Synthesis, crystal structure, DFT calculations, in-vitro and in-silico studies of novel chromone-isoxazoline conjugates as antibacterial and anti-inflammatory agents by Rachid Bouzammit, Naoufal El Hachlafi, Mohamed El fadili, Mouna El Khabchi, Youssra Kanzouai, Rachid Salghi, Mohammed M. Alanazi, Mohammed Chalkha, Alexandra M. Pop, Emese Gal, Luiza Ioana Gaina, Ghali Al Houari

“…The docking analyses provided insights into the inhibition mechanisms, revealing specific interactions of the synthesized molecules with target proteins relevant to both their antibacterial and anti-inflammatory activities. Finally, density functional theory (DFT)-based calculations were performed to optimize the geometric structures and analyze the structural and electronic properties of the hybrid compounds. …”
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Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy by Qingsong Chen, Tao Li, Tao Zhang, Yue Zhou, Weifeng Huang, Hui Li, Li Shi, Jianxiao Li, Qi Zhang, Man Ma, Pan Wang, Hui Hu, Gongbin Wei, Jiangxia Xiang, Yuan Cheng, Jun Yang, Guangbin Huang, Yongming Li, Dingyuan Du

“…The multifactor regulation network provided insights into complex gene regulatory mechanisms. This study presents a detailed genetic and molecular profile of TIC. …”
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Effect of continuous fiber reinforcement on mechanical and tribological characteristics of cellulose and human hair fiber polymer composites by K․S․Ashraff Ali, Samraj Ravi, Vinayagam Mohanavel, Manikandan Ayyar, Selvakumar Kathiresan, Sathish Kannan, Arunkumar Munimathan, Manzoore Elahi M. Soudagar, Seeniappan Kaliappan

“…Frictional materials present a new challenge in today's automotive and manufacturing sectors as they improve the capacity for self-lubrication while meeting functional criteria like reduced noise, friction, and heat resistance. …”
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Deep-Learning-Based Land Cover Mapping in Franciacorta Wine Growing Area by Girma Tariku, Isabella Ghiglieno, Andres Sanchez Morchio, Luca Facciano, Celine Birolleau, Anna Simonetto, Ivan Serina, Gianni Gilioli

“…Land cover mapping is essential to understanding global land-use patterns and studying biodiversity composition and the functioning of eco-systems. The introduction of remote sensing technologies and artificial intelligence models made it possible to base land cover mapping on satellite imagery in order to monitor changes, assess ecosystem health, support conservation efforts, and reduce monitoring time. …”
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Identification of key modules and hub genes for sepsis-induced myopathy using weighted gene co-expression network analysis by Siming Lin, Siming Lin, Siming Lin, Kexin Cai, Kexin Cai, Kexin Cai, Ai Chen, Weibin Wu, Guili Lian, Shaodan Feng, Shaodan Feng, Zhihong Lin, Zhihong Lin, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie

“…Additionally, we performed functional enrichment analyses using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network approaches.ResultsOur findings revealed that the identified gene clusters predominantly pertained to immune response, inflammation, and apoptosis pathways. …”
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Are cocoa plantations suitable habitats? Network between parasites (Diptera: Hippoboscidea) and hosts (Mammalia: Chiroptera) in cocoa-dominated landscapes of the Brazilian Amazon by Samantha Valente Dias, Rafaela Jemely Rodrigues Alexandre, Letícia Lima Correia, Ludmilla M. S. Aguiar, Gustavo Graciolli, Daniel Maximo Correa Alcantara, Thiago Bernardi Vieira, Thiago Bernardi Vieira

“…Five bat species were present in all three environments, each infested with infracommunities. …”
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Cutaneous dysbiosis in girls with vulvar lichen sclerosus by Liying Sun, Huihui Gao, Hongyu Chen, Chenfei Ren, Junwen Zhang, Qiuxiang Shen, Li Zhu, Dandan Chen, Lingling Jin, Chaoqun Wang, Fengxia Li, Lan Yu

“…Microbial diversity was assessed using α diversity, β diversity, and LEfSe, and functional microbial pathways were predicted. No differences were observed in α diversity among groups. …”
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IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC by Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

“…In vitro and in vivo functional studies were conducted to evaluate the role and mechanisms of IFITM3 in modulating tumor sensitivity to PD-1 inhibitors. …”
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Classification of SERS spectra for agrochemical detection using a neural network with engineered features by Mateo Frausto-Avila, Monserrat Ochoa-Elias, Jose Pablo Manriquez-Amavizca, María del Carmen González-López, Gonzalo Ramírez-García, Mario Alan Quiroz-Juárez

“…Notably, we performed feature engineering to optimize the input data; specifically, we derived 20 key features from transformation functions applied to the SERS spectra. The model demonstrates strong predictive performance, achieving high precision and recall values across all classes, with an overall classification accuracy of 98.5% for organophosphate pesticides and their mixtures. …”
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Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study by Misbah Unnisa, Mahya Faghih, Asbjørn Mohr Drewes, Vikesh K. Singh, Dhiraj Yadav, Rupjyoti Talukdar, Søren Schou Olesen, Anna Evans Phillips

“…Background and Aims: Chronic pancreatitis (CP) is a disease that is present in multiple different geographic populations and is treated similarly around the world. …”
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EarthRanger: An open‐source platform for ecosystem monitoring, research and management by Jake Wall, Jes Lefcourt, Chris Jones, Chris Doehring, Dan O'Neill, Dennis Schneider, Jordan Steward, Joshua Krautwurst, Tiffany Wong, Bruce Jones, Karen Goodfellow, Ted Schmitt, Kathleen Gobush, Iain Douglas‐Hamilton, Frank Pope, Eric Schmidt, Jonathan Palmer, Emma Stokes, Andrea Reid, L. Mark Elbroch, Peter Kulits, Catherine Villeneuve, Victor Matsanza, Geoff Clinning, Jordi vanOort, Kristen Denninger Snyder, Alina Peter Daati, Wesley Gold, Stephen Cunliffe, Batian Craig, Barry Cork, Grant Burden, Marc Goss, Nathan Hahn, Sarah Carroll, Eric Gitonga, Ray Rao, Jared A. Stabach, Frédéric Dulude‐de Broin, Patrick Omondi, George Wittemyer

“…EarthRanger consists of seven main components (Core Server, API, Storage, Gundi, Web App, Mobile App, Ecoscope) that provide functionality for data (i) aggregation & collection, (ii) storage & management, (iii) real‐time and post hoc analysis, (iv) visualisation and (v) dissemination. …”
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Proteomics signatures associated with hip arthropathy in ankylosing spondylitis by Xianghui Wen, Xianghui Wen, Linkai Fang, Zena Chen, Dong Liu, Shenghui Wen, Jinwei Li, Qiuxia Li, Qiujing Wei, Shuangyan Cao, Peng Zhang, Jieruo Gu, Jieruo Gu

“…Enriched GO terms represented by DAPs included the Wnt signaling pathway, MAPK cascade, and antigen processing and presentation of exogenous peptide antigen via MHC class I. …”
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A multicenter validation and calibration of automated software package for detecting anterior circulation large vessel occlusion on CT angiography by Kyu Sun Yum, Jong-Won Chung, Sue Young Ha, Kwang-Yeol Park, Dong-Ick Shin, Hong-Kyun Park, Yong-Jin Cho, Keun-Sik Hong, Jae Guk Kim, Soo Joo Lee, Joon-Tae Kim, Woo-Keun Seo, Oh Young Bang, Gyeong-Moon Kim, Myungjae Lee, Dongmin Kim, Leonard Sunwoo, Hee-Joon Bae, Wi-Sun Ryu, Beom Joon Kim

“…The category of LVO probabilities was associated with follow-up infarct volumes and functional outcome. Conclusion In this multicenter study, we proved the clinical efficacy of the software in detecting LVO on CTA.…”
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Three Decades of Land Cover Dynamics in a Boreal Coastal Basin: A Multisensor Spectral Index and Machine Learning Approach Using Landsat Data and GB-SAR Data by Jinsong Zhang, Bochi Zou, Yifei Yuan, Asad Khan, Muhammad Bilawal Junaid, Qaiser Abbas, Rana Muhammad Zulqarnain, Nazih Y. Rebouh, Olga D. Kucher, Hassan Alzahrani

“…Boreal coastal habitats, with their complex hydrological, ecological, and geological functions, play a pivotal role in regulating regional climate, supporting biodiversity, and sustaining local communities. …”
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Identification of gastroenteropancreatic neuroendocrine tumor patients with high liver tumor burden based on clinicopathological features by Nuerailaguli Jumai, Luohai Chen, Xiaoxuan Lin, Qiao He, Man Liu, Yuan Lin, Yanji Luo, Yu Wang, Min-hu Chen, Xiangsong Zhang, Zhirong Zeng, Ning Zhang

“…Abstract Background Metastatic liver tumor burden (LTB) is a prognostic factor affecting the survival of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), but evaluation of the LTB usually depends on radiologic and functional imaging. This study aimed to develop a clinical model based on easily accessible clinicopathological markers to predict LTB level in GEP-NET patients. …”
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<i>PRKAG2</i> Syndrome: Clinical Features, Imaging Findings and Cardiac Events by Maria Sudomir, Przemysław Chmielewski, Grażyna Truszkowska, Mariusz Kłopotowski, Mateusz Śpiewak, Marta Legatowicz-Koprowska, Monika Gawor-Prokopczyk, Justyna Szczygieł, Joanna Zakrzewska-Koperska, Mariusz Kruk, Jolanta Krzysztoń-Russjan, Jacek Grzybowski, Rafał Płoski, Zofia T. Bilińska

“…At the first evaluation, 3 carriers were in New York Heart Association (NYHA) functional class II–III, while the remaining were in NYHA class I. …”
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Viscoelastic to elastic transformation of soft polymer properties for accelerated materials selection based on tissue dynamics in tissue engineering applications by Kamil Elkhoury, Guan-Lin Chen, Erfan Noorbakhsh Noshahri, Julio Zuazola, Nikhil Gupta, Sanjairaj Vijayavenkataraman

“…This dynamic behavior is critical for tissue functionality, influencing the design of biomaterials for tissue engineering. …”
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Prenatal diagnosis of a compound heterozygous variation in the FBXL4 gene by trio-WES and imaging monitoring: a case report by Yujia Zhai, Yujia Zhai, Jing Chen, Jing Chen, Shuo Yang, Shuo Yang, He Wang, He Wang, Yuanyuan Xiao, Yuanyuan Xiao, Shanling Liu, Shanling Liu

“…The variations in the FBXL4 gene can give rise to encephalomyopathy mitochondrial DNA depletion syndrome-13 (MTDPS13) characterized by the reduction of mtDNA copy number, leading to deficiencies in mitochondrial functions, which is a serious and rare autosomal recessive genetic disorder. …”
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Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of <i>Mycobacterium tuberculosis</i> by Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan

“…<i>Results</i>: Our findings reveal that the substrate-binding domain (SBD) of IrtA functions as an active monomer, while Rv2895c, which facilitates the uptake of siderophore-bound iron, exists in a dynamic equilibrium between dimeric and monomeric forms. …”
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Domestication is an excellent model for studying adaptation processes, involving recent adaptation and diversification, convergence following adaptation to similar conditions, as well as degeneration of unused functions. Geotrichum candidum is a fungus used for cheese making and is also found in other environments such as soil and plants. …”
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