The influence of the ratio of liver cells and bone marrow in the implantable cell-engineering structures of the liver on the recovery efficiency of functional and morphological par... by M. Yu. Shagidulin, N. A. Onishchenko, M. E. Krasheninnikov, A. O. Nikolskaya, E. A. Volkova, I. M. Iljinsky, N. P. Mogeiko, V. I. Sevastianov, S. V. Gautier

“…Themselves, which allows predicting their long-term regulatory effect on the liver tissue in CLF and maintaining its normal structural and functional state.Conclusion. The effective correction of chronic liver failure can be carried out by using the implanted liver CECs, in which donor liver cells and MMSC BM where presented in ratios – 1 : 1; 5 : 1 and 10 : 1. …”
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Grand Challenges at the Interface of Engineering and Medicine by Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller

“…The Workshop identified five grand challenges with cross-cutting themes and provided a roadmap for new technologies, identified new training needs, and defined the types of interdisciplinary teams needed for addressing these challenges. The themes presented in this paper include: 1) accumedicine through creation of avatars of cells, tissues, organs and whole human; 2) development of smart and responsive devices for human function augmentation; 3) exocortical technologies to understand brain function and treat neuropathologies; 4) the development of approaches to harness the human immune system for health and wellness; and 5) new strategies to engineer genomes and cells.…”
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Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia by Andrea González-Torbay, Andrea González-Torbay, Keren Reche-Yebra, Álvaro Clemente-Bernal, Yolanda Soto Serrano, Luz Yadira Bravo-Gallego, Luz Yadira Bravo-Gallego, Almudena Fernández López, Almudena Fernández López, Rebeca Rodríguez-Pena, Rebeca Rodríguez-Pena, Rebeca Rodríguez-Pena, María Bravo García-Morato, María Bravo García-Morato, María Bravo García-Morato, Eduardo López-Granados, Eduardo López-Granados, Eduardo López-Granados, Lucía del Pino-Molina, Lucía del Pino-Molina

“…To further explore IL2RG functionality we selected downstream signaling readouts, namely STAT3 and STAT5 phosphorylation, NK degranulation and B- and T-cell proliferation capacity in vitro, which can be measured by flow cytometry, that reflect the strength of homeostatic signaling pathways in resting cells and after activation.ResultsThe patient presented reduced CD132 expression and conserved T- and B-cell proliferation capacity in vitro. …”
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Software tool for evaluation of reliability and survivability of complex technical system based on logical-probabilistic methodology by V. Yu. Skobtsov, N. V. Lapitskaya

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The role of probiotics in the correction of the gastrointestinal disorders in children by D. A. Khavkina, P. V. Chukhliaev, T. A. Ruzhentsova

“…The article presents a review of studies devoted to the study of the effectiveness and safety of probiotics in the complex therapy of gastrointestinal disorders in children of various ages. …”
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Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties by Nilufer P. Seth, Rui Xu, Matthew DuPrie, Amit Choudhury, Samuel Sihapong, Steven Tyler, James Meador, William Avery, Edward Cochran, Thomas Daly, Julia Brown, Laura Rutitzky, Lynn Markowitz, Sujatha Kumar, Traymon Beavers, Sayak Bhattacharya, Hsin Chen, Viraj Parge, Karen Price, Yang Wang, Siddharth Sukumaran, Yvonne Pao, Katie Abouzahr, Fiona Elwood, Jay Duffner, Sucharita Roy, Pushpa Narayanaswami, Jonathan J. Hubbard, Leona E. Ling

“…Nipocalimab selectively reduces circulating IgG levels without detectable effects on other adaptive and innate immune functions. In vitro experiments and in vivo studies in mice and cynomolgus monkeys generated data that align with observations from clinical studies of nipocalimab in IgG autoantibody- and alloantibody-mediated diseases.…”
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Lateralized brain connectivity in auditory verbal hallucinations: fMRI insights into the superior and middle temporal gyri by Vyara Zaykova, Sevdalina Kandilarova, Rositsa Paunova, Ferihan Popova, Drozdstoy Stoyanov

“…Dysfunction in the temporal cortex has been associated with the development of psychosis. The aim of the present study was to explore the functional connectivity and laterality of superior and middle temporal gyri in patients with auditory verbal hallucinations.MethodsResting-state functional magnetic resonance imaging data was obtained from a total of 105 subjects including 63 healthy controls and 42 patients diagnosed with schizophrenia experiencing auditory verbal hallucinations. …”
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Toward Personalized Stationary Chromatography Phases: Equipping Commercial Silica Phases with Selected Peptide‐Based Binding Domains to Tailor Affinity by Steffen A. Busche, Lukas D. Bangert, Raoul D. Brand, Tommy Kröger, Enrico Heyl, Hans G. Börner

“…These sequences are C‐terminally functionalized with 1,2,4,5‐tetrazine (Tz) moieties to enable IEDDA ligation to silica material presenting endo‐ /exo‐norbornene (Nb) moieties to give pyridazine (Pz)‐linkages. …”
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Social profiles among youth with attention-deficit/hyperactivity disorder (ADHD): Evidence from the ABCD study by Rosario Pintos Lobo, Julio A. Peraza, Taylor Salo, Alan Meca, Donisha D. Smith, Kathleen E. Feeney, Katherine M. Schmarder, Matthew T. Sutherland, Raul Gonzalez, Erica D. Musser, Angela R. Laird

“…We hypothesized that an ADHD classification system based on social functioning would better predict real-world psychosocial and academic outcomes compared to traditional Diagnostic and Statistical Manual of Mental Disorders (DSM-5) nosology of ADHD presentations. …”
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Spatial navigation entropy suggests allocentric dysfunction in PPPD by Felipe Faúndez, Camilo Arévalo-Romero, Karen Villarroel, Claudio Lavín, Kevin Alarcón, Kevin Alarcón, Gustavo Vial, Francisco Artus, Pablo Billeke, Paul H. Delano, Paul H. Delano, Paul H. Delano, Hayo A. Breinbauer, Hayo A. Breinbauer

“…The present studies attempt to unravel the neural mechanisms that underlie spatial navigation in PPPD.MethodsFifty-two participants completed the study: 19 PPPD patients, 20 control subjects with vestibular disorders but without PPPD (with comparable peripheral vestibular function to the PPPD group, and 13 healthy volunteers). …”
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Asymptotical expansions in the Kubilius theorem of large deviations by Rimantas Skrabutėnas

“… In the present paper, a local theorem of large deviations for arithmetic functions defined in Knopfmacher’s semigroup is obtained. …”
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Identification of the most suitable probability models for local joint flexibility in T/Y-connections stiffened with collar or doubler plates by Hossein Nassiraei

“…The reliability-based design of steel structures requires accurate probability density functions (PDFs) of the relevant random variables. …”
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Time-Domain ADC and Security Co-Design for SiP-Based Wireless SAW Sensor Readers by Zhen Mao, Bing Li, Linning Peng, Jinghe Wei

“…The signal-processing architecture of passive surface acoustic wave (SAW) sensors presents significant implementation challenges due to its radar-like operational principle and the inherent complexity of discrete component-based hardware design. …”
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An observer-based control of linear systems with uncertain parameters via LMI approach by Hiba Hizazi, Mustapha Lhous, El Mostafa Magri, Ayoub Sakkoum

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Ovarian tissue cryopreservation for a girl with combined severe hemolytic anemia due to pyruvate kinase deficiency: a case report and literature review by Lingling Jiang, Xiangyan Ruan, Juan Du, Jiaojiao Cheng, Yanglu Li, Muqing Gu, Yanqiu Li, Fengyu Jin, Jinshan Zhang, Jianji Xu, Alfred O. Mueck

“…Objective To present a young girl with pyruvate kinase deficiency (PKD) and concurrent severe hemolytic anemia who underwent fertility preservation and cryopreservation. …”
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Airy-based equilibrium mesh-free method for static limit analysis of plane problems by Canh V. Le, Phuc L. H. Ho, Hoa T. Nguyen

“… This paper presents a numerical procedure for lower bound limit analysis of plane problems governed by von Mises yield criterion. …”
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CONSIDERATIONS ON ENTITY'S RISK ANALYSIS by MIRELA MONEA

“…The methods used to estimate bankruptcy risk are based on the score function which helps to find if an entity is confronted with financial difficulties. …”
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Generation of Typical Seawater Temperature Year and Its Application by Duanmu Lin, Xu fei

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Factors associated with early hospital readmission for acute decompensation of cirrhosis - prospective cohort study by Tamara Liana Zocche, Cláudia Maccali, Fernanda Cristina de Augustinho, Elayne Cristina de Morais Rateke, Camila Matiollo, Ariane Borgonovo Rayes, Dariana Carla Maggi, Esther Buzaglo Dantas-Corrêa, Leonardo de Lucca Schiavon, Janaina Luz Narciso-Schiavon

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Factors associated with early hospital readmission for acute decompensation of cirrhosis - prospective cohort study by Tamara Liana Zocche, Cláudia Maccali, Fernanda Cristina de Augustinho, Elayne Cristina de Morais Rateke, Camila Matiollo, Ariane Borgonovo Rayes, Dariana Carla Maggi, Esther Buzaglo Dantas-Corrêa, Leonardo de Lucca Schiavon, Janaina Luz Narciso-Schiavon

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