Clinical effectiveness and cost-effectiveness of the rehabilitation enablement in chronic heart failure facilitated self-care rehabilitation intervention for people with heart fail... by John G F Cleland, Kate Jolly, Christi Deaton, Louise Taylor, Rod S Taylor, Aynsley Cowie, Alex McConnachie, Julia Frost, Colin Greaves, Chim C Lang, Emma McIntosh, Valerie Smith, Samantha van Beurden, Patrick J Doherty, Hasnain M Dalal, Tracy Ibbotson, Melvyn Hillsdon, Anna Placzek, Jessica C Bollen, Iain Squire, Emma Burrell, Nick Hartshorne-Evans, Elizabeth A Thomson, Claire O’Hare, Katie Dudman, Heather Fraser, Mohammad Jarallah

“…Introduction Heart failure with preserved ejection fraction (HFpEF) is common and causes functional limitation, poor health-related quality of life (HRQoL) and impairs prognosis. …”
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In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling by Yu Tian, Xin Bao, Shan Lei, Youcai Huang, Xiaoling Wang, Yanyang Tu, Qinglian He, Feixiang Zhang, Haicheng Xu, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Zhirui Zeng

“…However, its clinical efficacy is limited due to drug resistance, resulting in modest improvements in patient survival. Hence, the present study has been designed to identify critical molecular targets associated with sorafenib resistance and investigate the potential inhibitors in overcoming this therapeutic challenge. …”
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The 3′ region of the ZPA regulatory sequence (ZRS) is required for activity and contains a critical E-box by Kathryn F. Ball, Kathryn F. Ball, Stephen Manu, Abbie K. Underhill, Jeanyoung Kim, Jessica C. Britton, Sarah R. Rudd, Madison M. Malone, Japhet Amoah, Allen Cooper, Charmaine Pira, Kerby C. Oberg

“…In addition, two Hoxd13 sites are present in the 5′ and central subdomains. Hand2 purportedly binds the ZRS through the central E-box, and both Hand2 and Hoxd13 have been shown to activate the ZRS in vitro. …”
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Reducing greenhouse gas emissions via harvest residue management in eucalyptus afforestation on Brazilian sandy soils by Jackson Freitas Brilhante de São José, Bruno Britto Lisboa, Frederico Costa Beber Vieira, Josiléia Acordi Zanatta, Elias Frank Araujo, Juscilaine Gomes Martins, Andressa Classer Bender, Eduardo Carniel, Cimelio Bayer, Luciano Kayser Vargas

“…The soil consistently functioned as a methane sink across all management systems, with CH4 fluxes ranging from –2.56 to –3.91 kg C-CH4 ha−1 year−1. …”
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TEIPP-vaccination in checkpoint-resistant non-small cell lung cancer: a first-in-human phase I/II dose-escalation study by Mitchell Emmers, Marij J. P. Welters, Michelle V. Dietz, Saskia J. Santegoets, Sanne Boekesteijn, Anouk Stolk, Nikki M. Loof, Daphne W. Dumoulin, Annemarie L. Geel, Lauri C. Steinbusch, A. Rob P. M. Valentijn, Danielle Cohen, Noel F. C. C. de Miranda, Egbert F. Smit, Hans Gelderblom, Thorbald van Hall, Joachim G. Aerts, Sjoerd H. van der Burg

“…Abstract Functional loss of the intracellular peptide Transporter associated with Antigen Processing (TAP) fosters resistance to T-cell based immunotherapy. …”
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Tumor suppressor SLC9A2 inhibits colorectal cancer metastasis and reverses immunotherapy resistance by suppressing angiogenesis by Zizhen Zhang, Shengde Liu, Ting Xu, Nan Chen, Cheng Liu, Hong Yang, Yuanmeng Shi, Zhiwei Li, Xujiao Feng, Yanhong Yao, Xiaorui Duan, Gehan Xu, Cheng Zhang, Zhenghang Wang, Jian Li, Lin Shen

“…Abstract Background Colorectal cancer (CRC) is a common and aggressive malignancy that frequently metastasizes to the liver, presenting significant therapeutic challenges. Despite its clinical importance, the mechanisms underlying CRC liver metastasis and resistance to immune therapy remain poorly understood. …”
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Computational modeling of superparamagnetic nanoparticle-based (affinity) diagnostics by Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Antoine A. Ruzette, Vlad Tereshenko, Haïzam Oubari, Haïzam Oubari, Haïzam Oubari, Yanis Berkane, Yanis Berkane, Jonathan Cornacchini, Jonathan Cornacchini, Filip Thiessen EF, Filip Thiessen EF, Filip Thiessen EF, Filip Thiessen EF, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Korkut Uygun, Korkut Uygun, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch

“…Superparamagnetic IONPs, which exhibit magnetization only in the presence of an external field, can be functionalized with ligands for targeted affinity diagnostics. …”
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Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24 by Yu Liu, Xiaoli Zhang, Kun Chen, Hongying Wang, Junhu Yuan, Yiming Ma, Jianhui Ma, Fanyu Zhang, Bing-zhi Wang, Yinong Wang, Xinhua Zhao

“…Furthermore, PAR2 blockade combined with an anti-EGFR antibody (cetuximab (CTX)) synergistically enhanced the phagocytic ability of macrophages and suppressed liver metastasis in vivo.Conclusions NET-derived elastase inactivated PAR2 canonical signaling and promoted phagocytosis by downregulating CD24, which functions as a phagocytotic checkpoint in CRC liver metastasis. …”
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Faecalibacterium prausnitzii enhances intestinal IgA response by host-microbe derived inecalcitol in colitis by Wenfei Qin, Nuoming Yin, Binqiang Xu, Qixiang Mei, Yang Fu, Junjie Fan, Yingying Lu, Guangqiang Wang, Lianzhong Ai, Zhanjun Lu, Yue Zeng, Chunlan Huang

“…Results F. prausnitzii markedly ameliorated colitis by alleviating intestinal inflammation and barrier dysfunction, with significantly decreased abundance of pro-inflammatory taxa (Enterococcus, Desulfovibrio, Escherichia-Shigella, and Enterorhabdus) and increased abundance of Lachnospiraceae NK4A136_group. Functions related to intestinal immune network for IgA production pathway were up-regulated shown by transcriptomics and KEGG pathway analysis. …”
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FI-Lab predicts all-cause mortality, but not successful rehabilitation, among patients aged 65 and older after hip or pelvic fracture by Evgeniya Zikrin, Evgeniya Zikrin, Abdu El Karim Hilali, Abdu El Karim Hilali, David Shacham, David Shacham, Reut Frenkel, Reut Frenkel, Olga Abel, Olga Abel, Muhammad Abo Abed, Muhammad Abo Abed, Ahmed Abu-Ajaj, Ahmed Abu-Ajaj, Natalia Velikiy, Natalia Velikiy, Tamar Freud, Tamar Freud, Tamar Freud, Yan Press, Yan Press, Yan Press, Yan Press, Yan Press, Yan Press

“…PurposeOver the past decade, the Frailty Index based on Laboratory data (FI-Lab index) has been effective in predicting complications during hospitalization, length of hospital stay, changes in functional status, and even mortality. The aims of the present study were to examine the associations between FI-Lab, rehabilitation outcomes, and mortality following hip and pelvic fractures.MethodsA retrospective study of patients 65 years of age and above who underwent rehabilitation after hip or pelvic fracture in the Geriatric Department, between January 2018 and December 2024. …”
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Mobile genetic elements mediating antimicrobial resistance drive the evolutionary process of Clostridioides difficile ST37/RT017 by Tao Lv, Xiajing Bi, Lisi Zheng, Yuhong Zhao, Yizheng Zhou, Tao Wu, Ping Shen, Danhua Zhu, Shiyao Chen, Yunbo Chen

“…Furthermore, other functional genes, especially srtB, were notable in C. difficile ST37/RT017, which gradually acquired resistance genes from VL I to VL II and VL III. …”
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Pulmonary arterial hypertension: Navigating the pathways of progress in diagnosis, treatment, and patient care by Miguel Azaredo Raposo, Daniel Inácio Cazeiro, Tatiana Guimarães, Nuno Lousada, Céline Freitas, Joana Brito, Susana Martins, Catarina Resende, Peter Dorfmüller, Rita Luís, Susana Moreira, Pedro Alves da Silva, Luís Moita, Mário Oliveira, Fausto J. Pinto, Rui Plácido

“…If left untreated, this progressive disease presents with symptoms of incapacitating fatigue causing marked loss of quality of life, eventually culminating in right ventricular failure and death. …”
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Candidate Phyla Radiation (CPR) bacteria from hyperalkaline ecosystems provide novel insight into their symbiotic lifestyle and ecological implications by Yu He, Shiyan Zhuo, Meng Li, Jie Pan, Yongguang Jiang, Yidan Hu, Robert A. Sanford, Qin Lin, Weimin Sun, Na Wei, Shuming Peng, Zhou Jiang, Shuyi Li, Yongzhe Li, Yiran Dong, Liang Shi

“…Additionally, two presumed auxotrophic hosts, incapable of forming tetrahydrofolate (THF) due to the absence of folA, were identified as potential hosts for some CPR bacteria harboring folA genes. The functionality of these CPR-derived folA genes was experimentally verified by heterologous expression in the folA-deletion mutant Escherichia coli MG1655 ΔfolA. …”
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The prevalence, patterns, and antifungal drug resistance of bloodstream infection-causing fungi in Sichuan Province, China (2019–2023): a retrospective observational study using na... by Jin Deng, Jin Deng, Jin Deng, Ya Liu, Ya Liu, Ya Liu, Ling Shu, Ling Shu, Ling Shu, Dan Zhou, Dan Zhou, Dan Zhou, Yi Xie, Yi Xie, Yi Xie, Ying Ma, Ying Ma, Ying Ma, Mei Kang, Mei Kang, Mei Kang

“…BackgroundThe rising global burden of invasive fungal infections and the growing issue of antifungal resistance present critical public health threats. By using multicenter surveillance data from Sichuan Province, we conducted the largest five-year study on fungemia to date. …”
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Artificial Intelligence in Medical Care – Patients' Perceptions on Caregiving Relationships and Ethics: A Qualitative Study by Jana Gundlack, Sarah Negash, Carolin Thiel, Charlotte Buch, Jan Schildmann, Susanne Unverzagt, Rafael Mikolajczyk, Thomas Frese, PEAK consortium

“…Perceived main advantages of AI were its efficient and flawless functioning, its ability to process and provide large data volume, and increased patient safety. …”
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Flavonoids as Potential Modulators of Pancreatic Lipase Catalytic Activity by Sílvia Rocha, Carina Proença, Alberto N. Araújo, Marisa Freitas, Ismael Rufino, Natália Aniceto, Artur M. S. Silva, Félix Carvalho, Rita C. Guedes, Eduarda Fernandes

“…Pancreatic lipase (PL), the enzyme primarily responsible for the absorption of dietary lipids, presents a potential target for obesity management. …”
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Phenome-wide association studies between SERINC2 and neuropsychiatric disorders by Ping Liu, Xinqun Luo, Liping Cao, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Xinghua Pan, Ruilan Yang, Zewen Tan, Yunlong Tan, Chiang-shan Li, Xiaoyun Guo, Zhiren Wang, Xingguang Luo, Xingguang Luo

“…ObjectivesSERINC2 has been associated with alcoholism, bipolar disorder and autism, but the comparability and specificity issues of the findings remain unaddressed. The present study aimed to comprehensively analyze various neuropsychiatric disorders pinpoint the most reliable conditions predisposed by SERINC2.MethodsA total of 2,187 imputed SNPs across SERINC2 were examined in 1,167,439 subjects from 72 independent cohorts with 18 different neuropsychiatric disorders. …”
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Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease by Angelika Hettenbach, Tanja Elger, Muriel Huss, Gerhard Liebisch, Marcus Höring, Johanna Loibl, Arne Kandulski, Martina Müller, Hauke Christian Tews, Christa Buechler

“…The present study measured the serum levels of PCSK9, FC, and 15 CE species in IBD patients, focusing on the associations of these molecules with sex, each other, and with disease severity. …”
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Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges by Saeid Safiri, Saeid Safiri, Amir Ghaffari Jolfayi, Asra Fazlollahi, Soroush Morsali, Soroush Morsali, Aila Sarkesh, Amin Daei Sorkhabi, Behnam Golabi, Reza Aletaha, Kimia Motlagh Asghari, Sana Hamidi, Sana Hamidi, Seyed Ehsan Mousavi, Sepehr Jamalkhani, Nahid Karamzad, Nahid Karamzad, Ali Shamekh, Reza Mohammadinasab, Mark J. M. Sullman, Mark J. M. Sullman, Fikrettin Şahin, Ali-Asghar Kolahi

“…These pathological changes lead to widespread neuronal damage, significantly impacting daily functioning and quality of life.ObjectiveThis comprehensive review aims to explore various aspects of Alzheimer's disease, including its epidemiology, risk factors, clinical presentation, diagnostic advancements, management strategies, caregiving challenges, and emerging therapeutic interventions.MethodsA systematic literature review was conducted across multiple electronic databases, including PubMed, MEDLINE, Cochrane Library, and Scopus, from their inception to May 2024. …”
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Can routinely collected primary healthcare data be used to assess Aboriginal children's health and wellbeing longitudinally? A retrospective analysis of electronic medical records... by Catherine Lloyd-Johnsen, John Boffa, Vahab Baghbanian, Rachel Walpole, Shuaijun Guo, Sandra Eades, Anita D'Aprano, Sharon Goldfeld

“…However, crucial data on risk factors, maternal health, and family functioning were either not collected by the service, not provided to the service from external sources, or stored in inaccessible free-text fields. …”
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