Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer by Bo Yin, Wei Wang, Ang Li, Mengjie Li, Huijuan Zhou, Haoran Hu, Jianyi Ding, Yashi Zhu, Xinxin Xu, Meiqin Yang, Tiefeng Huang, Yifan Kou, Zilale Rahim, Baoyou Huang, Lingfei Han

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Long term efficacy and safety of MICT of cardiopulmonary function in patients after TAVR extended follow up of ENERGY study by Yu-Shan Li, Qiang Ren, Xing-Bo Mu, Kai Xu, Yan-Chun Liang, Jian Zhang, Geng Wang, Yan-Xia Wang, Cai-Lian Wang, Yi Zhang, Sheng-Yi Wang, Quan-Yu Zhang, Ya-Ling Han

“…Abstract The ENERGY study demonstrated that 3-month moderate-intensity continuous training (MICT) improved the cardiopulmonary function and exercise capacity for patients after transcatheter aortic valve replacement (TAVR). …”
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Deciphering the secret codes in N7‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases by Huan Fang, Jing He, Dan Du, Xue Wang, Xinyu Xu, Linping Lu, Yefan Zhou, Yangyang Wen, Fucheng He, Yingxia Li, Hongtao Wen, Mingxia Zhou

“…This review describes the various biological functions of METTL1, summarises recent advances in understanding its pathogenic and disease‐suppressive functions and discusses the underlying molecular mechanisms. …”
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Exploring the functional role of POU5F1 using CRISPR RNP electroporation of zygote (CRISPR-EZ) in buffaloes by Meeti Punetha, Dharmendra Kumar, Suman Choudhary, Sheetal Saini, Kamlesh Kumari Bajwa, Surabhi Sharma, Manu Mangal, P. S. Yadav, T. K. Datta

“… POU5F1, a key transcription factor, plays a pivotal role in maintaining pluripotency and cellular differentiation, making it of immense interest in developmental biology and animal husbandry. In the present study, we employ state-of-the-art CRIS-PR ribonucleoprotein (RNP) electroporation of zygotes (CRIS-PR-EZ) methodology to precisely manipulate the POU5F1 gene in buffalo zygotes for exploring the phenotypic and functional outcomes of embryonic development. …”
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Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study by Chen Yang, Huiyan Zhang, Zihan Ma, Yanjun Fan, Yanan Xu, Jian Tan, Jing Tian, Jiancang Cao, Wenwen Zhang, Gang Huang, Lianping Zhao

“…Hippocampal subfield volume positively correlates with total cholesterol and triglycerides and negatively correlates with fasting insulin. Conclusion The present study found that T2DM‐MCI patients have structural and functional alterations in hippocampal subfields, and IR is a negative factor influencing the alteration of hippocampal subfields volume. …”
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An X-Band Dual Function Transceiver Utilizing Digital Predistortion for Radar and Communication in 250 nm GaN HEMT by Tae-Hoon Kim, Jun Kwon, Mun-Kyo Lee, Bok-Hyung Lee, Jung-Dong Park

“…We present an X-band transceiver with memory polynomial digital predistortion (MP-DPD) and neural network digital predistortion (NN-DPD) for a dual-function radar and communication (DFRC) system targeting 6G FR3 in <inline-formula> <tex-math notation="LaTeX">$0.25\mu $ </tex-math></inline-formula>m GaN High Electron Mobility Transistor (HEMT) technology. …”
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Assessment of an integrated therapeutic protocol for sheep with acute ruminal impaction: diagnostic and prognostic significance of rumen functions and hepatorenal biomarkers by Enas Elmeligy, Ebtsam S. Abdel-lah, Abdulaziz H. Almuhanna, Eman A. R. Abdelghffar, Eman A. R. Abdelghffar, Mustafa Shukry, Mahmoud Saber, Ashraf M. Abu-Seida, Sayed Fathi El-Hawari, Sayed Fathi El-Hawari, Laila A. Al-Shuraym, Lamya Ahmed Alkeridis, Khaled A. Khesruf, Arafat Khalphallah

“…Except for hepatorenal functions, all estimated laboratory indices restored their physiological intervals on the 15th day post-therapy. …”
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Population-level impact of COVID-19 on thyroid function tests: Results from a repeated cross-sectional study by Gabriel Berkebile, Françoise Barbé, Catherine Malaplate, Lauriane Le Collen, Jean-Louis Guéant, Marc Klein, Abderrahim Oussalah

“…We aimed to assess the impact of the COVID-19 pandemic on thyroid function tests at the population level. Methods: We conducted a repeated cross-sectional study on consecutive patients who underwent thyroid function tests between March 1 and April 15, 2020, during the first wave of COVID-19 in northeastern France, and compared the results with those from the same period in 2018 and 2019. …”
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Nitrogen Fertilizer Reduction in Rice–Eel Co-Culture System Improves the Soil Microbial Diversity and Its Functional Stability by Mengqian Ma, Weiguang Lv, Yu Huang, Juanqin Zhang, Shuangxi Li, Naling Bai, Haiyun Zhang, Xianpu Zhu, Chenglong Xu, Hanlin Zhang

“…The ecological rice–eel co-culture system is not only beneficial for enhancing productivity and sustainability in agriculture but also plays a crucial role in promoting environmental health. In the present study, based on the long-term positioning trial of the rice–eel co-culture system that began in 2016 and was sampled in 2023, the effects of reduced nitrogen fertilizer application on soil physico-chemical properties and the bacterial community were investigated. …”
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Efficacy of 0.05% cyclosporine A on tear inflammatory cytokines and goblet cell function after corneal refractive surgery by Wenzhe Qian, Yue Wu, Xin Liu, Yuying Liu, Min Li, Ting Zhao, Na Chen, Bilian Ke

“…Cyclosporine A (CsA) has been employed in the treatment of dry eye due to its ability to suppress T cell-mediated immune responses and reduce inflammation. The present study was designed to assess the early effect of 0.05% cyclosporine A (CsA) eye drops on tear film stability, ocular surface inflammation and goblet cell function in patients following corneal refractive surgery. …”
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Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations by Xiaoyuan Zhong, Robert Mitchell, Christine Billstrand, Emma E. Thompson, Noboru J. Sakabe, Ivy Aneas, Isabella M. Salamone, Jing Gu, Anne I. Sperling, Nathan Schoettler, Marcelo A. Nóbrega, Xin He, Carole Ober

“…Results Heritability enrichment analysis suggested a shared role of immune cells in the development of both AOA and COA while highlighting the distinct contribution of lung structural cells in COA. Functional fine-mapping uncovered 21 and 67 credible sets for AOA and COA, respectively, with only 16% shared between the two. …”
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Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum? by Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A. Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R. Grosshans, Radhe Mohan

“…Further analysis showed that microdosimetric spectrum (the probability density function of the stochastic physical quantity lineal energy y) was helpful for interpreting observed differences in biological effects. …”
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Adolescent and Current Exercise Habits in Chronic Obstructive Pulmonary Disease: Associations with Body Composition, Physical Activity, and Pulmonary Function by Iriyama T, Matsuo Y, Tsunoda Y, Yamazaki A, Uchida Y, Nakagawa H, Kinose D, Yamaguchi M, Nakano Y, Ogawa E

“…However, the associations of exercise habits during adolescence compared to current exercise habits on physical activity (PA), body composition, pulmonary function, and CT imaging parameters remain unclear. …”
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Clinical and functional characterization of a novel TNFRSF9 variant causing immune dysregulation with predisposition to EBV-driven lymphomagenesis by Peiwei Zhao, Peiwei Zhao, Kailan Chen, Li Yang, Chunhui Wan, Lei Zhang, Sukun Luo, Xuelian He, Xuelian He

“…Additionally, there was a notable decrease in IFN-γ secretion in CD8+ T cells, suggesting impaired cytotoxic T-cell function. These findings align with the clinical presentation of immunodeficiency and lymphoproliferation observed in the patients. …”
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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses by Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

“…Methods We conducted a multi-omics analysis—encompassing DNA methylation, total RNA sequencing, and microRNAs (miRNAs; N = 800) profiling on primary CICs and differentiated tumor cell lines, including autologous pairs. Functional immunological assays were performed to assess the impact of miRNA modulation. …”
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A shortened 10-item Spine Functional Index: clinimetric properties indicate a reliable, responsive and practical measure by Hamid Reza Mokhtarinia, Antonio Cuesta-Vargas, Almir Vieira Dibai-Filho, Markus Melloh, Agnieszka Bejer

“…Abstract Background To assess the 10-item Spine Functional Index (SFI-10) clinimetric properties in a general musculoskeletal disorder (MSD) spine population. …”
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Phenotype and functions of human dendritic cells derived from CD14+ monocyte subsets opposed to CD16 expression by E. R. Chernykh, T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, Yu. D. Kurochkina, E. A. Oleynik, L. V. Sakhno, A. A. Ostanin

“…The aim of the study was to analyze the relationship between monocyte subpopulations and phenotype/ functions of monocyte-derived dendritic cells (DCs), as well as DC sensitivity to the tolerogenic effect of dexamethasone.Materials and methods. …”
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A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells by Yuzhou Gu, Lu Chen, Shuying Chen, Yuhao Wu, Shengjie Hao, Feiyin Sheng, Jiali Yuan, Zhenwei Qin, Di Wu, Yu Han, Zengying Yao, Zhijian Chen, I. Michael Wormstone, Yibo Yu, Junbin Qian, Qiuli Fu, Ke Yao

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The hematopoietic function, histological characteristics, and transcriptome profiling of Wanxi white geese ovary during nesting and late-laying stages by Chunfang Zhao, Tao Jin, Kefeng Yang, Xinyu Liu, Man Ren, Deyong She, Qianqian Hu, Shenghe Li

“…Despite several factors influencing reproduction in geese, but the precise molecular mechanisms of egg cessation are not fully understood. In the present study, the hematopoietic parameters and serum hormone levels in Wanxi white geese were analyzed. …”
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Performance of the 2021 Estimated Glomerular Filtration Rate CKD-EPI Refit and the European Kidney Function Consortium (EKFC) Formulas by Evelyn O. Ilori, Casey R. Cai, Fatou Sahor, Brianna Wilson, Tanooha Veeramachaneni, Samir M. Parikh, Ibrahim A. Hashim

“…<b>Background</b>: The glomerular filtration rate (GFR) is a universal clinical measure central to assessing kidney function and to the management of kidney disorders. …”
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