Eleutheroside B alleviates oxidative stress and neuroinflammation by inhibiting the JAK2/STAT3 signaling pathway in a rat high altitude cerebral edema model by Yacong He, Hongying Zhang, Xiu Zhang, Yue Han, Huxinyue Duan, Wenqian Song, Qingqing Tian, Yilan Wang, Guang Li, Chunjie Wu, Zhenxing Wang, Tianzhu Zhao

“…Eleutheroside B (EB), the primary natural active compound found in the Eleutheroside senticosus, has demonstrated various biological functions. It has also shown significant potential in addressing acute mountain sickness and various neurological disorders. …”
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Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation te... by Kentaro Sakaki, Takaaki Murakami, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Daisuke Otani, Shinya Otsuki, Hironori Shimizu, Kazuyuki Nagai, Takumi Nomura, Daisuke Yabe, Yuji Nakamoto, Nobuya Inagaki

“…BackgroundInsulinomas, the most common functional pancreatic neuroendocrine tumors, cause hypoglycemia due to excessive insulin production, leading to severe clinical symptoms like coma or death. …”
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Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…BackgroundKRAS is a commonly mutated gene that is present in approximately 30% of NSCLC patients. Currently, the identification of effective therapies for KRAS-mutant NSCLC is difficult for reasons of the structural and biochemical characteristics of the KRAS protein. …”
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Abemaciclib plus non-steroidal aromatase inhibitor or fulvestrant in women with HR+/HER2− advanced breast cancer: Final results of the randomized phase III MONARCH plus trial by Xichun Hu, Qingyuan Zhang, Tao Sun, Yongmei Yin, Huiping Li, Min Yan, Zhongsheng Tong, Man Li, Yue’e Teng, Christina Pimentel Oppermann, Govind Babu Kanakasetty, MA Coccia Portugal, Liu Yang, Wanli Zhang, Zefei Jiang, Sihan Zhou, Xiuyuan Hao

“…Abemaciclib did not cause clinically meaningful changes in patient-reported global health, functioning, or most symptoms vs. placebo. Conclusions:. …”
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Mandibular reconstruction outcomes for in-house patient-specific solutions by Matthew D. Marquardt, Erin Cowen, Rachel Fenberg, Natalia von Windheim, Margaret Lashutka, Abigail E. Reid, Amit Agarwal, Enver K. Ozer, Ricardo L. Carrau, James W. Rocco, Catherine T. Haring, Stephen Y. Kang, Nolan B. Seim, Matthew O. Old, Kyle K. VanKoevering

“…The advent of computer-aided design and manufacturing (CAD/CAM) has enhanced aesthetic and functional outcomes in mandibular reconstruction by enabling patient-specific solutions like 3D-printed anatomic models. …”
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Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway by Yangxin Fang, Lin Chen, Yin Yuan, Sining Zhou, Jiamin Fu, Qi Zhang, Ning Zhang, Yuqi Huang, Yifei Li, Li Yuan, Lijun Chen, Charlie Xiang

“…Our study also potentially presents novel avenues for clinical antifibrotic therapy.…”
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Impact of Climate and Soil on Plant Dynamics and Ecosystem Stability in Argan Orchards by Maryem Telmoudi, Chaima Afi, Naima Chabbi, Said Labbassi, Assma Oumasst, Mohamed Ouknin, Rachid Bouharroud, Abdelaziz Mimouni, Mimoun El Kaoua, Driss Hsissou, Abdelghani Tahiri, Naima Ait Aabd

“…The majority of the plants present in the study area were annual and biennial herbaceous types, exhibiting minimal seasonal stability within the plant communities. …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…Screening tests for cognitive impairment (MMSE) and functional status (ADL, IADL) were performed. BPSD were evaluated with the Neuropsychiatric Inventory (NPI). …”
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Trp31 Residue of Trx-1 Is Essential for Maintaining Antioxidant Activity and Cellular Redox Defense Against Oxidative Stress by Zongmao He, Yi Yan, Xijun Guo, Tong Wang, Xinqiao Liu, Ren-Bo Ding, Yuanfeng Fu, Jiaolin Bao, Xingzhu Qi

“…We found that the content of free thiol groups specifically participating in disulfide bond formation was significantly lower in Trp31 mutant hTrx-1 than in wild-type hTrx-1; that was speculated to affect the formation of disulfide bonds between Cys32 and Cys35 by virtual analysis, thus abolishing the antioxidant activity of hTrx-1 in cleaving oxidized groups and defending against oxidative stress. The present study provided valuable insights towards understanding the importance of Trp31 residue of hTrx-1 in maintaining the correct conformation of the Trx fold structure, the antioxidant functionality of hTrx-1 and the cellular redox defense capability against oxidative stress.…”
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Co-Highly Expressed SLC17A9 and KCNH1 as Potential Prognostic Biomarkers and Therapeutic Targets in Clear Cell Renal Cell Carcinoma by Zongpan Ke, Zhiwang Tang, Deyun Shen, Yixun Liu, Yawei Shu, Xiangyu Mu, Zexuan Li, Ping Xiang, Bing Zhong, Xuechun Hu, Ruoyun Tan, Jun Xiao

“…A comprehensive understanding of the role of SLC17A9 and its associated protein markers presents substantial potential for the advancement of targeted therapeutic interventions. …”
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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Although cancer cells can maintain viability independently of mitochondrial energy metabolism, they remain reliant on mitochondrial functions for the synthesis of new DNA strands. This dependency underscores a potential link between mitochondrial energy metabolism and drug resistance. …”
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Baseline assessments of research capacity, capability and culture in UK local authorities: reflections from evaluators embedded in Health Determinants Research Collaborations by Lauren Bell, Rachel Chapman, Charlotte Ashton, Claire Batey, Jack Brazier, Elizabeth Castle, Arundeep Chaggar, Julian Elston, Faye Esat, Hannah Goldwyn Simpkins, Leonard Ho, Cath Quinn, Jessica Sheringham, Demelza Smeeth, Irene Stylianou, Simon Twite, James Woodall, Beck Taylor

“…Where measured, collaborations were functioning well, with recommendations to enhance communication. …”
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Characterization of the small RNAs carried by outer membrane vesicles produced by hlyF-positive Shiga toxin-producing Escherichia coli by Giorgia Barbieri, Giorgia Barbieri, Alessia Stefano, Agostina Pietrantoni, Federica Fratini, Serena Cavallero, Rosangela Tozzoli, Paola Chiani, Arianna Boni, Stefano Morabito, Valeria Michelacci

“…Our results indicate that OMVs release may exert regulatory functions, putatively influencing the crosstalk with the host and the gut microbiota during the infection process.…”
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Unraveling the in vitro antioxidant and neuroprotective potential of green amalgamated gold nanoparticles from Chang shuo huang ma (Corchorus olitorius (L)): Insights on SK-N-SH ne... by Basheerahmed Abdulaziz Mannasaheb, Ibrahim Ahmed Shaikh, Gurmeet Kaur Surindar Singh, Noordin Othman, Mohammed M. Ghoneim, Hanish Singh Jayasingh Chellammal

“…The FTIR revealed the presence of bioactive functional groups on the surface of CO-AuNP. XRD analysis showed crystalline structure and DLS indicated a particle size of 101.7 nm with moderate stability (-0.3 mV) from zeta potential. …”
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Gut dysbiosis is associated with difficult-to-treat rheumatoid arthritis by Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Arkaitz Mucientes, Arkaitz Mucientes, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Rocío Redondo-Rodriguez, Rocío Redondo-Rodriguez, Laura Cano-García, Laura Cano-García, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…The gut microbiota was analyzed using 16S rRNA gene sequencing; bioinformatics analysis was performed using QIIME2, and its functionality was inferred through PICRUSt. We recorded data on clinical findings, inflammation, and cytokines. …”
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Bone marrow mesenchymal stem cells transport connexin43 via tunneling nanotubes to alleviate isopreterenol-induced myocardial hypertrophy by Jianghui Zhang, Hongfeng Jiang, Sa Liu, Zhong Xian, Limin Zhao, Yue Li, Wenxiu Lu, Changrong Shao, Sanbao Chai

“…TNTs mediate the transmission of multiple signaling molecules, enabling cells to exert different biological functions. In the present study, we investigated the role of TNTs in MSC-based therapy for myocardial hypertrophy. …”
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Molecular Clouds in the Outer Milky Way Disk: Sample, Integrated Properties, and Radial Trends with Galactocentric Radius by Yan Sun, Ji Yang, Qing-Zeng Yan, Shaobo Zhang, Yang Su, Xuepeng Chen, Xin Zhou, Yuehui Ma, Lixia Yuan

“…We present a catalog of 32,162 ^12 CO molecular clouds that covers the northern outer Galactic plane ( l = [15°, 165°] and l = [195°, 230°], and b = [−5.°25, +5.°25]). …”
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Spatially varying parameters improve carbon cycle modeling in the Amazon rainforest with ORCHIDEE r8849 by L. Zhu, L. Zhu, L. Zhu, L. Zhu, P. Ciais, Y. Yao, D. Goll, S. Luyssaert, I. Martínez Cano, A. Fendrich, A. Fendrich, L. Li, H. Yang, S. Saatchi, W. Li, W. Li

“…Current dynamic global vegetation models (DGVMs), which use one or two plant functional types for tropical rainforests, fail to capture observed biomass and mortality gradients in this region, raising concerns about their ability to predict forest responses to global change drivers. …”
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Fate and risks of potentially toxic elements associated with lacustrine groundwater discharge: quantification, modeling, and biogeochemistry by Shen Qu, Juliang Wang, Keyi Zhang, Mengyu Fan, Yuanzhen Zhao, Xu Yang, Zhongli Wang, Helena I. Gomes, Rachel L. Gomes, Limin Duan, Shaogang Dong, Ruihong Yu

“…Thus, self-organizing maps (SOM) and positive matrix factorization (PMF) were employed in present work to decipher source of selected PTE (Li, V, Mn, Cr, Co, Ni, Cu, Zn, Ba, Pb, U, Sr) in Ulansuhai Lake basin (Inner Mongolia, China). …”
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Diagnosis of celiac disease on a gluten-free diet: a multicenter prospective quasi-experimental clinical study by Sara Gómez-Aguililla, Sergio Farrais, Natalia López-Palacios, Beatriz Arau, Carla Senosiain, María Corzo, Nora Fernandez-Jimenez, Ángela Ruiz-Carnicer, Fernando Fernández-Bañares, Bárbara P. González-García, Eva Tristán, Ana Montero-Calle, María Garranzo-Asensio, Isabel Casado, Mar Pujals, Juana María Hernández, Jorge Infante-Menéndez, Garbiñe Roy, Carolina Sousa, Concepción Núñez

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