Effect of <i>Bifidobacterium bifidum</i> supernatant on the morphological and functional characteristics of human fibroblasts in real time during an <i>in vitro</i> experiment by A. A. Markov, E. G. Kostolomova, T. Kh. Timokhina, G. S. Solovyev, Ya. I. Paromova, E. D. Polyanskih, K. A. Voronin

“…The key role in healing of wound defects belongs to fibroblasts due to the secretion of the extracellular matrix components, metabolites, signal factors for the surrounding cells, and tissue metabolism regulation. The paper presents the results of the study of the effect of Bifidobacterium bifidum supernatant (10 ml/mL) on the morphological and functional properties of human fibroblasts in real time during the in vitro experiment. …”
Get full text

Quality of life, neurocognitive functioning, psychological issues, sexuality and comorbidity more than 2 years after commencing immune checkpoint inhibitor treatment by Melanie M van der Klauw, T Jeroen N Hiltermann, Mathilde Jalving, Emoke Racz, Sjoukje Oosting, Anna K L Reyners, Wellington Candido, Annemarie Cecile Eggen, Ingeborg Bosma, Reinate D Horinga, Kelly C van Heuvelen, Janine Nuver

“…We assessed QOL, neurocognitive function, psychological issues, sexual function and comorbidity in survivors. …”
Get full text

Itaconate derivative 4-OI inhibits M1 macrophage polarization and restores its impaired function in immune thrombocytopenia through metabolic reprogramming by Qiang Liu, Anli Liu, Shaoqiu Leng, Xiaoyu Zhang, Xiaolin Wang, Zhang Cheng, Shuwen Wang, Jun Peng, Qi Feng, Sihan Zhou, Xiuyuan Hao

“…Macrophage polarization, antigen-presenting functions, and phagocytic capability were measured via flow cytometry and enzyme-linked immunosorbent assay (ELISA). …”
Get full text

Development and characterization of gold nanoparticle-based colorimetric sensing assay functionalized with L-cysteine for the detection of calcium carbide in ripened mango and bana... by Aishwarya Dixit, Sonam Sonwal, Ashutosh Upadhyay, Vivek K. Bajpai, Yun Suk Huh, Shruti Shukla

“…Calcium carbide (CaC2) is generally used as an artificial ripening agent in the agricultural and food sectors but has been prohibited due to its negative impacts on the environment and human. Therefore, in the present study, a novel and cost-effective detection technique was developed for the detection of CaC2 using L-cysteine functionalized gold nanoparticles (AuNPs). …”
Get full text

Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study by Yang Z, Liang X, Ji Y, Zeng W, Wang Y, Zhang Y, Zhou F

“…Additionally, radiomic wavelet features were correlated with Montreal Cognitive Assessment (MoCA) and Hamilton Anxiety Scale, present pain intensity scores in cognitively impaired LBLP patients (P < 0.05, with Bonferroni correction).Conclusion: Hippocampal functional radiomic features are valuable for diagnosing cognitively impaired patients from LBLP.Keywords: cognitive impairment, resting-state functional MRI, low-back-related leg pain, radiomic, logistic regression algorithm…”
Get full text

Multi-Functional Alginate Lyase <i>AlgVR7</i> from <i>Vibrio rumoiensis</i>: Structural Insights and Catalytic Mechanisms by Zhe Huang, Shuai Liang, Wulong Jiang, Li Wang, Yuan Wang, Hua Wang, Lianshun Wang, Yuting Cong, Yanan Lu, Guojun Yang

Get full text

Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary by István Virga, István Virga, Karolina Kósa, Anna Illés, Zsófia Miltényi, Zsófia Miltényi, Tibor Ivánka, Roland Berecz, Anikó Égerházi, Árpád Illés, Árpád Illés, Ferenc Magyari, Ferenc Magyari

“…A well-known side effect is cognitive dysfunction that appears in HL patients after chemotherapy (chemobrain). In the present longitudinal study, we measured cognitive function in our HL patients, in search of potential correlations between patient-related factors, the signs and symptoms of their diseases, and therapeutic factors.MethodsPatients underwent a computer-assisted assessment (CANTAB) of cognitive function (especially domains of visual memory, attention, working memory, and planning) and filled out psychological questionnaires (standardized, self-administered and validated for Hungarian language) before treatment (n=30, T1) and after the first-line treatment (n=25, T2), and 8.6 years after the end of chemotherapy (n=19, T3).ResultsThe median age of 16 females and 14 males was 35 years (20-69), 35 years (21-63) after chemotherapy, and 43 years (29-70) at the end of the long-term follow-up, when the study was completed. 77% of all patients showed cognitive impairment before treatment. …”
Get full text

Function and structure of broadly neutralizing antibodies against SARS-CoV-2 Omicron variants isolated from prototype strain infected convalescents by Dan Li, Caiqin Hu, Junwei Su, Shuo Du, Ying Zhang, Wanqi Ni, Li Ren, Yanling Hao, Yi Feng, Changzhong Jin, Shuo Wang, Xinxian Dai, Zheng Wang, Biao Zhu, Junyu Xiao, Yiming Shao

Get full text

Genome-wide characterization of monoacylglycerol lipase (MAGL) gene family in soybean and functional analysis of GmMAGLs in storage lipid metabolism and drought resistance by Haiqing Jing, Yan Sun, Bicheng Wang, Juhua Ma, Kun Wan, Zhanqian Li, Yali Zhou, Runzhi Li, Haiping Zhang, Jinai Xue

“…The present data establish a foundation for further elucidation of the biological functions of GmMAGL genes and provide valuable target genes for genetic improvement in soybean and other crops.…”
Get full text

GLIMPSE: An Ultrafaint ≃105 M⊙ Pop III Galaxy Candidate and First Constraints on the Pop III UV Luminosity Function at z ≃ 6–7 by Seiji Fujimoto, Rohan P. Naidu, John Chisholm, Hakim Atek, Ryan Endsley, Vasily Kokorev, Lukas J. Furtak, Richard Pan, Boyuan Liu, Volker Bromm, Alessandra Venditti, Eli Visbal, Richard Sarmento, Andrea Weibel, Pascal A. Oesch, Gabriel Brammer, Daniel Schaerer, Angela Adamo, Danielle A. Berg, Rachel Bezanson, Rychard Bouwens, Iryna Chemerynska, Adélaïde Claeyssens, Miroslava Dessauges-Zavadsky, Anna Frebel, Damien Korber, Ivo Labbe, Rui Marques-Chaves, Jorryt Matthee, Kristen B. W. McQuinn, Julian B. Muñoz, Priyamvada Natarajan, Alberto Saldana-Lopez, Katherine A. Suess, Marta Volonteri, Adi Zitrin

“…Detecting the first generation of stars, Population III (Pop III), has been a long-standing goal in astrophysics, yet they remain elusive even in the JWST era. Here we present a novel NIRCam-based selection method for Pop III galaxies, and carefully validate it through completeness and contamination simulations. …”
Get full text

An EcDNA gene-based risk model and functional verification of a key ec-lncRNA AC016394.2 for prostate cancer by JiangPing Qiu, Jiang Wu, Nan Zhou, Cong Lai, Xin Huang, Cheng Liu, XiaoQing Yuan, Kewei Xu

“…Conclusions This study presents a novel ecDNA gene-based prognostic risk model for PCa, highlighting the functional importance of ec-lncRNA AC016394.2. …”
Get full text

Microbiome gut community structure and functionality are associated with symptom severity in non-responsive celiac disease patients undergoing a gluten-free diet by Laura Judith Marcos-Zambrano, Blanca Lacruz-Pleguezuelos, Elena Aguilar-Aguilar, Helena Marcos-Pasero, Alberto Valdés, Viviana Loria-Kohen, Alejandro Cifuentes, Ana Ramirez de Molina, Alberto Diaz-Ruiz, Vera Pancaldi, Enrique Carrillo de Santa Pau

“…ABSTRACT Non-responsive celiac disease (NRCD) challenges clinicians due to persistent symptoms despite a gluten-free diet (GFD). We present a cross-sectional pilot study including 39 NRCD patients to describe the underlying mechanisms contributing to symptom persistence by integrating different levels of data (fecal shotgun metagenomics, mucosal integrity markers, and metabolomic profiles) and using microbial networks to unravel the community structure of the patient’s microbiome. …”
Get full text

Assessing the Success of Ferula assa-foetida L. Plantation Restoration Operations in Semi-Steppe Rangelands by Linking Plant Functional Traits to Species Diversity by Esfandiar Jahantab, Azam Khosravi Mashizi, Mohsen Sharafatmandrad

“…By studying the dynamics of plant communities, we can understand how the structure, composition, and function of plant communities respond to restoration operations. …”
Get full text

The effects of vitamin C supplementation on oxidative and immune response and post exercises inflammation by Aleksandra Durzyńska, Patryk Gutowski, Katarzyna Drozdowska, Katarzyna Żołądkiewicz, Agnieszka Słojkowska

“…Interaction of this antioxidant with many other compounds and body tissues revels its free radicals scavenging properties and the main possible role in body functioning. However, the benefits of using this vitamin are still controversial and the presented properties, like those of many other antioxidants, are questioned. …”
Get full text

Improving Modularity Regularization Techniques for Estimating Structures in Complex Network by Samaa F. Ibraheem, Basad Al-Sarray

“…In this paper, a model selection for stochastic block models is presented based on the optimization of the log-likelihood function to find the best number of communities K detected by the regularized convex modularity maximization method. …”
Get full text

Engineering Zn/Fe Mixed Metal Oxides with Tunable Structural and Magnetic Properties for Magnetic Particle Imaging by Qianyi Zhang, Bing Sun, Saeed Shanehsazzadeh, Andre Bongers, Zi Gu

Get full text

THE COMPUTER-AIDED CONTROLLING OF TECHNICAL AND TECHNOLOGICAL PLANTS IN THE WAVELET MEDIUM by Fedosenkov D.B., Tokarev S.V., Simikova A.A., Iskhakov R.R., Fedosenkov B.A.

“…Methods of formalizing material flows created in certain knots of structure-and-functional diagram of the mixture producing aggregate are considered, that are founded on transforming one-dimensional initial flow signals into multi-dimensional ones. …”
Get full text

ITS amplicon sequencing revealed that rare taxa of tea rhizosphere fungi are closely related to the environment and provide feedback on tea tree diseases by Yuanqi Zhao, Weiwei Ran, Wenming Xu, Yuehua Song

“…Additionally, abundant taxa presented a wider range of environmental feedback, whereas the rare taxon diversity presented a stronger positive association with the soil Z score. …”
Get full text

LANDAU–KLEFFNER SYNDROME (ACQUIRED EPILEPTIC APHASIA) WITH A FOCUS ON ELECTROENCEPHALOGRAPHIC CRITERIA by K. Yu. Mukhin

“…There has been currently evidence that prolonged diffuse epileptiform activity has a damaging effect on a child’s developing brain, which is seen in impairments of speech and other higher mental functions. The age of patients with manifestations of LKS (3–5 years) is a critical period for the development of speech function. …”
Get full text

Plithogenic Hypersoft based Plithogenic Cognitive Maps in Sustainable Industrial Development by N. Angel, P. Pandiammal, Nivetha Martin

Get full text