Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-function tumors by Xinghao Wang, Yajun Wang, Min Xie, Shichao Ma, Yilin Zhang, Lele Wang, Yangfeng Ge, Guobin Li, Mengxi Zhao, Sheng Chen, Chenxi Yan, Hailong Zhang, Wei Sun

“…Previous studies have suggested that PRC2 is important for the proliferation of tumors with SWI/SNF loss-of-function mutations. In the present study, we have developed an EED-directed allosteric inhibitor of PRC2 termed BR0063, which exhibits anti-proliferative properties in a subset of solid tumor cell lines harboring mutations of the SWI/SNF subunits, SMARCA4 or ARID1A. …”
Get full text

Predictors of Quality of Life Among Older Residents in Rural and Urban Areas in Indonesia: An Approach Using the International Classification of Functioning, Disability, and Health by Dwi Rosella Komalasari, Chutima Jalayondeja, Wattana Jalayondeja, Yusuf Alam Romadon

“…Objectives The International Classification of Functioning, Disability, and Health (ICF) model provides a comprehensive framework for understanding health and quality of life (QoL) in older adults in both rural and urban settings, each presenting unique advantages and challenges. …”
Get full text

Enhanced Joint Heart and Respiratory Rates Extraction from Functional Near-infrared Spectroscopy Signals Using Cumulative Curve Fitting Approximation by Navid Adib, Seyed Kamaledin Setarehdan, Shirin Ashtari Tondashti, Mahdis Yaghoubi

“…Background: Functional near-infrared spectroscopy (fNIRS) is a valuable neuroimaging tool that captures cerebral hemodynamic during various brain tasks. …”
Get full text

Density Functional Theory Insight in Photocatalytic Degradation of Dichlorvos Using Covalent Triazine Frameworks Modified by Various Oxygen-Containing Acid Groups by Shouxi Yu, Zhongliao Wang

“…In this work, density functional theory (DFT) calculations were employed to investigate the impact of various oxygen-containing acid groups (-COOH, -HSO₃, -H₂PO₃) on DDVP photodegradation performance. …”
Get full text

The effect of mannitol on postoperative renal function in patients undergoing coronary artery bypass surgery: A double-blinded randomized controlled trial by Masumeh Hemmati Maslakpak, Eisa Bilejani, Sohrab Negargar, Ahmadali Khalili, Vahid Alinejad, Amir Faravan

“…The study also found no statistically significant difference in the diuresis rate between the two groups (P=0.10). Conclusion: The present study has shown that adding mannitol to the prime has no effect on kidney function, length of time connected to mechanical ventilation, length of stay in the ICU, or 30-day mortality. …”
Get full text

Electrochemical Detection of Bisphenol S Based on Molecularly Imprinted Polymers Grafted on Functionalized Multiwalled Carbon Nanotubes: A Facile Sensor Fabrication Approach by Christopher Mwanza, Lin Zhao, Qing Zhang, Shou-Nian Ding

“…The sensor was constructed by grafting molecularly imprinted polymers (MIPs) onto vinyl-functionalized multiwalled carbon nanotubes (f-MWCNTs). …”
Get full text

Investigating the Physicochemical and Antioxidant Properties of Goat Milk Enriched With Rice Extract Fermented by Exopolysaccharide-Producing Lactic Bacteria for Functional Yogurt... by Mohammad Hossein Maleki, Milad Daneshniya, Farzaneh Abdolmaleki

“…In recent years, the development of functional dairy products incorporating plant-based ingredients has gained considerable attention due to growing consumer interest in health-promoting foods. …”
Get full text

Like-layers resolution deficiency in structure function-based thermal test for multilayer semiconductor device and its potential cure by interface design by Xintian Gao, Junjie Wu, Yulin Chen, Haotian Huang, Yuan Zhu

“…In this work, we focus on the challenge it poses to the 3D architected semiconductor devices or integrated circuits (ICs). Structure function method (SFM) as an important commercialized measurement method for layered analysis of thermal resistance and thermal capacity, has been widely used and keeps attracting broad research interests from industry. …”
Get full text

Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing by Qiang Zhang, Qiang Zhang, Qiang Zhang, Qiang Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Hui Chen, Hui Chen, Hui Chen, Hui Chen, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang

Get full text

Spectroscopic Ultraluminous Lyα Luminosity Functions at z = 5.7 and z = 6.6 from HEROES: Evidence for Ionized Bubbles by A. J. Taylor, A. J. Barger, L. L. Cowie, E. M. Hu, A. Songaila

“…We present spectroscopic Ly α luminosity functions (LFs) at z = 5.7 and z = 6.6 based on a large 209 source sample of Ly α emitter (LAE) candidates identified in Subaru/Hyper Suprime-Cam narrowband imaging and confirmed with Keck II/DEIMOS spectroscopy over a multiyear observing campaign. …”
Get full text

Role of Inflammation and Motility Disorders in the Development, Course and Consequences of Functional Gastrointestinal and Biliary Tract Diseases (Literature Review and Expert Pane... by V. T. Ivashkin, D. S. Bordin, T. L. Lapina, M. A. Livzan, A. V. Okhlobystin, E. A. Poluektova, A. S. Trukhmanov, Yu. P. Uspenskiy, Yu. O. Shulpekova

“…Aim: to present the results of the Expert Panel with a discussion of modern concepts of the pathogenesis of functional gastrointestinal diseases and the possibilities of multitarget therapy with trimebutine.   …”
Get full text

ALMA Observations of Massive Clouds in the Central Molecular Zone: External-pressure-confined Dense Cores and Salpeter-like Core Mass Functions by Zhenying Zhang, Xing Lu, Tie Liu, Sheng-Li Qin, Adam Ginsburg, Yu Cheng, Hauyu Baobab Liu, Daniel L. Walker, Xindi Tang, Shanghuo Li, Qizhou Zhang, Thushara Pillai, Jens Kauffmann, Cara Battersby, Siyi Feng, Suinan Zhang, Qi-Lao Gu, Fengwei Xu, Wenyu Jiao, Xunchuan Liu, Li Chen, Qiu-yi Luo, Xiaofeng Mai, Zi-yang Li, Dongting Yang, Xianjin Shen, Meizhu Liu, Zhiqiang Shen

“…Combined with the possible top-heavy initial mass functions (IMFs) in the CMZ, our result suggests that gas accretion and further fragmentation may play important roles in transforming the CMF to the IMF.…”
Get full text

Case Report: Repetitive peripheral magnetic stimulation and task-oriented training improve motor function in chronic severe post-stroke paralysis by Satoshi Yamamoto, Toshiyuki Aoyama, Daisuke Ishii, Daisuke Ishii, Kiyoshige Ishibashi, Yutaka Kohno

“…BackgroundSevere upper-limb motor paralysis following chronic stroke presents a significant rehabilitation challenge, often with limited recovery. …”
Get full text

How is copepod functional diversity shaped by 2015-2016 El Niño and seasonal water masses in a coastal ecosystem of Southwest Atlantic? by Bárbara Santos Menezes, Érica Caroline Becker, Flora Balcão Agnelli, Luis Carlos Pinto de Macedo Soares, Cristina de Oliveira Dias, Andrea Santarosa Freire

“… Functional traits, short life cycles, and the pivotal role in the ocean make copepod diversity a solid foundation for assessing the effect of global changes in marine food webs and ecosystem functioning. …”
Get full text

RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties by Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz

“…In all, the RUBY format has attractive mAb-like attributes and offers the possibility to mitigate many of the development challenges linked to other bsAb formats, facilitating both high functionality and developability.…”
Get full text

Identification and functional validation of a new gene conferring resistance to Soybean Mosaic Virus strains SC4 and SC20 in soybean by Muhammad Muzzafar Raza, Huiying Jia, Muhammad Khuram Razzaq, Bowen Li, Kai Li, Junyi Gai

Get full text

Genome-wide characterization of the BBX gene family in perennial ryegrass and functional insights into the potentiality of LpBBX3 in drought and salt tolerance by Qingchun Liu, Yi Song, Yanfeng Liu, Xiao Xu, An Shao, Meng Wei, Yang He, Xinpei Zhang, Wei Wang

“…However, comprehensive characterization of the BBX gene family in perennial ryegrass has not been performed, and their potential functions in response to abiotic stress remain unclear. …”
Get full text

How is copepod functional diversity shaped by 2015-2016 El Niño and seasonal water masses in a coastal ecosystem of Southwest Atlantic? by Bárbara Santos Menezes, Érica Caroline Becker, Flora Balcão Agnelli, Luis Carlos Pinto de Macedo Soares, Cristina de Oliveira Dias, Andrea Santarosa Freire

“… Functional traits, short life cycles, and the pivotal role in the ocean make copepod diversity a solid foundation for assessing the effect of global changes in marine food webs and ecosystem functioning. …”
Get full text

Left Dominant Coronary Circulation is Associated with Poorer Left Ventricular Function but Not Long-Term Mortality After ST Elevation Myocardial Infarction by Yusuf Bozkurt Şahin, Emrullah Kızıltunç, Salih Topal, Adnan Abacı

“…Objective: To evaluate the effect of coronary dominance (CD) on the left ventricular systolic function in patients with first ST-elevational myocardial infarction (STEMI), and to evaluate the relationship between CD and long-term mortality. …”
Get full text

Assessment of Respiratory Symptoms and Pulmonary Function Status among Workers of Flour Mills in Addis Ababa, Ethiopia: Comparative Cross-Sectional Study by Dessalegn Demeke, Diresibachew W. Haile

“…Flour dust in the respiratory tract affects lung function. Flour dust is a heterogeneous organic substance which can have a tendency to cause respiratory ailments. …”
Get full text