Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma by Lin Shi, Lin Shi, Lin Shi, Lin Shi, Dongqi Yuan, Dongqi Yuan, Dongqi Yuan, Fuyi Zhu, Yuchao He, Yuchao He, Ran Zuo, Ran Zuo, Liwei Chen, Liwei Chen, Yi Luo, Yi Luo, Yu Wang, Yu Wang, Dingzhi Huang, Dingzhi Huang, Peng Chen, Peng Chen, Hua Guo, Hua Guo

“…Finally, the biological functions of the key gene were examined by in vitro and in vivo experiments.ResultsThe score model was used to divide patients with MPM into low- and high-risk groups. …”
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Genetically-engineered Salmonella typhimurium expressing FGF21 promotes neurological recovery in ischemic stroke via FGFR1/AMPK/mTOR pathway by Dongchen Xu, Min Wen, Bingwa Lebohang Anesu, Xijun Chen, Yuhao Chen, Wenqi Qian, Chenguang Yang, Jin Hai Zheng, Yinan Zhou, Haoqi Ni, Kunlin Jin, Qichuan Zhuge, Su Yang

“…Results S.t-ΔpGFGF21 selectively colonized peri-infarct regions and secreted functional FGF21, reducing neurologic deficits (48%) and infarct volume (46%) versus controls (p < 0.01). …”
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Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model by David Boll, Simon Reiss, Heidi R. Cristina Schmitz, Christian Weber, Julien Thielmann, Felix Spreter, Kian Tadjalli Mehr, Diana Chiang, Markus Jäckel, Lukas Heger, Jonathan Rilinger, Dirk Westermann, Constantin von zur Mühlen, Timo Heidt, Michael Bock, Alexander Maier

“…CMR was performed at a clinical 3 T system including functional imaging, T1 and T2 mapping and late gadolinium enhancement (LGE) 2–5 h or three days post-reperfusion. …”
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Needs assessment for a decision support tool in oral cancer requiring major resection and reconstruction: a mixed-methods study protocol by David Goldstein, John R de Almeida, Rosemary Martino, Douglas B Chepeha, David Forner, Paul Hong, Martin Corsten, Valeria E Rac, Andrew G Shuman, Anna M Sawka, Jonathan C Irish, Dale H Brown, S Mark Taylor, Patrick J Gullane, Jonathan R Trites, Ralph Gilbert, Matthew H Rigby, Jolie Ringash

“…Given the potential for suboptimal oncological and functional outcomes in this vulnerable patient population, promotion and performance of shared decision making (SDM) is crucial.Decision aids (DAs) are useful instruments for facilitating the SDM process by presenting patients with up-to-date evidence regarding risks, benefits and the possible postoperative course. …”
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Orchard variable-rate spraying method integrating GNSS and wind-excited audio-conducted leaf area density by Hangxing Zhao, Hangxing Zhao, Hangxing Zhao, Shenghui Yang, Shenghui Yang, Shenghui Yang, Wenwei Li, Wenwei Li, Han Feng, Han Feng, Shijie Jiang, Shijie Jiang, Weihong Liu, Weihong Liu, Jingbin Li, Yongjun Zheng, Yongjun Zheng, Songchao Zhang

“…As a result, few fully functional variable-rate spraying systems have been developed based on this parameter.MethodsThis study presents a variable-rate spraying method that integrates global navigation satellite system (GNSS) positioning with wind-excited audio-conducted estimation of canopy leaf area density. …”
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Comorbidity Burden in Chronic Thromboembolic Pulmonary Hypertension: Implications and Outcome by Burcak Kilickiran Avci, Ibrahim Basarici, Mehmet Akbulut, Halil Atas, Yalin Tolga Yaylali, Umit Yasar Sinan, Ersan Atahan, Murat Meric, Baris Kaya, Kardelen Ohtaroglu Tokdil, Ozden Calay, Hasan Tokdil, Bulent Mutlu, Mehmet Serdar Kucukoglu, Zeki Ongen

“…<i>Conclusions</i>: A high comorbidity burden is common in CTEPH and influences functional status, hemodynamics, and operability decisions. …”
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A GWAS of angiotensin-converting enzyme inhibitor-induced angioedema in a South African population by Jacquiline W. Mugo, PhD, Cascia Day, Cert Allergy (Phys), Ananyo Choudhury, PhD, Maria Deetlefs, Dip Allergy (SA), Robert Freercks, MPhil, Sian Geraty, MMed, Angelica Panieri, MBChB, Christian Cotchobos, MBChB, Melissa Ribeiro, MBChB, Adelein Engelbrecht, MMed, Lisa K. Micklesfield, PhD, Michèle Ramsay, PhD, Sarah Pedretti, PhD, Jonny Peter, PhD

“…Further increased sampling across the continent and matched functional work are needed to confirm the importance of genetic variation in understanding the biology of AE-ACEI.…”
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Progressive resistance training in young people with Prader-Willi syndrome: protocol for a randomised trial (PRESTO) by Kim L Bennell, Nicholas F Taylor, Nora Shields, David Levitt, Jennifer J Watts, Luke Prendergast, Joseph Proietto, Lauren J Rice, Zoë McCallum, Alesha Southby, Tania Markovic, Christine Bigby, Cara Schofield, Georgina Loughnan, Janet Franklin, Viral Chikani, Susan Blair

“…Secondary outcomes are muscle mass, functional strength, physical activity, community participation, health-related quality of life and behaviour. …”
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Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo by Xiaowen Yang, Yiting Zhan, Yifei Li, Yifei Li, Xinzhuang Shen, Xinzhuang Shen, Yuqiu Ma, Zongjun Liu, Zongjun Liu, Yipeng Liu, Chengjin Liang, Xiaoyuan Zhang, Yehao Yan, Wenzhi Shen

“…PurposeThe global incidence and mortality rates associated with cancer are increasing annually, presenting significant challenges in oncology, particularly regarding the efficacy and toxicity of antineoplastic agents. …”
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A strain of Lactobacillus plantarum from piglet intestines enhances the anti-PoRV effect via the STING-IFN-I pathway by Anqi Sun, Xin Shan, Ruihan Liu, Zhengxu Tang, Jingshu Huang, Shihan Zhang, Lihong Bian, Yumeng Shi, Zixuan Liu, Jingtao Hu, Chunfeng Wang

“…Lactobacillus plantarum, a ubiquitous probiotic in natural ecosystems, has demonstrated multifaceted biological functions. The stimulator of the interferon gene (STING) is involved in type I interferon (IFN-I) mediated host antiviral innate immunity, which is a pivotal adaptor in response to the microbial DNA/RNA-activated signaling pathways. …”
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HpFBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya by Xiaowei Cai, Ling Xiao, Xiangmei Nie, Qiandong Hou, Sulin Wen, Kun Yang, Xiaopeng Wen

“…Previously, FLOWERING BHLHs (FBHs) have been identified as positive regulators of flower formation. In the present work, a total of eight FBHs were identified in pitaya. …”
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The Coral Reefs and Fishes of St. Brandon, Indian Ocean Archipelago: Implications for Sustainable Fisheries by Melanie Ricot, Sruti Jeetun, Shakeel Yavan Jogee, Deepeeka Kaullysing, Nawsheen Taleb-Hossenkhan, Maina Joseph Mbui, Beatriz Estela Casareto, Yoshimi Suzuki, Diah Permata Wijayanti, Ranjeet Bhagooli

“…This study presents the first report on fish biomass surveys in St. …”
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Isolation and molecular characterization of the FLOWERING LOCUS C gene promoter sequence in radish (Raphanus sativus L.) by Yuan-yuan XU, Jing WANG, Shan-shan NIE, Dan-qiong HUANG, Yan WANG, Liang XU, Rong-hua WANG, Xiao-bo LUO, Li-wang LIU

“…FLOWERING LOCUS C (FLC) plays a key role in plant flowering by functioning as a repressor. Two genomic DNA sequences, a 3 046-bp from an early- and a 2 959-bp from a late-bolting radish line were isolated and named as RsFLC1 and RsFLC2, respectively, for they share approximately 87.03% sequence identity to the FLC cDNA sequences. …”
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Virtual reality solution to promote adapted physical activity in older adults: outcomes from VR2Care project exploratory study by Vincenzo De Luca, Malak Qbilat, Alessandra Cuomo, Antonio Bianco, Francesca Cesaroni, Chiara Lanari, Ad van Berlo, Telma Mota, Lucia Pannese, Michael Brandstötter, Matthieu Arendse, Vania Mota, Willeke van Staalduinen, Hugo Paredes, Guido Iaccarino, Guido Iaccarino, Maddalena Illario

“…Virtual reality (VR) and serious games (SG) are promising tools to improve physical and cognitive functioning. As part of the VR2Care project activities, four pilot sites explored the capabilities of the VR environment in a remote psychomotor training with SG and a hybrid approach with local groups of older adults performing physical activity.ObjectiveThe present study aimed to explore and measure the impact on older adults’ quality of life and physical activity of using VR2Care solution and the level of usability, satisfaction and acceptance.MethodsThe study is a mixed method study, using qualitative and quantitative surveys to evaluate quality of life and physical activity of older users, and usability, satisfaction and acceptance of the solution. …”
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AVATAR Virtual Reality Social therapy (AVATAR_VRSocial) for distressing voices and their interference in social everyday life in early psychosis: protocol of a single-blind paralle... by Tom K J Craig, Silvia Schneider, Philippa Garety, Thomas Ward, Mar Rus-Calafell, Melina Luker, Maren Marzinzik, Phuong-Mi Nguyen, Tobias Teismann, Nils Ehrbar, Ekincan Tas, Xiao Chi Zhang, Clementine Edwards, Mark Huckvale

“…Introduction Around 70% of people with psychosis experience auditory verbal hallucinations (AVHs), which can cause distress and impair the social functioning of the individual. AVATAR therapy works by facilitating a ‘face-to-face’ dialogue between the person and a digital representation (avatar) of their persecutory voice. …”
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Phytochemical analysis, antioxidant, anti-inflammatory and enzyme inhibitory activities of bean pear (Pyrus calleryana fruit) by Huan Zhao, Huan Zhao, Qinqin Wang, Lanlan Yang, Lanlan Yang, Yuanquan Ran, Qiong Hu, Yi Hong, Minyi Tian, Minyi Tian, Minyi Tian

“…Thus, P. calleryana fruit has great potential for application in functional food products.…”
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Parameter Estimation Precision with Geocentric Gravitational Wave Interferometers: Monochromatic Signals by Manoel Felipe Sousa, Tabata Aira Ferreira, Massimo Tinto

“…We present a Fisher information matrix study of the parameter estimation precision achievable by a class of future space-based, “mid-band”, gravitational wave interferometers observing monochromatic signals. …”
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TECHNOLOGY-ASSISTED TEACHING ACTIVITIES IN AN ESAP CONTEXT: AN ECOLOGICAL PERSPECTIVE by Adina-Maria MEZEI

“… Technology-Assisted Teaching Activities in an ESAP Context: An Ecological Perspective. The present article focuses on the design of various technology-assisted teaching activities as part of a practical English for Specific Academic Purposes (ESAP) course addressed to undergraduate students in Biology and Geology, Babeș-Bolyai University. …”
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Quantitative imaging datasets of surface micro- to mesoplankton communities and microplastic across the Pacific and North Atlantic oceans from the Tara Pacific expedition by Z. Mériguet, G. Bourdin, N. Kristan, L. Jalabert, O. Bun, M. Picheral, L. Caray-Counil, J. Maury, M.-L. Pedrotti, A. Elineau, D. A. Paz-Garcia, L. Karp-Boss, G. Gorsky, F. Lombard

“…<p>This paper presents the quantitative imaging datasets collected during the Tara Pacific expedition (2016–2018) carried out on the schooner <i>Tara</i>. …”
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Identification and expression characterization of apple β-tubulin gene family in apple by HUANG Huiling, WANG Yanxiang, WANG Yue, NING Qinqin, LI Ming, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, JIAO Jian, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo

“…However, little is known about apple tubulin family genes and their potential functions. Therefore, the present study was to identify the apple β-tubulin family genes and to determine the candidate β-tubulin genes involved in regulating apple dwarfing. …”
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