The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis). by Carol S Palackdkharry, Stephanie Wottrich, Erin Dienes, Mohamad Bydon, Michael P Steinmetz, Vincent C Traynelis

“…<h4>Discussion & conclusion</h4>DLMs are common. The LM clinically functions as an organ with critical CNS-sustaining roles involving the SAS-pia structure, enclosed cells, lymphatics, and biologic pathways. …”
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Comparison of respiratory symptoms and pulmonary functions of adult male cigarette smokers and non-smokers in Sri Lanka; A comparative analytical study. by Prasanna Herath, Savithri Wasundara Wimalasekera, Thamara Dilhani Amarasekara, Manoj Sanjeewa Fernando, Sue Turale

“…Additionally, the present research represents the first-ever Lung function study conducted in Sri Lanka specifically targeting cigarette smokers.…”
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Effects of antibacterial peptide microcin J25 on growth performance, antioxidant capacity, intestinal barrier function and intestinal microbiota in pigeon squabs by Heng Cao, Yinglin Lu, Xingyu Zhang, Jing Zhou, Fan Li, Zaixu Pan, Shanjin Xu, Minli Yu

“…The present study aims to evaluate the effects of the antibacterial peptide Microcin J25 (ABP MccJ25) on growth performance, intestinal barrier function, antioxidant capacity and ileal microbiota in pigeon squabs. …”
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Association between early-life exposure to the Great Chinese Famine and poor physical function later in life: a cross-sectional study by Tao Tao, Lingyan Dai, Yusi Li, Zhuoyuan Guo

“…A similar connection between prenatal and early postnatal exposure to the Great Chinese Famine and the prevalence of poor physical function in midlife, however, was not observed from female adults.Conclusions Males who were exposed to the Great Chinese Famine (1959–1961) present considerably decreased physical function in their later life.…”
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Application of Cyberlindnera fabianii isolate as a potential starter culture in type IV sourdough to improve techno-functional capabilities of barley bread by Alireza Sadeghi, Fahimeh Hajinia, Hossein Purabdolah, Maryam Ebrahimi, Sara Shahryari, Maryam Pahlavani

“…Indigenous sourdough (SD) yeasts have promising potential applications as starter culture in processing of the baked goods. In the present study, techno-functional capabilities of the predominant yeasts isolated from barley SD were characterized to select a proper starter culture for type IV SD. …”
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Predictive value of serum initial brain natriuretic peptide and troponin on functional prognosis in noncardiogenic patients with anterior and posterior circulation cerebral infarct... by Wan-Ting Lu, Wen-Ting Du, De-Sheng Lu, Jie You, Hong-yan Li

“…Objective To explore the predictive value of serum initial BNP and troponin on the functional prognosis of patients with noncardiogenic ACI and PCI. …”
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Physical functioning outcome measures in the lumbar spinal surgery population and measurement properties of the physical outcome measures: protocol for a systematic review by Alison B Rushton, Jai Mistry, Michael J Lukacs, Katie L Kowalski, Maren Goodman

“…Introduction Low back pain can lead to substantial decline in physical functioning. For disabling pain not responsive to conservative management, surgical intervention can enhance physical functioning. …”
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Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination by Melanie Lohrberg, Lena Sünke Mortensen, Carolina Thomas, Franziska Fries, Franziska van der Meer, Alexander Götz, Carolin Landt, Hong Jun Rhee, JeongSeop Rhee, David Gómez-Varela, Manuela Schmidt, Wiebke Möbius, Torben Ruhwedel, Luis A. Pardo, Linus Remling, Nadine Kramann, Claudia Wrzos, Erik Bahn, Christine Stadelmann, Alonso Barrantes-Freer

“…Further, deficiency of MyD88, an adaptor protein of the innate immune response, associated with a functional recovery in facilitation, reduced changes in the differential expression of synaptic and glutamate transport proteins, and reduced transcription levels of inflammatory cytokines. …”
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Curcumin derivative C210 induces Epstein–Barr virus lytic cycle and inhibits virion production by disrupting Hsp90 function by Linli Chen, Xiaojing Guo, Wen Lin, Yingying Huang, Suling Zhuang, Qianfeng Li, Jianhua Xu, Shengnan Ye

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Prognostic and functional role of PPAR-alpha and SNP receptor (Leu162Val) in acute coronary syndrome: a potential novel target by Abdullah Abdulsattar Raeef, Hassan H. Al-Saeed, Sami Mekhlif Mishlish

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Effectiveness of Combined Whole-Body Vibration and Intensive Therapeutic Exercise on Functional Capacity in Children with Cerebral Palsy: A Randomized Controlled Trial by Iñigo Monzón-Tobalina, Rosa María Ortiz-Gutiérrez, Ángela Concepción Álvarez-Melcón, Álvaro Pérez-Somarriba, Patricia Martín-Casas, María José Díaz-Arribas

“…<i>Background and Objectives:</i> Whole-body vibration (WBV) therapy presents controversial evidence regarding its effectiveness in improving lower limb functional capacity in children with cerebral palsy (CP), particularly when applied continuously as an adjunct to a physiotherapy program with demonstrated efficacy. …”
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Conceptual foundations of a REFRAME-based approach to discriminate across total knee implant designs based on the positions of functional centres of rotation by Adrian Sauer, Ariana Ortigas-Vásquez, Christoph Thorwaechter, Peter E. Müller, Henning Windhagen, Allan Maas, Thomas M. Grupp, William R. Taylor, Matthias Woiczinski

“…The identification of an implant design that optimally fits to a patient’s native kinematic patterns and functional requirements could provide a basis towards subject-specific phenotyping. …”
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Effectiveness of Home-Based Stretching and Strengthening Training for Improving Flexibility, Strength, and Physical Function in Older Adults with Leg Tightness and/or Suspected Sar... by Pornpimol Muanjai, Sirawee Chaovalit, Nongnuch Luangpon, Wirasinee Srijunto, Pongrung Chancharoen, Juntip Namsawang, Piyapong Prasertsri, Sigitas Kamandulis, Tomas Venckunas, Orachorn Boonla

“…Background/Objectives: The aim of the present study was to assess the effectiveness of flexibility or strengthening exercises to improve flexibility, strength, muscle architecture, and functional performance in older adults with leg tightness and/or suspected sarcopenia. …”
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Analysis of the expression profile and biological function of plasma miRNAs in chronic lymphocytic leukemia and multiple myeloma patients occupationally exposed to pesticides by Luiza Flavia Veiga Francisco, Willian Garcia Birolli, Welinton Hirai, Caroline Rocha Nunes, Iara Zapparoli Gonçalves, Fabiana de Lima Vazquez, Álvaro José dos Santos Neto, Fernando Barbosa Junior, Márcia Maria Chiquitelli Marques, Henrique C.S. Silveira

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JWST, ALMA, and Keck Spectroscopic Constraints on the UV Luminosity Functions at z ∼ 7–14: Clumpiness and Compactness of the Brightest Galaxies in the Early Universe by Yuichi Harikane, Akio K. Inoue, Richard S. Ellis, Masami Ouchi, Yurina Nakazato, Naoki Yoshida, Yoshiaki Ono, Fengwu Sun, Riku A. Sato, Giovanni Ferrami, Seiji Fujimoto, Nobunari Kashikawa, Derek J. McLeod, Pablo G. Pérez-González, Marcin Sawicki, Yuma Sugahara, Yi Xu, Satoshi Yamanaka, Adam C. Carnall, Fergus Cullen, James S. Dunlop, Eiichi Egami, Norman Grogin, Yuki Isobe, Anton M. Koekemoer, Nicolas Laporte, Chien-Hsiu Lee, Dan Magee, Hiroshi Matsuo, Yoshiki Matsuoka, Ken Mawatari, Kimihiko Nakajima, Minami Nakane, Yoichi Tamura, Hiroya Umeda, Hiroto Yanagisawa

“…We present the number densities and physical properties of the bright galaxies spectroscopically confirmed at z ∼ 7–14. …”
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Characteristics of Physical Exercise Programs and Their Effects on Quality of Life and Functional Capacity in Individuals with Chronic Obstructive Pulmonary Disease: A Scoping Revi... by Rafael Oliveira, João Paulo Brito, Halil İbrahim Ceylan, Maria de Brito Soares, Alexandre Duarte Martins, Tiago Vasconcelos, João Moutão, Susana Alves

“…Therefore, the objective of this study was to conduct a scoping review on the characteristics—frequency, intensity, time, and type (FITT)—and the effects of exercise programs on quality of life and functional capacity in individuals with COPD. <i>Materials and Methods:</i> The present review included 21 studies that were scoping-reviewed to describe their main findings and training characteristics. …”
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A novel MPDENet model and efficient combined loss function for real-time pixel-level segmentation detection of tunnel lining cracks by Ningyu Zhao, Yi Song, Hao Liu, Ailin Yang, Haifei Jiang, Haihong Tan

“…However, the performance of CNNs is often hindered by the sample imbalance in crack images, and the existing model architectures are often too computationally expensive, presenting challenges for real-time detection. In this study, an efficient combined loss function was proposed to address the sample imbalance issue, and a novel lightweight model, MPDENet, was introduced for real-time pixel-level segmentation detection of tunnel lining cracks of interference backgrounds. …”
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Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice by Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi

“…ABSTRACT Aims/Introduction We previously showed that glucokinase haploinsufficiency improves the glucose tolerance of db/db mice by preserving pancreatic β‐cell mass and function. In the present study, we aimed to determine the effects of glucokinase haploinsufficiency on the β‐cell mass and function of long‐term high‐fat, high‐sucrose (HFHS) diet‐fed mice. …”
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P-16 UNLOCKING S-PINDOLOL'S POTENTIAL FOR MASLD: BENEFICIAL EFFECTS ON MUSCLE MASS AND FUNCTION AND LIVER HISTOLOGY IN WESTERN- DIET FED MICE by Daniel Cabrera, Loreto Aguilar, Faride Saud, Lisbell Estrada, Marcelo Andia, Marco Arrese, Juan Pablo Arab, Luis Antonio Diaz, Francisco Barrera, Rene Baudrand, Claudio Cabello-Verrugio

“…The present data underscore S-pindolol's therapeutic potential in MASLD.…”
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IL-15 functionalized biomimetic hybrid mRNA vaccine for enhanced NSCLC immunotherapy via synergistic activation of T cells and NK cells by Jueshuo Guo, Li Peng, Penglong Ma, Yaping Mai, Ting Gao, Na Yu, Wenbao Zuo, Jianhong Yang

“…Herein, we developed an IL-15 functionalized biomimetic hybrid mRNA vaccine (LMPR) that activates NK cells in collaboration with CD8+T cells, compensating the MHC-dependent limitation to boost antitumor therapy. …”
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