LightCDD: Application of a Capability-Driven Development Method for Start-ups Development by Hasan Koç, Marcela Ruiz, Sergio España

“…Novice innovators and entrepreneurs face the risk of designing naive business models. In fact, lack of viability in business models is perceived to be a major threat for the start-up success. …”
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The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons by Catherine Schaefers, Simone Rothmiller, Horst Thiermann, Theo Rein, Annette Schmidt

“…Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. There are many hiPSC differentiation protocols that pursue to imitate the multistep process of motor neurogenesis in vivo. …”
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Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…For example, obesity and type 2 diabetes have been linked to ER stress-induced failure of insulin-producing pancreatic beta cells, and current research efforts are aimed at developing drugs that ameliorate cellular stress and thereby protect beta cell function. …”
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Converting from Seepage Irrigation to Plasticulture for Vegetable Production: A Case Study by Charles E. Barrett, Lincoln Zotarelli, Lucas G. Paranhos, Mark W. Warren

“… This article is intended to provide information to producers and Extension agents that are interested in using drip irrigation for vegetable production. …”
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Increased overwintering temperature reduces reproductive success of the solitary bee species Osmia bicornis by Sarah Müller, Jana Collatz, Henning Richter, Robert Zboray, Matthias Albrecht

“…Abstract Solitary wild bees play a key role as pollinators of wild plants and crops, but they are increasingly at risk from anthropogenic global change, such as climate warming. …”
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ANALYSIS OF SHRINKAGE PERFORMANCE OF U-SHAPED RUBBER OUTER WINDSHIELD OF HIGH-SPEED TRAIN AT LOW TEMPERATURE by GU Cheng, XU Lei, YU Chengtao, WANG Jiazheng

“…Based on the low temperature tensile test data of the rubber, Ansys software was used to fit the Mooney-Rivlin hyperelastic constitutive model of rubber material parameters, and the thermo-solid coupling simulation was carried out on the U-shaped rubber outer windshield according to three real working conditions, and the influence of different working conditions on the U-shaped rubber deformation was studied.The low temperature test was carried out on U-shaped rubber outer windshield and three rubber samples with different batten thicknesses， the influence of temperature and batten thickness on its deformation was studied.The results show that the U-shaped rubber deformation is mainly caused by the temperature change, the U-shaped rubber height decreases obviously, and the shape variable of the side wall thickness and the rubber length is small.In addition, the batten thickness has a greater influence on the rubber shape variable at the bolt hole.Compared with the batten of 5 mm and 6 mm thickness, the 4 mm batten produces a larger deformation under the bolt preload action, resulting in a larger deformation at the bolt hole, and then increasing the batten thickness can effectively reduce the hole removal risk.Comparing the finite element simulation data with the low temperature test results, it is found that the two results are basically consistent，which indicates the finite element analysis feasibility and the low temperature test reliability.The research results provide some guidance basis for the U-shaped rubber outer windshield under low temperature application reliability.…”
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YOUTH PARTICIPATION AND ELECTORAL DEMOCRACY IN KOGI STATE; ISSUES AND PROSPECTS by MICHAEL DANIEL, DUNCAN GANYU ADAMSON

“…The paper recommends youth sensitization on political culture, with the view to exposing the risk associated with money politics and electoral violence in Nigeria. …”
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Safety Assessment and a Parametric Study of Forward Collision-Avoidance Assist Based on Real-World Crash Simulations by MohammadReza Seyedi, MohammadReza Koloushani, Sungmoon Jung, Arda Vanli

“…A total number of 16000 simulations have been conducted which produced input-output datasets for further investigations. …”
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Non-O1, Non-O139 Vibrio cholerae Bacteremia in an Autoimmune Pancreatitis Patient by Cheng-Jing Gu, Ming-Dong Ding, Da-Ming Zhou, Jie Li, Wen-Qing Yu, Yong-Lin Yang

“…Non-O1/non-O139 V. cholerae serogroups generally do not produce the cholera-causing toxin but do sporadically cause gastroenteritis and extra-intestinal infections. …”
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The Functional Movement Screen: Exploring Interrater Reliability between Raters in the Updated Version by Ricky Morgan, Steven LeMire, Lindsey Knoll, Emily Schuster, Cooper Tietz, Austin Weisz, Gary Schindler

“…The updated FMS™ may be reliably used to assess risk for future injury. # Level of Evidence 3…”
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Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration by Zihan Li, Chuwei Zhang, Lei Wang, Qingrong Zhang, Yipeng Dong, Xinyu Sha, Bolin Wang, Zhihan Zhu, Wenmiao Wang, Yongjun Wang, Youlang Zhou, Yi Zhang

“…Abstract Diabetic wounds are notoriously difficult to heal due to impaired cell repair mechanisms, reduced angiogenesis, and a heightened risk of infection. Fibroblasts play a vital role in wound healing by producing extracellular matrix (ECM) components and various growth factors, but their function is inhibited in diabetic wounds. …”
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The Impact of Training Intervention on Levels of Indicator Bacteria and Prevalence of Selected Pathogens in Raw Milk From Smallholder Women Dairy Farmers in Central Ethiopia by Achenef Melaku Beyene, Seleshe Nigatu, Juan C. Archila-Godinez, Kebede Amenu, Barbara Kowalcyk, Desalegne Degefaw, Binyam Mogess, Baye Gelaw, Mucheye Gizachew, Araya Mengistu, Ahmed G. Abdelhamid, James Barkley, Ahmed Yousef

“…Contamination of milk is a serious public health risk, particularly in developing countries such as Ethiopia. …”
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Facilitating active participation in anticoagulant decisions in advanced kidney disease: co-production of a question prompt list by Kathrine Parker, Abigail Needham, Jecko Thachil, Sandip Mitra, Penny Lewis

“…Abstract Background People with chronic kidney disease are at increased risk of thrombotic and bleeding episodes making anticoagulant treatment decisions challenging. …”
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Impact of Alkaline Pretreatment to Enhance Volatile Fatty Acids (VFAs) Production from Rice Husk by Qian Fang, Sinmin Ji, Dingwu Huang, Zhouyue Huang, Zilong Huang, Yunyi Zeng, Yu Liu

“…The experimental results show that when comparing the total VFA (TVFA) yields from the alkaline-pretreated risk husk with those from the untreated rice husk, over 14 d and 2 d, the maximum value reached 1237.7 and 716.0 mg·L−1 with acetic acid and propionic acid and with acetic acid and butyric acid, respectively. …”
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Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis by Yanan Hao, Yanan Hao, Yanan Hao, Xin Du, Chang Cai, Yong Zhao, Yonglin Ren

“…Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) of combined studies.ResultsOur findings revealed that the internal NH3 and/or H2S were negatively related to the Lactobacillus, which is beneficial to male fertility, whereas NH3 and H2S were positively related to Bacteroides, which showed negative effects on male fertility. …”
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Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection by Aleksandra Kuć-Szymanek, Daria Kubik-Machura, Klaudia Kościelecka, Tomasz Męcik-Kronenberg, Lidia Radko

“…Food contamination with mycotoxin-producing fungi increases the risk of many diseases, including neurological diseases closely related to the neurotoxicity of these toxins. …”
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Snowfall in the Northwest Iberian Peninsula: Synoptic Circulation Patterns and Their Influence on Snow Day Trends by Andrés Merino, Sergio Fernández, Lucía Hermida, Laura López, José Luis Sánchez, Eduardo García-Ortega, Estíbaliz Gascón

“…This creates snowfalls that are considered both an important water resource and a transportation risk. In this work, we develop a classification of synoptic situations that produced important snowfalls at observation stations in the major cities of Castilla y León from 1960 to 2011. …”
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Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus by Pierina De Muro, Antonio Junior Lepedda, Gabriele Nieddu, Michela Idini, Hai Quy Tram Nguyen, Omar Lobina, Pietro Fresu, Marilena Formato

“…T2DM often remains undiagnosed for many years because hyperglycemia develops gradually and may not produce any symptoms. As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease management. …”
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Case Report: Button battery ingestion—an underestimated emergency in children by Karin Konzett, Stefanie Gang, Lukas Poyntner, Eberhard Reithmeier, Susanne Dertinger, Burkhard Simma

“…Pathological workup showed necrosis with secondary aortoesophageal fistula due to battery-induced colliquation necrosis caused by caustic soda produced at the minus pole. We conclude, that preclinical risk scores, excellent clinical pathways (e.g., from Children's Hospital of Philadelphia) and detailed approaches from the National Capital Poison Center in the USA and also the European Society of Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) offer clear and concise instructions for the management of button battery ingestion, but clinical awareness for vascular complications must be heightened. …”
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Tracking rapid and slow ice-dammed lake changes through optical satellites and local knowledge: a case study of Tystigbreen in Norway by Jogscha Miriam Abderhalden, Kristine Katherine Bly, Ronja Lappe, Liss Marie Andreassen, Irina Rogozhina

“…The number of glacial lakes has grown globally concurrently with the retreat of glaciers in the last few decades, increasing the risk of potentially hazardous glacial lake outburst floods (GLOFs) and posing a threat to downstream communities. …”
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