Outcomes Following Observation of Small Non-Functioning Neuroendocrine Tumors of the Pancreas. Data from the Registry of the Loginov Moscow Clinical Scientific Center by I. E. Khatkov, D. A. Salimgereeva, I. Yu. Feidorov, A. A. Konyakhina, A. L. Petrova

“…Six patients (5.2 %) were excluded from the study: three refused to be observed, three demonstrated tumor growth. 109 patients diagnosed with non-functioning pancreatic neuroendocrine tumor were included in the analysis: 78 (71.6 %) women and 31 (28.4 %) men aged from 22 to 86 years (58.5 ± 10.8 years) at the time of presentation. …”
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Using Highly Functional Cr2O3 Interfacial Layer to Enhance the Electrical Performance of Au/InP Schottky Diodes by Sreedhar Gari Sai Krupa, Dandala Surya Reddy, Ambadi Lakshmi‐Narayana, Varra Rajagopal Reddy, Chintalapalle V. Ramana

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Discriminative Validity and Reliability of the Single-Leg Squat and Single-Leg Landing Frontal Plane Kinematics in Individuals with Lower Limb Functional Deficits by Jean Marlon Machado, Marcelo Peduzzi de Castro, Amandda de Souza, Carlos Alberto Atherinos Pierri, Francisco Xavier de Araujo, Heiliane de Brito Fontana, Caroline Ruschel

“…It is necessary to identify variables and tests with adequate reliability and with the capability to discriminate individuals with and without lower limb functional deficits. This study aimed to determine which single-legged test (single-leg squat and single-leg landing) and variables (angle at deepest instant and range of motion) present the best reliability and capability to discriminate individuals with and without lower limb functional deficits. …”
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Soil–Plant Biochemical Interactions Under Agricultural Byproduct Amendments and Potassium Humate: Enhancing Soil Function and Bioactive Compounds in Sunflower Sprouts by Thidarat Rupngam, Patchimaporn Udomkun, Thirasant Boonupara, Puangrat Kaewlom

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Development of Bioactive Cotton, Wool, and Silk Fabrics Functionalized with <i>Origanum vulgare</i> L. for Healthcare and Medical Applications: An In Vivo Study by Aleksandra Ivanovska, Anica Petrović, Tamara Lazarević-Pašti, Tatjana Ilic-Tomic, Katarina Dimić-Mišić, Jelena Lađarević, Jovana Bradić

“…<b>Background:</b> This study presents an innovative approach to developing bioactive natural fabrics for healthcare and medical applications. …”
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Preliminary results of the EPIDIA4Kids study on brain function in children: multidimensional ADHD-related symptomatology screening using multimodality biometry by Yanice Guigou, Alexandre Hennequin, Théo Marchand, Théo Marchand, Mouna Chebli, Lucie Isoline Pisella, Pascal Staccini, Pascal Staccini, Vanessa Douet Vannucci, Vanessa Douet Vannucci

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Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats by Evan Fuini, Arnold Chang, Richard J. Ortiz, Richard J. Ortiz, Taufiq Nasseef, Josh Edwards, Marc Latta, Elias Gonzalez, Taylor J. Woodward, Bryce Axe, Ashwath Maheswari, Noah Cavallaro, Heather B. Bradshaw, Praveen P. Kulkarni, Craig F. Ferris, Craig F. Ferris

“…This is the first study to use MRI to follow functional changes in brain activity in response to different doses of psilocybin in fully awake, drug naive rats. …”
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Does the type of pushing at delivery influence pelvic floor function at 2 months postpartum? A pragmatic randomized trial—The EOLE study by Chloé Barasinski, Anne Debost‐Legrand, Denis Savary, Pamela Bouchet, Sandra Curinier, Françoise Vendittelli

“…Abstract Introduction Maternal pushing techniques during the second stage of labor may affect women's pelvic floor function. Our main objective was to assess the impact of the type of pushing used at delivery on the mother's medium‐term pelvic floor function. …”
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Exploring the interplay between pain processing mechanisms, psychosocial factors, and functional outcomes in patients with chronic low back pain: an exploratory study by Jaime Jordán-López, María D. Arguisuelas, Julio Doménech, M. Lourdes Peñalver-Barrios, Marta Miragall, Rocío Herrero, Rosa M. Baños, Juan J. Amer-Cuenca, Juan F. Lisón

“…This present study aimed to explore correlations between pain intensity and pain processing mechanisms (quantitative sensory testing [QST]), psychological factors (kinesiophobia, catastrophising, and anxiety), and functional outcomes (lumbar flexion-evoked pain thresholds and functional capacity) in individuals with CLBP.Methods In this exploratory study we recruited 50 patients with CLBP from a tertiary hospital in Valencia, Spain. …”
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Intranasal Human-Recombinant Nerve Growth Factor Enhances Motor and Cognitive Function Recovery in a Child with Severe Traumatic Brain Injury by Lorenzo Di Sarno, Lavinia Capossela, Serena Ferretti, Luigi Manni, Marzia Soligo, Susanna Staccioli, Eleonora Napoli, Riccardo Burattini, Antonio Gatto, Antonio Chiaretti

“…<b>Discussion</b>: Following hr-NGF treatment, the child demonstrated notable advancements in motor function, achieving independent standing and walking. …”
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Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes by Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhong

“…Moreover, multielectrode array recordings revealed that glucagon-like peptide-1 functionally augmented the photoresponses of ON-type retinal ganglion cells. …”
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Functional improvement by tendon transfer for residual wrist dysfunction after botulinum therapy for severe upper limb spasticity: a case report by Takatoshi Hara, Yuta Miyazaki, Daisuke Nishida, Naho Takahashi, Keiko Sone, Yuki Hara, Ayano Matsui, Masahiro Abo

“…This case illustrates the critical role of tendon transfer surgery as a complementary intervention to overcome the limitations of conservative treatments, leading to substantial functional recovery. Future studies should aim to establish clear criteria for selecting candidates for tendon transfer surgery to ensure optimal functional outcomes for patients with severe spasticity.…”
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Identification and Functional Characterization of a Novel <i>SOX4</i> Mutation Predisposing to Coffin–Siris Syndromic Congenital Heart Disease by Zi Yan, Bin-Bin Dong, Yan-Jie Li, Chen-Xi Yang, Ying-Jia Xu, Ri-Tai Huang, Xing-Yuan Liu, Yi-Qing Yang

“…The nonsense variation was absent from 262 healthy controls. Functional analysis demonstrated that the Glu111*-mutant SOX4 lost transactivation on <i>NKX2.5</i> and <i>GATA4</i>, two well-established genes that are causative factors for CHD. …”
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Effects of γ-PGA application on soil physical and chemical properties, rhizosphere microbial community structure and metabolic function of urban abandoned land by Tu Shiheng, Tu Shiheng, Ge Fanglan, Xu Yong, Sun Qingyi, Xie Fugui, Ren Yao, Du Juan, Chu Can, Xu Boyuan, Li Wei, Li Wei

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Cardiovascular function shows early impairment in asymptomatic adolescents diagnosed with type 1 diabetes mellitus: an ultrasound-derived myocardial work study by Martina Ghirardo, Martina Ghirardo, Irene Cattapan, Irene Cattapan, Jolanda Sabatino, Jolanda Sabatino, Alice Pozza, Alice Pozza, Jennifer Fumanelli, Jennifer Fumanelli, Martina Avesani, Joaquin Gutierrez De Rubalcava Doblas, Carlo Moretti, Biagio Castaldi, Giovanni Di Salvo

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X-RAY PROGRESSION AND ITS IMPACT ON THE FUNCTIONAL STATUS OF PATIENTS WITH EARLY RHEUMATOID ARTHRITIS DURING A 5-YEAR FOLLOW-UP by Yu. A. Ermakova, D. E. Karateev, E. L. Luchikhina, N. V. Demidova, A. V. Smirnov

“…Objective: to assess progression of X-ray joint changes and their impact on functional status of patients with early rheumatoid arthritis (RA).Subjects and methods. …”
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Differential associations between synthetic endocrine disruptors and renal function impairment across varying degrees in middle-aged and older adult populations by Junfang Mu, Yajing Li, Yajing Li, Lu He, Lu He, Mingyan Ma, Mohan Zhang, Xin Wang, Danhui Mao, Danhui Mao, Danhui Mao

“…BackgroundExisting research has revealed that various factors, including environmental pollutants, can affect renal function. This study aims to explore the association between various synthetic Endocrine Disruptors(EDs), which are widely present in the environment, and the renal function of middle-aged and older adult populations.MethodsBased on data from the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2018, a total of 1,199 participants, with a median age of 57 years, who had CKD or at least one CKD complication (such as dyslipidemia, hypertension, diabetes, or hyperuricemia), were included. …”
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CLEAR Thrombectomy Score: An Index to Estimate the Probability of Good Functional Outcome With or Without Endovascular Treatment in the Late Window for Anterior Circulation Occlusi... by James E. Siegler, Manisha Koneru, Muhammad M. Qureshi, Mohamed Doheim, Raul G. Nogueira, Nicolas Martinez‐Majander, Simon Nagel, Mary Penckofer, Jelle Demeestere, Volker Puetz, Marc Ribo, Mohamad Abdalkader, João Pedro Marto, Alhamza R. Al‐Bayati, Hiroshi Yamagami, Diogo C. Haussen, Marta Olive‐Gadea, Simon Winzer, Mahmoud H. Mohammaden, Robin Lemmens, Kanta Tanaka, Pekka Virtanen, Anne Dusart, Flavio Bellante, Daniel P. O. Kaiser, Francois Caparros, Hilde Henon, João Nuno Ramos, Santiago Ortega‐Gutierrez, Sunil A. Sheth, Stefania Nannoni, Lieselotte Vandewalle, Johannes Kaesmacher, Sergio Salazar‐Marioni, Liisa Tomppo, Rita Ventura, Syed F. Zaidi, Mouhammad Jumaa, Alicia C. Castonguay, Milagros Galecio‐Castillo, Ajit S. Puri, Adnan Mujanovic, Piers Klein, Liqi Shu, Behzad Farzin, Hannah Moomey, Hesham E. Masoud, Jessica Jesser, Markus A. Möhlenbruch, Peter A. Ringleb, Daniel Strbian, Osama O. Zaidat, Shadi Yaghi, Davide Strambo, Patrik Michel, Daniel Roy, Shinichi Yoshimura, Kazutaka Uchida, Jean Raymond, Thanh N. Nguyen

“…There was a significant interaction between the score and EVT for good functional outcome, functional independence, and poor outcome (all Pinteraction<0.001), with greater benefit favoring patients with lower and midrange scores. …”
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CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…The hypertensive cell type-specific CD40(L) knockout animals showed only a minor effect on endothelial function, blood pressure, and oxidative stress. Therefore, we conclude that targeting CD40 directly on adipocytes, B-cells, T-cells, or CD40L on platelets is not a promising target to prevent hypertension complications.In summary, TRAF6 inhibition but not adipocyte, B-cell, or T-cell-specific CD40 or platelet-specific CD40L deficiency reduces pathophysiological vascular inflammation in hypertensive mice, suggesting TRAF6 inhibition as a potential therapeutic target in hypertensive patients.…”
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Correlation between fetal-placental doppler indices and maternal cardiac function in pregnant women with late-Onset preeclampsia or fetal growth restriction by Yiling Chen, Meihong Huang, Donghua Shi, Jinmiao Lin, Jingyi Guo, Yiru Yang, Shilin Li, Guorong Lyu

“…Conclusions In direct response to our primary aim investigating maternal-fetal hemodynamic coupling, we conclude that: FGR manifests as maternal hemodynamic failure (low-CO/high-UtA-PI) causing placental hypoperfusion; Late-onset PE presents volume overload with preserved uteroplacental function; Dual UtA-PI and CO assessment provides phenotype-specific biomarkers to guide targeted therapy.…”
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