Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis by Kornelius Schulze, Tim Daniel Rose, Lorenz Adlung, Manuela Peschka, Francesca Pagani, Joao Gorgulho, Thorben W. Fründt, Ismail Labgaa, Philipp K. Haber, Carolin Zimpel, Darko Castven, Arndt Weinmann, Teresa Garzia-Lezana, Moritz Waldmann, Thomas Renné, Hannah Voß, Manuela Moritz, Dorian Orlikowski, Hartmut Schlüter, Jan Baumbach, Myron Schwartz, Ansgar W. Lohse, Samuel Huber, Bruno Sangro, Rocio I.R. Macias, Laura Izquierdo-Sanchez, Jesus M. Banales, Henning Wege, Jens U. Marquardt, Augusto Villanueva, Josch Konstantin Pauling, Johann von Felden

“…In vitro knockdown confirmed a functional role in proliferation and migration, as exemplified for PYCR2. …”
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Effective cellular and neutralizing immunity against SARS-CoV-2 after mRNA booster vaccination is associated with pDC and B cell activation by Dorit Fabricius, Carolin Ludwig, Carolin Ludwig, Matthias Proffen, Matthias Proffen, Janina Hägele, Janina Hägele, Judith Scholz, Judith Scholz, Christiane Vieweg, Christiane Vieweg, Immanuel Rode, Immanuel Rode, Simone Hoffmann, Simone Hoffmann, Sixten Körper, Sixten Körper, Hubert Schrezenmeier, Hubert Schrezenmeier, Bernd Jahrsdörfer, Bernd Jahrsdörfer

“…Peripheral B cell frequencies and activation markers (MHC class I/II, CD86) were significantly upregulated post-booster. pDCs demonstrated enhanced antigen-presenting capacity and significantly promoted SARS-CoV-2-specific T cell IFN-γ responses in vitro. …”
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Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany by Anne-Kathrin Ruß, Stefan Schreiber, Wolfgang Lieb, J. Janne Vehreschild, Peter U. Heuschmann, Thomas Illig, Katharina S. Appel, Maria J. G. T. Vehreschild, Dagmar Krefting, Lennart Reinke, Alin Viebke, Susanne Poick, Stefan Störk, Jens-Peter Reese, Thomas Zoller, Lilian Krist, David Ellinghaus, Bärbel U. Foesel, Christian Gieger, Bettina Lorenz-Depiereux, Martin Witzenrath, Gabriele Anton, Michael Krawczak, Jan Heyckendorf, Thomas Bahmer

“…The SNP is located in a region including the NEK6, PSMB7 and ADGRD2 genes which, however, does not immediately suggest an etiological connection to PCS. As regards functional plausibility, variants of a possible effect mapped to the olfactory receptor gene region (lead SNP rs10893121 at position chr11:123,854,744; p = 2.5 × 10− 6). …”
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Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer by Jeffrey S Miller, Martin Felices, Peter Hinderlie, James Lim, Naomi Fujioka, Shee Kwan Phung, Yvette Soignier, Joshua T Walker, Melissa A Geller, Madison Shackelford, Carly Selleck, Philippa R Kennedy, Mihir Shetty, Melissa J Khaw, Paolo P Provenzano, Nicholas A Zorko, Laura E Bendzick, Riley C Lyons, Elise L Femino, Terran Stenger, Tumpa Dasgupta, Laura E Kotz, Eng Hock Lee, Quynhanh Lu, Zachary B Davis, John E Wagner, Margaret L MacMillan

“…These highly translational studies present an innovative therapy for patients with HNSCC and will be developed further for clinical application.…”
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Insights into the Stearoyl-Acyl Carrier Protein Desaturase (SAD) Family in Tigernut (<i>Cyperus esculentus</i> L.), an Oil-Bearing Tuber Plant by Zhi Zou, Xiaowen Fu, Chunqiang Li, Xiaoping Yi, Jiaquan Huang, Yongguo Zhao

“…Though FAB2d and AAD2 are also broadly present in monocots, they are more likely to be lost in the Cyperaceae ancestor sometime after the split with its close family, Juncaceae. …”
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Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment by Qiuming Zou, Xiaofeng Zhou, Jianqin Lai, Haixia Zhou, Jinxuan Su, Zhijing Zhang, Xiaosong Zhuang, Lili Liu, Ruijie Yuan, Sijia Li, Siyu Yang, Xinyi Qu, Jiezhu Feng, Yongqi Liu, Zisheng Li, Shiting Huang, Zhi Shi, Yu Yan, Zhiming Zheng, Wencai Ye, Qi Qi

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Synthesizing the Academic Administrators&rsquo; Competencies: Developing of a Model by Homa Rahmani, Asadollah Khadivi

“…</p> <ol style="text-align: left;" start="3"> <li><strong>Methodology</strong></li> </ol> <p style="text-align: left;">The current research serves a functional purpose, employing a qualitative approach. …”
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Le fromage en Gaule à l’âge du Fer et à l’époque romaine : état des lieux pour sa production et analyse de sa place dans le monde antique by Alain Ferdière, Jean-Marc Séguier

“…However, the search for this documentation required a strict functional and morphological definition of the concept of cheese strainer. …”
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Acute Coronary Syndrome in Patients With 2 Type Diabetes Mellitus (Review of Literature; Description of the Clinical Case) by Bilous Z., Abrahamovych О., Mazur N., Ryabokon S., Ilenkiv N., Bevza N.

“…According to modern presentations, diabetes is considered a condition of acute inflammation with prothrombogenic changes in hemostasis and fibrinolysis, which increases the risk of vascular damage. …”
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تقييم تأثير وسائل الاعلام والدعاية على إدراک المستخدمين للعمارة والعمران "دراسة حالة مشروعات الاسکان في مصر"... by محمود سليمان, ولاء زقدان

“…Where the mass media vision of architecture and construction is limited to the notion th athousing projects are merely architectural designs imbedded within investment enterprises, that target profit at the first place, and that such projects are no longer inconsistent compliance with the basic needs of the units users, in terms of: functional spaces, the social or environmental needs, in accordance with the community's cultureand its distinctive characteristics.Consequently, this research sheds light on the influence exercised by the mass media on the society's culture, consciousness, awareness, and perception of the essence ofarchitecture and settlement. …”
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Measuring and estimation of suspended sediment variation using sediment rating curve approach in Mereg River by Sohila Aghabeigi Amin, Heidar Mirzaei

“…As a major component of hydrological, geomorphological, and ecological functioning of rivers, suspended sediment has been identified as the leading direct cause of river instabilities. …”
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Regional Design by Verena Balz

“…A distance between actors with roles in these functions is required to enhance legitimacy and accountability. …”
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Oral–gut microbiome axis in a Korean cohort with inflammatory bowel disease and ankylosing spondylitis (INTEGRATE): a prospective and observational study protocol by June-Young Lee, Tae-Hwan Kim, Sungsin Jo, Yeon-Ah Lee, Sang Won Lee, Chang Kyun Lee, Bora Nam, Soo-Kyung Park, Hyun Sik Kim, Bo-Hyung Kim, Shin Ju Oh, Jae-Yun Lee, Dong Il Park

“…The results of this study will be disseminated to healthcare and academic professionals through publications in peer-reviewed journals and presentations at international conferences.Trial registration number This prospective observational study is registered at ClinicalTrials.gov ((ID: NCT06124833, data first posted: 9 November 2023); (ID: NCT06076083, data first posted: 21 November 2023) and (ID: NCT06183697, data first posted: 27 December 2023)).…”
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CLINICAL AND IMMUNOLOGICAL STATUS OF PATIENTS WITH GENERALIZED PARODONDITIS ASSOCIATIED WITH CHRONIC HEPATITIS B VIRUS (HBV) INFECTION by V.I. Fesenko, S.V. Shvets

“…The clinical picture of parodontitis has a clear connection with laboratory parameters characterizing the functional liver condition. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…The significant correlations observed between behavioral measures and pro-inflammatory and metabolic alterations in WD-fed mice suggest the importance of liver-brain interactions and their role in the aberrant behaviors exhibited by Sert-/- mutants. This study presents the first evidence that altered liver functions are associated with pathological behaviors arising from genetic SERT deficiency.…”
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Photocatalytic chloride-to-chlorine conversion by ionic iron in aqueous aerosols: a combined experimental, quantum chemical, and chemical equilibrium model study by M. K. Mikkelsen, J. B. Liisberg, M. M. J. W. van Herpen, K. V. Mikkelsen, M. S. Johnson

“…However, there has not been a detailed analysis of the mechanism that includes the aqueous formation equilibria and the absorption spectra of the iron chlorides nor has there been an analysis of which iron chloride is the main chromophore. Here we present the results of experiments measuring the photolysis of FeCl<span class="inline-formula">₃</span> <span class="inline-formula">⋅</span> 6H<span class="inline-formula">₂</span>O in specific wavelength bands, an analysis of the absorption spectra of FeCl<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M6" display="inline" overflow="scroll" dspmath="mathml"><mrow><msubsup><mi/><mi>n</mi><mrow><mn mathvariant="normal">3</mn><mo>-</mo><mi>n</mi></mrow></msubsup></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="17pt" height="16pt" class="svg-formula" dspmath="mathimg" md5hash="fb86d1cea1d2072e93be953ab610af6f"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="ar-2-31-2024-ie00001.svg" width="17pt" height="16pt" src="ar-2-31-2024-ie00001.png"/></svg:svg></span></span> (<span class="inline-formula"><i>n</i>=1</span> … 4) made using density functional theory, and the results of an aqueous-phase model that predicts the abundance of the iron chlorides with changes in pH and iron concentrations. …”
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Thermal Decomposition and Kinetic Analysis of Amazonian Woods: A Comparative Study of <i>Goupia glabra</i> and <i>Manilkara huberi</i> by Mark Dany Veloso Junior, Fidel Guerrero, Felipe Moura Araújo da Silva, Glenda Quaresma Ramos, Robert Saraiva Matos, Ștefan Țălu, Dung Nguyen Trong, Henrique Duarte da Fonseca Filho

“…FTIR-ATR analysis highlighted the presence of key functional groups in both species, with strong absorption bands in the 3330–3500 cm⁻¹ region corresponding to O-H stretching vibrations, indicative of hydroxyl groups in cellulose and hemicellulose. …”
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Evaluation on Carbon Sequestration Capacity of 30 Common Landscaping Tree Species in Beijing by Jing QIAN, Sidong SHEN, Shuxin FAN, Li DONG

“…On the basis of fulfilling other functional needs, from the perspective of carbon sink, landscaping tree species with high carbon sequestration capacity should be fully applied. …”
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Immune mechanism of n-butanol extract of Clerodendrum bungei against loach infected with Aeromonas hydrophila by Ya-Jie Li, Xin-Ya Dong, Hong-Hui Li, Hong-Hui Li, Jin-Guo Luo, Xing-Yu Chen, Xu-Dong Zhou

“…The Unique Reads were aligned with the non-coding RNA sequences in the Rfam 13 database using Blast to screen out the non-coding RNAs and identify their types and numbers for further analysis of their functions and regulatory mechanisms. The Reads Count value of miRNA was calculated, and the expression data of the conserved miRNA in each sample were sorted out. …”
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Feasibility, classification and potential clinical impact of non-invasive delineation of abdominal lymphatic vessels in patients following TCPC with T2 weighted MRI by Anja Hanser, Michael Hofbeck, Melanie Hofmeister, Petros Martirosian, Andreas Hornung, Michael Esser, Fritz Schick, Thomas Küstner, Renate Kaulitz, Jörg Michel, Konstantin Nikolaou, Jürgen Schäfer, Christian Schlensak, Winfried Baden, Johannes Nordmeyer, Ludger Sieverding

“…Abstract Recent research in patients with functionally univentricular hearts (UVH) is focusing on pathologies of the lymphatic vessels. …”
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