In-vitro and in-vivo assessment of biocompatibility and efficacy of ostrich eggshell membrane combined with platelet-rich plasma in Achilles tendon regeneration by Omid Koohi-Hosseinabadi, Reza Shahriarirad, Amireza Dehghanian, Laleh Amini, Sajjad Barzegar, Afrooz Daneshparvar, Omid Alavi, Seyedeh-Parvin Khazraei, Saba Hosseini, Ali Arabi Monfared, Roya Khorram, Nader Tanideh, Soheil Ashkani-Esfahani

“…Abstract Tendon injuries present significant medical, social, and economic challenges globally. …”
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Why is Multi-Business Forestry Needed to Overcome the Low Performance of Forestry Governance and Food Security in Indonesia? by Suryanto Suryanto, Dodik Ridho Nurrochmat, Suria Darma Tarigan, Iskandar Zulkarnaen Siregar, Ishak Yassir, Mangarah Silalahi, Irdika Mansur, Rhett D. Harisson, Agus Wahyudi, Lutfy Abdulah

“…The SM Mb-F simulation on two sample concession units produces a projected increase in wood supply, employment, and state revenue, plus the provision of new functions such as food, NTFP, and environmental services. …”
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Diagnosis and treatment of synthetic mid-urethral sling complications by Helen E. O’Connell, Christopher K. Harding, Gaurav Khatri, Phyllis Glanc, Eric Bautrant, Sarah Love-Jones, Karen Ward, Henry H. Yao, Ventia Hoe, Charlotte Korte, Nicolle Germano, Sanjeevan Kalavampara, Sherif Mourad, Hashim Hashim

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Clinical, electromyographic, and biophysical characterization of the rare Nav1.4 channel mutation SCN4A L1436P by François Charles Wang, François Charles Wang, Olivier Bouquiaux, Olivier Bouquiaux, Isabelle Lievens, Bernard Lakaye, Laura Vandries, Margaux Poleur, Samira Abdou Ide, Nurcan Inci, Vincent Seutin

“…IntroductionOur aims were to provide an integrated clinical and biophysical characterization of the rare variant NM_000334.4(SCN4A) c.4307T>C (p.Leu1436Pro; L1436P), affecting the skeletal muscle sodium channel Nav1.4, and to compare its functional consequences with both wild-type (WT) channels and the well-established pathogenic variant p.Arg1448His (R1448H).MethodsWe retrospectively analyzed nine unrelated patients carrying the heterozygous L1436P variant. …”
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Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma by Hyemin Hwang, Jimin Kim, Tae-Hun Kim, Yeonju Han, Dayoung Choi, Sua Cho, Seunghwan Kim, Sanghee Park, Taehyun Park, Filippo Piccinini, Won Jong Rhee, Jae-Chul Pyun, Misu Lee

“…Abstract Background Hepatocellular carcinoma (HCC) stands as the sixth most prevalent cancer globally, presenting a substantial health challenge, particularly due to late-stage diagnoses that limit treatment effectiveness. …”
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Neutrophil Extracellular Trap Formation Suppressed by Ro 106-9920 Enhances Diabetic Wound Healing by Blocking NLRP3 Inflammasome Activation by Hua Li, Lihua Xu, Jingying Chen, Huijuan Huang, Feiteng Liang, Shuxiao Li, Fuda Huang, Junyu Guo

“…However, potential therapeutic agents remain underexplored. Our present study aimed to explore the effects of Ro 106-9920, a specific nuclear factor kappa B (NF-κB) inhibitor, on diabetic wound healing and to elucidate the underlying mechanisms. …”
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Moonlighting activity of threonine synthase in cyanobacterial cell death by Wonjae Kim, Yongjun Son, Yerim Park, Minkyung Kim, Reagan Lee, Keu Eun San Kim, Sung Jae Shin, Woojun Park

“…PyMoL-based structural prediction and in vitro biochemical assays unveiled the moonlighting functions of ThrC in both threonine biosynthesis and deamination. …”
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The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial by Chahrazed Mekadim, Jakub Mrazek, Kateřina Olša Fliegerová, Hana Sechovcová, Tiziana Maria Mahayri, Radka Jarošíková, Jitka Husáková, Veronika Wosková, Petr Tůma, Jan Polák, Dominika Sojáková, Andrea Němcová, Michal Dubský, Vladimíra Fejfarová

“…Predicted pathways like “Transporters”, “ABC transporters” and “Phosphotranspherase system (PTS)” were upregulated in the gut microbiome of patients treated with bolus regime which may lead to increased intestinal barrier permeability. Conclusion The present study reported alterations in gut microbiota composition and functionality and provided the bacterial markers as well as potential metabolic signatures associated with each administration mode in patients with iDFUs, which may be used as a reference set for future studies of the effect of antibiotics administration on the gut microbiome of patients with iDFUs. …”
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A consortium of seven commensal bacteria promotes gut microbiota recovery and strengthens ecological barrier against vancomycin-resistant enterococci by Alan Jan, Perrine Bayle, Nacer Mohellibi, Clara Lemoine, Frédéric Pepke, Fabienne Béguet-Crespel, Isabelle Jouanin, Marie Tremblay-Franco, Béatrice Laroche, Pascale Serror, Lionel Rigottier-Gois

“…Interestingly, five strains belong to species shared among humans and mice, and the other two have human functional equivalents. Conclusions An innovative approach based on mathematical modelling of the microbiota composition permitted to identify a mixture of commensal bacterial strains, which improves the ecological barrier effect against VRE. …”
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Accompanying Therapy in the Surgical Treatment of Pathological Fractures of the Long Bones and Chronic Fractures of the Trochanteric Region by A. A. Antonov, A. К. Antonov, K. A. Antonov, Yu. K. Antonov, R. V. Gorenkov, R. N. Komarov, V. A. Kochemasov, A. F. Lazarev, A. V. Simonova, E. I. Solod, I. A. Talipov

“…The article presents a study of palliative surgical treatment of patients with pathological fractures of the long bones and chronic trochanteric fractures. …”
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Three-Leaf-Clover Thyroid and Minimally Invasive Trans-Cervical Synchronous Thyroidectomy and Ectopic Mediastinal Thyroid Tissue Removal: Does the Age of the Patient Count amid a M... by Claudiu Nistor, Mihai-Lucian Ciobica, Oana-Claudia Sima, Anca-Pati Cucu, Mihai Costachescu, Adrian Ciuche, Lucian-George Eftimie, Dana Terzea, Mara Carsote

“…This innovative surgical procedure offers the advantage of avoiding a sternotomy incision which has clear functional and aesthetic implications, while the video-assisted approach allows optimal visualization of the mediastinal anatomy and safe vascular sealing under visual control, without the risk of a major hemorrhage.…”
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Comparative efficacy and safety of Faricimab with other intravitreal anti-vascular endothelial growth factor in the treatment of Neovascular age related macular degeneration- A Sys... by Renuga Devi Kaliaperumal, Nandhini P, Reena Mohan, Nallamuthu P, Jenifer Florence Mary J

“…Using RevMan 5 software, mean visual, anatomical, and functional outcomes were pooled from the selected studies. …”
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Ecological Concrete-Based Modular System for Heavy Metal Removal in Riparian Transition Zones: Design, Optimization and Performance Evaluation by Guangbing Liu, Da Ke, Hasnain Moavia, Chen Ling, Yanhong Zhang, Yu Shen

“…This study presents the development and evaluation of an innovative modular ecological transition zone system for riparian restoration. …”
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<i>PD-L1</i> and <i>PD-L2</i> gene expression in human glioblastoma cells resistant to chemo- and radiotherapy by A. A. Pinevich, N. L. Vartanyan, L. N. Kiseleva, I. I. Bode, I. Yu. Krutetskaya, A. V. Kartashev, V. E. Makarov, T. E. Poneza, I. V. Smirnov, M. P. Samoilovich

“…Membrane molecules PD-L1 and PD-L2, ligands of T lymphocytes PD1 receptor, perform immunoregulatory functions. Their binding to the receptor leads to inhibition of proliferation, reduction of cytokine production, cytotoxic response, and apoptosis of T lymphocytes. …”
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Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions by Tarikul I. Milon, Titli Sarkar, Titli Sarkar, Yixin Chen, Jordan M. Grider, Feng Chen, Jun-Yuan Ji, Seetharama D. Jois, Konstantin G. Kousoulas, Vijay Raghavan, Wu Xu

“…In some instances, a direct correlation between structures and functions was successfully established.…”
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The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke by Monika Thapa, Jordyn Courville, Reese Leonhard, Prabandh Buchhanolla, Mohammad Abdurrehman Sheikh, Rahul Shah, Prashant Rai, Himanshu Chokhawala, Md Ismail Hossain, Mohammad Alfrad Nobel Bhuiyan, J. Dedrick Jordan, Roger E. Kelley

“…Our results revealed that WBV at high and low shear rates did not impact the functional outcome of mechanical thrombectomy. This result might be affected by the potential limitation of the formula used to derive the given shear rates. …”
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The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…In this study, we formulated a hypothesis suggesting that carvacrol (Car), an aromatic hydrocarbon present in some plant species, might decrease I/R injury by implication of its antioxidant, anti-apoptotic, and anti-inflammatory functions. …”
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Development of in vitro laboratory models of the tumor immune microenvironment to evaluate quality parameters and specific efficacy of the dendritic cell vaccine by T. L. Nekhaeva, A. B. Danilova, E. I. Fedoros, N. A. Efremova, N. V. Emelyanova, M. L. Blokhina, M. N. Yurova, M. L. Tyndyk, I. A. Baldueva

“…Requirements for the quality of personalized autologous DCs, including control of immunophenotypic characteristics were developed, and functional activity of Tlymphocytes during induction of mature vaccine DCs was evaluated. …”
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Lessons learnt in the response to COVID-19 in Mozambique: enabling readiness for the next pandemic by Mariana E. Posse, Grace Njeri Muriithi, Daniel Malik Achala, Elizabeth Naa Adukwei Adote, Chinyere Ojiugo Mbachu, Senait Alemayehu Beshah, Senait Alemayehu Beshah, Chijioke Osinachi Nwosu, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba

“…The risk of another pandemic occurring is ever-present requiring countries to document factors that influenced the response to COVID-19 to guide the response to future pandemics. …”
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Hemorrhage Expansion Rates Before and After Minimally Invasive Surgery for Intracerebral Hemorrhage: Post Hoc Analysis of MISTIE II/III by Wendy C. Ziai, Shervin Badihian, Natalie Ullman, Carol B. Thompson, Meghan Hildreth, Pirouz Piran, Nataly Montano, Paul Vespa, Neil Martin, Mario Zuccarello, Steven W. Mayo, Issam Awad, Daniel F. Hanley

“…Postsurgical ICH expansion occurred in 24 patients (6.9%) and was associated with delay in achieving stability, number of alteplase doses, and fewer CT hypodensities on diagnostic CT but not with functional outcome. Conclusion In patients with a large ICH eligible for surgical evacuation, about two thirds of HE events stabilize within 12 hours and most within 24 hours. …”
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