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Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Published 2022-03-01“…To mimic the feature of T-cell receptor (TCR) that recognizes the complex of major histocompatibility class I and peptide on the cell surface derived from the processed intracellular antigen, we used NY-ESO-1, a cancer-testis antigen, to develop a TCR-like fully human IgG1 antibody and its derivative, CAR-T cells, for cancer immunotherapy.Methods Human single-chain variable antibody fragment (scFv) phage library (~10∧11) was screened against HLA-A2/NY-ESO-1 (peptide 157–165) complex to obtain target-specific antibodies. …”
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The radial limits and boundary uniqueness
Published 2024-11-01“…The paper sheds a new light on the fundamental theorems of complex analysis due to P. Fatou, F. and M. Riesz, N. …”
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Blockchain-Based Value-Added Tax System: A Systematic Review
Published 2024-06-01“…Encryption alone cannot guarantee the privacy of electronic invoices, and while zero-knowledge proofs seem to be a suitable solution, they come with considerable complexities. …”
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