Genetic insights from whole-exome sequencing in Moroccan patients with non-small cell lung cancer: a case report by Meryem Fakhkhari, Manikandan Vinu, Houda Chaibi, Mame Massar Dieng, Meryem Chebak, Khadija Hajjout, Rachida Zahraoui, Nawal Bouyahyaoui, Jamal-Eddine Bourkadi, Youssef Idaghdour, Khalid Sadki

“…This study aimed to investigate the genetic susceptibility and molecular alterations associated with NSCLC in Moroccan patients. Cases Presentation Whole-exome sequencing (WES) was performed on three Moroccan patients diagnosed with NSCLC, recruited from Moulay Youssef Hospital in Rabat, using the Illumina HiSeq System. …”
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A Spatial Decision Support System for climate-adapted agriculture designed with and for stakeholders in West Africa by Katrin Ziegler, Daniel Abel, Lorenz König, Torsten Weber, Insa Otte, Mike Teucher, Christopher Conrad, Michael Thiel, Imoleayo Ezekiel Gbode, Vincent Olanrewaju Ajayi, Amadou Coulibaly, Seydou B. Traoré, Benewinde Jean-Bosco Zoungrana, Heiko Paeth

“…This paper presents a Spatial Decision Support System (SDSS) designed to assist stakeholders in West Africa in analysing critical climate and land use indicators for risk management in agriculture and further sectors being affected by extreme precipitation and temperature events. …”
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Combining discotic mesogens with AIE luminogens for advanced optoelectronic applications: Design, synthesis, mesomorphism, self-assembly and optical properties of tetraphenylethyle... by Hang Lin, Ke-Xiao Zhao, Bi-Qin Wang, Ping Hu, Ke-Qing Zhao, Bertrand Donnio

“…The combination of different molecular entities with their own and specific functionalities within a single molecule enables the generation of potentially original multifunctional materials with unique properties and a broad range of applications across various fields. …”
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CK2α Deletion in the Hematopoietic Compartment Shows a Mild Alteration in Terminally Differentiated Cells and the Expansion of Stem Cells by Rajesh Rajaiah, Muhammad Daniyal, Marudhu Pandiyan Shanmugam, Hannah Valensi, Koby Duke, Katherine Mercer, Morgann Klink, Matthew Lanza, Yasin Uzun, Suming Huang, Sinisa Dovat, Chandrika Gowda Behura

“…Casein Kinase II (CK2) is a ubiquitously present serine/threonine kinase essential for mammalian development. …”
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Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria by Hazim O. Khalifa, Hazim O. Khalifa, Atef Oreiby, Atef Oreiby, Temesgen Mohammed, Mohamed A. A. Abdelhamid, Mohamed A. A. Abdelhamid, Essam Nageh Sholkamy, Hamada Hashem, Ragab M. Fereig, Ragab M. Fereig

“…The escalating prevalence of multidrug-resistant (MDR) bacteria presents a critical global health challenge, necessitating the urgent development of alternative antimicrobial strategies. …”
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Differences in virulence and drug resistance between Clostridioides difficile ST37 and ST1 isolates by Zirou Ouyang, Jing Yang, Huimin Zhang, Min Zhao, Huimin Yang, Jiafeng Zhao, Yaxuan Yang, Cuixin Qiang, Zhirong Li, Pu Qin, Weigang Wang, Yanan Niu, Jianhong Zhao

“…Although C. difficile ST37 only produces a functional toxin B, it causes disease as severe as that caused by hypervirulent ST1. …”
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Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal by Carley N Gray, Manickam Ashokkumar, Derek H Janssens, Jennifer L Kirchherr, Brigitte Allard, Emily Hsieh, Terry L Hafer, Nancie M Archin, Edward P Browne, Michael Emerman

“…We found that INTS12 is present on chromatin at the promoter of HIV and therefore its effect on HIV may be direct. …”
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Using Landscape Metrics of Pixel Scale Land Cover Extracted from High Spatial Resolution Images to Classify Block-Level Urban Land Use by Haofeng Luo, Xiaomei Yang, Zhihua Wang, Yueming Liu, Huifang Zhang, Ku Gao, Qingyang Zhang

“…It can be achieved in the form of high-frequency full coverage without biases based on the data of high-spatial-resolution remote sensing images (HSRRSIs), which social sensing data like POI data or mobile phone data cannot provide. However, at present, the extraction of quantitative features from HSRRSIs for BLULUC primarily relies on computer vision or deep learning methods based on image signal characteristics rather than land cover patterns, like vegetation, water, or buildings, thus disconnecting existing knowledge between the landscape patterns and their functions as well as greatly hindering BLULUC by HSRRSIs. …”
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Performance of Ankle Exoskeletons on Irregular Terrains: Key Design Principles and Benchmarking Tests by L. Liguori, G. Mariani, J. Taborri, I. Mileti, D. Torricelli, L. Mattioli, E. Palermo, F. Patane, S. Rossi

“…Specifically, the first prototype (S-RANK) accommodates a single DoF in the sagittal plane, whereas the second prototype (M-RANK) extends the functionality to include ankle inversion/eversion and internal/external rotation. …”
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ICP-Based Mapping and Localization System for AGV with 2D LiDAR by Felype de L. Silva, Eisenhawer de M. Fernandes, Péricles R. Barros, Levi da C. Pimentel, Felipe C. Pimenta, Antonio G. B. de Lima, João M. P. Q. Delgado

“…This work presents the development of a functional real-time SLAM system designed to enhance the perception capabilities of an Automated Guided Vehicle (AGV) using only a 2D LiDAR sensor. …”
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Effect of metabolic disorders on reactive gliosis and glial scarring at the early subacute phase of stroke in a mouse model of diabetes and obesity by Julien Clain, David Couret, Matthieu Bringart, Olivier Meilhac, Christian Lefebvre d’Hellencourt, Nicolas Diotel

“…It nevertheless raises the question of the functional integration of the new neurons in db/db mice given the observed dense ECM, known to be repulsive for neuronal migration. …”
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Cross-linking of fungal β-glucosidase on Al2O3 nanocrystals synthesized using Cajanus cajan L. Millsp. extracts for in suit genistein manufacture by Sikander Ali, Afra Ejaz, Muhammad Umar Hayyat, Muhammad Usman Ahmad, Zafar Siddique, Baber Ali, Sezai Ercisli, Tabarak Malik, Reem M. Aljowaie, Mohamed Soliman Elshikh, Muhammad Ammar Javed

“…Abstract This present study deals with the cross-linking of fungal β-glucosidase on Al2O3 nanocrystals (NCs) synthesized in C. cajan for in-suit genistein production. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…A protein-protein interaction (PPI) network was then constructed, and core targets were screened with the Cytoscape plug-in. Molecular functions and pathways were analyzed through GO and KEGG pathway enrichment analyses. …”
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Effect of regional nerve block on tourniquet-related injury in pediatric patients undergoing lower limb surgery: a randomized controlled study by Qin Xia, Rui Chen, Chao Lin, Bohan Zhang, Liuyan Zhou, Jingnan Xiong, Zhou Lv, Yanfei Mao, Rongrong Ren

“…However, few studies have explored their effectiveness in mitigating tourniquet-related injuries and promoting functional recovery in lower limb surgery patients.Methods : Sixty-four pediatric patients aged 6–12 undergoing knee arthroscopic surgery under general anesthesia. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…Next, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate associated biological functions and signaling pathways. Meanwhile, molecular docking between core targets and SSA was performed using Autodock software. …”
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Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease by Lisa Budzinski, Gi-Ung Kang, René Riedel, Toni Sempert, Leonie Lietz, René Maier, Janine Büttner, Bettina Bochow, Marcell T. Tordai, Aayushi Shah, Amro Abbas, Tanisha Momtaz, Jannike L. Krause, Robin Kempkens, Katrin Lehman, Gitta A. Heinz, Anne E. Benken, Stefanie Bartsch, Kathleen Necke, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen, Tilmann Kallinich, Tobias Alexander, Bosse Jessen, Carl Weidinger, Britta Siegmund, Andreas Radbruch, Anja Schirbel, Benjamin Moser, Hyun-Dong Chang

“…In addition, we identified phenotypic signatures in the CD microbiota which not only reflected remission after 6 weeks of anti-TNF treatment, but were also able to predict remission before the start of an adalimumab treatment course in a pilot study. We here present the proof-of-concept demonstrating that multi-parameter single-cell bacterial phenotyping by mMFC could be a novel tool with high translational potential to expand current microbiome investigations by phenotyping of bacteria to identify disease- and therapy-associated cellular alterations and to reveal novel target properties of bacteria for functional assays and therapeutic approaches.…”
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Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy by Hongyan Li, Rong Gan, Jiadi Liu, Duling Xu, Qiyue Zhang, Haidong Tian, Huijun Guo, Haijun Wang, Zhimin Wang, Xianwu Zeng

“…Peptide-conjugated PEGlated liposomes containing Dox (peptide-Lipo@Dox) were prepared for radionuclide and drug delivery. Glioma cell functions were determined based on cell cycle and viability, apoptosis, cell invasion and migration, and colony-formation assays. …”
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Repurposing statins for the treatment of larval cestodiases: in silico evaluation of statin-HMG-CoA reductase interactions and assessment of statin effects on a cestode model by Marina Monteiro Guedes, Jeferson Camargo de Lima, Jéssica Andrade Paes, María del Pilar Cevasco Contreras, Ana María Celentano, Arnaldo Zaha, Karina Mariante Monteiro, Mara Cecilia Rosenzvit, Henrique Bunselmeyer Ferreira

“…Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a main enzyme in the mevalonate pathway, which is vital for the synthesis of non-steroidal isoprenoids and the maintenance of normal cell functioning. A survey for HMG-CoA reductase encoding genes showed that they are present in a single copy in the genomes of parasitic helminths and their mammal hosts. …”
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Synergistic potential of bone marrow mesenchymal stem cells and miR181-a combinational therapy against multiple sclerosis by Xin Xiu, Sijia Chen, Yumei Liu, Bo Sun, Hulun Li, Sifan Zhang, Xixi Yang, Yu Wei, Xichen Peng, Yan Wang, Yanping Wang, Junfeng Wu, Yao Zhang, Lili Mu, Qingfei Kong, Xijun Liu

“…Bone marrow mesenchymal stem cells (BMSCs), exhibiting neuroimmune-modulatory functions to alleviate various autoimmune diseases, show great potential in the treatment of MS. …”
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Exploring the Potential of a New Nickel(II):Phenanthroline Complex with L-isoleucine as an Antitumor Agent: Design, Crystal Structure, Spectroscopic Characterization, and Theoretic... by Jayson C. dos Santos, João G. de Oliveira Neto, Ana B. N. Moreira, Luzeli M. da Silva, Alejandro P. Ayala, Mateus R. Lage, Rossano Lang, Francisco F. de Sousa, Fernando Mendes, Adenilson O. dos Santos

“…This study presents the synthesis, physicochemical characterization, and biological evaluation of a novel ternary nickel(II) complex with isoleucine and 1,10-phenanthroline ligands, [Ni(Phen)(Ile)₂]∙6H₂O, designed as a potential antitumor agent. …”
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