DPImpute: A Genotype Imputation Framework for Ultra‐Low Coverage Whole‐Genome Sequencing and its Application in Genomic Selection by Weigang Zheng, Wenlong Ma, Zhilong Chen, Chao Wang, Tao Sun, Wenjun Dong, Wenjing Zhang, Song Zhang, Zhonglin Tang, Kui Li, Yunxiang Zhao, Yuwen Liu

“…Remarkably, DPImpute demonstrated accurate SNP imputation from low‐coverage sequencing data from single blood cells and single blastocyst cells, highlighting its potential in embryo GS. …”
Get full text

The mechanism of RNA methylation writing protein-related prognostic genes in lung adenocarcinoma based on bioinformatics by Sha Yin, Guangyan Luo, Lei Luo

“…The identified prognostic genes also play significant roles in immune cell infiltration in LUAD. This study provides new theoretical references for subsequent in-depth research on LUAD.…”
Get full text

The possibilities of optical coherence tomography of the anterior segment in the angio mode (AS-OCTA) in the diagnosis and tactics of surgical treatment of corneal diseases by B.E. Malyugin, S.Yu. Kalinnikova, R.S. Isabekov, O.P. Antonova, A.V. Fomin

“…Fremont, California, USA) in the «OCT» and «Angio OCT» modes using the AngioVue program and the SSADA algorithm. Results. In the presented clinical cases, the use of AS-OCTA makes possible to accurately assess the depth, area and architectonics of the vessels, and helps to determine the tactics of surgical treatment and type of keratoplasty. …”
Get full text

Bone marrow composition features and possibilities of tumor involvement diagnosing in patients with classic Hodgkin’s lymphoma by F. M. Abbasbeyli, P. A. Zeynalova, M. A. Vernyuk, A. A. Fedenko, T. Yu. Mushkarina, A. A. Melnikova, V. Yu. Kovalskaya, L. Yu. Grivtsova

“…In addition, it was found that the majority of cases with CD20+/± and CD15+/± expression in the primary tumor were observed in the group of patients without bone marrow involvement. when assessing the cellular composition of bone marrow aspirates, it was revealed that in patients with bone marrow tumor infiltration, an increase in cellularity and megakaryocytes number along with a decrease in the plasma cells number is observed.   Conclusion. The results suggest further study of bone marrow immunomorphological features in order to identify prognostic factors and search for new therapeutic targets. a more extended analysis of bone marrow aspirate immunomor-phological characteristics using new modern diagnostic methods, minimal residual disease status as a surrogate marker seems to be relevant and necessary to confirm the depth of the antitumor response achieved. …”
Get full text

A network-based approach to overcome BCR::ABL1-independent resistance in chronic myeloid leukemia by Valeria Bica, Veronica Venafra, Giorgia Massacci, Simone Graziosi, Sara Gualdi, Gessica Minnella, Federica Sorà, Patrizia Chiusolo, Maria Elsa Brunetti, Gennaro Napolitano, Massimo Breccia, Dimitrios Mougiakakos, Martin Böttcher, Thomas Fischer, Livia Perfetto, Francesca Sacco

Get full text

The orobasal organ (of Ackerknecht) is present in prenatal mice by Sven Schumann, Sven Schumann, Sven Schumann, Jan R. Munk, Michael J. Schmeisser, Michael J. Schmeisser, Moritz Staeber

Get full text

Prospects for Use of Heptral in Hemoblastoses by V. B. Larionova, E. G. Gorozhanskaya

“…At the same time a hepatocyte, the principal hepatic parenchymal cell, is likely to be the focus of organ pathology. …”
Get full text

Effects of targeted care using a risk warning model on burn site infection by Chenchen Sun, Xiaowu Wang, Dong Wu

“…This study aimed to establish an infection risk warning model based on the clinical characteristics of burn patients, by formulating targeted care programs according to the risk warning factors, and analyzing the effects of these programs on wound infection in burn patients. …”
Get full text

Heart Rate, Hematological, and Biochemical Responses to Exercise on Water Treadmill with Artificial River in School Horses by Urszula Sikorska, Małgorzata Maśko, Barbara Rey, Małgorzata Domino

“…WT exercise with AR represents a low-to-moderate intensity aerobic workload for horses, which increases with water depth from fetlock to carpal levels. However, further research is required to evaluate its inclusion in training or rehabilitation programs for athletic horses and its potential beneficial effects.…”
Get full text

Genome wide association analysis for body measurements in Jabal Akhdar Omani goats

“…Some of these genes were involved in cell growth (ISM1), early brain development (ADK), and muscle development (ATP2A1). …”
Get full text

Research Progress on Cancer Risk and Its Pathogenesis of Gastric Precancerous Conditions by WANG Yuxin, PENG Wenwan, ZHOU Zheng, HUANG Haiyang, LU Xiaomin, DONG Mingguo

“…In the microenvironment of gastric mucosa, imbalance and disorder of oxidation and antioxidant effect, energy metabolism, immune homeostasis, cell proliferation and death are the pathogenesis of gastric precancerous conditions. …”
Get full text

Role of haptic feedback technologies and novel engineering developments for surgical training and robot-assisted surgery by Imán Laga Boul-Atarass, Imán Laga Boul-Atarass, Mercedes Rubio Manzanares Dorado, Andrés Padillo-Eguía, Jesús Racero-Moreno, Ignacio Eguía-Salinas, Sheila Pereira-Arenas, Sheila Pereira-Arenas, Rosa María Jiménez-Rodríguez, Javier Padillo-Ruiz, Javier Padillo-Ruiz

Get full text

Virseqimprover: an integrated pipeline for viral contig error correction, extension, and annotation by Haoqiu Song, Saima Sultana Tithi, Connor Brown, Frank O. Aylward, Roderick Jensen, Liqing Zhang

Get full text

Integrated promoter-capture Hi-C and Hi-C analysis reveals fine-tuned regulation of the 3D chromatin architecture in colorectal cancer by Ajay Kumar Saw, Ayush Madhok, Anupam Bhattacharya, Anupam Bhattacharya, Soumyadeep Nandi, Sanjeev Galande, Sanjeev Galande

“…The analysis focused on identifying fine-scale interactions within topologically associated domains (TADs) while incorporating histone modification landscapes (H3K27ac, H3K4me3) and transcriptomic signatures from CRC cell lines and the TCGA database. For experimental validation, ChIP-quantitative PCR was performed at the promoters of target genes using the highly malignant colorectal cell line HT29 and compared it to an embryonic cell line NT2D1.Results:Our integrated analysis revealed significant genomic structural instability in CRC cells, closely associated with tumor-suppressive transcriptional programs. …”
Get full text

Evaluating the Effectiveness of Various Small RNA Alignment Techniques in Transcriptomic Analysis by Examining Different Sources of Variability Through a Multi-Alignment Approach by Xinwei Zhao, Eberhard Korsching

“…DNA and RNA nucleotide sequences are ubiquitous in all biological cells, serving as both a comprehensive library of capabilities for the cells and as an impressive regulatory system to control cellular function. …”
Get full text

Ferroptosis plays a role in osteoarthritis by Ruba Altahla, Jamal Alshorman, Xu Tao

“…Ferroptosis provides a new view of programmed cell death. It is initiated by the oxidation of lipids, reactive oxygen species (ROS) formation and iron buildup within cells, leading to their demise. …”
Get full text

Dual threat: Susceptibility mechanisms and treatment strategies for COVID-19 and bacterial co-infections by Keda Chen, Ruiqi Weng, Jiaxuan Li, Hao Wu, Xiaotian Tie, Hongyu Li, Yuanyuan Zhang

“…Emerging therapeutic strategies include antiviral agents, immunomodulators, artificial liver support systems, and cell-based therapies. Public health policy recommendations focus on antimicrobial stewardship programs, biomarker-guided antibiotic use, and investment in rapid diagnostic technologies. …”
Get full text

The role of formin-like protein 1 in pancreatic cancer and its specific effects on immunity by Jian Liu, Junli Ding, Liang Chen, Shoupeng Shao, Jie Mei, Xuejing Yang

“…Conclusions Formin-like protein 1 is a biomarker of an inflamed tumor microenvironment and positively modulates epithelial–mesenchymal transition and programmed cell death 1 ligand 1 expression in pancreatic cancer, which could be utilized as a novel target for antitumor immunity for more in-depth studies.…”
Get full text

Acoustic Detection and Quantification of Fish in Lancang Waters of Seribu Islands, Indonesia by Syahrul Purnawan, Henry M. Manik, Agustina Sartika Manik, La Elson, Myounghee Kang

Get full text

Using Active and Passive Smartphone Data to Enhance Adolescents’ Emotional Awareness in Forensic Outpatient Setting: A Qualitative Feasibility and Usability Study by Merel M L Leijse, Levi van Dam, Tijs Jambroes, Amber Timmerman, Arne Popma

“…App usage included completing a brief emoji survey 3 times a day (active data) and allowing Feelee to track the call logs, Bluetooth devices in proximity, cell tower IDs, app usage, and phone status (passive data). …”
Get full text