Evaluation of Efficacy and Safety of Etanercept and Etanercept + Methotrexate Therapy in Patients with Juvenile Idiopathic Arthritis without Systemic Manifestations by T. M. Bzarova, Ye. I. Alekseeva, S. I. Valieva, R. V. Denisova, K. B. Isaeva, Ye. G. Chistyakova, A. M. Chomakhidze, T. V. Sleptsova, A. N. Fetisova, O. L. Lomakina, M. A. Soloshenko

“…Background: At present, it is urgent to find ways to overcome the inefficiency of and intolerance to the methotrexate therapy in patients with juvenile idiopathic arthritis (JIA). …”
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A progressive knowledge strategy for monitoring soil microbiological activity by microscale spectroscopic detection by Heidy Soledad Rodríguez-Albarracín, José A.M. Demattê, Nícolas Augusto Rosin, Jorge Tadeu Fim Rosas, Aquiles Enrique Darghan, Hudson Wallace Pereira de Carvalho

“…Distinct spectral features associated with enzymatic activity were identified with R2 ranging from 0.45 to 0.7, particularly in the functional groups CH, NH, CO, COH, and PO. Beta-glucosidase activity was linked to labile SOM compounds, displaying pronounced peaks in the POM fraction that were markedly reduced in the MAOM fraction. …”
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Quantifying Land Subsidence Probability and Intensity Using Weighted Bayesian Modeling in Shanghai, China by Chengming Jin, Qing Zhan, Yujin Shi, Chengcheng Wan, Huan Zhang, Luna Zhao, Jianli Liu, Tongfei Tian, Zilong Liu, Jiahong Wen

“…In this study, we employ a weighted Bayesian model to explicitly present the spatial distribution of land subsidence probability and map hazard zoning in Shanghai. …”
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Cannabis sativa genotypes with larger leaf areas have higher potential to adjust stomatal size and density in response to water deficit: The effect on stomatal conductance and phys... by Matthew Haworth, Andrea Carli, Vincenzo Montesano, Dilek Killi, André Fabbri, Raffaella Balestrini, Giovanni Marino, Mauro Centritto

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Building a virtual community of practice for medical students: The Global Emergency Medicine Student Leadership Program by Ashley Pickering, Andrés Patiño, Stephanie C. Garbern, Dania Abu‐Jubara, Alexandra Digenakis, Anthony Rodigin, Michaela Banks, Kimberly Herard, Stacey Chamberlain, Elizabeth L. DeVos

“…GEM‐SLP fosters relationships through (1) themed mentoring calls (career paths, work/life balance, etc); (2) functional mentorship through didactics and academic projects; and (3) near‐peer mentoring, provided by mentors near the mentees’ stage of education and experience. …”
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PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2/GPX4 axis by Qiang Zheng, Jihong Xing, Xiaozhou Li, Xianming Tang, Dongshan Zhang

“…PLGA-encapsulated formononetin presents a promising therapeutic approach.…”
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Coastal carbon at risk: forecasting the impacts of sea-level rise on future land cover by Mojtaba Tahmasebi, Julie Bruck, Michael Volk, Emre Tepe, Abhinav Alakshendra, Afsheen Sadaf, Jack A. Puleo

“…By quantifying the ecological and economic consequences of SLR-driven LC change, this study advances the understanding of carbon dynamics in vulnerable coastal landscapes and reinforces the necessity of proactive management to sustain their climate-regulating functions.…”
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The Influence of the ACTN3 R577X Genotype on Performance in Brazilian National-Level Decathlon Athletes: A Pilot Study by Jose Ricardo de Assis Nunes, Halil Ibrahim Ceylan, Paulo F. de Almeida-Neto, Eugenia Murawska-Ciałowicz, Nicola Luigi Bragazzi, Gilmara Gomes de Assis

“…Background: Decathlon is a multimodality sport that requires the combination of endurance, strength, speed, and agility. A polymorphism present in the gene encoding for alpha-actinin-3 (<i>ACTN3</i>) potentially influences sports performance, since this protein is a structural component of skeletal muscle contributing to muscle contraction effectiveness. …”
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Methyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction by Huimei Huang, Chuman Huang, Yinghua Li, Xingwei Liang, Namhyung Kim, Yongnan Xu

“…Studies indicate that MP functions as an endocrine-disrupting compound with estrogenic properties, negatively affecting mitochondrial bioenergetics and antioxidant activity in testicular germ cells. …”
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Therapeutic apheresis in the complex pathogenetic therapy of anti-NMDA encephalitis associated with ovarian teratoma at a late stage of the disease by S. N. Bardakov, D. I. Skulyabin, A. N. Moshnikova, S. V. Lapin, A. A. Sokolov, E. A. Kondratyeva, T. V. Bulgakova, A. S. Manuilov, M. V. Zakharov, A. N. Belskikh, V. A. Tsargush, R. V. Deev

“…Symptom regression was achieved by the end of the first cycle, and full recovery to the initial level of cognitive functions occurred after the second cycle, while maintaining the anti‑NMDA antibody titer to 1:160. …”
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ROC analysis determines optimal cutoff and doubtable interval of the Bath ankylosing spondylitis metrology index in a multicenter case control study by Genggeng Guo, Juanjuan He, Jianwen Liu, Xiaoye Yan, Meng Zhou, Chenmin Wu, Diantian Lin, Zhihan Chen, Qing Yan, Fei Gao, Zugang Xie, Feng Huang, Shengli Zhang

“…We subsequently prepared the BASMI ROC curve, calculated the Youden index, and determined the optimal cutoff value and doubtable value interval. In the present study, 246 patients with AS (patient group) and 246 healthy controls (control group) were recruited. …”
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Natural pigments: innovative extraction technologies and their potential application in health and food industries by Ayu Masyita, Gemala Hardinasinta, Ayun Dwi Astuti, Firdayani Firdayani, Dian Mayasari, Aki Hori, Ira Nur Ainun Nisha, Firzan Nainu, Takayuki Kuraishi

“…Natural pigments, or natural colorants, are frequently utilized in the food industry due to their diverse functional and nutritional attributes. Beyond their color properties, these pigments possess several biological activities, including antioxidant, anti-inflammatory, anticancer, antibacterial, and neuroprotective effects, as well as benefits for eye health. …”
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Characteristics of patients with chronic heart failure with mildly reduced ejection fraction: clinical and demographic aspect by M. T. Duishenalieva, A. G. Polupanov, F. T. Rysmatova, E. Zh. Myrzabekova, N. E. Esenbekova, N. Ch. Cholponbekova, E. Sh. Altymyshova, A. T. Arykova, N. B. Cheskidova, E. D. Djyshambaev

“…Patients with functional class III (NYHA) predominated among those with HFmrEF (54,5 %) and HFrEF (56,3 %).Conclusion. …”
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Repeated intestinal perforations in vascular Ehlers-Danlos syndrome: a case report of a novel mutation in the COL3A1 gene by Taichi Horino, Yuji Miyamoto, Mayuko Ohuchi, Katsuhiro Ogawa, Naoya Yoshida, Takatoshi Ishiko, Chieko Kukinaka, Rumi Sasaki, Takashi Ohba, Hideo Baba

“…In addition, she was diagnosed with small bowel perforation 53 days after the first operation and consequently underwent a third operation—partial resection of the jejunum with functional end-to-end anastomosis. Fifty-eight days after the first operation, she complained of acute abdominal pain. …”
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Massage positively influences daytime brain activity and reduces arousal state in poor sleepers: a randomized controlled trial by Ilias Ntoumas, Christina Karatzaferi, Fotini Boubougiatzi, Nefeli Manakou, Artemis Aslanidi, Christoforos D. Giannaki, Fotini Papanikolaou, Efthimios Dardiotis, Eleftherios Lavdas, Giorgos K. Sakkas

“…Brain activity was monitored using a polysomnography EEG system, while vitals and relaxation/stress state were assessed by validated questionnaires and functional tests. The Pittsburgh Sleep Quality Index Score > 5 was used as cut off for distinguishing poor sleeper. …”
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Bleomycin Electrosclerotherapy (BEST) for Slow-Flow Malformations of the Upper Aerodigestive Tract by Veronika Vielsmeier, Vanessa F. Schmidt, Florian Obereisenbuchner, Natascha Platz Batista da Silva, Walter A. Wohlgemuth, Daniel Puhr-Westerheide, Max Seidensticker, Jens Ricke, Thomas Kühnel, Christopher Bohr, Moritz Wildgruber, Caroline T. Seebauer

“…Postprocedural complications and functional outcomes were systematically recorded. <b>Results:</b> A total of 29 BEST sessions were performed. …”
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Bio-orthogonally double cross-linked alginate-gelatin hydrogels with tunable viscoelasticity for cardiac tissue engineering by Daniele Testore, Alice Zoso, Camilla Paoletti, Sara Groppo, Elena Marcello, Valeria Chiono

“…Alginate and gelatin were functionalized with azide groups and cross-linked by a 4-arm-dibenzocyclooctyne (DBCO) crosslinker using strain-promoted azide-alkyne cycloaddition (SPAAC) with 0.5:1 (AG_Click(R0.5)) and 1:1 (AG_Click(R1)) DBCO:azide molar ratios. …”
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Dietary Supplementation with Algae Powders and Carotenoids Enhances Growth Performance and Tissue-Specific Carotenoid Accumulation in Penaeus Vannamei by Pujiang Liu, Chengwei Huang, Qian Shen, Qijun Luo, Rui Yang, Haimin Chen, Wei Wu, Juanjuan Chen

“…These findings suggest that targeted supplementation of algal-derived carotenoids can enhance both growth and pigmentation in <i>P. vannamei</i>, providing a theoretical basis for the development of functional feeds to improve shrimp commercial quality.…”
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Mir-218-5p from Extracellular Vesicles of Endometrium in Patients with Recurrent Implantation Failure Impairs Pre-Implantation Embryo Development by Cai L, Lv M, Wei J, Liu C, Li Y, Liao Z, Li T, Zhang H, Xi L, Sui C

“…In this study, we discovered that miR-218-5p is one of the functional molecules inside the RIF-EVs, and it disrupts the development of the embryo into a blastocyst. …”
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Transcriptomic Profiles for Elucidating Response of Bladder Intracavitary Hyperthermic Perfusion Chemotherapy in High‐Risk Nonmuscular Invasive Bladder Cancer by Zhicheng Huang, Tianhui Zhang, Jinghua Pan, Guihao Zhang, Linjun Jiang, Huiming Jiang, Pei Wan, Ying Peng, Wenchao Zou, Qinghua Liu, Nanhui Chen

“…Gene ontology and pathway analysis were conducted to explore the biological functions and pathways enriched in the DEGs. Additionally, the expression of specific immune‐related genes was evaluated for their association with HIPEC response. …”
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