model discrepancies by Yasser F. Nassar, Hala J. El-Khozondar, Mohamed M. Khaleel, Abdussalam A. Ahmed, Abdulgader H. Alsharif, Monaem Elmnifi, Mark Amoah Nyasapoh

“…The results matched satisfactorily with other researchers’ outputs without exceeding 3.5 % of error. A unique TM has been recommended for the entire world corresponding to each interval of β.…”
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Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…We conclude that oncogenic PIK3CA H1047R corrupts information transfer in a growth factor-dependent manner and suggest new opportunities for tuning of receptor-specific PI3K pathway outputs for therapeutic benefit.…”
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A collaborative network analysis for the interpretation of transcriptomics data in Huntington’s disease by Ozan Ozisik, Nazli Sila Kara, Tooba Abbassi-Daloii, Morgane Térézol, Elsa C. Kuijper, Núria Queralt-Rosinach, Annika Jacobsen, Osman Ugur Sezerman, Marco Roos, Chris T. Evelo, Anaïs Baudot, Friederike Ehrhart, Eleni Mina

“…The resulting significantly enriched Reactome pathways were then summarized using the ontological hierarchy which allowed the integration and interpretation of outputs from multiple methods. Among the resulting enriched pathways, there are pathways that have been shown previously to be involved in Huntington’s disease and pathways whose direct contribution to disease pathogenesis remains unclear and requires further investigation. …”
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SYMBOLIC ANALYSIS OF CLASSICAL NEURAL NETWORKS FOR DEEP LEARNING by Vladimir Milićević, Igor Franc, Maja Lutovac Banduka, Nemanja Zdravković, Nikola Dimitrijević

“…With the symbolic expression of outputs obtained from inputs and parameters, including pure symbolic activation functions, many other properties can be derived in closed form, such as classification with respect to a single system parameter, activation function, or inputs. …”
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Larval anchovy and sardine dispersal patterns in South Africa’s exclusive economic zone by Tshikana Rasehlomi, Tshikana Rasehlomi, Marjolaine Krug, Marjolaine Krug, Mari S. Myksvoll, Mari S. Myksvoll

“…., inshore of the 200 m isobath), and 2) to assess the impact of model resolution on the dispersal patterns by comparing outputs of a 3-km-grid coastal and regional ocean community model, and the 8-km-grid global ocean physics reanalysis product. …”
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A Constrained-Based Optimization Method for Real-Time Kinematics Using Magneto-Inertial Signals: Application to Upper Limb Joint Angles Estimation During Prolonged Recordings by Marco Caruso, Elisa Digo, Laura Gastaldi, Stefano Pastorelli, Andrea Cereatti

“…By comparing results with stereophotogrammetric tracking outputs, the application of constraints - leveraging a priori knowledge of the workspace boundaries for joint centers - enhanced the accuracy of shoulder and elbow angle estimations and effectively mitigated the impact of sensor orientation drift over extended periods. …”
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Adaptation of Diverse Maize Germplasm to Spring Season Conditions in Northeast China by Yi Li, Zhiyuan Yang, Yong Shao, Zhenguo Jin, Li Gao, Yang Yu, Fengyi Zhang, Yuxing Zhang, Yuantao Nan, Mingshun Li, Degui Zhang, Zhuanfang Hao, Jianfeng Weng, Xinhai Li, Hongjun Yong

“…Northeast China (NEC) is a major spring maize (<i>Zea mays</i> L.) growing belt, and the outputs substantially influence national grain production. …”
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Figuring Out Gas and Galaxies In Enzo (FOGGIE). VIII. Complex and Stochastic Metallicity Gradients at z > 2 by Ayan Acharyya, Molly S. Peeples, Jason Tumlinson, Brian W. O’Shea, Cassandra Lochhaas, Anna C. Wright, Raymond C. Simons, Ramona Augustin, Britton D. Smith, Eugene Hyeonmin Lee

“…By tracking the metallicity gradient at a rapid cadence of simulation outputs (∼5–10 Myr), we find that theoretical gradients are highly stochastic: the FOGGIE galaxies spend ∼30%–50% of their time far away from a smoothed trajectory inferred from analytic models or other, less high-cadence simulations. …”
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The stock status of narrow-barred Spanish mackerel, Scomberomorus commerson (Lacépède, 1800) in the southern Arabian Gulf: a case study using multiple length-based assessment appro... by Mohamed AlMusallami, Mark Dimech, Franklin Francis, Waleed Hamza, Aaron C. Henderson, Sabir Bin Muzaffar, Giuseppe Scarcella, Nazli Demirel, Dario Pinello

“…These outcomes underscore the importance of ongoing data-limited assessment methods in monitoring exploited stocks, providing evidence that restrictive measures have positively impacted biomass recovery. The convergence of outputs across methods, such as the indication of overfishing in S. commerson stocks, suggests that implementing multiple models enhances the robustness of management recommendations, including the enforcement of minimum size limits or reductions in fishing efforts or restriction of certain fishing methods. …”
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