Genetic variations in the IDUA gene in Tunisian MPS I families: Identification of a novel microdeletion disrupting substrate binding and structural insights by Mariem Rebai, Yessine Amri, Chaima Sahli, Hajer Foddha, Taieb Messaoud, Hela Boudabous, Hassen Ben Abdennebi, Salima Ferchichi, Latifa Chkioua

“…Background: Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder caused by a deficiency in alpha-L-iduronidase (IDUA), leading to the accumulation of glycosaminoglycans. MPS I presents with a broad spectrum of clinical phenotypes, ranging from severe to mild. …”
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Role of Obstructive Sleep Apnoea in Sensorineural Hearing Loss: A Cross-sectional Study by J Shanmugh, RB Namasivaya Navin, K Gowthame, S Prabakaran, D Balaji, R Muthukumar, S Rajasekaran

“…Aim: To assess hearing functions in patients with OSAS, aiming to elucidate the relationship between the disorder and sensorineural hearing loss. …”
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The basal cisternostomy for management of severe traumatic brain injury: A retrospective study by Tangrui Han, Zhiqiang Jia, Xiaokai Zhang, Hao Wu, Qiang Li, Shiqi Cheng, Yan Zhang, Yonghong Wang

“…Inclusion criterias were patients between the ages of 18 and 70 years who met the diagnostic criteria for severe TBI at first presentation and who underwent surgical intervention. …”
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Adopting drone technology for blood delivery: a feasibility study to evaluate its efficiency and sustainability by Pammi Gauba, Anita Nangia, Shalini Bahadur, Sangeeta Pahuja, Shweta Dang, Rambha Pathak, Kiran Agarwal, Sunita Sharma, Deepti Ambalkar, Manoj Jha, Ranju Singh, Priyanka Virdi, Rakesh Gupta, Shambhavee Singh, Ravindra Pandey, Bhuvan Adhlakha, Pragati Agarwal, Kuldeep Nigam, Sumit Aggarwal

“…Moreover, the logistical challenges associated with blood product transport are substantial and maintaining the cold chain throughout the supply route is crucial to sustain their functional integrity as the temperature fluctuations can compromise its oxygen-carrying capacity. …”
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Disturbance intensity drives structural, compositional and diversity attributes in tropical dry forests of Central India by Satendra Kumar Rathaude, Shairq Irtiqa, P.P. Abdul Rahim, Zishan Ahmad Wani, Subashree Kothandaraman, Javid Ahmad Dar

“…Disturbance intensity plays an important role in influencing the structural and functional dynamics of ecosystems. The present study was undertaken in the tropical dry deciduous forests of Central India under varying disturbance intensities to understand their influence on structure, diversity and compositional attributes. …”
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High-entropy diboride: A novel high-temperature self-lubricating ceramic with enhanced mechanical and tribological properties by Jicheng Li, Yunfeng Su, Shuna Chen, Hengzhong Fan, Xiande Zheng, Qiuan Sun, Junjie Song, Litian Hu, Yongsheng Zhang

“…Benefiting from the excellent high-temperature mechanical and lubrication potential of novel high-entropy borides, the present work innovatively proposed a strategy of using high-entropy ceramic components to provide lubrication functions and successfully designed and prepared a novel high-entropy (Ti0.2V0.2Nb0.2Ta0.2Mo0.2)B2 system based on the tribological element design principles. …”
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Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2 by Vineetha Shaji, Vineetha Shaji, Ahmad Rafi, Mukhtar Ahmed, Athira Perunelly Gopalakrishnan, Athira Perunelly Gopalakrishnan, Sowmya Soman, Amjesh Revikumar, Ganesh Prasad, Abhithaj Jayanandan, Rajesh Raju

“…IntroductionViruses exploit host kinases to phosphorylate their proteins, enabling viral replication and interference with host-cell functions. Understanding phosphorylation in SARS-CoV-2 proteins necessitates identifying viral phosphoproteins, their phosphosites, and the host kinase–viral protein interactions critical for evading host antiviral responses.MethodsEmploying the protein kinase substrate sequence-preference motifs derived by Poll B G. et. al., 2024, we performed kinase-substrate phosphomotif pattern analysis on the SARS-CoV-2 proteome. …”
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Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adult Ascaris excretory/secretory antigens in pigs by Zaneta D. Musimbi, Alexandra Laubschat, Larissa Oser, Robert M. Mugo, Benjamin-Florian Hempel, Philipp Höfler, Josephine Schlosser-Brandenburg, Josephine Schlosser-Brandenburg, Ankur Midha, Sebastian Rausch, Susanne Hartmann

“…We further point out distinct mucosal/systemic IgA responses in Ascaris infection which deserve further functional investigations.…”
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Genetically Engineered Bacterial Ghosts as Vaccine Candidates Against <i>Klebsiella pneumoniae</i> Infection by Svetlana V. Dentovskaya, Anastasia S. Vagaiskaya, Alexandra S. Trunyakova, Alena S. Kartseva, Tatiana A. Ivashchenko, Vladimir N. Gerasimov, Mikhail E. Platonov, Victoria V. Firstova, Andrey P. Anisimov

“…<b>Conclusions:</b> Therefore, this study presents novel perspectives for future research on <i>K. pneumoniae</i> ghost vaccines.…”
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Assessment of Pain, Diet, and Analgesic Use in Orthodontic Patients: An Observational Study by Bianca Maria Negruțiu, Claudia Elena Staniș, Ligia Luminița Vaida, Abel Emanuel Moca, Cristina Paula Costea, Raluca Iurcov, Alexandru Nicolae Pîrvan, Marius Rus

“…<i>Background/Objectives</i>: Orthodontic treatment offers significant functional and aesthetic benefits, but it often causes discomfort, impacting patients’ daily activities, including diet and medication use. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…This research works to establish the convective heat transfer coefficient (CHTC) of new improved ternary hybrid functionalized nanofluids with CuO, Fe2O3, and SiO2 nanoparticles in polymeric fluid. …”
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A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma by Wenjiao Tang, Yan Li, Zhongqing Zou, Jian Cui, Fangfang Wang, Yuhuan Zheng, Li Hou, Ling Pan, Bing Xiang, Hong Chang, Li Zhang, Ting Niu

“…Abstract Objective Despite the availability of new agents, elderly patients with multiple myeloma (MM) usually present with poor outcomes due to the heterogeneity of disease conditions, especially immune deficiency. …”
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Novel Lung Cell-Penetrating Peptide Targets Alveolar Epithelial Type II Cells, Basal Cells, and Ionocytes by Jin Wen, Gajalakshmi Singuru, Jeffrey Stiltner, Sanjay Mishra, Kyle S. Feldman, Kayla McCandless, Raymond Yurko, Kazi Islam, Ray Frizzell, Hisato Yagi, Jonathan M. Brown, Maliha Zahid

“…<b>Background:</b> Cell-penetrating peptides cross cell membrane barriers while carrying cargoes in a functional form. Our work identified two novel lung-targeting peptides, S7A and R11A. …”
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Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells by You Li, Ankit Gupta, Brian N. Papas, David Aponte-Diaz, Jayden M. Harris, Ichiro Misumi, Jason K. Whitmire, Craig E. Cameron, Marcos Morgan, Stanley M. Lemon

“…However, transfecting exogenous hsRNA into TENT4-depleted cells failed to rescue HAV replication, leaving the functional role of hsRNA unresolved. These findings reveal a novel picornaviral subgenomic RNA species while highlighting mechanistic differences in the manner in which HAV and HBV exploit the host ZCCHC4-TENT4 complex for their replication.…”
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Evaluation of anti-vibriocidal, antioxidant properties and cytotoxicity of bio fabricated/green synthesized silver nanoparticles using Euphorbia hitra L. leaf extract by Abhinash Marukurti, Alavala Matta Reddy, Silpa Rani Medapalli, Phanindra Babu Kasi, P. Tirupathi Rao, Rohini Anupoju, D. Ramachandran, B. Mallikarjuna, Kommoju Sarojani, Pangi Vijaya Nirmala

“…The obtained gAgNPs were subjected to evaluate the physico-chemical properties such as Surface Plasmon Resonance (SPR), functional groups, and crystalline structure, were verified by UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and X-ray diffraction (XRD). …”
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Endoplasmic Reticulum-Targeted Phototherapy Remodels the Tumor Immunopeptidome to Enhance Immunogenic Cell Death and Adaptive Anti-Tumor Immunity by Weidong Xiao, Mingquan Gao, Banghui Mo, Xie Huang, Zaizhi Du, Shufeng Wang, Jianhong Chen, Shenglin Luo, Haiyan Xing

“…Immunopeptidomics profiling was used to identify high-affinity major histocompatibility complex class I (MHC-I) ligands. In vitro functional studies were conducted to evaluate dendritic cell maturation and T lymphocyte activation, while in vivo experiments were performed by combining the identified peptide with poly IC to evaluate anti-tumor immunity. …”
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Supramolecular Co-Assembled Fmoc-FRGDF/Hyaluronic Acid Hydrogel for Quercetin Delivery: Multifunctional Bioactive Platform by Xian-Ni Su, Yu-Yang Wang, Muhammed Fahad Khan, Li-Na Zhu, Zhong-Liang Chen, Zhuo Wang, Bing-Bing Song, Qiao-Li Zhao, Sai-Yi Zhong, Rui Li

“…<b>Background:</b> During food processing and storage, traditional protein-based delivery systems encounter significant challenges in maintaining the structural and functional integrity of bioactive compounds, primarily due to their temporal instability. …”
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Nano-Bacillus amyloliquefaciens as a dietary intervention in nile tilapia (Oreochromis niloticus): Effects on resistance to Aeromonas hydrophila challenge, immune-antioxidant respo... by Mohammed E. Hassanin, Abdelhakeem El-Murr, Amr R. EL-Khattib, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Mohamed M.M. Metwally, Sameh H. Ismail, Simon J. Davies, Afaf N. Abdel Rahman, Rowida E. Ibrahim

“…The investigation included the impact on the growth, digestive functions, immune-antioxidant indices, and resistance to Aeromonas hydrophila challenge. …”
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Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats by Hui Guan, Wenyuan Zhang, Hui Liu, Yang Jiang, Feng Li, Dan Wang, Yang Liu, Fatao He, Maoyu Wu, Geoffrey Ivan Neil Waterhouse, Dongxiao Sun-Waterhouse, Dapeng Li

“…Quercetin and catechin are flavonoid antioxidants present in plant foods and possess chemopreventive and chemotherapeutic activities. …”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…ABSTRACT Honeybees (Apis mellifera), as social insects, exhibit complex social behaviors and cognitive functions. The short lifespan and stable gut microorganisms of honeybees provide certain availability as a rapid and high-flux animal model for aging research. …”
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