iTRAQ-based quantitative proteomic profiling of the regulatory mechanisms on immune functions and blood lipids in aged mice fed with Lentinula edodes-derived polysaccharides by Xiaofei Xu, Xiaofei Liu, Jin Chen, Jingjing Guan, Donghui Luo

“…In the present study, after assessing the impacts of one type of Lentinula edodes-derived polysaccharides, named L2, on immune functions and blood lipid profiles, isobaric tags for relative and absolute quantification (iTRAQ)-based proteomic profiling of the small intestinal tissues from aged mice treated with L2 was performed. …”
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Effects of sumac aqueous extract along with eating and drinking modification on functional dyspepsia symptoms in comparison with omeprazole: An open-label, randomized, controlled c... by Mahdi Saravani, Zahra memariani, Nasser Behnampour, Mohammadreza Seyyedmajidi, fatemeh kolangi

“…Objective: Functional dyspepsia (FD), a common gastrointestinal problem. …”
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Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids by Tatsuya Inui, Yusei Uraya, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

“…In recent years, the air–liquid interface (ALI) culture model was developed, allowing for the culture of epithelial tissue under conditions that mimic the in vivo environment. In the present study, we applied ALI culture to ELC-org-mono for further improvement of intestinal functions. …”
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Prospective Analysis of Functional Outcome of Patella Fracture Management by a Novel Method (FiberWire Fixation): A 2-year Follow-up Study by Ravichandran Kennedy, Gopinath K Ramalingam, D Alagurajesh, KV Karthick Raj, P Velazhagan

“…In this study, we assessed the functional results of patella fractures treated using FiberWire. …”
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PET Foils Functionalized with Reactive Copolymers as Adaptable Microvolume ELISA Spot Array Platforms for Multiplex Serological Analysis of SARS-CoV-2 Infections by Sylwia Pniewska, Marcin Drozd, Alessandro Mussida, Dario Brambilla, Marcella Chiari, Waldemar Rastawicki, Elżbieta Malinowska

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Dietary Fiber with Functional Properties Counteracts the Thwarting Effects of Copper Nanoparticles on the Microbial Enzymatic Activity and Short-Chain Fatty Acid Production in the... by Jerzy Juśkiewicz, Bartosz Fotschki, Anna Stępniowska, Ewelina Cholewińska, Dorota Napiórkowska, Aleksandra Marzec, Łucja Brzuzan, Joanna Fotschki, Ewa Żary-Sikorska, Katarzyna Ognik

“…The present study aimed to scrutinize the hypothesis that the dietary addition of fiber with functional properties would prevent the thwarting effects of copper nanoparticles (Cu-NP) on fecal microbial metabolic activity. …”
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Multiple Chaperone DnaK–FliC Flagellin Interactions are Required for Pseudomonas aeruginosa Flagellum Assembly and Indicate a New Function for DnaK by Gabriella Molinari, Sara S. Ribeiro, Katrin Müller, Benjamin E. Mayer, Manfred Rohde, Alejandro Arce‐Rodriguez, Juan José Vargas‐Guerrero, Albert Avetisyan, Josef Wissing, Werner Tegge, Lothar Jänsch, Mark Brönstrup, Antoine Danchin, Martina Jahn, Kenneth N. Timmis, Simon Ebbinghaus, Dieter Jahn, José Manuel Borrero‐de Acuña

“…These results expand the classical view of DnaK chaperone functioning and introduce a new participant in the Pseudomonas flagellar system, an important trait for bacterial colonisation and virulence.…”
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Engineering a functionality-integrated artificial cornea stromal Substitute: Janus bio-adhesive implant with a collagen-based multi-scale biomimetic skeleton by Miao Lei, Yue Ji, Shaohua Zhang, Bing Hou, Yi Lu, Jianguo Sun, Changsheng Liu, Xue Qu

“…Corneal transplantation presents an urgent demand for artificial cornea stromal substitutes (ACSs) with comprehensive functional design, spanning from material biology to clinical application. …”
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Development of an Algorithm for a National Microprocessor-Based Centralization System With a Modular Architecture KZ-MPC-MA Featuring Advanced Intelligent Control Functions by Kanibek M. Sansyzbay, Yelena A. Bakhtiyarova, Teodor Iliev, Gennady S. Patokin, Laura T. Tasbolatova, Daniyar B. Sagmedinov

“…As a result of the conducted research, not only a prototype of the national microprocessor-based interlocking system KZ-MPC-MA, designed for controlling switches and signals at railway stations, was developed, furthermore ñomprehensive indicators of the functional safety of this system are defined to demonstrate compliance with the SIL4 according to CENELEC (European Committee for Electrotechnical Standardization) and TR/CU (Technical regulations in force within the Customs Union) requirements.…”
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Immediate treatment effects of high-dose methotrexate and cranial irradiation on neuropsychological functions of children treated for acute lymphoblastic leukemia at a regional can... by Sundaramoorthy Chidambaram, Arun Seshachalam, Vidhubala Elangovan, Rejiv Rajendranath

“…Context: Overall cure rates for pediatric acute lymphoblastic leukemia (ALL) have improved; however, the neuropsychological sequelae of ALL treatment have not been adequately documented in India. Aims: The present study assesses the immediate effects of ALL treatment on neuropsychological functioning, at the Regional Cancer Center in Chennai, South India. …”
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A Multidisciplinary Approach to Unplanned Conversion from Off-Pump to On-Pump Beating Heart Coronary Artery Revascularization in Patients with Compromised Left Ventricular Function by Georgia Tsaousi, Antonis A. Pitsis, George D. Ioannidis, Dimitrios G. Vasilakos

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Community re-entry program on global functioning and medication adherence among bipolar affective disorder patients- A randomized controlled trial pilot study by Jaishri, Sreevani Rentala, Preethy Kathiresan, Mukesh Swami

“…This quantitative study to explores the effectiveness of community re-entry program on global functioning and medication adherence for patients with bipolar affective disorder. …”
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CRISPR/Cas12a-mediated gene silencing across diverse functional genes demonstrates single gene-specific spacer efficacy in Mycobacterium smegmatis by Megha Sodani, Chitra S. Misra, Savita Kulkarni, Devashish Rath

“…We engineered a Cas12a-based CRISPR interference (CRISPRi) system and assessed its functionality. Targeting 45 genes with a single sgRNA per gene, we achieved efficient gene repression, leading to marked phenotypic changes. …”
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The First Saint Petersburg Regional Inflammatory Bowel Diseases Registry on the Basis of the Regional Health Information System: Principles of Functioning, Testing Results, Plan of... by Yu. P. Uspenskiy, A. M. Sarana, L. N. Melentyeva, A. V. Yazenok, S. V. Petrov, Yu. A. Fominykh, S. V. Ivanov, A. V. Shotik, A. M. Segal, T. V. Gorbacheva, S. D. Plotnikova, K. V. Dronov

“…Aim: to present the principles of functioning of the regional registry of inflammatory bowel disease (IBD) patients in Saint Petersburg on the basis of the City Health Information System (Saint Petersburg IBD Registry).Key points. …”
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Tumor-promoting function of paternally expressed gene 10 and its immunogenicity in inducing anti-tumor helper T cells in head and neck squamous cell carcinoma by Hiroki Komatsuda, Toshihiro Nagato, Akemi Kosaka, Takayuki Ohkuri, Takaaki Sasaki, Takumi Kumai, Michihisa Kono, Hidekiyo Yamaki, Risa Wakisaka, Shunsuke Yasuda, Takahiro Inoue, Ryusuke Hayashi, Nanami Ujiie, Ryosuke Sato, Kenzo Ohara, Kan Kishibe, Tatsuya Hayashi, Miki Takahara, Hiroya Kobayashi

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The Early Sex-Specific Expression of the Fruitless Gene in the Asian Tiger Mosquito <i>Aedes albopictus</i> (Skuse) and Its Functional Conservation in Male Courtship by Marianna Varone, Paola Di Lillo, Katerina Nikolouli, Ayca Eda Özel, Francesca Lucibelli, Gennaro Volpe, Sarah Maria Mazzucchiello, Angela Carfora, Serena Aceto, Giuseppe Saccone, Kostas Bourtzis, Marco Salvemini

“…Gaining a deeper understanding of its reproductive biology offers valuable insights into its evolutionary success and may inform the development of sustainable strategies to control its spread. This study presents a comprehensive structural and functional characterization of the <i>fruitless</i> gene in <i>Ae. albopictus</i> (<i>Aalfru</i>), a pivotal regulator of sexual behavior in insects. …”
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WDJ-S4, a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice by Seung-Ju Hwang, Chang-Seob Seo, Dong-Cheol Baek, Tae-Wook Woo, Jing-Hua Wang, Jin-Seok Lee, Yu-Jin Choi, Ji-Yeon Gu, Dong-Seon Kim, Chang-Gue Son

“…Context WDJ-S4, a standardized herbal formula, has been prescribed for refractory functional dyspepsia (FD) in Korea, but the detailed mechanisms are lacking.Objective The present study investigates the acceleration of gastrointestinal (GI) motility by WDJ-S4 and its potential mechanisms.Materials and methods For five days, WDJ-S4 (50, 100 and 200 mg/kg) or mosapride (3 mg/kg) was orally given to BALB/c mice. …”
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[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation by Isabel Day, Mikayla Tamboline, Lindsay Lueptow, Irina Zhuravka, Taryn Diep, Ilona Tkachyova, Shili Xu, Andreas Schulze, Gerald S. Lipshutz

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A Systems Biology Approach to Elucidating Functional and Genomic Signatures in Host-Pathogen Interactions of Triple Infections: Tuberculosis, HIV, and SARS-CoV-2 by Mohd. Imran, Hayat Ali Alzahrani, Ranya Mohammed Elmagzoub, Zia Ur Rehman, Khadiga G. Abd Elaleem, Ahlam S. Mohamed, Aida A. Elsharief, Hayaa M. Alhuthali

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Use of Intravenous Paracetamol Preoperatively Favors Lower Risk of Delirium and Functional Recovery in Elderly Patients with Hip Fracture: A Propensity Score-Matched Analysis by Junfei Guo, Tao Wang, Xuehong Zheng, Yubin Long, Xin Wang, Qi Zhang, Junchuan Liu, Guolei Zhang, Junpu Zha, Zhiyong Hou, Yingze Zhang

“…We aimed to investigate whether the use of intravenous paracetamol (IVP) preoperatively in intertrochanteric fracture (IF) patients aged 65 years or over receiving intramedullary fixation had significantly benefits on the pain score at discharge, delirium incidence, length of hospital stay (LOS), functional outcomes, and mortality. A retrospective analysis of all surgically treated patients presenting with IF was conducted at a single Level I trauma center in China between Jan. 2016 and Jan. 2020. …”
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