Altered IgG <i>N</i>-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab <i>N</i>-Glycans by Branimir Plavša, Najda Rudman, Flemming Pociot, Olga Gornik

“…<b>Background</b>: <i>N</i>-glycosylation is a post-translational modification involving the attachment of oligosaccharides to proteins and is known to influence immunoglobulin G (IgG) effector functions and even antigen binding. IgG contains an evolutionarily conserved <i>N</i>-glycosylation site in its fragment crystallizable (Fc) region, while during V-D-J recombination and somatic hypermutation processes it can also obtain <i>N</i>-glycosylation sites in its antigen binding fragment (Fab). …”
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Effectiveness of acute in-hospital physiotherapy with knee-extension strength training in reducing strength deficits in patients with a hip fracture: A randomised controlled trial. by Lise Kronborg, Thomas Bandholm, Henrik Palm, Henrik Kehlet, Morten Tange Kristensen

“…The present data provides an important basis and call for future investigations including longer term interventions.…”
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Study protocol for the validation of a new patient-reported outcome measure (PROM) of listening effort in cochlear implantation: the Listening Effort Questionnaire-Cochlear Implant... by Frances Rapport, Alan Watkins, Sarah E Hughes, Isabelle Boisvert, Catherine M McMahon, Hayley A Hutchings

“…Dissemination will be in high-quality journals, conference presentations and SEH’s doctoral dissertation.…”
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Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells. by Kumar N Alagramam, Richard J Goodyear, Ruishuang Geng, David N Furness, Alexander F J van Aken, Walter Marcotti, Corné J Kros, Guy P Richardson

“…Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present report describes functional and structural analyses of hair cells from Pcdh15(av3J) (av3J), Pcdh15(av6J) (av6J) and Cdh23(v2J) (v2J) mice. …”
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Effect of Melatonin on Oxaliplatin Induced Neuropathy in Patients Receiving Folfox Chemotherapy Regimens for Stage II–IV Colorectal Cancer: A Randomized, Placebo Controlled, Double... by Raziyeh Kheshti, Mehdi Dehghani, Soha Namazi, Dena Firouzabadi, Laleh Mahmoudi, Elham Haem

“…Conclusion Reduction in grade 3 neuropathy based on NCI‐CTCAE and OSS can be of great importance, as it is the higher‐grade neuropathy that may lead to functional impairment. Given that to date no medication has been approved for prevention of OXIPN and considering the limited number of patients in the present study, conducting a larger clinical trial on the effect of melatonin may lead to beneficial results in this group of patients. …”
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Factors predicting rehabilitation outcome in patients after unilateral transtibial amputation due to peripheral vascular disease by Majstorović Biljana, Pešta Mladen

“…Male patients had better functional results compared to females obtained by all analysed outcome measures (p < 0.01). …”
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Method and verification of strength determination for dense filling coal mining filling body in comprehensive mechanized unit by Pengliang LIU, Xiaoqing WANG

“…The comprehensive mechanized unit dense filling coal mining technology combines the functions of rock movement control and solid waste disposal, and has advantages such as parallel mining and filling, flexible process, and low investment. …”
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Minimally invasive biportal endoscopic spinal surgery for central canal stenosis in low-grade degenerative lumbar spondylolisthesis: clinical outcomes and implications: a retrospec... by Wongthawat Liawrungrueang, Ho-Jin Lee, Sang Bum Kim, Sang Hyeok Lee, Sang Shin Lee, Ju-Eun Kim

“…It offers substantial symptom relief and functional improvement without jeopardizing spinal stability, making it a viable alternative to conventional fusion surgery.…”
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Analysis of Antioxidant Activity and Volatile Components in Rapeseed Flower-Enriched Persimmon Wine by Zhijie Li, Kaishuo Sun, Yanyan Wang, Fang Yu, Zhiwen Liu

“…This study employed Luotian sweet persimmons and Brassica napus (rapeseed) as core ingredients for producing functional fermented wine. Using GC-MS, rapeseed polysaccharides were subjected to trifluoroacetic acid hydrolysis and then derivatized via silylation for qualitative analysis of their monosaccharide composition. …”
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Portulaca oleracea (purslane) aqueous extract reduced the adverse metabolic outcomes and favored liraglutide activities in streptozotocin-induced cardiometabolic disorders of male... by Adewumi O. Oyabambi, Blessing B. Aindero, Adeoba M. Awolola, Aisha Y. Adebayo, Ifeoluwa B. Iluromi, Kehinde S. Olorunniyi

“…Portulaca oleracea resulted in reduced plasma fasting blood glucose (FBG), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF- α) and increased pancreatic beta cell functions (HOMA-B) compared to the diabetic rats (p < 0.05). …”
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Regulation of mesenchymal stem cell-derived exosomes on helper T cells in periodontitis by WEN Yuqi, GUO Shujuan, DING Yi

“…In addition, microRNAs exhibit immunoregulatory functions: periodontal ligament stem cell-derived exosomes contain miRNA-155-5p, which targets sirtuin-1 to suppress Th17 cell differentiation. …”
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Simulation Model to Optimize Turnover Schedule for Train Locomotives by P. A. Kozlov, S. P. Vakulenko

“…It is first time the problem was formulated as a strict optimization model - a dynamic transportation problem. On the functional level, the main goal was to minimize overall costs which are directly related to locomotives operation and to losses due to train delays. …”
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Identification of Ascorbate Oxidase Genes and Their Response to Cold Stress in <i>Citrus sinensis</i> by Xiaoyong Xu, Xingchen Miao, Naiyi Deng, Mengge Liang, Lun Wang, Lijuan Jiang, Shaohua Zeng

“…Phylogenetic analysis categorized the <i>CsAAO</i> family into three main clades (Clade A–C), suggesting distinct biological functions. Collinearity and Ka/Ks analysis revealed three duplicate gene pairs within the <i>CsAAO</i> gene family, with all duplicated CsAAOs primarily evolving under purifying selection. …”
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fMRI study of brain activation associated with earnings management techniques in proximity to debt covenant violations by Hassan R. HassabElnaby, Ahmed Abdel-Maksoud, Amal Said, Andrew S. Cotton, Ashley Y. Wang, Haitham Elsamaloty

“…During the fMRI scans, fifty participating business managers read the text presentations of multiple scenarios where companies were at different proximities (FAR or CLOSE) to debt covenant violations. …”
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Development of enterprise architecture management methodology for teaching purposes by Dmitry V. Kudryavtsev, Evgeny P. Zaramenskikh, Maxim Y. Arzumanyan

“…Enterprise architecture allows describing, analyzing and designing the company from the point of view of its structure, functioning and goal setting (motivation).In the context of this approach, the enterprise is viewed as a system of services, processes, goals and performance indicators, organizational units, information systems, data, technical facilities, etc. …”
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Effect of ultrasonication and use of aminopeptidase from Aeromonas proteolytica on quality parameters of fish protein hydrolysates from side streams of Atlantic mackerel (Scomber s... by Janna Cropotova, Kristine Kvangarsnes, Janne Stangeland, Amélie Le Gall, Turid Rustad

“…In the present study, both ultrasonication (US) and enzymatic treatment with aminopeptidase from Aeromonas proteolytica (AAP) were applied as a post-treatment to fish protein hydrolysates (FPH) recovered from Atlantic mackerel. …”
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Evaluation of university sports culture in the new era, based on philosophical context by Ming Lei, Hong Ma

“…However, in the new era, university sports culture presents problems, such as valuing intelligence over physical fitness, lacking in sports culture concepts, and separating spirit and material. …”
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TREATMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA ACCORDING ON THE SPECIFIC MOLECULAR FEATURES OF THE TUMOR (A LITERATURE REVIEW) by A. I. Stukan, R. A. Murashko, V. N. Bodnya, O. Yu. Chukhray, E. V. Dulina

“…Intratumoral heterogeneity should be taken into account when implementing new treatment approaches. We present an overview of studies published between 1989 and 2014. …”
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Secure Biometric Identification Using Orca Predators Algorithm With Deep Learning: Retinal Iris Image Analysis by Louai A. Maghrabi, Mohammed Altwijri, Sami Saeed Binyamin, Fouad Shoie Alallah, Diaa Hamed, Mahmoud Ragab

“…The retina and iris are exclusive and constant functional features of the human eye that can be employed for individual identification. …”
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Label-free masterful spectrofluorimetric systems for minuscule tracking of natural antioxidant vincamine in the pharmaceutical, environmental, and biological samples: Comparative g... by Eman Yosrey, Heba Elmansi, Shereen Shalan, Jenny Jeehan Nasr

“…In this work, we present two label-free spectrofluorimetric systems for the swift quantification of vincamine (VN) in various matrices without the need for knotty fluorescent dyes, drastic conditions, or expensive instrumentation, which are key merits of the quantifying procedures. …”
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