In-depth exploration of programmed cell death-related subtypes and development of a prognostic signature model in lung adenocarcinoma by Desheng Zhou, Yachao Cui, Jing Guo, Zhenpeng Wu, Lin Li, Wenguang Yin, Min Deng, Meiyuan Liu

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Recent Advancements in Toxin and Antitoxin Systems Involved in Bacterial Programmed Cell Death by Ming-xi Hu, Xiao Zhang, Er-li Li, Yong-Jun Feng

“…Programmed cell death (PCD) systems have been extensively studied for their significant role in a variety of biological processes in eukaryotic organisms. …”
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Integrating machine learning and multi-omics analysis to unveil key programmed cell death patterns and immunotherapy targets in kidney renal clear cell carcinoma by Fanyan Ou, Yi Pan, Qiuli Chen, Lixiong Zeng, Kanglai Wei, Delin Liu, Qian Guo, Liquan Zhou, Jie Yang

“…Studies have indicated that programmed cell death (PCD) can modulate the activity of immune cells and participate in the regulation of antitumor immune responses. …”
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Programmed death ligand 1 (PD-L1) expression in gastric cancer: literature review by T. N. Sotnikova, N. V. Danilova, P. G. Malkov, T. V. Polushkina

“…Immunological checkpoint inhibitors have previously demonstrated  their effectiveness and safety in various solid tumors, however, with regard to stomach cancer, to date, ambiguous results have been presented. Tumor cells express programmed death ligand 1 (PD-L1), which binds to its programmed death receptor 1 (PD-1). …”
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Global research trends on Chinese patent drugs inducing programmed cell death in cancer: a bibliometric analysis (1998–2024) by Min Song, Chunyan Teng, Xiaodong Zheng, Shizhen Tan, Yipeng Guo

“…Abstract Background Chinese patent drugs, standardized formulations rooted in traditional Chinese medicine, have gained attention for their potential to induce programmed cell death (PCD) in cancer cells. Emerging evidence suggests that these formulations may affect multiple PCD pathways, including apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis, thus offering a multifaceted approach to tumor suppression. …”
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Real-world clinical impact of first-line immune checkpoint inhibitor-based therapy in advanced esophageal squamous cell carcinoma by M. Tamba, K. Chin, H. Osumi, M. Ogura, S. Fukuoka, S. Udagawa, K. Shimozaki, K. Yoshino, T. Wakatsuki, E. Shinozaki, K. Yamaguchi, A. Ooki

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In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome by Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Fernanda Gutierrez-Rodrigues, Massimiliano Bissa, Xingmin Feng, Emma M. Groarke, Haoran Li, Lemlem Alemu, Diego Quinones Raffo, Ivana Darden, Sachiko Kajigaya, Peter C. Grayson, Genoveffa Franchini, Neal S. Young, Bhavisha A. Patel

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Comparative analysis of the performance of the large language models ChatGPT-3.5, ChatGPT-4 and Open AI-o1 in the field of Programmed Cell Death in myeloma by Wu Kun, Tao Bo, Li Yuntao, Cheng Shenju, Li Yanhong, Luo Shan, Zeng Yun, Nie Bo, Shi Mingxia

“…Conclusion Open AI-o1 outperforms ChatGPT-3.5 and ChatGPT-4 in accuracy, depth, and reliability when addressing complex clinical questions related to Programmed Cell Death in multiple myeloma. …”
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An inclusive assessment of apoptosis mechanisms in Leishmania species: A narrative literature review by Soheil Sadr, Iraj Sharifi, Solmaz Morovati, Helia Sepahvand, Shakiba Nazemian, Mehdi Bamorovat, Zahra Rezaeian, Baharak Akhtardanesh

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Features of apoptosis and blebbing of the lymphocyte plasma membrane in bronchial asthma by I. A. Solovieva, I. V. Demko, E. A. Sobko, A. Yu. Kraposhina, N. V. Gordeeva, D. A. Anikin, D. A. Anikina

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Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains by Xiangling Feng, Yingjie Gao, Fan Chu, Yuwen Shan, Meicheng Liu, Yaoyi Wang, Ying Zhu, Qing Lu, Mingfeng Li

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Deciphering cancer therapy resistance via patient-level single-cell transcriptomics with CellResDB by Tianyuan Liu, Huiyuan Qiao, Liping Ren, Xiucai Ye, Quan Zou, Yang Zhang

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Metabolic landscape uncovers remodeling of T cell immunity affected by fatty acid desaturase in Parkinson’s disease at single-cell resolution by Shi Yan, Xue Zhao, Yao Si, Xinyu Zhang, Di Wang, Lifen Yao, Linlin Sun

“…Here, combining metabolic gene expression profiling and pathway activity algorithm, we studied the metabolic programs in PD-associated T cells. Results Cytotoxic T cells (CTLs) with adhesive properties dominated the proportion in PD patients based on the distribution of T cell types at single-cell resolution. …”
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Natural killer cell engagers for cancer immunotherapy by Shahryar Khoshtinat Nikkhoi, Geng Li, Arash Hatefi, Arash Hatefi

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Optimizing Muza-Smoked Salted Egg Production: A SWOT Analysis of an Empowerment Program Leveraging the Triple Helix Model by Suwigda Agung Novandinata, Siti Azizah, Abdul Manab, Irfan H Djunaidi, Achadiah Rachmawati, Rositawati Indrati, Rosyida Fajri Rinanti

“…The IE matrix shows that the empowerment strategy is on the “V” cell, which has a "hold and maintain" strategy. Thus, the programs given were not efficient, and strategic planners need to focus on product quality improvement. …”
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Radiotherapy for cutaneous squamous cell carcinoma: current standards and outlooks by A. R. Gevorkov, A. V. Boyko, A. P. Polyakov, A. V. Chernichenko, V. A. Gerasimov, I. A. Meshcheryakova, A. D. Kaprin

“…The most significant risk factors for locoregional recurrence include tumor location (head and neck), size (>2 cm), depth of invasion (>4 mm), tumor differentiation grade, perineural invasion, immune system disorders (immunosuppression), severe concomitant diseases, and previous treatment.In patients with advanced cutaneous squamous cell carcinoma, 1-year, 2-year, and 3-year survival rates are 50–80, 30–35 and 15–16 %, respectively. …”
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Immunogenic Cell Death Traits Emitted from Chronic Lymphocytic Leukemia Cells Following Treatment with a Novel Anti-Cancer Agent, SpiD3 by Elizabeth Schmitz, Abigail Ridout, Audrey L. Smith, Alexandria P. Eiken, Sydney A. Skupa, Erin M. Drengler, Sarbjit Singh, Sandeep Rana, Amarnath Natarajan, Dalia El-Gamal

“…Moreover, immunotherapeutic success in CLL has been stifled by its pro-tumor microenvironment milieu and low mutational burden, cultivating poor antigenicity and limited ability to generate anti-tumor immunity through adaptive immune cell engagement. Previously, we have demonstrated how a three-carbon-linker spirocyclic dimer (SpiD3) promotes futile activation of the unfolded protein response (UPR) in CLL cells through immense misfolded-protein mimicry, culminating in insurmountable ER stress and programmed CLL cell death. …”
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Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse by Marie E. Esper, Caroline E. Brun, Alexander Y. T. Lin, Peter Feige, Marie J. Catenacci, Marie‐Claude Sincennes, Morten Ritso, Michael A. Rudnicki

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Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas by Yu Tian, Shuqin Liu, Hongtao Shi, Jianjun Li, Xinglong Wan, Yujiang Sun, Huayun Li, Ning Cao, Zhixi Feng, Teng Zhang, Junjie Wang, Wei Shen

“…However, the understanding of donkey physiological characteristics at the cellular level remains poor. Thus, single‐cell transcriptome sequencing is used to construct a detailed transcriptional atlas based on 20 tissues from the Dezhou donkey (in total 84 cell types and 275 050 high quality cells) to perform an in‐depth investigation of molecular physiology. …”
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Recommendations for the effective use of T-cell–redirecting therapies: a Canadian consensus statement by Guido Lancman, Kevin Song, Darrell White, Tina Crosbie, Ismail Sharif, Marianne Emond, Muhammad Saleem Raza, Martine Elias, Rayan Kaedbey, Michael P. Chu

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