New horizons in B-cell lymphoma immunotherapy: From immune checkpoints to precision medicine by RuiXin Zheng, YuXiao Li, KaiXin Shi, YuanYuan Pan, KaiYi Liu, JinCheng Song, Li Li

“…Novel chemotherapeutic strategies demonstrate promising potential in B-cell lymphoma management, particularly through targeting immune checkpoints such as PD-1 (Programmed Cell Death Protein 1), LAG-3 (Lymphocyte-activation Gene 3), TIM-3 (T-cell Immunoglobulin and Mucin-domain containing-3), and TIGIT (T-cell Immunoreceptor with Ig and ITIM Domains) play pivotal regulatory roles within the immune system. …”
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Human naïve B cells show evidence of anergy and clonal redemption following vaccination by Brian L. P. Dizon, Prasida Holla, Evan C. Mutic, Paul Schaughency, Susan K. Pierce

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Research progress of HGF/c-Met signaling pathway in oral squamous cell carcinoma by SHI Jiafan, GONG Lingling, SUN Mingze, LIU Lulu, ZHANG Huilin, LI Ming

“…However, HGF/c-Met can also mediate immune escape by promoting lactate secretion increase, inducing programmed death ligand 1 (PD-L1) expression upregulation, activating and expanding myeloid-derived suppressor cells, and promoting the proliferation of regulatory T cells (Tregs). …”
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Transcriptional landscape of the cell cycle in a model thermoacidophilic archaeon reveals similarities to eukaryotes by Miguel V. Gomez-Raya-Vilanova, Jérôme Teulière, Sofia Medvedeva, Yuping Dai, Eduardo Corel, Philippe Lopez, François-Joseph Lapointe, Debashish Bhattacharya, Louis-Patrick Haraoui, Elodie Turc, Marc Monot, Virginija Cvirkaite-Krupovic, Eric Bapteste, Mart Krupovic

“…To study whether and which other processes are cell cycle-coordinated, we synchronized cultures of S. islandicus and performed an in-depth transcriptomic analysis of samples enriched in cells undergoing the M-G1, S, and G2 phases, providing a holistic view of the S. islandicus cell cycle. …”
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Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines by Mariana Leguia, Antón Vila-Sanjurjo, Diana Juarez, Alejandra Garcia-Glaessner, Ana I. Gil, Mayita Alvarez, Rubelio Cornejo, Sami Cherikh, Casey E. Gelber, Johannes B. Goll, Leigh M. Howard, Natalia Jimenez-Truque, Kathryn M. Edwards, C. Buddy Creech, Claudio F. Lanata

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Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation. by Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee

“…Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. …”
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The distribution characteristics of PD-1 pathway-related immune cells in esophageal cancer tissue and their prognostic significance. by Dehua Kong, Chunyan Gao, Yang Yu, Lu Yang, Ji Ma, Shimin Tang, Ying Mao, Yong Li, Na Li

“…<h4>Objective</h4>This study aims to elucidate the distribution patterns of immune cells associated with the programmed cell death protein 1 (PD-1) pathway within esophageal cancer (EC) tissues and to determine their correlation with patient prognosis.…”
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Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cells by Amélie Nadeau, Thupten Tsering, Mohamed Abdouh, Laura Kienzle, Jenna Cleyle, Lorne Taylor, Noélie Douanne, Kyle Dickinson, Peter M. Siegel, Julia V. Burnier

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Metformin Protects against Spinal Cord Injury and Cell Pyroptosis via AMPK/NLRP3 Inflammasome Pathway by Yajiang Yuan, Xiangyi Fan, Zhanpeng Guo, Zipeng Zhou, Weiran Gao

“…Pyroptosis is a recently found and proven type of programmed cell death that is characterized by a reliance on inflammatory caspases and the release of a large number of proinflammatory chemicals. …”
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Paeoniflorin alleviates high glucose-induced endothelial cell apoptosis in diabetes mellitus by inhibiting HRAS-activated RAS pathway by Wenting Yu, Hongchun Jiang

“…Protein molecular docking verification was completed by AutoDockTools and Pymol programs. Human umbilical vein endothelial cells (HUVECs) were separately treated with HG, Pae (5, 10, 20 μM) and/or HRAS overexpression plasmids (oe-HRAS). …”
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Th role of counselling to reduce parental fears and anxiety about newborn screening for sickle cell disease in Northern Ghana by Enyonam Duah, Samuel T. Chatio, Lucy O. Ababio, Nicola Lister, Olufolake Egbujo, Kwaku Marfo, Isaac Odame, Patrick Ansah

“…Methods This study used qualitative research approach where 16 focus group discussions and 19 in-depth interviews were conducted with participants between April and June 2022. …”
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Vibration Analysis of Lithium-Ion Batteries and Proton Exchange Membrane Fuel Cells in Electric Vehicles: A Comprehensive Survey by Hadi Eidinejad, Alessandro Rivola, Marco Troncossi, Alberto Martini

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A Phenomenological Study of the Lived Experiences of Tagumpay National High School Teachers Involved in Online Learning Action Cell Session by Ann Michelle S. Medina, Aldren E. Camposagrado, Mari Cris O. Lim

“…To capture the lived experience of teachers, an in-depth interview with a purposive sample of one TNHS teacher is done in the process. …”
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Circadian Regulator-Mediated Molecular Subtypes Depict the Features of Tumor Microenvironment and Indicate Prognosis in Head and Neck Squamous Cell Carcinoma by Ling Aye, Zhanying Wang, Fanghua Chen, Yujun Xiong, Jiaying Zhou, Feizhen Wu, Li Hu, Dehui Wang

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Topologically associating domains of chromatin on single-cell Hi-C data: a survey of bioinformatic tools and applications in the light of artificial intelligence by Hongqiang Lyu, Yao Li, Xinran Chen, Yuan Liu, Erhu Liu, Xiaoliang Cheng

“…Unfortunately, the contact matrix for a single cell is ultra-sparse due to the low sequencing depth. …”
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Microsatellite Status, Tumor Budding, CD3 and CD8 T Cell Densities in Relation to Invasiveness, Lymph Node Involvement in Colorectal Adenocarcinoma by Rebecca Noerjani Angka, Aru Wisaksosno Sudoyo, Nurjati Chairani Siregar, Wifanto Saditya Jeo, Melva Louisa, Demak Lumban Tobing

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Microsatellite Status, Tumor Budding, CD3 and CD8 T Cell Densities in Relation to Invasiveness, Lymph Node Involvement in Colorectal Adenocarcinoma by Rebecca Noerjani Angka, Aru Wisaksosno Sudoyo, Nurjati Chairani Siregar, Wifanto Saditya Jeo, Melva Louisa, Demak Lumban Tobing

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scHiCSRS: a self-representation smoothing method with Gaussian mixture model for imputing single cell Hi-C data by Qing Xie, Wang Meng, Shili Lin

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Comparative Examination of Feline Coronavirus and Canine Coronavirus Effects on Extracellular Vesicles Acquired from A-72 Canine Fibrosarcoma Cell Line by Sandani V. T. Wijerathne, Rachana Pandit, Chioma C. Ezeuko, Qiana L. Matthews

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Accumulating evidence from meta-analyses of prognostic studies on oral cancer: towards biomarker-driven patient selection by Alhadi Almangush, Rasheed Omobolaji Alabi, Matti Pirinen, Antti Mäkitie, Ilmo Leivo

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