T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…Resultant amplicons were sequenced via the Ion Torrent and TRBV allele profiles constructed for each individual was correlated with irAE annotations to identify haplotypes associated with severe irAEs (≥ grade 3).Results Our study included 81 patients who had irAEs when treated with immunotherapy for cancer. By using principal component analysis of the 81 TRBV allele profiles followed by k-means clustering, we identified six major TRBV haplotypes. …”
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Adjunctive diagnostic tool for histopathological classification of congenital mesoblastic nephroma based in molecular genetic findings by Hiroshi Hamada, Kenichi Kohashi, Takeshi Iwasaki, Mikiko Hashisako, Yuko Hino, Masahiro Fukuhara, Amane Kamouchi, Naonori Kawakubo, Tatsuro Tajiri, Yoshinao Oda

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L’étalement urbain au péril des activités agro-pastorales à Abidjan. by Kouakou Yao Etienne, Koné Brama, Bonfoh Bassirou, Kientga Sonwouignandé Mathieu, N’Go Yao Alexis, Savane Issiaka, Cissé Guéladio

“…For 94 % of agricultural actors in the studied site, agriculture was the principal source of income and land insecurity remained the principal concern of the farmers. …”
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Study on the Influence of In Situ Stress Distribution on the Stability of Roadway Surrounding Rock by Tao Li, Hao Gong, Guoliang Xu

“…In order to understand the instability characteristics of surrounding rock in the process of deep roadway excavation, a three-dimensional numerical model was established by FLAC3D to systematically analyze the influence of roadway surrounding rock stability under different in situ stress distribution forms, and the environmental coefficient of mining-induced stress η was defined, the larger the environmental coefficient of mining-induced stress is, the larger the surrounding rock stress environment is, and the range where the η coefficient is greater than 0.2 is called with the destruction-danger zone. When the initial vertical stress is maximum principal stress and minimum principal stress, by comparing the roadway along the middle ground stress direction and minimum or maximum in-situ stress direction, the variation characteristics of displacement, failure zone and failure hazard zone of roadway surrounding rock are obtained, which provides theoretical basis for the treatment of disaster accidents such as roadway surrounding rock instability and rock burst caused by deep high in-situ stress.…”
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Anti-tumor role and molecular mechanism of vanillic acid by Xunxing Hao, Zhixiao Gao, Mingzhe Hu

“…Furthermore, VA disrupts the cancer cell cycle, arresting most cancer cells at the G1 phase, curtails cell migration, invasion, angiogenesis, and potentiates the therapeutic efficacy of chemotherapeutic drugs, all while minimizing adverse reactions. …”
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Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier by Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar, Michael M. Gottesman

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A Clinicopathological Study of 24 Cases of DFSP by Miyako Kachi, Atsumori Hamahata, Kohei Oashi, Hisato Konoeda, Miho Kirita, Masashi Ishikawa, Hirotaka Koyanagi, Hiroyuki Sakurai

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Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling by Konstantin Okonechnikov, David R. Ghasemi, Daniel Schrimpf, Svenja Tonn, Martin Mynarek, Jan Koster, Till Milde, Tuyu Zheng, Philipp Sievers, Felix Sahm, David T.W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Kristian W. Pajtler, Andrey Korshunov

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Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells by Callinice D. Capo-chichi, Jennifer L. Smedberg, Malgorzata Rula, Emmanuelle Nicolas, Anthony T. Yeung, Richard F. Adamo, Andrey Frolov, Andrew K. Godwin, Xiang-Xi Xu

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Gastric Intestinal Metaplasia: Demographic and Epidemiological Characterization in Puerto Rican Hispanics (2012-2014) by Jorge J. Cruz-Cruz, María González-Pons, Adrián Cora-Morges, Marievelisse Soto-Salgado, Giancarlo Colón, Kimberly Alicea, Kathia Rosado, Douglas R. Morgan, Marcia Cruz-Correa

“…Background and Aims. Gastric cancer is the 5th leading cause of cancer mortality worldwide and the leading infection-associated cancer. …”
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Caracterización de pacientes con tumores esofágicos atendidos en el Hospital Celestino Hernández Robau (2016-2017) by Lis Soto Riquelme, Jorge Ernesto González García, Dianelys Molina Macías

“…<p><strong>Fundamento</strong>: el cáncer de esófago es una de las neoplasias más agresivas del tubo digestivo, y se asocia a alta morbilidad y mortalidad; similar al cáncer de pulmón, hígado, páncreas y estómago. …”
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Paciente con carcinoma papilar de mama ulcerado by Leyanis González Baigorría, Ilian Esteban Tarife Romero, Luis Manuel Abreu Pereira, Adriel Herrero Díaz

“…Introducción: El cáncer de mama es la principal causa de muerte por neoplasias en mujeres entre los 45 y 65 años. …”
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Predefined and data-driven CT radiomics predict recurrence-free and overall survival in patients with pulmonary metastases treated with stereotactic body radiotherapy. by Pascal Salazar, Patrick Cheung, Balaji Ganeshan, Anastasia Oikonomou

“…The best multivariate Cox model for predicting OS combined CTTA-based features-skewness and kurtosis-with size and "lung primary cancer origin" with a C-index of 0.67 (0.61-0.74).…”
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Molecular Pathogenesis of Cholangiocarcinoma by G. Fava, I. Lorenzini

“…The bad prognosis related to CC justifies why a better identification of the molecular mechanisms involved in the growth and progression of this cancer is required for the development of effective preventive measures and valid treatment regimens. …”
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Bioaccumulation, sources and health risk assessment of polycyclic aromatic hydrocarbons in Lilium davidii var. unicolor. by Haixu Sun, Tianxiang Xia, Hongguang Cheng, Zhenzhen Wu, Qianding Cheng, Lu Lu, Chunbao Fu

“…Baked bulbs exhibited a higher cancer risk than raw bulbs. Local adults had low carcinogenic risks from consuming lily bulbs. …”
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Characteristics Defining Broccoli Cultivars from Different Seed Producers by Elena Ordiales, Domingo J. Iglesias, María Victoria Alarcón, Lorena Zajara, Jesús Gil, Juan Ignacio Gutiérrez, Julio Salguero

“…Broccoli (Brassica oleracea L. var. italica) is currently considered a main vegetable food in the markets due to its high nutritional value, containing elevated levels of phytochemicals widely described to have beneficial effects against cancer and other illnesses. Broccoli is an interesting crop with a high commercial value because it complements the tomato industry, the main agricultural income in Badajoz, Spain. …”
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Division and Effect Evaluation of Fracking Outburst Elimination Zones in Surface Extraction Wells of Coalbed Methane by Jianbao Liu, Zhimin Song, Bing Li, Jiangang Ren, Hongyan Zhang, Nuo Cheng

“…The results showed that the standard-reaching rate of extraction was high, and the danger of outburst could be completely eliminated. …”
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Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components by Andres Sánchez, Ricardo Cardona, Marlon Munera, Victor Calvo, Manuela Tejada-Giraldo, Jorge Sánchez

“…IgE sensitization (atopy) to pets is commonly evaluated using pet dander extracts. However, the diagnosis by components seems to be more adequate to evaluate the clinical relevance (allergy) of sIgE sensitization. …”
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PREDICTION OF MULTIAXIAL LOAD FATIGUE LIFE FOR RUBBER BUSHING by YIN Fang, FAN RangLin, FENG ChengCheng, QI SongQiang, ZENG ZhaoSheng

“…The calculation methods of the maximum principal engineering strain,maximum principal logarithmic strain,maximum principal Green-Lagrange strain,and maximum principal Euler strain and octahedron shear strain peak under uniaxial and multiaxial loading stress condition are studied. …”
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Matching Subsequence Music Retrieval in a Software Integration Environment by Zhencong Li, Qin Yao, Wanzhi Ma

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